Pharmacological properties
Pharmacodynamics.
stoptussin is a combination drug with antitussive, mucolytic and expectorant effects. butamirate citrate is a non-opioid antitussive agent with peripheral action and exhibits a local anesthetic effect on nerve endings that transmit ascending signals from the respiratory tract. unlike opioid antitussives, it does not cause a central inhibitory effect, does not depress the respiratory center, and does not cause dependence. The antitussive effect of butamirate citrate is complemented by the expectorant effect of guaifenesin.
Guaifenesin reveals secretolytic (due to directly enhancing the secretion of bronchial glands and stimulating the elimination of acidic glycoproteins from acinar cells) and secretomotor properties (reduces the viscosity of sputum and facilitates the evacuation of mucus and its coughing).
Pharmacokinetics. Butamirate citrate is quickly and completely absorbed, 98% binds to blood plasma proteins. As a result of metabolism, two metabolites are formed that have an antitussive effect, and more than 90% of them are excreted by the kidneys; only a small part is excreted in the feces. Biological T½ is about 6 hours.
Guaifenesin after oral administration is quickly and easily absorbed from the gastrointestinal tract. A small part of it binds to plasma proteins. It is excreted by the kidneys, mainly in the form of metabolites, rarely in unchanged form. Biological T½ - 1 hour.
Application
The dose of the drug depends on the patient’s body weight.
Stoptussin tablets: body weight 50 kg - ½ tablet 4 times a day; 50–70 kg - 1 tablet 3 times; 70–90 kg - 1½ tablets 3 times; 90 kg - 2 tablets 3 times a day. The interval between individual doses should be 4–6 hours. The tablet can be divided in half. It is recommended to take the drug after meals with a sufficient amount of liquid (water, tea, juice).
Stoptussin drops: body weight 7 kg - 8 drops every 6–8 hours (3–4 times a day); 7–12 kg – 9 drops every 6–8 hours (3–4 times); 13–20 kg - 14 drops every 8 hours (3 times); 21–30 kg – 14 drops every 6–8 hours (3–4 times); 31-40 kg - 16 drops every 6-8 hours (3-4 times); 41–50 kg - 25 drops every 8 hours (3 times); 51–70 kg - 30 drops every 8 hours (3 times); from 71 kg - 40 drops every 8 hours (3 times a day). The drug is recommended to be taken after meals. The appropriate number of drops is diluted in 100 ml of liquid (water, tea or fruit juice). For children who are unable to drink 100 ml of liquid, the amount of liquid can be reduced to ensure the required dose is taken.
The maximum daily dose of guaifenesin for children aged 6 months to 2 years is 300 mg (102 drops), for children aged 2–6 years – 600 mg (204 drops), 6–12 years – 1200 mg/day, for adults and children over 12 years of age - 2400 mg/day.
Do not take the drug for longer than 7 days without consulting a doctor.
Stoptussin syrup: intended for use in children aged 6 months and older and adults. The dosage should be selected depending on the patient’s body weight: up to 12 kg - 1.25 ml 3-4 times a day; 12–20 kg - 2.5 ml 3 times a day; 20–40 kg - 2.5 ml 3–4 times a day; 40–70 kg - 5 ml 3 times a day; 70–90 kg - 5 ml 4 times a day; 90 kg - 7.5 ml 3-4 times a day.
The interval between doses should be 4–6 hours.
It is recommended to take the drug after meals with a sufficient amount of liquid (water, tea, fruit juice).
Without consulting a doctor, do not take the drug for more than 7 days.
Stoptussin Phyto syrup 100ml No. 1
Name
Stoptussin phyto syrup in bottle. 100ml per pack. No. 1
Description
Brown syrup with a thyme scent. Over time, a small sediment appears, which does not affect the effectiveness of the drug
Release form
Syrup
pharmachologic effect
Pharmacodynamics
Thyme and thyme extracts have an expectorant effect. The polysaccharides contained in plantain extract have an enveloping effect on the mucous membrane of the upper respiratory tract and help reduce the cough reflex.
