Pain in the abdominal cavity is often associated with disorders of intestinal motility. Spasms of the muscles of both the small and large intestines lead to difficulty passing stool and abdominal pain. Trimedat successfully relieves unpleasant symptoms by normalizing intestinal muscle tone.
pharmachologic effect
Myotropic antispasmodic that regulates the motility of the digestive system. The active substance affects the enkephalinergic system of the intestine and regulates peristalsis. Trimebutine has an antispasmodic effect in hyperkinesis of smooth muscle tissue of the digestive tract, and in hypokinetic conditions it stimulates intestinal function.
The drug enhances peristalsis and promotes gastric emptying, reduces pressure on the esophageal sphincter, acts throughout the intestine, enhances the response of the smooth muscle tissue of the large intestine to various food irritants.
For diseases of the digestive tract associated with impaired motility, trimebutine helps restore the physiological activity of the intestine.
Trimedat
Trimedat (active ingredient trimebutine) is a domestic pharmaceutical drug whose main pharmacological function is the regulation of gastrointestinal motility (GIT). It is used for various functional diseases of the digestive system, dyspeptic disorders, as well as for the recently widespread irritable bowel syndrome (its universal markers are abdominal pain and colic, intestinal spasms, increased gas formation, diarrhea or constipation). Trimedat acts throughout the digestive tract, including the bile ducts along with the gallbladder. In clinical practice, there are often cases of patients having diverse motor disorders of the gastrointestinal tract, with a predominance of various pathogenetic components. To identify a specific type of disorder, complex and not always accessible instrumental studies are required for a wide range of patients, such as: endoscopic manometry of the sphincter of Oddi, study of the motor function of the digestive tract with radioactive gold, etc. The lion's share of motor dysfunctions have a complex pathogenesis, so a gastroenterologist simply must have drugs in his arsenal that can have a beneficial effect on motor skills, regardless of what type of disorder occurs in this particular case. Trimedat is one such medicine. It eliminates both hypomotor and spastic dyskinesia of the intestines and biliary tract. Such universalism of trimedat makes it possible to influence the pathological process at its very initial stage and reduce the volume of necessary diagnostic interventions (as well as, of course, their cost).
The substance trimebutine was synthesized in France in 1969 and for many years was known under the trade name debridate.
In 2008, the Russian pharmaceutical company entered the market with its new brainchild - the drug trimedat, which was created on the basis of trimebutine. Trimedat interacts with peripheral opiate receptors, “scattered” throughout the gastrointestinal tract. They are located mainly in the nerve plexuses of the intestine. Among the opiate receptors, there are 3 subtypes: mu-, delta- and kappa. The first two are responsible for conducting excitation, and the last one is responsible for inhibition. Trimedat does not have an affinity for any one subtype of receptor, interacting with all of them at once. Being normokinetic, it has a dual regulatory effect. By binding to kappa receptors, trimedate suppresses motor activity, and by performing the same action in relation to mu and delta receptors, it stimulates it. Thus, trimedate, depending on the circumstances (read: the initial state of the motor function of the digestive tract), can act both as an antispasmodic and as a prokinetic. Trimedat affects the humoral regulation of the digestive organs, increasing the level of motilin (this hormone is one of the main regulators of gastrointestinal motility), reducing the level of gastrin, insulin, glucagon, pancreatic polypeptide, vasoactive intestinal peptide. As a result, the following clinically significant effects are modulated: gastric evacuation accelerates, motor function of the colon and visceral sensitivity change. The effectiveness of trimedat has been proven in a number of randomized studies. For example, in the treatment of irritable bowel syndrome, it was about 83%, which allows us to consider this drug as a universal regulator of the motor function of the gastrointestinal tract.
Indications for use of Trimedat
What Trimedat tablets are used for:
- motility disorder in functional gastrointestinal pathology;
- gastroesophageal reflux disease;
- dyspeptic disorders due to gastroduodenal pathology (vomiting, epigastric pain, nausea, digestive disorders);
- paralytic intestinal obstruction after surgery;
- irritable bowel syndrome , accompanied by pain, stool disorders, spasms, colic;
- preparation for examination of the digestive tract (endoscopic manipulations, x-ray examination).
The use of the drug in pediatric practice makes it possible to successfully relieve dyspeptic disorders in gastrointestinal motility disorders.
