How to beat the flu: the basics of vaccination in five questions

Ultrix Quadri is a quadrivalent inactivated split influenza vaccine. Registration certificate: LP-005594 Trade name: Ultrix Quadri Group name: Vaccine for the prevention of influenza (inactivated) Dosage form: Solution for intramuscular administration Country of origin: Fort, Russia Preliminary examination: not required Cost of the vaccine: 1500 rubles (examination is paid additionally before vaccination) Applicable: from 6 months Conditions for dispensing from pharmacies: Packs of 1 syringe or 1 bottle - according to a doctor's prescription, Packs of 10 bottles - for medical institutions Availability of the vaccine: in stock Analogs of this vaccine: Vaccine "Vaxigrip" (Vaxigrip) ) (for adults and children from 6 months) Influvac vaccine (for adults and children from 6 months)

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DESCRIPTION OF THE MEDICINE

Ultrix quadri (Ultrix) is a mixture of protective surface and internal antigens of influenza viruses type A and type B. The antigenic composition of the vaccine changes every year in accordance with the epidemic situation and WHO recommendations.

Appearance: Colorless or slightly yellowish transparent liquid, slight opalescence may be present. Pharmacotherapeutic group: MIBP vaccine ATC code: J07BB02

Immunological properties

The vaccine forms high specific immunity against influenza types A and B. After vaccination, antibodies appear within 8-12 days, immunity lasts up to 12 months.

Additional Information

Is it possible to purchase Ultrix from us or where to buy Ultrix in Moscow?

The City of Childhood clinic on Taganka and Zhulebino does not sell the Ultrix vaccine, we vaccinate.

Where to get the Ultrix vaccination in Moscow?

You can get vaccinated with Ultrix at the City of Childhood clinic on Taganka and Zhulebino, the Ultrix vaccine is available. Vaccination requires a mandatory examination before vaccination, the vaccination itself and observation after vaccination.

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COMPOUND

Composition: 1 dose (0.5 ml) contains:

Active substances:

• Influenza virus type A (H1N1) antigen – (15±2.0) µg GA
• Influenza virus type A antigen (H3N2) – (15±2.0) µg GA
• Influenza virus type B antigen (Yamagata line) – (15±2.0) µg GA
• Influenza virus type B antigen (Victoria line) – (15±2.0) µg GA

Excipients:

• Polysorbate 80 – no more than 250 mcg
• Octoxynol 10 – no more than 150 mcg
• Phosphate-buffered saline solution – up to 0.5 ml.

Note: composition of phosphate-buffered saline solution: sodium chloride, disodium hydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, water for injection.

Which flu vaccine to choose

All flu vaccines contain strains of influenza viruses that are relevant for the coming season. The vaccine contains antigens from three or four of the expected four strains - such vaccines are called trivalent or quadrivalent .

What are the pros and cons? Vaccines containing antigens from all four strains provide more complete protection. Trivalent vaccines are less likely to cause any negative reactions to the vaccine.

INDICATIONS FOR USE

Active annual preventive immunization against seasonal influenza for people aged 6 months to 60 years:

1. For people at high risk of illness and complications from influenza:
   persons who often suffer from acute respiratory viral infections
2. persons suffering from chronic somatic diseases, including diseases and malformations of the cardiovascular, respiratory and central nervous systems, chronic kidney diseases, metabolic diseases, diabetes mellitus, chronic anemia, allergic diseases (except allergy to chicken proteins), congenital or acquired immunodeficiency, including those infected with the human immunodeficiency virus.
3. Persons who, due to the nature of their educational or professional activities, have a high risk of contracting influenza or infecting others with it:
   workers of medical and educational institutions, transport, public utilities and social spheres
4. police, military personnel, etc.

Flu vaccination by risk group

It is especially undesirable for children of preschool and school age, pregnant women, the elderly, people with a weakened immune system and chronic diseases of the heart and lungs, central nervous system, and diabetes to get sick.
In these people, the flu can be extremely severe, with complications and a high probability of death. That is why they are vaccinated first. It is also important for their relatives and immediate circle to undergo preventive vaccination in order to reduce the risk of encountering an infection within the family. Please register and ask all questions by phone: +7.

