Erespal 80 mg No. 30 tablet p.o.

Compound

The composition of the tablets is as follows: each tablet contains the active ingredient fenspiride hydrochloride , as well as additional substances: hypromellose, calcium hydrogen phosphate, macrogol 6000, silicon dioxide, povidone, titanium dioxide, magnesium stearate, glycerol .
The composition of cough syrup is as follows: active substance fenspiride hydrochloride , additional substances: flavoring agent, glycerol, licorice extract, Sunset Yellow S, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sucrose, saccharin, potassium sorbate, water.

Release form, composition and packaging

Orange syrup Formation of sediment is possible, which disappears upon shaking.

Excipients:

flavoring composition with hints of honey smell, licorice root extract, vanilla tincture, glycerol, sunset yellow dye (sunset yellow S), methyl parahydroxybenzoate, propyl parahydroxybenzoate, saccharin, sucrose, potassium sorbate, purified water.

150 ml - brown plastic bottles (1) - cardboard packs.

Pharmacodynamics and pharmacokinetics

Erespal (Eurespal) prevents bronchoconstriction and slows down exudation . The anti-inflammatory effect that fenspiride is due to inhibition of arachidonic acid metabolism. Antibronchoconstrictor effects are produced due to inhibition of the process of secretion of biologically active substances: histamine , serotonin , bradykinin . In addition, the drug blocks α-adrenergic receptors, upon stimulation of which there is an increase in the production of bronchial secretions.

Prevents bronchospasm . If the drug is prescribed in large doses, it reduces the production of various inflammatory factors.

The medicine is well absorbed from the gastrointestinal tract. The highest concentration of the active substance in the blood plasma is observed approximately 2.5 hours after oral administration. The half-life is 12 hours.

Approximately 90% of the drug is excreted through the kidneys, the remaining 10% is excreted through the intestines.

pharmachologic effect

The anti-inflammatory and anti-bronchoconstrictor activity of Erespal® is due to the fact that fenspiride reduces the production of a number of biologically active substances (cytokines, especially tumor necrosis factor α (TNF-α), arachidonic acid derivatives, free radicals), which play an important role in the development of inflammation and bronchospasm.

Inhibition of arachidonic acid metabolism by fenspiride is potentiated by blockade of histamine H1 receptors, because histamine stimulates the formation of its products (prostaglandins and leukotrienes). Fenspiride blocks α-adrenergic receptors, the stimulation of which is accompanied by an increase in the secretion of the bronchial glands. Thus, fenspiride reduces the effect of a number of factors that contribute to the hypersecretion of proinflammatory factors, the development of inflammation and bronchial obstruction.

Fenspiride also has an antispasmodic effect.

Indications for use of Erespal

What are the tablets and syrup for? Indications for the use of the drug are diseases of the upper and lower respiratory tract of humans.

What does the medicine help with:

• laryngitis , nasopharyngitis ;
• bronchitis;
• tracheobronchitis;
• bronchial asthma (as part of complex treatment);
• hoarseness, cough, tickling, disturbing patients with whooping cough , influenza , measles ;
• infectious respiratory tract diseases, the symptom of which is cough;
• sinusitis , otitis media .

Thus, according to the annotation, indications for the use of Erespal are diseases accompanied by cough and other symptoms of respiratory tract diseases. Indications for the use of syrup are the same as for the use of the drug in tablets. When prescribing a treatment complex, the doctor determines which form of the drug is preferable.

Erespal 2mg/ml 150ml syrup

pharmachologic effect

Anti-inflammatory, antispasmodic, antihistamine.

Composition and release form Erespal 2 mg/ml 150 ml syrup

Syrup – 100 ml:

• active substance: fenspiride hydrochloride - 0.2 g;
• excipients: flavoring composition with hints of honey smell (flavors, including natural ones, sunflower honey, water, ethanol*) - 0.5 g; licorice root extract - 0.2 g; vanilla tincture (natural vanilla flavor and other components, including ethanol*) - 0.4 g; glycerol - 22.5 g; methyl parahydroxybenzoate - 0.09 g; propyl parahydroxybenzoate - 0.035 g; saccharin - 0.045 g, sucrose - 60 g; potassium sorbate - 0.19 g; purified water - up to 100 ml.

