Compound
The active substance is ketotifen in the form of ketotifen fumarate .
Ketotifen tablets contain 1 mg of active ingredient. Additional substances: lactose monohydrate, starch, magnesium stearate.
The syrup contains 1 mg/5 ml of active ingredient.
Eye drops contain 0.25 mg/ml of active substance. Additional substances: sodium hydroxide, benzalkonium chloride, Trilon B, dextran , sodium chloride, purified water, citric acid.
Ketotifen tablets 1 mg No. 10x3
Name
Ketotifen tablets, 1 mg in blister packs, 30 pcs.
Description
Tablets are white or almost white, biconvex.
Main active ingredient
Ketotifen.
Release form
Pills.
Dosage
1 mg.
pharmachologic effect
Pharmacological action - membrane stabilizing, antiallergic, antihistamine, antiasthmatic. Prevents the development of bronchospasm (does not have a bronchodilator effect). Has a depressant effect on the central nervous system.
Indications for use
Prevention and treatment of multisystem allergic diseases:
- chronic idiopathic urticaria (eg, cold urticaria);
- allergic rhinitis with or without concomitant bronchial asthma;
- allergic conjunctivitis;
- atopic dermatitis.
The use of Ketotifen does not replace treatment with corticosteroids (inhaled or systemic) if corticosteroids are indicated for the treatment of bronchial asthma.
Directions for use and doses
The drug is taken orally with meals. Adults are prescribed 1 mg (1 tablet) twice a day (morning and evening). In patients prone to sedation, a slow dose increase is recommended during the first week. It is recommended to start taking 1 tablet once a day in the evening and increase the dose over 5 days to the full daily dose. If necessary, the daily dose can be increased to 4 mg (4 tablets) and divided into two doses. When using higher doses, a faster onset of effect can be expected. Children over 3 years of age are prescribed 1 mg (1 tablet) twice a day (morning and evening). Given that pharmacokinetic studies have shown a high rate of metabolism of ketotifen, in children it may be necessary to prescribe higher doses of the drug per kilogram of body weight to achieve optimal effect. However, the tolerability of such doses remains good. Simultaneous use of bronchodilators. When taking ketotifen, the frequency of taking bronchodilators may be reduced. Use in the elderly. When prescribing ketotifen to elderly people, no dose adjustment is required. Duration of therapy It takes several weeks to achieve the full therapeutic effect of ketotifen. If the patient does not have a reaction to taking ketotifen within several weeks, its further use should continue for at least 2-3 months to achieve a lasting effect. Ketotifen should be discontinued gradually over 2-4 weeks, which may result in an exacerbation of the symptoms of an allergic disease. If a pill is missed, it should be taken as early as possible, and the next one should be taken at the appointed time. Do not take a double dose to make up for a missed dose.
Use during pregnancy and lactation
Although there is no evidence of a teratogenic effect, taking ketotifen during pregnancy is not recommended. Ketotifen is excreted in breast milk, so mothers receiving ketotifen should not breastfeed their infants.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms
Ketotifen may reduce the patient's response. During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Precautionary measures
Abrupt cancellation of previous treatment with beta-adrenergic stimulants, glucocorticosteroids, adrenocorticotropic hormone preparations in patients with bronchial asthma and bronchospastic syndrome after joining ketotifen therapy is undesirable; cancellation is carried out for at least 2 weeks, gradually reducing the dose. Treatment is stopped gradually, over 2-4 weeks (relapse of asthmatic symptoms is possible). For persons sensitive to sedative effects, the drug is prescribed in small doses in the first 2 weeks. Not intended to relieve an attack of bronchial asthma. In patients concomitantly receiving oral hypoglycemic drugs, the platelet count in the peripheral blood should be monitored. During treatment with ketotifen, seizures are extremely rare. Since ketotifen may lower the seizure threshold, it is contraindicated in patients with epilepsy (see section "Contraindications"). In patients with chronic idiopathic urticaria, there have been no studies of the effectiveness and long-term (over 4 weeks) use of ketotifen. In case of intercurrent infections, therapy with ketotifen should be supplemented with antibacterial treatment. Ketotifen tablets contain lactose. Patients with rare hereditary galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption should not take ketotifen.