CONTRAINDICATIONS

• Allergic reactions to previous vaccinations with influenza vaccines;
• Allergic reactions to chicken protein and other components of the vaccine;
• Acute febrile, acute infectious and non-infectious diseases, conditions or exacerbations;
• Chronic disease;
• Age up to 6 years.

For mild ARVI and acute intestinal diseases, vaccination is carried out after the body temperature of the vaccinated person has normalized; for chronic diseases in the acute stage, vaccinations are carried out after recovery (remission).

Our doctors

Pastushnaya Victoria Sergeevna

Pediatrician, Chief Physician, Expert, Vaccine Prevention 25 years of experience

Gammel Elizaveta Nikolaevna

Pediatrician, Vaccine prevention, Gastroenterologist, Functional diagnostics (Taganka, Zhulebino) Experience 13 years

Ilyina Larisa Anatolyevna

Pediatrician, Vaccine prevention (Zhulebino) Experience 33 years

Konovalova Elena Borisovna

Pediatrician, Vaccine prevention (Zhulebino) Experience 35 years

Filippov Andrey Nikolaevich

Pediatrician, Vaccine prevention (Taganka) Experience 30 years

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PRECAUTIONARY MEASURES

1. Do not administer intravenously.
2. Before vaccination, those vaccinated must be examined by a doctor (paramedic) with mandatory thermometry. If the body temperature is above 37C, vaccination is not carried out.
3. Rooms where vaccination is carried out must be equipped with anti-shock therapy. The vaccinated person should be under the supervision of a health care worker for 30 minutes after vaccination.

Use during pregnancy and breastfeeding

Experience with the use of inactivated influenza vaccines shows that vaccination of women during breastfeeding does not have a toxic effect on the child .

The final decision to vaccinate pregnant and breastfeeding women should be made individually by a physician, taking into account the risk of contracting influenza and possible complications caused by influenza.

The safest period for vaccination of pregnant women is the second and third trimesters of pregnancy.

How to help your child feel comfortable during vaccinations

Vaccination works better when the baby is calm and not afraid. To avoid scaring your child, try the following:

• Distract and calm your baby, hug him, talk softly to him
• Be calm, confident, smile. Maintain eye contact with your child, communicate with him, show him that you are nearby and everything is okay.
• Let your child hold a favorite toy or blanket.
• Ask your doctor if you can hold your baby on your lap and gently rub his back during vaccination.
• Be sure to praise your child after vaccination, tell him how great he is and how proud you are of him. Support your baby, even if he couldn't help but cry.

METHOD OF APPLICATION AND DOSAGE

Vaccination is carried out annually in the autumn-winter period. Vaccination is possible at the beginning of an epidemic rise in the incidence of influenza.

The vaccine is administered intramuscularly in a dose of 0.5 ml once in the area of ​​the deltoid muscle (the upper third of the outer surface of the shoulder).

The drug is not suitable for use in syringes/vials with damaged integrity or markings, if the physical properties (color, transparency) have changed, if there are foreign particles in the solution, if the expiration date has expired, or if the requirements for storage conditions are violated.

Opening of syringes/vials and vaccination is carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in opened syringes/vials.

Benefits of vaccination in any pediatric healthcare setting

RESPONSIBILITY FOR THE LIFE AND HEALTH OF THE PATIENT

• vaccination is carried out only in specially equipped and licensed pediatric medical centers
• all drugs used are approved for use on the territory of the Russian Federation and have the necessary certificates
• the quality of drugs, expiration dates and storage conditions are carefully controlled
• medical personnel performing vaccinations are certified as “vaccination nurses” and undergo regular additional training and certification
• Before vaccination with any vaccines, all patients are required to be examined by an immunoprophylaxis doctor. The purpose of the examination is to make sure that the patient’s body condition is normal, there are no contraindications or medical exemptions from vaccination, and there is no risk of developing post-vaccination complications.
• After vaccination, the patient must remain in the medical center for at least 30 minutes under the supervision of a vaccination nurse
• the next day after vaccination, the vaccination nurse will definitely call you, check your health status, and make sure that the vaccination was successful
• If necessary, or if post-vaccination complications develop, a pediatrician or immunoprophylaxis specialist will come to your home free of charge within 24 hours after vaccination and provide the necessary assistance.