Pharmacokinetics
There is no information available because herbal medicines contain various biologically active substances.
Indications for use
The drug is used as an expectorant in the complex therapy of acute respiratory diseases.
Directions for use and doses
Children from 4 to 12 years: 1-2 teaspoons (1 teaspoon = 5 ml) 3 times a day after meals (due to the possibility of decreased appetite). Children over 12 years of age and adults: 1 tablespoon (1 tablespoon = 15 ml) up to 4 times a day. The duration of the course of treatment is determined by the doctor, taking into account the characteristics of the disease, tolerability of the drug and the achieved effect. If symptoms persist for more than 1 week, you should consult your doctor. It is not recommended to take the medicine for a long time due to the ethyl alcohol content. The duration of use in children should be minimal.
Use during pregnancy and lactation
The safety of the drug during pregnancy and lactation has not been proven. Due to the lack of sufficient data and the ethyl alcohol content, use during pregnancy and breastfeeding is not recommended.
The ability to influence the reaction rate when driving a vehicle or working with other mechanisms
The medicine contains ethyl alcohol! During the treatment period, it is recommended to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Precautionary measures
If within 3 days of treatment your condition does not improve or the signs of the disease worsen, you should consult a doctor. If you miss another dose of the drug, you should take the next dose as soon as possible. However, if it is time for your next dose, do not take the missed dose, but return to your normal treatment regimen. The drug contains 62 g of sucrose. One teaspoon (5 ml) contains up to 3.1 g of sucrose, one tablespoon (15 ml) contains up to 9.3 g of sucrose. Therefore, the drug should be used with caution in patients with diabetes mellitus and in people on a low-carbohydrate diet. The drug contains 3.4% ethanol by volume. One teaspoon (5 ml) contains up to 0.14 g of ethanol, one tablespoon (15 ml) contains up to 0.41 g of ethanol. In this regard, the drug may have adverse effects in patients suffering from alcoholism. Patients with epilepsy, diseases and brain injuries are also at risk. In case of overdose or accidental use of the drug by a child, consult a doctor. If symptoms persist while taking the drug or if the condition worsens (breathing problems, fever, sputum mixed with pus or blood), you should immediately consult your doctor.
Interaction with other drugs
Concomitant use with antitussive drugs, as well as with drugs that reduce the formation of sputum, is not recommended, as this makes it difficult to cough up liquefied sputum. The simultaneous use of other medications containing ethyl alcohol should be avoided. Interactions associated with the presence of ethyl alcohol in the composition: drugs that cause a disulfiram-like reaction (feeling of heat, redness of the skin, vomiting, tachycardia) when taken together with alcohol: disulfiram, cefamandole, cefoperazone, latamoxef, chloramphenicol, chlorpropamide, glibenclamide, glipizide, tolbutamide and other hypoglycemic drugs, griseofulvin, metronidazole, ornidazole, tinidazole, ketoconazole, procarbazine; drugs that inhibit the functions of the central nervous system.
Contraindications
Hypersensitivity to thyme, thyme, plantain, other components of the drug, as well as to plants of the Lamiaceae family. Pregnancy, lactation period. Children's age up to 4 years. Congenital fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency. With caution: liver disease, alcoholism, epilepsy, traumatic brain injury and other brain diseases with a decrease in the seizure threshold.
Compound
active ingredients: 100 ml of syrup contains: liquid thyme extract (1:1.11) 4.1624 g (extractant ethanol 25% (v/v)) (Thymi extraction fluidum), liquid thyme extract (1:1.3 ) 4.1630 g (extractant ethanol 25% (v/v)) (Serpylli extraction fluidum), liquid plantain extract (1:1.1) 4.1666 g (extractant ethanol 34% (v/v) ) (Plantaginis extractum fluidum); excipients: ethanol (as part of extracts), honey, sodium benzoate (E211), sucrose, glycerin 85% (E422), purified water. The medicinal product contains 3.4% (v/v) ethanol.