* The total ethanol content in 100 ml of syrup is no more than 0.29 mg.

Produced by Servier Industry Laboratory, France

Syrup 2 mg/ml. 150 ml of syrup in a brown plastic bottle (PVC) with a plastic cap with tamper evident. One bottle with instructions for medical use in a cardboard box.

During production at Pharmstandard-Leksredstva OJSC, Russia

Syrup 2 mg/ml. 150 ml or 250 ml of syrup in a brown plastic bottle (PVC) with a plastic cap with tamper evident. One bottle with instructions for medical use is placed in a cardboard box.

Description of the dosage form

Syrup: transparent or slightly opalescent liquid of brownish-yellow color. During storage, sediment may form that disappears with shaking.

Directions for use and doses

It is necessary to strictly follow the recommendations of your doctor.

Inside. Shake before use.

Adults and adolescents: 3 to 6 tablespoons of syrup (45–90 ml) per day, taken before meals.

Children over 2 years old: recommended dose - 4 mg/kg/day: for body weight up to 10 kg - from 2 to 4 teaspoons of syrup per day (or 10-20 ml), can be added to a bottle with food; more than 10 kg - from 2 to 4 tablespoons of syrup per day (or 30–60 ml), taken before meals.

1 tablespoon (15 ml of syrup) contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.

1 teaspoon (5 ml of syrup) contains 10 mg of fenspiride hydrochloride and 3 g of sucrose.

The duration of treatment is determined by the doctor.

Pharmacodynamics

An anti-inflammatory agent, has an antiexudative effect, prevents the development of bronchospasm. Shows antagonism with mediators of inflammation and allergy: serotonin, histamine (blockade of H1-histamine receptors), bradykinin. Has a myotropic antispasmodic effect. When administered in large doses, it reduces the production of various inflammatory factors (cytokines, arachidonic acid derivatives, free radicals).

Pharmacokinetics

Well absorbed from the gastrointestinal tract.

Cmax in blood plasma after oral administration is achieved after (2.3±2.5) hours (from 0.5 to 8 hours). T1/2 is 12 hours.

It is excreted mainly by the kidneys (90%), through the intestines - 10%.

Indications for use Erespal 2mg/ml 150ml syrup

Diseases of the upper and lower respiratory tract:

• rhinopharyngitis and laryngitis;
• tracheobronchitis;
• bronchitis (with or without chronic respiratory failure);
• bronchial asthma (as part of complex therapy);
• respiratory phenomena (cough, hoarseness, sore throat) with measles, whooping cough and influenza;
• infectious diseases of the respiratory tract accompanied by cough, for which standard antibiotic therapy is indicated.

Otitis and sinusitis of various etiologies.

Contraindications

• hypersensitivity to the active substance and/or any of the components of the drug;
• children under 2 years of age.

With caution: patients with fructose intolerance, glucose-galactose malabsorption, sucrase/isomaltase deficiency (due to the presence of sucrose in Erespal® syrup), patients with diabetes mellitus (due to the presence of sucrose in Erespal® syrup).

Use of Erespal 2mg/ml 150ml syrup during pregnancy and breastfeeding

There are no or limited data on the use of Erespal® in pregnant women.

Taking the drug during pregnancy is not recommended.

Fenspiride therapy is not a reason to terminate an ongoing pregnancy.

Erespal® should not be used during breastfeeding due to the lack of data on the penetration of fenspiride into breast milk.

special instructions

The drug contains parabens (parahydroxybenzoates), as a result of which taking this drug can provoke the development of allergic reactions, incl. deferred.

When prescribing the drug to patients with diabetes, it is necessary to take into account that Erespal® syrup contains sucrose (1 teaspoon - 3 g of sucrose = 0.3 XE; 1 tablespoon - 9 g of sucrose = 0.9 XE).