Dear parents! Please check in advance for up-to-date information about the availability of the vaccine you need at the medical center by phone.

SIDE EFFECTS

• Headache
• Excessive sweating
• Arthralgia, myalgia
• Pain, hyperemia at the injection site
• Induration, swelling and itching at the injection site
• Fever, chills, weakness

These adverse reactions may develop on the day of vaccination; usually disappear on their own after 1-3 days and do not require treatment.

Despite the lack of clinical data, the possibility of developing neurological disorders and allergic reactions characteristic of influenza vaccines (including immediate reactions to chicken protein and other components of the vaccine) cannot be excluded.

The patient should be informed of the need to inform the doctor about any adverse reactions expressed or not specified in this instruction.

What contraindications exist for Ultrix Quadri?

Vaccination should be postponed if the child is ill in the acute stage, for a period of 2 to 4 weeks - it is better to consult with your personal pediatrician about the necessary break. For mild respiratory or intestinal infections, you need to wait until the temperature drops, then, as a rule, you can get vaccinated. The vaccine should not be given if the child has had a strong reaction to previous flu vaccinations (no matter what kind of vaccine) or is allergic to any of the components, including chicken protein.

Patients who have recovered from covid-19 can be vaccinated against influenza 1 month after recovery.

Sources:

1. Instructions for use of the Ultrix Quadri vaccine
2. Rostec’s vaccine against four strains of influenza “Ultrix Quadri” has been approved for all ages.//Rostec, 09/21/2021
3. Creator of the new Russian flu vaccine Anton Katlinsky: We vaccinated Sergei Chemezov and Veronika Skvortsova.//Snob, 10/15/2019

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INTERACTIONS WITH OTHER MEDICINES

The vaccine can be used simultaneously with inactivated and live vaccines of the National Preventive Vaccination Calendar of the Russian Federation (with the exception of tuberculosis vaccines and inactivated vaccines of the preventive vaccination calendar for epidemiological indications (except for rabies). In this case, contraindications to each of the vaccines used must be taken into account; the drugs should be administered in different parts of the body with different syringes.

The vaccine can be administered against the background of basic therapy for the underlying disease. Vaccination of patients who have received immunosuppressive therapy (glucocorticosteroids, cytotoxic drugs, radiotherapy) may be less effective.

How to beat the flu: the basics of vaccination in five questions

05.11.2020

In Russia, as usual, mass flu vaccination started in September. This season it is especially important amid the coronavirus pandemic. Rostec's pharmaceutical holding Nacimbio is actively supplying anti-influenza vaccines - these are domestic drugs that have proven themselves well in past epidemic seasons. We tell you when and what to get vaccinated this fall and how seasonal flu vaccination is compatible with the new COVID-19 vaccine.

When should you get a flu shot?

Although the campaign against influenza has been going on since September, and October is considered the optimal time for prevention, November is not too late to get vaccinated. The peak of the spread of influenza usually occurs in the middle of winter, but even if the epidemic has already begun, vaccination will not be superfluous. A vaccine containing antigens from current influenza strains will “teach” the body to fight a real infection and help prevent the dangerous consequences of influenza.

Why do you need to get vaccinated every year?

The flu vaccine usually lasts for one epidemic season, approximately equal to a year. Therefore, the body’s resistance to the virus needs to be increased every year. Firstly, the immunity developed as a result of vaccination decreases over time. Secondly, different types of influenza circulate around the planet from year to year, and every year the World Health Organization (WHO) makes recommendations which strains of the virus will be most active this season. Based on this, national manufacturers are preparing appropriate vaccines.