Overdose
There is no information about cases of overdose. The drug contains ethyl alcohol; in case of overdose, children may develop alcohol intoxication. If children accidentally ingest large amounts of syrup, consult a doctor immediately.
Side effect
Allergic reactions (including anaphylactic shock and Quincke's edema) and gastrointestinal disorders are possible. If any adverse reactions occur, including those not listed in this instruction, you must stop taking the medicine and consult a doctor.
Storage conditions
Store at temperatures between 10 °C and 25 °C, protected from light and out of the reach of children. Shelf life: 4 years. Do not use after the expiration date stated on the package.
Side effects
If you adhere to the recommended dosage, patients tolerate the drug well. side effects usually disappear after the dose is reduced.
Metabolic disorders: lack of appetite.
From the nervous system: headache, drowsiness.
From the respiratory system: difficulty breathing.
Hearing impairment and vestibular disorders: dizziness.
From the gastrointestinal tract: discomfort, nausea, stomach pain, vomiting, diarrhea. If you experience stomach discomfort or other unusual effects, you should stop using the drug and consult your doctor.
From the skin and subcutaneous tissue: allergic reactions, including anaphylactic shock, angioedema, rash, itching, urticaria, exanthema.
From the urinary system: urolithiasis.
special instructions
When using the drug, you must refrain from drinking alcoholic beverages. the drug is not used in patients with:
- productive cough and/or persistent or chronic cough associated with smoking;
- BA;
- chronic bronchitis or emphysema.
The drug is used with caution for asthma, tuberculosis, and pneumococcosis.
If the cough persists or worsens, treatment should be reconsidered.
The drug in the form of drops contains 35.6 vol.% ethanol (alcohol), that is, 0.332 g / dose (40 drops), which is equivalent to 8.4 ml of beer or 3.5 ml of wine per dose.
The drug in syrup form contains liquid maltitol. Patients with known rare hereditary fructose intolerance should not take this drug.
During pregnancy and breastfeeding. There are no controlled studies in humans or animals in pregnant women.
An increased incidence of inguinal hernia in newborns has been reported with the use of guaifenesin in the first trimester of pregnancy. Therefore, the drug is contraindicated in the first trimester of pregnancy.
The use of the drug in the second, third trimester of pregnancy or during breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother exceeds the potential risk for the fetus/child.
It is not known whether butamirate citrate or guaifenesin passes into breast milk.
Taking into account safety, it is necessary to carefully weigh the benefits and risks of using the drug during breastfeeding. The use of the drug during breastfeeding is possible if, in the opinion of the doctor, the expected positive effect for the mother exceeds the potential risk for the child.
Children. The drug in tablet form is used in children over 12 years of age; in the form of drops and syrup - from 6 months in accordance with indications (dosages and method of administration are given in the APPLICATION section).
The ability to influence reaction speed when driving vehicles or working with other mechanisms. In rare cases, Stoptussin causes drowsiness, which may have some effect on the ability to drive or operate machines. Therefore, when driving vehicles or performing other work that requires attention (for example, when operating machinery), you should be careful.
Stoptussin-Phyto syrup 100 ml fl t/st/pack card x1
Trade name of the drug Stoptussin-Fito
International nonproprietary or generic name:
Plantain lanceolate leaf extract + Common thyme herb extract + Creeping thyme herb extract
Dosage form Syrup
Composition (per 100 ml):
Active ingredients: common thyme herbal extract liquid alcohol (Thyini extractum fluidiim etlianolum) - 4.1624 g.
creeping thyme herb liquid alcohol extract (Serpylli extractum fluidum etlianolum) - 4.1630 g.
lanceolate leaf plantain liquid alcohol extract (Plantaginis extractum fluidum etlianolum) - 4.1666 g.
Excipients: honey - 22.5000 g, sodium benzoate - 0.1250 g, sucrose - 62.0000 g, glycerol 85% - 0.0078 g, water - up to 100.0000 ml.
Description
Thick brown liquid with a specific odor.