No studies have been conducted to study the effect of Erespal® on the ability to drive vehicles and operate machinery. Patients should be aware of the possible development of drowsiness while taking Erespal®, especially at the beginning of therapy or when combined with alcohol intake, and should be careful when driving vehicles and performing work that requires a high speed of psychomotor reactions.

Overdose

In case of an overdose of the drug (cases of overdose have been reported when taking the drug at a dose of more than 2320 mg), you should immediately seek medical help.

Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia.

Treatment: gastric lavage, ECG monitoring. Maintaining vital body functions.

Side effects Erespal 2mg/ml 150ml syrup

It is necessary to inform the doctor about the appearance of any symptoms in the patient, incl. adverse reactions not mentioned in this description, as well as changes in laboratory parameters during therapy.

The most common adverse reactions to the drug Erespal® are observed in the digestive system.

The frequency of adverse reactions that may occur during therapy is given in the following gradation: very often (>1/10); often (>1/100, 1/1000, 1/10000,

From the cardiovascular system: rarely - moderate tachycardia, the severity of which decreases with decreasing dose of the drug; unknown frequency - palpitations, hypotension, possibly associated with tachycardia.

From the digestive system: often - gastrointestinal disorders, nausea, epigastric pain; unknown frequency* - diarrhea, vomiting.

From the side of the central nervous system: rarely - drowsiness; unknown frequency* - dizziness.

General disorders and symptoms: unknown frequency* - asthenia, increased fatigue.

From the skin and subcutaneous fat: rarely - erythema, rash, urticaria, angioedema, fixed erythema pigmentosa; unknown frequency - pruritus, toxic epidermal necrolysis, Stevens-Johnson syndrome.

*Post-registration data.

Drug interactions

No special studies have been conducted to study the interaction of fenspiride with other drugs.

Due to the possible increase in sedative effect when taking histamine H1 receptor blockers, it is not recommended to use Erespal® syrup in combination with drugs that have a sedative effect, or in combination with alcohol.

Contraindications

The following contraindications to taking the drug are noted:

• high level of sensitivity to the active substance or other components;
• children up to two years of age.

The syrup is used with caution to treat people who have fructose intolerance , glucose-galactose malabsorption , diabetes mellitus , sucrase or isomaltase deficiency, since the syrup contains sucrose.

Side effects

If Eurespal syrup or tablets cause any side effects, you should definitely consult a doctor and inform him in detail about what is happening.

When treated with Erespal, the following side effects may occur:

• In the functioning of the cardiovascular system: in rare cases, tachycardia , which decreases when the dose of the drug is reduced.
• In the functioning of the gastrointestinal tract: stomach and intestinal disorders, pain in the epigastrium, nausea are often observed; Sometimes vomiting and diarrhea .
• In the functioning of the central nervous system: drowsiness is rarely observed, dizziness is sometimes observed.
• Asthenia and severe fatigue may occur
• Skin reactions: in rare cases, urticaria , erythema , rash are observed, and sometimes skin itching may be bothersome.
• You may be sensitive to the dye contained in the product.

Instructions for use of Erespal (Method and dosage)

The drug in tablets is used only for the treatment of adult patients. During treatment, the instructions for use of tablets and syrup must be strictly followed.

Instructions for Erespal tablets

The medicine should be taken before meals. For chronic inflammatory diseases, it is recommended to take two 80 mg tablets per day - morning and evening. In the acute course of the disease, the doctor may prescribe a course of treatment that involves taking three tablets - morning, afternoon and evening. The doctor can prescribe an individual plan for how to take the pills. The duration of therapy is also determined individually.

Instructions for Erespal cough syrup

The syrup can be taken by adults; it is also prescribed for children after the age of twelve. You can take from 3 to 6 tablespoons of the product (45–90 ml) per day. The course of treatment for children and adults lasts as many days as prescribed by the attending physician.

