Pharmacodynamics and pharmacokinetics
The composition of the drug includes the active substance - sucralfate - a disaccharide, including aluminum hydroxide and sucrose sulfate. When taking the drug, rapid healing of peptic ulcers , prevention of the development of gastric and duodenal , and protection of the gastric mucous membranes from the influence of pepsin and hydrochloric acid .
Treatment with Venter can reduce pepsin by 30%, without having any particular effect on the acidity of gastric juice. In this case, the mechanism of action of the drug is based on the binding of sucralfate to the proteins of the affected tissues of the mucous membranes, causing the formation of a protective film on the surface of the ulcer. The drug accelerates the regeneration of damage, scarring of ulcers, prevents the development of relapses of ulcers and the formation of stress ulcers . The absorption of phosphates in the gastrointestinal tract also decreases.
When taken orally, the substance is slightly absorbed into the systemic circulation. In the body, the drug does not form clinically significant concentrations in plasma and does not exhibit a systemic effect. The substance is not metabolized inside the body. Partial excretion of the drug occurs through the kidneys, the rest - unchanged through the intestines.
Pharmacological properties of the drug Venter
A remedy for the treatment of peptic ulcers. Sucralfate protects the gastric mucosa without having a systemic effect and having virtually no effect on the acidity of gastric juice. Sucralfate binds to the proteins of necrotic tissue in the area of the ulcer, forming a protective coating that prevents the action of pepsin, hydrochloric acid of gastric juice and bile salts. Sucralfate reduces pepsin activity by approximately 30%. Accelerates the scarring of peptic ulcers of the stomach and duodenum, prevents their recurrence and the formation of stress ulcers, and also reduces the absorption of phosphates from the digestive tract. After oral administration, ≤5% of sucralfate is absorbed, as a result of which the drug has no systemic side effects. The absorbed part of the drug is excreted by the kidneys.
Side effects
During treatment with Venter, the following may develop: constipation , nausea , flatulence, vomiting , diarrhea , dry mouth, headache, drowsiness , dizziness, gastralgia , lower back pain, allergic reactions and so on.
Venter granules and tablets, instructions for use (Method and dosage)
According to the instructions for use of Venter, the drug in tablets or granules is taken orally. In this case, the tablets are swallowed whole with the required amount of water. When the whole tablet is difficult to swallow, it can be dissolved in water and then drunk. The granules must be pre-dissolved in water.
The prepared solution should be taken 30-60 minutes before meals. The duration of therapy is determined by a specialist, taking into account the complexity of the disorder and the individual characteristics of each patient.
For adult patients, the daily dosage is 2 tablets or 2 sachets - one taken before lunch, the second before bed.
If the patient is diagnosed with hyperphosphatemia , then the dosage is reduced. The presence of peptic ulcers allows the daily dose to be increased by 2 times. The therapeutic course for patients with peptic ulcers of the stomach and duodenum is about 12 weeks. The disappearance of symptoms is not a signal to discontinue the drug; as a rule, treatment is continued until a diagnostic examination that confirms scarring of the ulcers.
Prevention of stress ulcers is carried out by prescribing for adult patients one tablet or a bag of granules to be taken 6 times a day. To prevent relapse of peptic ulcers, take one tablet or sachet 2 times a day. The maximum permissible daily dosage is 8 tablets or sachets. In case of renal dysfunction, patients have a reduced therapeutic course.
Children over 4 years old are recommended to take 0.5-1 tablet no more than 4 times a day. It is not recommended to take the drug in the form of granules in childhood.
Special instructions for the use of the drug Venter
The small amount of aluminum contained in sucralfate is absorbed in the digestive tract and subsequently excreted in the urine. In case of severe renal dysfunction, aluminum may accumulate in the body with the development of its toxic effect. The risk of accumulation increases with simultaneous administration of other drugs containing aluminum (for example, some antacids). The safety and effectiveness of sucralfate in children under 4 years of age have not been sufficiently studied, so it is not recommended to prescribe the drug to children in this age group. The drug can be used during pregnancy only when the expected benefit to the expectant mother outweighs the potential risk to the fetus. There is no evidence that sucralfate passes into breast milk, so it should be used with caution during breastfeeding.
Overdose
This drug is generally well tolerated by patients, so the risk of overdose is minimized
However, when taking Venter in high doses, intolerance reactions or allergy symptoms may worsen. In this case, the following may develop: nausea, vomiting, abdominal pain, irritation and skin rashes. Such cases require symptomatic therapy.
If patients have renal failure, then with long-term treatment aluminum intoxication encephalopathy or osteomalacia . This requires urgent discontinuation of treatment, hemodialysis, hemofiltration, peritoneal dialysis and deferoxamine.
VENTER (tablets)
I understand perfectly well that it is not worth discussing the topic of “stomach disease” now.
Everyone knows what gastritis is. My gastritis likes to manifest itself with heartburn and cramps, and I don’t like to endure all this. Quite recently I discovered tablets called “Venter”, and by pure chance, and now I really want to share my opinion with you. They look the most ordinary way. Please note that there are already a hundred tablets in this package! And the cost of all this “happiness”, consider it ridiculous, is 243 rubles! Well, you see, there’s nothing to talk about being expensive if you still have a supply of stomach pills in your home medicine cabinet, even after drinking a course, that can help not even one person, but several people!