For example, the Ultrix, Sovigripp and Flu-M vaccines supplied by Nacimbio, the pharmaceutical holding of the Rostec State Corporation, as part of the Russian National Vaccination Calendar for the 2020-2021 season, are trivalent, that is, they contain three current strains of the virus flu And the newest quadrivalent vaccine, Ultrix Quadri, which is in use for the second season, includes another additional strain of influenza B virus. According to WHO forecasts, three new strains of influenza will come to Russia this year, for which collective immunity has not yet been developed.

How do flu and COVID-19 vaccinations work together?

Unfortunately, with the onset of the cold season, residents of Russia may face the spread of two respiratory viruses at once - seasonal influenza and Covid. Doctors do not yet have much experience in treating these two diseases together. But the creators of the first domestic coronavirus vaccine from the National Research Center named after. N.F. The Gamaleyans have already stated that the Covid vaccine will not conflict in the body with the flu vaccine. It is recommended to maintain a gap of three weeks between the two drugs.

As you know, the flu is dangerous not by itself, but by complications after it. These complications can also aggravate the course of the coronavirus infection. And a body weakened by the influenza virus will be more susceptible to contracting Covid. In addition, the symptoms of the COVID-19 virus may resemble the common flu - aching joints, fever, cough. Therefore, this season it is very important to get a flu shot, so that if characteristic symptoms appear, there is a high probability of distinguishing flu from covid.

Who should get the flu vaccine?

This season in Russia it is planned to cover about 60% of the population with flu vaccination, including 75% of those at risk. It is the latter that vaccination is especially indicated.

Those at risk include children, pregnant women, people over 60 years of age, people with chronic diseases and healthcare workers. There are not many contraindications for vaccination. These are allergic reactions to chicken protein, on which the vaccine is based, and its other components, the presence of signs of acute respiratory infections and acute chronic diseases. If you are unsure of your allergic status, it is recommended to stay in a medical facility for 15 minutes after the injection to observe your body's reaction to the drug.

What to vaccinate in the 2020-2021 season?

Flu vaccines are included in the list of vital and essential drugs, therefore their production and supply are regulated at the state level. There is no fundamental difference between domestic and foreign vaccines, but only domestically produced anti-flu drugs are included in the National Preventive Vaccination Calendar. This year, Russian patients are being vaccinated with domestic vaccines, which have proven themselves well in previous seasons.

As part of the annual mass flu vaccination campaign, Rostec's pharmaceutical holding Nacimbio will supply more than 75 million doses of vaccines for children and adults. These are the trivalent vaccines “Ultrix”, “Sovigripp”, “Flu-M” and the quadrivalent vaccine “Ultrix Quadri”. The latter will be supplied with 7.5 million doses this time – 40% more than last season.

As of 2021, WHO recommends quadrivalent vaccines as a priority for the prevention of influenza worldwide. In Russia, a state program is being implemented for a phased transition to such drugs. The expanded strain composition of Ultrix Quadri this season eliminates possible risks associated with the emergence and circulation of the Victorian and Yamagata lines of influenza. The vaccine contains 15 micrograms of hemagglutinin (antigen) of each strain per dose and does not contain preservatives or adjuvants. Russia, according to state plans, will switch completely to vaccinations with four strains by 2023.

Our country is part of a narrow circle of states capable of producing quadrivalent influenza vaccines in a full cycle. The quality of the new Russian drug is evidenced by the fact that people want to be vaccinated with it not only in our country, but also abroad. According to Rostec CEO Sergei Chemezov, this year foreign customers will receive more than 1 million doses of Ultrix Quadri.

Other news

Epidemiologist Nikolai Briko: the situation with coronavirus in Russia is quite difficult

The coronavirus pandemic has forced doctors and scientists to reassess the situation with infectious diseases in Russia. In particular, in recent years, the country has seen an increase in the incidence of meningococcal infection, which indicates the importance of implementing measures to prevent it. Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor Nikolai Briko spoke about which categories of citizens are most susceptible to meningococcal infection, the consequences of its combination with COVID-19, as well as the overall situation with coronavirus in the country.