The medicine in syrup form is not prescribed to children under 2 years of age.

Erespal for children

It is prescribed taking into account how old the child is and how much he weighs. In this case, the dosage of the syrup is carried out so that the daily dose of cough suppressant is not exceeded. The instructions for syrup for children stipulate that the daily dose is divided into 2 or 3 doses. The syrup should be drunk before meals.

The drug is not prescribed for children under 2 years of age. If treatment of respiratory diseases is required for children under one year of age, the doctor prescribes safe analogues for children of this age.

It is recommended to consume 4 mg of the drug per 1 kg of child’s body weight per day.

Children weighing less than 10 kg are prescribed 2-4 teaspoons of the product per day (10–20 ml). Children weighing more than 10 kg are prescribed 2-4 tablespoons of the product per day (20–60 ml).

How many days a child takes this remedy depends on the disease and the doctor’s recommendations. Reviews of the syrup indicate that an improvement in the condition is noted after 2-3 days of such treatment.

Dosage regimen

For adults

the drug is prescribed 80 mg (1 tablet) 2-3 times a day or 3-6 tablespoons (45-90 ml) of syrup per day. 1 tablespoon contains 30 mg of fenspiride hydrochloride and 9 g of sucrose.

The maximum daily dose is 240 mg. The duration of treatment is determined by the doctor.

Erespal® in tablet form is not intended for the treatment of children and adolescents under 18 years of age

. For use of the drug in this category of patients, Erespal® in the form of syrup is recommended.

Children and teenagers

the drug is prescribed at a rate of 4 mg/kg body weight/day.
Children aged 0 to 2 years (body weight up to 10 kg)
- 2-4 teaspoons of syrup (10-20 ml)/day, can be added to a bottle with food (1 teaspoon contains 10 mg of fenspiride hydrochloride and 3 g of sucrose ).
Children aged 2 to 16 years (body weight more than 10 kg)
- 2-4 tablespoons of syrup (30-60 ml)/day.

The drug should be taken before meals. The syrup should be shaken before use.

special instructions

Often patients have a question about whether Erespal is an antibiotic or not. In fact, treatment with Erespal cannot replace antibiotic therapy. Therefore, if necessary, an additional antibiotic is prescribed.

People with diabetes are prescribed the drug in tablets, since the syrup contains sucrose.

sunset yellow in the syrup, people with intolerance to acetylsalicylic acid , as well as other NSAIDs, may develop bronchospasm.

No studies have been conducted that would allow conclusions to be drawn about the effect of Erespal on the ability to drive vehicles and work with precision mechanisms. However, drowsiness may occur when using it, especially if the drug is combined with sedatives or alcohol. It should be noted that such a combination may lead to a reaction disorder.

Erespal 80 mg No. 30 tablet p.o.

