Indole-3-carbinol is a biologically active substance found in cruciferous vegetables: broccoli, Brussels sprouts, kale, cauliflower, mustard, turnips and rutabaga. Indole-3-carbinol is formed when these vegetables are cut and chewed. This substance can also be produced in a laboratory. It is necessary to understand that indole-3-carbinol has the desired effect only in certain, fairly high doses. It is simply impossible to consume so much broccoli (which is several kilograms), so indole-3-carbinol should be taken in the form of dietary supplements or medications.
Active substances
- Indole-3-carbinol (I3C) is a biologically active compound that normalizes the metabolism of female sex hormones estrogen, resulting in a reduction in the development of estrogen-dependent hyperplastic processes in a woman’s body. I3C inhibits the synthesis of the proliferative metabolite 16α-ONE1, which, firmly binding to estrogen-dependent receptors, causes uncontrolled proliferative processes, being a carcinogen in relation to the reproductive organs of not only women, but also men. I3C has a powerful antiproliferative effect, inhibits inflammation, growth and proliferation of transformed cells, prevents the synthesis of E7 protein in epithelial cells infected with human papillomavirus, including types 16 and 18, inhibiting the processes of malignancy. I3C activates the expression of the tumor suppressor gene BRCA1. Shows high antioxidant properties.
- Cruciferous vegetables are a source of active natural indole substances: ascorbinogen, diindolylmethane, food indole, as well as isothiocyanates, the most active of which is sulforaphane. The combined effect of these substances reduces the risk of malignant processes in the human body. Ascorbigen is a biologically active compound of the cruciferous family; when ascorbigen is combined with indole-3-carbinol, their effect is mutually enhanced. Ascorbigen acts as an immune system enhancer and prevents the absorption of toxins through the walls of the small and large intestines.
- Diindolylmethane is a compound formed by a combination of 2 I3C molecules, the effectiveness of which is significantly increased when used simultaneously with I3C.
- Sulforaphane is a biologically active compound from plants of the cruciferous family, which has antitumor, antidiabetic and antibacterial effects.
How does indole-3-carbinol work?
Epidemiological studies show that a diet high in cruciferous vegetables can reduce the risk of cancer.
Numerous clinical studies have proven the antitumor effects of indole-3-carbinol in the cells of the breast, prostate, endometrium, ovaries, colon, and pancreas.
Indole-3-carbinol may reverse cervical intraepithelial neoplasia (cervical dysplasia), a condition that can lead to cervical cancer. Indole-3-carbinol has also been shown to counteract the activity of human papillomavirus.
Recommendations for use
Recommended as an additional source of indole compounds and ascorbic acid. Helps prevent all proliferative processes in the female reproductive system.
"Indol-F®" is recommended for use:
- to normalize metabolic processes in a woman’s body in the reproductive organs and mammary glands;
- for diseases of the female reproductive system, which are based on the processes of pathological cell proliferation;
- in order to normalize estrogen metabolism in estrogen-dependent diseases: endometrial hyperplasia, uterine fibroids, endometriosis, menstrual irregularities, mastopathy;
- in order to reduce the frequency and severity of psychoemotional and neurovegetative disorders in women in the premenopausal and early menopausal periods;
- for cervical dysplasia, anogenital condylomas associated with HPV.
How does indole-3-carbinol work for breast cancer?
Reducing the risk of breast and cervical cancer when taking indole-3-carbinol occurs by regulating the metabolism of female sex hormones (estrogens): it removes “bad” metabolites from the body that cause the growth of tumors in the female reproductive organs. These same mechanisms allow indole-3-carbinol to enhance the effect of a number of anticancer drugs, for example, tamoxifen.
In Breast Cancer: Basic and Clinical Research, Canadian scientists tested indole-3-carbinol against placebo in 96 women. For 28 days, one group of women took one placebo capsule and the other took indole-3-carbinol twice a day. Blood and urine tests showed that women who took indole-3-carbinol had a significantly reduced risk of developing breast cancer and other estrogen-related cancers.