Rospotrebnadzor warned about the danger of “chickenpox parties”

Some people believe that it is better to have chickenpox in childhood, because a child supposedly tolerates this disease more easily than an adult. Therefore, there are still parents who try to “plan” for the disease: they go to visit sick friends and organize “chickenpox parties,” Alexander Gorelov, deputy director for scientific work at the Central Research Institute of Epidemiology of Rospotrebnadzor, noted in an interview with Sputnik radio.

In the Nizhny Novgorod region, 1.5 million people were vaccinated against influenza

In the Nizhny Novgorod region, flu vaccination is being completed, the press service of the regional government reported. The vaccination campaign covered less than half of the region’s population—1.5 million people, including 388 thousand children and adolescents.

In Bashkiria they talked about the benefits of vaccination against pneumococcus

Does the pneumococcal vaccination make it easier to cope with coronavirus in case of complications? Important information was presented at a briefing on the results of the activities of the healthcare sector in Bashkiria in 2021. As Industry Minister Maxim Zabelin said, indeed, vaccination against pneumococcus reduces the incidence of complications from Covid and the development of bacterial pneumonia.

Rostec began supplying Russian flu vaccines abroad

In 2021, FORT exported vaccines to the Republic of Belarus, Moldova, Kyrgyzstan, Turkmenistan and Uzbekistan. In the overall structure of supplies, the largest volume (over 90%) fell on the quadrivalent vaccine Ultrix Quadri. In addition, foreign partners purchased the trivalent Ultrix vaccine.

Nacimbio launched an application about vaccinations

, which is managed by the Nacimbio holding of the Rostec State Corporation, launched the “Vaccinations - Personal Calendar” mobile application. It helps users create an individual vaccination schedule and reminds them about scheduled vaccinations. The Vaccinations app is available for free on Android and iOS mobile phones.

Covid-19 vaccines will be included in the preventive vaccination calendar

Prime Minister Mikhail Mishustin instructed to include vaccines against the new coronavirus infection in the calendar of preventive vaccinations for epidemic indications, taking into account priority. Previously, COVID-19 vaccines were included in the VED. Mishustin noted that changes to the order of the Ministry of Health “On approval of the National Calendar of Preventive Vaccinations and the Calendar of Preventive Vaccinations for Epidemic Indications” must be made before December 17, 2020.

Vaccination against coronavirus has begun in Crimea

“Vaccination begins today in Crimea. First of all, high-risk medical workers who work with patients with a new coronavirus infection will be vaccinated. In the future, the daily number of vaccinated people will depend on the volume of vaccine received,” wrote the head of the republic, Sergei Aksenov, on his page on the VKontakte social network.

Cases of dangerous measles continue to be recorded in the Volgograd region

In the Volgograd region in 2021, measles was laboratory confirmed. This was reported by the regional department of Rospotrebnadzor. It is known that a dangerous disease manifests itself in those who have not been vaccinated. This year, 1 case of measles was confirmed in the region.

Scientists will combine the Oxford vaccine with Sputnik V

Scientists from the University of Oxford and the Russian Gamaleya Research Center for Epidemiology and Epidemiology will join forces to work on a vaccine for COVID-19. They agreed to conduct clinical trials of a combination of two drugs - the British vaccine and one of the two components of the Russian Sputnik V, the Russian Direct Investment Fund and the Swedish-British pharmaceutical company AstraZeneca reported.

RELEASE FORM

Solution for intramuscular administration.

• 0.5 ml (1 dose) in glass syringes with a soldered needle with a protective cap or glass bottles, hermetically sealed with rubber stoppers, rolled with aluminum or aluminum-plastic caps;
• 1 syringe in a blister pack, covered with aluminum foil or paper, in a cardboard pack along with instructions for use;
• 1 bottle in a cardboard pack along with instructions for use;
• 10 bottles in a cardboard pack with a cardboard insert along with instructions for use.