I also don’t see anything surprising in the form of tablets - it’s standard. >
It says on the packaging that the active ingredient here is sucralfate and I was curious about this topic on the Internet.
It turned out that this substance turns hydrochloric acid into a paste, thereby restoring metabolic processes. After I read all this, I realized why, first of all, after taking the pills, my heartburn disappears. Therefore, I advise those people who have been suffering from this infection for a long time to stock up on pills.
By the way, I really liked the brevity of the instructions. There are a minimum of incomprehensible words, everything is written in accessible language, and in my opinion, all the necessary information is available.
The doses are described here, and for an adult it is no more than eight grams per day - this is to avoid an overdose and side effects. To normalize metabolic processes, the manufacturer advises drinking two tablets twice a day. Well, that's what I did. I thought that if I took the pills in a course of about a month, it would become much easier for my stomach to deal with the abundance of acid. And then I remembered that the New Year holidays were ahead and I realized that I was not treating the stomach, but preparing for it.
At the moment, I have been taking this drug for exactly a week. I will immediately note the complete absence of heartburn. I really love stewed cabbage with tomatoes, but I had to deny myself this, because even if I just tried this dish, my chest immediately began to bake from the inside. Now I can calmly eat a small plate and there is not even a hint of pain or increased acidity.
Regarding stomach cramps, yes, they have passed. But still sometimes it sips somewhere inside. As I understand it, in cases of peptic ulcers, this drug is prescribed in combination with other, more effective drugs, but in my case, a small periodic dose was enough, so I wholeheartedly advise everyone who suffers to buy Venter.
Interaction
Concomitant use with antacids requires an interval between doses of at least 30 minutes.
Combination therapy can reduce the absorption of tetracyclines , cimetidine, ciprofloxacin, ranitidine, norfloxacin, digoxin , indirect anticoagulants, ofloxacin and theophylline . In this case, it is also necessary to maintain an interval that should be more than 2 hours.
The combination of Venter and Phenytoin reduces the absorption and normal concentration of phenytoin , which can cause resumption of seizures. Therefore, it is important to maintain a 2-hour interval.
Venter drug interactions
Antacids can be prescribed during treatment with sucralfate, but they should be taken at least 30 minutes before taking sucralfate or 1.5 hours after taking it. Medicines containing aluminum compounds (for example, some antacids) may cause aluminum to accumulate in the body in patients with kidney failure. Sucralfate may reduce the absorption of certain drugs, such as tetracycline, cimetidine, ranitidine, fluoroquinolones, digoxin, theophylline, warfarin, ketoconazole, levothyroxine, quinidine and phenytoin. These medications should be taken at least 2 hours before taking sucralfate. Sucralfate may bind to some food proteins. For patients being fed by gastric tube, sucralfate should be administered separately from food and other medications.
Venter's analogues
Level 4 ATC code matches:
Ventrisol
Novobismol
Vis-Nol
De-Nol
Gastrocepin
Dalargin
Vikair
Omez DSR
Omez D
Gastrofarm
Gaviscon
Vikalin
The main analogues of Venter are represented by the following drugs: Alsukral, Ankrusal, Sucralfate, Sukrat and Ulgastran.
Also, a similar effect is typical for: De-Nol, Maalox, Almagel and Rennie.
Reviews about Venter
Various forms of disorders of the digestive system and gastrointestinal tract bother many people. At the same time, for some, these may be minor deviations caused by overeating or other malnutrition, while for others, more complex and aggravated forms in the form of ulcers and gastritis . In any case, there are a lot of reviews about Venter and drugs that have a similar effect on the Internet.
Users report that this medicine affects different people differently and does not always help get rid of problems in the gastrointestinal tract. At the same time, they say that they started taking Venter after recommendations from friends, random people on the Internet, or pharmacy employees. It should be noted that in addition to this drug, they also took Omez, Phosphalugel, Rennie, and so on at different times.
Thus, it may take a long time to independently select a drug until the stomach pain increases significantly. Only after this do patients turn to a specialist who diagnoses them with a serious disorder. However, most people do not blame themselves for this, but the pills, which turned out to be useless and did not help them recover. Therefore, there is no need to prolong the pain until it worsens, but you should immediately consult a doctor.
Antepsin (analogue of Venter) tab. 1 g No. 60 - Instructions
Compound
The main active ingredient is sucralfate at a dose of 1 mg per tablet.
In addition, the composition includes: macrogol 6000, microcrystalline cellulose, calcium carmellose, magnesium stearate.
Release form
The drug is available in the form of biconvex, oblong, white tablets with a dividing line on one side. Packs of 60 pieces.
pharmachologic effect
Sucralfate works locally. As a result of its protective effect on the gastric mucosa, it accelerates the healing of ulcers. This is because it causes local production of prostaglandins and epidermal growth factors. At the site of injury, sucralfate binds to the mucosa due to electrostatic interactions between positively charged proteins in the exudate and negatively charged drug ions. Thus, a special protective shell is created over the ulcer, preventing the penetration of hydrogen ions. Sucralfate binds gastric enzymes and bile acids. Thus, it protects the ulcer niche from the acidic components of digestive juices.