Indole Forte capsules No. 30
Product description
"Indole Forte" - support the health of women's breasts Poor diet, sedentary lifestyle, frequent stress and hereditary diseases are factors that can undermine women's reproductive health in the long term. In conditions of constant “emergency” work, the body does not have enough strength to withstand negative influences from the outside and from the inside. Thus, the tissue of the mammary glands may change, and there is a risk of developing mastopathy and lipoma. Preparations containing biologically active substances will help keep the mammary glands healthy. "Indole Forte" from is a natural dietary supplement that does not contain synthetic hormones and does not cause corresponding side effects or addiction. The drug is designed to help: · maintain the balance of female sex hormones; · reduce the risk of developing mammary gland pathologies; prevent the formation of seals; Reduce chest pain; · reduce the likelihood of infection with HPV (human papillomavirus). High-risk HPV can cause breast cancer. The main active ingredient in the dietary supplement is indole-3-carbinol. Additionally, the drug is enriched with broccoli concentrate, which enhances the effect of indole-3-carbinol by almost 80 times1. Even one course of Indola-Forte allows you to achieve good results. For 1 course it is enough to buy 1 package. In studies conducted among women suffering from benign mammary dysplasia and taking indole-3-carbinol-containing drugs, significant improvements in the condition and well-being of the patients were noted. Thus, in 82% of women, breast tissue became softer and more uniform, and in 72% pain decreased. How the ingredients work Indole-3-carbinol is an organic compound found in cruciferous plants (cabbage, kohlrabi, turnips, rutabaga, radishes). The substance has a pronounced antitumor activity and antioxidant effect: 1. Activates special enzymes that bind to xenobiotics - foreign chemicals in the body - and neutralize them. Hormone-like xenobiotics are dangerous because they provoke the development of malignant tumors. 2. Inhibits the formation of dangerous metabolites (metabolic products) that arise during the transformation of estrogen. It has been proven that some metabolites are carcinogenic and stimulate the growth and degeneration of tissues of the uterus, mammary glands, and liver. 3. Slows down the formation of papillomatous formations (nevi, moles, warts). 4. Slows down the growth of blood vessels in formations without affecting healthy tissue. 5. Increases the efficiency of the natural detoxification system, slows down oxidative processes that lead to aging of the body. Broccoli contains indole-3-carbinol in high concentrations, as well as ascorbigen and sulforaphane - compounds that neutralize carcinogens and have an antibacterial effect. It has not yet been clearly established which of these three substances best protects breast tissue from change. However, their pronounced antitumor effect is beyond doubt. For greater effect, it is recommended to use complex preparations that contain all of the listed substances. It is worth noting that with long-term storage of vegetables and further heat treatment, most of the beneficial compounds are destroyed. In Indole Forte, all components remain biologically active until the expiration date of the drug. The product does not require special storage conditions.
Recommendations for use
The drug is taken orally, 1 capsule per day. This is enough to completely cover the daily requirement of the female body for indole-3-carbinol. The duration of treatment is 1 month, the period can be extended if necessary. The dietary supplement is available in packages of 30 and 60 capsules.
Contraindications
Individual intolerance to components, pregnancy, breastfeeding. Before use, you should consult your doctor.
Buy Indole Forte caps. 0.23 g No. 30 in the pharmacy
Price for Indole Forte caps. 0.23 g each No. 30
Instructions for use for Indole Forte caps. 0.23 g each No. 30
Indole-3-carbinol
Biologically active food supplement
Indole-3-Carbinol 150 mg
Not a medicine
Indole-3-Carbinol is an active ingredient of plant origin, the effectiveness and safety of which has been confirmed by the results of clinical studies. It is a universal non-hormonal corrector of pathological hyperplastic processes in the organs and tissues of the female reproductive system (breast, endometrium, myometrium, cervix, ovaries). Normalizes the balance of estrogen in the body and suppresses their negative stimulating effect, and also blocks other (hormone-independent) mechanisms that activate pathological cellular growth in the tissues of the mammary gland and uterus. It has the ability to cause selective death of cells with abnormally high proliferative activity.
Release form Capsules, 0.26 g. 15 capsules of 0.52 g each in a blister pack. 4 contour blister packs are placed in a pack.
Composition of the daily dose (2 capsules):
Active components:
| Biologically active components | 2 capsules (daily dose) | % of adequate consumption level1 |
| Indole-3-Carbinol | 300 mg | 600* |
* - Does not exceed the permissible level of consumption 1 - EurAsEC “Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control)”.
Excipients: microcrystalline cellulose (carrier), capsule (gelatin carrier, titanium dioxide dye), fatty acid calcium salts (anti-caking agent), amorphous silicon dioxide (anti-caking agent).
Biological properties Indole-3-carbinol - has pronounced antitumor activity and antioxidant effect. It promotes the activation of special enzymes that bind to xenobiotics (foreign chemicals in the body) and neutralize them. Hormone-like xenobiotics are dangerous because they provoke the development of malignant tumors. Indole inhibits the formation of dangerous metabolites (metabolic products) that arise during the transformation of estrogen and suppresses the induction of estrogen-dependent genes, thus the cell stops receiving excessive estrogen-dependent stimulation. Some of these metabolites are carcinogenic and stimulate the proliferation and degeneration of uterine and mammary gland tissue. Indole is also able to slow down the growth of blood vessels in formations, without affecting healthy tissue, and enhances the effectiveness of the body’s natural detoxification system, slows down oxidative processes that lead to aging of the body.
Area of application: as a dietary supplement to food - an additional source of indole-3-carbinol.
Recommendations for use: adults, 1 capsule 2 times a day with meals. Duration of treatment: 1 month. If necessary, the reception can be repeated.
Contraindications: individual intolerance to the components, pregnancy, breastfeeding. It is recommended to consult a doctor before use.
Shelf life: 2 years
Storage conditions: out of reach of children at a temperature not exceeding 25 0C.
Certificate of state registration: SGR No. RU.77.99.11.003.R.004134.11.19 dated 11/14/2019