Instructions for medical use of the drug ERESPALÒ Trade name ErespalÒ International nonproprietary name Fenspiride Dosage form Film-coated tablets, 80 mg Composition One tablet contains the active substance - fenspiride hydrochloride 80 mg, excipients: secondary calcium phosphate, methylhydroxypropylcellulose, polyvidone, anhydrous colloidal silicon dioxide , magnesium stearate, shell composition: titanium dioxide (E171), glycerol, macrogol, methylhydroxypropylcellulose, magnesium stearate. Description White, round, biconvex film-coated tablets. Pharmacotherapeutic group Drugs for the treatment of obstructive respiratory diseases. Other drugs for the treatment of obstructive airway diseases for systemic use. Fenspiride ATC code R03DX03 Pharmacological properties Pharmacokinetics The time to reach the maximum concentration of the drug (Tmax) in the blood is 6 hours. The half-life is 12 hours. The drug is excreted mainly in the urine. Pharmacodynamics Fenspiride has a bronchodilator and anti-inflammatory effect due to antagonistic activity at the level of H1-histamine receptors and a papaverine-like antispasmodic effect. The anti-inflammatory effect is the result of a decrease in the production of pro-inflammatory factors (cytokines, tumor necrosis factor alpha - TNFα, arachidonic acid derivatives and free radicals), some of which have a bronchoconstrictor effect. Indications for use Cough in diseases of the upper and lower respiratory tract: - nasopharyngitis and laryngitis - otitis and sinusitis - rhinotracheobronchitis - bronchitis - measles - influenza As a maintenance therapy for asthma and its complications. Directions for use and dosage Adults: 1 tablet 2-3 times a day, before meals. Side effects Very often (≥1/10), often (≥1/100, <1/10), infrequently (≥1/1000, <1/100), rarely (≥1/10000, <1/1000), very rare (≥1/100000, <1/10000), frequency not established (it is not possible to estimate the frequency of development based on the available data). Often - nausea, stomach pain Rarely - moderate tachycardia, stopping when the dose is reduced - drowsiness - allergic reactions: erythema, rash, urticaria, Quincke's edema, fixed erythema pigmentosa Frequency not established - diarrhea, vomiting - asthenia, fatigue, dizziness - rapid heartbeat and hypotension, possibly associated with tachycardia - skin itching, toxic epidermal necrolysis, Stevens-Johnson syndrome Contraindications - hypersensitivity to one of the components of the drug Drug interactions Since fenspiride increases the sedative effect of H1-antihistamines, it is not recommended to combine it with sedatives and alcohol. Special instructions Taking ErespalÒ should not delay, if necessary, the initiation of therapy with antibacterial drugs. Erespal® in tablet form is not intended for the treatment of children. For use of the drug in children, ErespalÒ in the form of syrup is recommended. Pregnancy and lactation At the moment, there is no reliable information about the toxic effect of the drug on the fetus and the excretion of fenspiride in breast milk. Taking ErespalÒ during pregnancy and lactation is not recommended. Features of the effect on the ability to drive a vehicle or potentially dangerous mechanisms Since Erespal can cause drowsiness, caution should be exercised when driving vehicles or other mechanisms, especially at the beginning of therapy. Overdose Symptoms: drowsiness or agitation, nausea, vomiting, sinus tachycardia. Treatment: gastric lavage, ECG monitoring, symptomatic. Release form and packaging 15 tablets each in a blister pack made of polyvinyl chloride film and aluminum foil. 2 blister packs together with instructions for use in the state and Russian languages ​​are placed in a cardboard pack. Storage conditions Store at a temperature not exceeding 30°C. Keep out of the reach of children! Shelf life: 2 years Do not use after the expiration date indicated on the package. Conditions for dispensing from pharmacies By prescription Manufacturer Les Laboratoires Servier Industrie (Le Laboratoire Servier Industry), France Holder of the registration certificate Les Laboratoires Servier (Le Laboratoire Servier), France Address of the organization that accepts claims from consumers on the quality of products (products) in the territory of the Republic of Kazakhstan: Representative office of Les Laboratoires Servier in the Republic of Kazakhstan 050020, Almaty, Dostyk Ave. 310g, Business center, 3rd floor Tel./63/64/65/70/71 Fax

Erespal's analogs

Level 4 ATX code matches:
Siresp

Daxas

Inspiron

In pharmacy chains you can find similar drugs that have the same properties. Analogs of Erespal syrup and tablets in terms of effects on the human body are Stoptussin , Fenspiride , Ascoril , Fluditek , Lazolvan , Ambrobene . The price of analogues can be either higher or lower. But, despite the desire to find cheaper analogues, you should ask your doctor about what you can replace 80 mg tablets or Erespal syrup with. In some cases, Erespal can be replaced with the drug Bronchicum . It is used for bronchitis, both dry and wet cough.

Which is better: Erespal or Sinekod?

Sinekod is a drug that is a direct-acting antitussive drug. Its active ingredient is butamirate . This remedy is used primarily for non-productive coughs. It is not recommended to take Erespal and Sinekod at the same time. In this case, you should definitely consult a doctor.