Pharmacokinetics
Sucralfate is poorly absorbed from the gastrointestinal tract after oral administration. This is about a few percent. In the acidic environment of the stomach, a small amount is broken down into aluminum hydroxide and sucrose octosulfate. The aluminum ions released as a result of dissociation partially combine with the phosphates present in the stomach to form slightly soluble or completely insoluble salts, which are only slightly absorbed. On the other hand, free aluminum ions in the acidic environment of the stomach bind to positively charged proteins in the gastric mucosa. Under the influence of hydrochloric acid, sucrose sulfate is also formed, which is not metabolized.
Neither sucralfate nor the sucrose sulfate formed from it is metabolized in the stomach under the action of hydrochloric acid, nor aluminum.
Extraction occurs mainly through the gastrointestinal tract. A small percentage (less than 2%) is excreted in the urine through the kidneys. On the other hand, sucrose sulfate, formed under the influence of hydrochloric acid, is almost completely (more than 90%) excreted unchanged in feces.
Indications for use
Peptic ulcer of the stomach and duodenum is an indication for the use of Antepsin.
Contraindications
If you are hypersensitive to the composition of the drug, it should not be used.
Antepsin should not be used long-term in patients with severe renal failure, uremia, or disease states with low levels of inorganic phosphate in the blood.
The drug is contraindicated in patients on dialysis. These patients may experience aluminum accumulation in the body and its toxic effects (osteodystrophy, osteomalacia, encephalopathy).
Uremia and hypophosphatemia are also contraindications to the use of this drug.
Side effects
Most often, the drug can cause the following negative reactions: dry mouth, nausea, rash, formation of an insoluble mass in the intestines (bezoar).
Drug interactions
Antepsin is a drug containing aluminum, so during treatment they should limit the use of other drugs containing this element to avoid its accumulation in the body.
In addition, antacids should be taken 30 minutes before taking the drug.
Concomitant use of Antepsin may reduce the bioavailability of certain drugs, including fluoroquinolones such as ciprofloxacin and norfloxacin, tetracycline, ketoconazole, sulpiride, digoxin, warfarin, phenytoin, theophylline, levothyroxine, quinidine and antagonists. The bioavailability of these agents can be restored by separating the administration of these agents from Antepsin by two hours.
Because of Antepsin's ability to alter the absorption of some drugs from the gastrointestinal tract, separating Antepsin administration from other agents should be considered when changes in bioavailability are considered critical for concomitantly administered drugs.
Taking Antepsin with food can increase the bioavailability of the drug. This is due to the fact that the drug can bind to food proteins. Therefore, it is recommended to use the drug one hour before meals or two hours after it.
Application and dosage
Antepsin should be taken in the morning on an empty stomach, half an hour to an hour before the first meal.
When treating stomach and duodenal ulcers, the therapeutic dose is 4 g. The medicine should be taken 30-60 minutes before main meals and immediately before bedtime, with plenty of water or dissolved in water. Duration of treatment is 4-6 weeks. You can take a maximum of 8 g per day.
For peptic ulcers, up to 4 g of Antepsin per day should be taken for at least 4-8 weeks or until the ulcer has healed.
In patients with renal failure, the dose should be adjusted after consultation with a specialist physician.
Children over 4 years old are prescribed up to 4 g per day, i.e. 320 mg per kg body weight per day.
Overdose
There are no specific symptoms of Antepsin poisoning. In case of overdose, aluminum salts can accumulate in the body and have a toxic effect on the body.
Therapy is carried out in accordance with the emerging symptoms.
special instructions
Antepsin can bind to dietary proteins and some medications and therefore may cause the accumulation of undigested substances (intestinal stones) in patients with slow gastric transit. The situation is similar for people fed through a nasogastric tube. Therefore, such patients should receive the drug after a significant period of time compared to food and other medications.
Due to insufficient data on the safety of Antepsin in children under 14 years of age, use of the drug in this age group is not recommended.
Use during pregnancy and breastfeeding
Antepsin should not be used during pregnancy. The exception is when the doctor considers such therapy absolutely necessary.
Breastfeeding women should not take medications containing sucralfate.
Impact on the ability to drive vehicles and operate machinery
It has not been observed that the use of Antepsin negatively affects the ability to drive vehicles and operate machinery.
Storage conditions
At temperatures up to 25 degrees Celsius. The shelf life is 3 years.
Terms of sale
On prescription.
Venter price, where to buy
The price of Venter in tablets in Russian pharmacies varies between 200-250 rubles.
It is quite difficult to buy the drug in granules in Russian pharmacies. In Ukraine, its cost is 133 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Venter granules 1g No. 50
RUB 4,880 order - Antepsin (analogue of Venter) 1 g tablet No. 60
2700 rub. order
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Pharmacy24
- Venter 1 g No. 50 tablets KRKA, Slovenia
206 UAH. order