Interaction with other drugs
Strengthens the effect of sedatives, hypnotics, antihistamines, ethanol. When taking ketotifen and oral hypoglycemic drugs together, it is necessary to monitor platelet levels due to an increased likelihood of developing thrombocytopenia.
Contraindications
Hypersensitivity to any of the components of the drug, pregnancy, lactation (if it is necessary to use the drug, breastfeeding should be stopped), children under 3 years of age, epilepsy and a history of seizures. With caution: liver failure.
Compound
Each tablet contains: active substance - ketotifen (in the form of ketotifen fumarate) - 1 mg; excipients - microcrystalline cellulose, croscarmellose sodium, magnesium stearate, colloidal anhydrous silicon dioxide, lactose monohydrate.
Overdose
Symptoms: drowsiness, nystagmus, confusion, disorientation, brady- or tachycardia, decreased blood pressure, shortness of breath, cyanosis, convulsions, increased excitability (especially in children), coma may develop. Treatment: induction of vomiting, gastric lavage (if a little time has passed since administration), administration of activated charcoal, saline laxatives; symptomatic treatment, with the development of convulsive syndrome - short-acting barbiturates and benzodiazepines. Dialysis is ineffective.
Side effect
The frequency of side effects is given in the following gradation: very often (≥ 1/10); often (≥ 1/100,
Storage conditions
In a place protected from moisture and light at a temperature not exceeding 25°C. Keep out of the reach of children.
Buy Ketotifen tablet 1 mg in container pack No. 10x3 in the pharmacy
Price for Ketotifen tablet 1 mg in container pack No. 10x3
Instructions for use for Ketotifen tablet 1 mg in container pack No. 10x3
Pharmacodynamics and pharmacokinetics
The drug acts as follows: it inhibits the release of histamine, as well as other mediators from mast cells, it also blocks histamine H1 receptors , while inhibiting the PDE enzyme. of cAMP increases in mast cells . Ketotifen suppresses the effects of platelet-activating factor. If the drug is used independently, then attacks of bronchial asthma are not stopped. At the same time, the drug prevents their occurrence and significantly reduces the intensity and duration of these attacks. In some cases they stop completely. In blood plasma, the maximum concentration of the drug is observed after 2–4 hours. Metabolization of most of the drug dose occurs in the liver.
Pharmacological properties of the drug Ketotifen
Antiallergic and antiasthmatic agent. Exhibits antiallergic activity, suppressing the action of endogenous inflammatory mediators; does not have a bronchodilator effect. Ketotifen suppresses the release of allergy mediators (histamine, leukotrienes), inhibits the sensitization of eosinophilic granulocytes by cytokines, leading to suppression of the migration of eosinophilic granulocytes to areas of inflammation; suppresses the development of bronchial hyperreactivity, caused both by activation of platelets when exposed to platelet activating factor, and stimulation by sympathomimetics or allergens. In addition, ketotifen inhibits the enzyme phosphodiesterase, resulting in an increase in the level of cAMP in tissues. These properties of ketotifen determine its anti-asthmatic effect. Ketotifen also has a pronounced antiallergic effect, is able to non-competitively block H1 receptors and therefore can be used instead of their classical antagonists. After oral administration, ketotifen is almost completely absorbed, its bioavailability is about 50% due to metabolism during the first pass through the liver. The maximum concentration in blood plasma is achieved within 2–4 hours. Binding to blood plasma proteins is 75%. The elimination of ketotifen from the body is biphasic with a half-life of 3–5 hours and 21 hours. After instillation into the conjunctival sac, the antihistamine effect begins quickly and lasts 8–12 hours. Ketotifen reduces the severity of symptoms of allergic conjunctivitis (itching, hyperemia, etc.).