How to take Trimedat for constipation
The causes of constipation and its nature determine the duration of medication use. In case of one-time stool retention due to poor nutrition and low mobility, it is enough to take the drug three times a day in a standard dosage until the intestines can empty. Most often this takes a day, less often – up to 5 days. In this case, the absence of relapse can be guaranteed by the patient himself by changing eating habits and adjusting daily physical activity.
In case of constipation that occurs due to intestinal obstruction caused by circulatory disorders in the inferior vena cava, Trimedat is taken over a long course, starting from 4 weeks. To avoid relapse and worsen the situation, the patient is prescribed a diet high in fiber-rich plant products. This approach to nutrition will ensure softness of the stool, which will significantly facilitate its passage through the intestines, and will eliminate cases of injury to the walls by hard lumps of feces.
Instructions for Trimedat (Method and dosage)
How to take: orally, without chewing and with water. Instructions for use of Trimedat recommend a standard treatment regimen: 100-200 mg three times a day. The maximum dose is 600 mg per day.
In order to prevent relapse of irritable bowel syndrome, the drug is prescribed at 300 mg per day. The medicine can be taken for 4 months.
Instructions for the use of tablets in pediatric practice
25 mg three times a day for children 3-5 years old. Children 5-12 years old are prescribed 50 mg three times a day. How to take Trimedat: before or after meals? Taking medication is not associated with food intake.
How to take Trimedat
For chronic abdominal pain, Trimedat is taken orally, 1 tablet.
The frequency of administration for adults and children over 12 years of age is three times a day.
Children from three to five years old can take the drug in a dose equal to a quarter of a tablet containing 100 mg of trimebutine, that is, 1 dose = 25 mg.
Children from 5 to 12 years old are given half a tablet containing 100 mg of trimebutine.
For both age groups, it is recommended to take it three times a day.
Trimedat's analogs
Level 4 ATC code matches: Aprofen
Meverin
Niaspam
Sparex
Duspatalin
- trimebutine
- Tribudate
- Debridat
- Neobutin
The price of analogues in Ukraine is less than the original drug. For example, the analogue of Trimedat Tribudat can be bought for 40 UAH.
How to take Trimedat: before or after meals
The drug begins to work an hour after it enters the gastrointestinal tract. To prevent food intake from causing pain, belching, bloating and other unpleasant symptoms, Trimedat should be taken 20-30 minutes before the intended meal. When the food is processed by gastric juice and enters the duodenum, the drug will already begin to act and will not allow the food to stagnate, which will reduce the risk of developing rotting processes, which cause flatulence, nausea and belching.
Reviews for Trimedat
The drug is well tolerated, acts quickly enough, relieving spasms, pain, and stabilizing intestinal function. For constipation , the medication enhances peristalsis, ensuring quick, painless emptying of the large intestine.
Reception by children, reviews from parents
In case of irritable bowel syndrome, the drug stabilizes motility, restoring the full functioning of the digestive system.
Reviews from doctors about Trimedat
An effective, affordable drug, widely used for pathologies of the digestive system.
How long to take Trimedat
The course of therapy depends on the symptoms and diagnosis. For episodic, sudden and short-term pain, it is enough to take the drug for 24 hours to get rid of the symptoms. This situation is typical for non-toxic food poisoning, when the unpleasant symptoms cease with the cleansing of the intestines. In this case, Trimedat will relieve spasms and normalize sudden contractions of the intestines, leading to pain.
If irritable bowel syndrome is diagnosed, two-week therapy is prescribed. After the disappearance of unpleasant symptoms, therapy is not stopped. To maintain the positive effect, in order to exclude relapse, Trimedat continues to be taken for another 3 months.
Trimedat price, where to buy
The cost depends on the country, region and pharmacy chain. The price of 200 mg tablets No. 30 in Russia is 600-700 rubles.
You can buy it in Ukraine at an average price of 300 UAH.
- Online pharmacies in RussiaRussia
ZdravCity
- Trimedat tablets 200 mg 30 pcs. JSC Valenta Pharm
523 rub. order - Trimedat tablets 100 mg 10 pcs. JSC Valenta Pharm
RUR 348 order
- Trimedat Forte tablets p.p.o. with prolonged release 300 mg 20 pcs. JSC Valenta Pharmaceuticals
RUR 553 order
- Trimedat forte tablets with prolong. release p.o.p 300mg 60pcs JSC Valenta Pharmaceuticals
RUB 1,164 order
- Trimedat por. d/prig. susp. for oral administration 152.5 mg vial. with measure stack 250mlAbdi Ibrahim Ilyach Sanayi ve Tij A.Sh.
580 rub. order