Pharmacotherapeutic group Expectorant of plant origin.
ATX code: R05X
Pharmacological properties The drug has an expectorant, anti-inflammatory effect, and helps reduce the viscosity of sputum.
Indications for use
As part of complex therapy for acute and chronic inflammatory diseases of the respiratory tract, accompanied by cough with difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis).
Contraindications
Hypersensitivity to the components of the drug, in patients with known intolerance to chalk and bee products, chronic heart failure (in the decompensation stage), liver and kidney diseases, congenital fructose intolerance, glucose-galactose malabsorption, sucrase/isomaltase deficiency, pregnancy, breastfeeding, children's age up to 1 year.
Carefully
Alcoholism, epilepsy, traumatic brain injury, brain diseases, diabetes.
Use during pregnancy and breastfeeding
The use of the drug during pregnancy and breastfeeding is contraindicated.
Directions for use and doses
Orally, after meals (due to the possibility of decreased appetite).
Children from 1 year to 5 years - 1/2-1 teaspoon 2-3 times a day, from 5 to 10 years - 1-2 teaspoons 3 times a day, from 10 to 15 years - 2-3 teaspoons 3 times a day, children over 15 years old and adults - 1 tablespoon 3-5 times a day. The course of treatment is 7 days. Increasing the duration and conducting repeated courses of treatment is possible on the recommendation of a doctor.
Side effects
Allergic reactions: dyspnea, skin rash, urticaria, and swelling of the face, mouth or throat (Quincke's edema).
Digestive system disorders: cramps, nausea, vomiting.
In these cases, as well as in the event of the development of any adverse events not listed in the instructions, you must stop using the drug and consult a doctor.
Overdose
To date, there have been no reports of cases of overdose when using the drug.
Interaction with other drugs
The drug Stoptussin-Fito should not be used simultaneously with drugs containing codeine and other antitussive drugs, as this makes it difficult to cough up liquefied sputum.
special instructions
If the patient’s condition does not improve or if there are attacks of suffocation, purulent sputum, or an increase in body temperature, you should immediately consult a doctor.
The drug Stoptussin-Fito contains 62% sucrose, so it should be used with caution in patients with diabetes mellitus and people on a low-carbohydrate diet. 1 teaspoon of Stoptussin-Fito contains up to 3.1 g of sucrose (which corresponds to 0.28 XE). in 1 tablespoon - up to 9.3 g of sucrose (which corresponds to 0.85 XE).
The drug Stoptussin-Fito contains 3.4% (volume) ethanol: 1 teaspoon of syrup (5 ml) contains up to 0.14 g of absolute ethyl alcohol: 1 tablespoon of syrup (15 ml) - up to 0.41 g of absolute ethyl alcohol: in the maximum daily A dose of Stoptussin-Fito for adults (75 ml) contains up to 2.05 g of absolute ethyl alcohol.
Impact on the ability to drive vehicles and machinery
During the period of treatment with Stoptussin-Fito, you should refrain from performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).
Release form
Syrup.
100 ml in dark glass bottles with a measuring cap.
Each bottle, along with instructions for use, is placed in a cardboard box.
Storage conditions
At a temperature not exceeding 25 ° C in a place protected from light. Keep out of the reach of children!
Best before date
4 years. Do not use after the expiration date stated on the package.
Conditions for dispensing from pharmacies Without a prescription.
Interactions
Since butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided, as this can lead to stagnation of mucus in the respiratory tract, which increases the risk of bronchospasm and respiratory tract infection.
Lithium and magnesium enhance the effect of guaifenesin.
Guaifenesin enhances the analgesic effect of paracetamol and acetylsalicylic acid, and also enhances the effect of alcohol and other drugs that depress the function of the central nervous system. Centrally acting muscle relaxants may increase the side effects of guaifenesin, especially muscle weakness.