Side effects
During treatment with this drug, some side effects may develop. Quite often a state of drowsiness, dry mouth, increased drowsiness, and dizziness appears. There may be problems with the gastrointestinal tract - constipation , nausea, vomiting. These phenomena disappear spontaneously during treatment. Also, due to increased appetite, weight may increase. Symptoms of irritability and agitation and hypersensitivity occur less frequently. Children may experience seizures. hepatitis , cystitis , jaundice , and dark colored urine may occur Overdose may cause drowsiness, hypotension , dizziness, vomiting and nausea, and convulsions in children. In this situation, urgent gastric lavage and taking symptomatic medications are necessary.
Overdose of the drug Ketotifen, symptoms and treatment
Manifested by drowsiness, confusion, disorientation, tachycardia and arterial hypotension, increased excitability, convulsions, especially in children, coma. In case of overdose, gastric lavage is recommended; if necessary, symptomatic treatment and monitoring of the state of the cardiovascular system are carried out; for agitation or convulsions, short-acting barbiturates and benzodiazepines are prescribed.
List of pharmacies where you can buy Ketotifen:
- Moscow
- Saint Petersburg
Instructions for use of Ketotifen (Method and dosage)
Ketotifen tablets, instructions for use
Consume during meals, with a small amount of water. One tablet contains 1 mg of the drug. Adults take one tablet twice a day. Those patients who experience severe sedation should gradually increase the dose of the drug. This is done over seven days, you need to start with 0.5 mg. This dose is taken before bedtime, and the amount of the drug is gradually increased to a therapeutic dose. Children over three years old take 1 tablet twice a day - morning and evening. The drug is taken in the same way during meals.
Ketotifen Sopharma is used similarly.
Ketotifen syrup, instructions for use
Children from one to three years old can take Ketotifen exclusively in the form of syrup, which is prescribed at a dose of 0.25 ml per kg of the child’s weight twice a day. Children over 3 years old should take 5 ml of syrup twice a day with food.
Instructions for eye drops
Starting from 3 years, you can instill one drop twice a day into the conjunctival sac.
Treatment with Ketotifen takes a long period. In this case, a noticeable effect after taking it will be achieved after 2-3 weeks of therapy. The general course of treatment can be two to three months. Those patients who did not experience any visible effect after several weeks of taking the medication should take this medication for a particularly long period. Treatment with this drug is stopped gradually over several weeks. This is done to avoid recurrence of asthmatic symptoms .
Ketotifen, tablets 1 mg, 30 pcs.
Manufacturer
Irbitsky Chemical Plant, Russia
Compound
1 tablet contains: active ingredient: ketotifen hydrofumarate 1.38 mg (corresponds to 1 mg of ketotifen)
pharmachologic effect
Ketotifen has a pronounced antihistamine, weakly antiserotonin effect, without an anticholinergic effect. In higher doses it has a slightly depressant effect on the central nervous system.
Pharmacodynamics
The mechanism of action of Ketotifen is associated with the ability to inhibit the release of histamine and other inflammatory mediators from mast cells due to the stabilization of membranes, as well as due to the blockade of histamine H1 receptors.
Ketotifen inhibits the enzyme phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate in mast cells. The drug reduces or suppresses reactions of the skin and bronchi caused by the antigen, which determines its use for prophylactic purposes.
When used as monotherapy, it does not relieve asthma attacks, but leads to a decrease in the number, duration and intensity of these attacks, and in some cases they completely disappear. Reduces eosinophilia, reduces the need and frequency of use of antiasthmatic drugs: corticosteroids, bronchodilators, etc.
Pharmacokinetics
The drug is characterized by good and rapid resorption, without the danger of accumulation in the body. Bioavailability is approximately 50%, which is due to “first pass” metabolism through the liver. The time to reach maximum plasma concentration is 2-4 hours, and plasma protein binding is 75%.
Excretion from the body occurs in two phases, and within 48 hours the main part of the taken single dose is excreted in the urine. The therapeutic effect develops after 2 weeks of the course of taking the drug.
Indications
- Atopic bronchial asthma, allergic rhinitis,
- allergic conjunctivitis, hay fever (hay fever)
- Ketotifen Sopharma effectively prevents attacks of bronchial asthma and other manifestations of immediate allergic reactions
Contraindications
There are no absolute contraindications. The drug should not be taken during pregnancy, while taking oral antidiabetic drugs, as this may lead to thrombocytopenia; with sedatives and alcohol. Hypersensitivity to the components of the drug.