Which is better: Erespal or Lazolvan?

Only a doctor should prescribe a drug for the treatment of an adult or child. Erespal more effectively reduces inflammatory processes, and Lazolvan promotes the liquefaction and removal of sputum. That is, Lazolvan is used for wet coughs. Often patients are also interested in whether it is possible to take Erespal and Lazolvan at the same time. The compatibility of these drugs is acceptable. However, only a doctor can prescribe Lazolvan and Erespal together, since compliance with a special regimen for taking these drugs is required.

Which is better: Erespal or Ambrobene?

Patients also wonder whether Erespal and Ambrobene can be used together during treatment. The active ingredient of the drug Ambrobene, like Lazolvan, is ambroxol hydrochloride . Therefore, the answer to the question of what to prefer, Erespal or Ambrobene, is similar.

Which is better: Prospan or Erespal?

Prospan is a drug with a mucolytic effect, the basis of which is a dry extract of ivy leaves. However, only a doctor can determine which drug should be used for a cough, runny nose, etc.

Which is better: Erespal or Askoril?

The drug Ascoril contains three active substances - salbutamol , bromhexine and guaifenesin . It acts on the body as a bronchodilator and mucolytic. Erespal and Ascoril are prescribed at the same time, only by a doctor according to indications. The patient also cannot independently answer which is better - Erespal or Ascoril, since the diagnosis and individual characteristics of the patient must be taken into account.

People very often have questions about combining Erespal with other cough medicines. For example, can Erespal and Fluditec together? Is cough treatment carried out in such a way that Erespal and ACC can be used together in one treatment regimen? Despite the fact that there are no strict instructions on the incompatibility of these drugs, you cannot combine any cough suppressants on your own, without consulting a doctor.

Thus, before answering which cough to take this or that drug, you need to carefully study the instructions and consult with your doctor. For which cough a particular syrup or tablet is prescribed and drunk depends on its active substance and effect on the body.

Reviews about Erespal

Reviews of Erespal tablets and syrup are both positive and negative. Positive reviews are mainly left by those who took the product or gave it to children after a doctor’s prescription. In particular, the rapid action of the drug, a decrease in the manifestations of the disease - cough, shortness of breath, and an improvement in the general well-being of the patient are noted. Reviews from doctors about Erespal syrup are also mostly positive.

However, there are also negative opinions about the drug on various resources. Patients note the manifestation of some side effects - weakness, insomnia, tachycardia, nausea, etc. Often negative opinions are left by those who started treatment with the drug on their own, without determining what kind of cough this medicine is used for, whether it can be taken for a dry cough, how to take it - before or after eating. It should be borne in mind that Erespal is a potent medicine, so it should not be used based only on the statement of forum members that the drug was recommended by Dr. Komarovsky or another expert.

Erespal price, where to buy

Important! On February 14, 2021, the healthcare surveillance service Roszdravnadzor announced the withdrawal from circulation of the drug Erespal in the form of syrup and tablets. This decision was made by the manufacturer of the drug itself, due to the suspension by the French agency ANSM of the registration certificates of drugs containing fenspiride .

Before the ban, the price of Erespal cough syrup 150 ml averaged 250-300 rubles. The price of Erespal in tablets was approximately 400-500 rubles. for 30 tablets of 80 mg. The cost of tablets in Ukraine is approximately 120-140 UAH. for 30 tablets.

How much Erespal tablets or syrup cost in cities such as Odessa, Kharkov can be found out exactly at specific points of sale.

• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

Pharmacy24

• Erespal 200 mg/100 ml 150 ml syrup Laboratories Serv'e Industry, France
  82 UAH.order
• Erespal 80 mg No. 30 tablets Laboratories Serv'e Industry, France

  118 UAH order

PaniPharmacy

• Erespal liquid Erespal syrup 200mg/100ml 150ml France, Servier Industrie

  97 UAH order

• Erespal tablets Erespal tablets. 80 mg No. 30 France, Servier Industrie

  136 UAH order

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