Impact on laboratory test results
Guaifenesin may cause false-positive results in diagnostic tests that measure 5-hydroxyindoleacetic acid (photometric method using nitrosonaphthol as a reagent) and vanillylmandelic acid in urine. Therefore, treatment with Stoptussin must be stopped 48 hours before urine collection for this analysis.
Stoptussin phyto syrup 100 ml (vial with measuring cap)
Release form: Syrup. Packaging 100 ml of syrup in a dark glass bottle. The package contains 1 bottle complete with a measuring cap. Pharmacological action Has an expectorant, anti-inflammatory effect, helps reduce the viscosity of sputum. Indications As part of complex therapy of acute and chronic inflammatory diseases of the respiratory tract, accompanied by cough with difficult to separate sputum: Tracheitis. Bronchitis. Tracheobronchitis. Contraindications Hypersensitivity to the components of the drug. Decompensation of cardiac activity. Liver and kidney diseases. Congenital fructose intolerance. Impaired absorption of glucose and galactose. Lack of enzyme that breaks down sucrose and isomaltose. Pregnancy. Lactation period. Children's age up to 1 year. The drug should be used with caution (due to the presence of ethanol and sucrose in the drug) in patients with: Alcoholism. Epilepsy. Diseases and injuries of the brain. Diabetes mellitus. Persons on a low carbohydrate diet. Use during pregnancy and breastfeeding The drug is contraindicated for use during pregnancy and lactation (breastfeeding). Special instructions If your condition does not improve or if you experience attacks of suffocation, purulent sputum, or if your body temperature rises, you should immediately consult a doctor. The drug contains 62% sucrose, so it should be used with caution in patients with diabetes mellitus and in people on a low-carbohydrate diet. 1 teaspoon of the drug contains up to 3.1 g of sucrose (which corresponds to 0.28 XE), 1 tablespoon contains up to 9.3 g of sucrose (which corresponds to 0.85 XE). The drug contains 3.4 vol.% ethanol 1 teaspoon (5 ml) contains up to 0.14 g of ethanol 1 tablespoon (15 ml) - up to 0.41 g of ethanol. The drug contains 62% sucrose, so it should be used with caution in patients with diabetes mellitus and in people on a low-carbohydrate diet. 1 teaspoon of the drug contains up to 3.1 g of sucrose, 1 tablespoon - up to 9.3 g of sucrose. Use in pediatrics The drug should be prescribed with caution to children (due to the possible negative effects of ethanol). Effect on the ability to drive vehicles and operate machinery During the period of taking the drug Stoptussin-Fito, you should refrain from performing potentially hazardous activities that require special attention, coordination of movements and quick reactions (driving a car and other vehicles, working with moving mechanisms, working as a dispatcher and operator, etc.). Composition 100 g of syrup contains: Liquid thyme extract 4.1666 g. Liquid thyme extract 4.1666 g. Liquid plantain extract 4.1666 g. Excipients Purified honey, sodium benzoate, propylparaben, sucrose, purified water. Method of administration and dosage The drug is prescribed orally, after meals (due to the possibility of decreased appetite). Children: From 1 year to 5 years - 1/2-1 teaspoon 2-3 times a day. From 5 to 10 years - 1-2 teaspoons 3 times a day. From 10 to 15 years - 2-3 teaspoons 3 times a day. Adults and children over 15 years old - 1 tablespoon 3-5 times a day. The average course of treatment is 7 days. Increasing the duration of treatment and repeat courses is possible on the recommendation of a doctor. Side effects Allergic reactions Dyspnea, skin rash, urticaria, swelling of the face, mouth and/or throat (Quincke's edema). From the digestive system: Cramps, nausea, vomiting. Drug interactions Stoptussin-Fito should not be used simultaneously with drugs containing codeine and other antitussive drugs, because this makes it difficult to cough up thin mucus. Storage conditions Store in a place protected from light at temperatures up to 25°C. Keep out of the reach of children. Shelf life: 4 years. Active ingredient: Plantain extract, Thyme extract, Thyme extract Dosage form: oral solution
Note!
Description of the drug Stoptussin-Teva syrup fl. 100ml on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