Side effects
In the first days, drowsiness, dry mouth, mild dizziness, fatigue, and slower mental reactions may appear, usually disappearing after a few days. It is recommended to use a lower dose (5 ml per day) during the first week. Less common is an increase in appetite and an associated increase in body weight.
Patients taking ketotifen should refrain from potentially hazardous activities that involve increased alertness (for example, driving a car).
The drug can be used during lactation only if necessary, since it passes into breast milk.
Interaction
The use of ketotifen in patients who have systematically taken corticosteroids requires a gradual reduction in previous corticosteroid therapy, as there is a risk of developing adrenal insufficiency.
Combination with oral antidiabetic agents sometimes leads to the development of thrombocytopenia.
The simultaneous use of Ketotifen and sedatives, hypnotics, antihistamines and alcohol can lead to an increase in their effect.
How to take, course of administration and dosage
Inside, during meals.
Adults: 1 tablet (1 mg) 2 times a day (morning and evening). For patients experiencing significant sedation, a slow dose increase is recommended over the first week, starting with 0.5 mg in the evening before bedtime, until the therapeutic dose is gradually achieved.
Children over 3 years old - 1 tablet (1 mg) 2 times a day (morning and evening)
Duration of treatment. The treatment is long-term, the therapeutic effect is achieved after several weeks of therapy. Treatment should be continued for at least 2–3 months, especially in patients who did not experience an effect in the first weeks. Treatment with ketotifen should be discontinued gradually over 2–4 weeks.
Overdose
When the dose is increased, mild tremors of the limbs, anxiety and tachycardia may be observed, which disappear after the dose is reduced.
Special instructions
Patients taking ketotifen should refrain from potentially hazardous activities that involve increased alertness (for example, driving a car). The drug can be used during lactation only if necessary, since it passes into breast milk.
Release form
Pills
Storage conditions
In a dry place, protected from light
Best before date
3 years
Active substance
Ketotifen
Conditions for dispensing from pharmacies
On prescription
Dosage form
pills
Purpose
Children as prescribed by a doctor, Children over 3 years old, Adults as prescribed by a doctor
Indications
Allergic conjunctivitis, Dermatitis, Urticaria, Allergy, Allergic rhinitis, Bronchial asthma, Hay fever
Barcode and weight
Barcode: 4603276003698 Weight: 0.013 kg
special instructions
The drug is not used to relieve asthmatic attacks . When starting therapy with this drug, treatment with other anti-asthma drugs should not be abruptly stopped. This is especially true for systemic GCS . People who are dependent on steroids may develop adrenal insufficiency.
This drug has the property of lowering the seizure threshold, therefore, it is carefully prescribed to those patients who exhibit seizures. During pregnancy, this drug is prescribed only when there are direct indications and the benefits of taking it outweigh the risk to the woman and fetus. When taking the drug, you must stop breastfeeding. Due to the possible manifestation of drowsiness, ketotifen is recommended to be used very carefully by drivers and people working with potentially dangerous units.
According to the Sportsweeks website, the drug increases the sensitivity of beta-2 adrenergic receptors, as a result of which it is often used in bodybuilding and for weight loss. We advise you to consult your doctor about the possibility of using this medication.
Ketotifen's analogs
Level 4 ATC code matches:
Polynadim
Vizin Alergy
Zaditen
Cromohexal
Lecrolin
Opatanol
An analogue can be called the medicine Zaditen .
Ketotifen price
The price of Ketotifen in 1 mg tablets is 50 rubles per pack of 30 pieces.
The price of Ketotifen eye drops is 170 rubles.
The cost of syrup is 70 rubles.
You can buy the drug in Ukraine at the following prices:
- tablets - 10 UAH.
- syrup - 20 UAH.
- eye drops – 15 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Zaditen (Ketotifen) tablets 1 mg No. 30
RUB 2,150 order
ZdravCity
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74 RUR order
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84 rub. order
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127 RUR order
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85 rub. order
Pharmacy Dialogue
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Pharmacy24
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