Compound
One capsule of Negrustin contains 0.425 g of dehydrated extract of the herb St. John's wort .
It also contains additional ingredients: MCC, lactose, aerosil, calcium dihydrogen phosphate, talc, gelatin, magnesium stearate, copper chlorophyll complex, sodium lauryl sulfate, iron oxide, titanium dioxide, water.
The Negrustin solution contains St. John's wort herb extract .
It also contains additional components: 1,2-propanediol, glycerin, sorbitol, flavoring.
Release form
The product is available in the form of hard, opaque gelatin capsules, which have a matte red body and a green cap. The capsules contain green-brown or gray-brown granules with a specific odor. The tablets are packaged in blisters of 10 pieces; cardboard packs may contain 3, 4, 6 or 10 blisters.
The solution for internal use has a brown or red-brown color, it is transparent, and has a pleasant aroma. If the solution is stored for a long time, it may become cloudy or precipitated. The solution is packaged in dark glass bottles of 50 ml or 100 ml. The bottle is packaged in a cardboard box, which also contains a measuring cup.
pharmachologic effect
Negrustin has a sedative effect on the body and has antidepressant and anxiolytic activity. The drug acts on the central and autonomic nervous system.
St. John's wort affects the enzyme monoamine oxidase (type A and B), inhibiting their activity. Therefore, during the treatment process in the human body there is no drop in the level of neurotransmitters, as happens in depressive conditions.
The level of neurotransmitters during treatment with Negrustin rises to optimal levels. The bioflavonoid composition of the product allows you to get a slight calming effect. As a result, when treated with the drug, general mood improves, problems with falling asleep disappear, appetite increases, and performance increases.
Pharmacological properties
Pharmacodynamics:
A herbal product that has a sedative and antidepressant effect. The main active substances of St. John's wort - hypericin, pseudohypericin, hyperforin and flavonoids - have a positive effect on the functional state of the central and autonomic nervous system, which improves mood, increases mental and physical activity, and normalizes sleep. The antidepressant effect is due to the ability to inhibit the reuptake of serotonin and other neurotransmitters, as well as the effect on melatonin metabolism.
Pharmacokinetics:
St. John's wort herb extract is a complex mixture of numerous components. After taking single doses of 300, 900 or 1800 mg of St. John's wort extract, the maximum plasma concentrations (Cmax) of hypericin ranged from 2 to 20 µg/l, pseudohypericin - from 3 to 30 µg/l. The rate of absorption of these substances is different (absorption of hypericin begins after 1.9 hours, pseudohypericin - after 0.4 hours). The half-life (T1/2) is approximately 24-48 hours for hypericin and 18-24 hours for pseudohypericin.
Contraindications
Negrustin should not be used if the patient has the following conditions and diseases:
- severe forms of depression;
- endogenous depression;
- photodermatitis;
- pregnancy and feeding ;
- high sensitivity to the components of the product;
- taking MAO inhibitors ;
- therapy with cyclosporine , digoxin ;
- treatment with drugs with which unsafe interactions may occur.
Side effects
If a patient uses Negrustin tablets or solution, he may experience the following undesirable effects:
- eczematous rashes on the skin;
- urticaria , severe itching of the skin ;
- manifestations of asthenia ;
- anorexia;
- dry mouth;
- headache;
- nausea, epigastric pain;
- increased sensitization to household allergens;
- Iron-deficiency anemia.
Side effects
Skin and subcutaneous tissue disorders: skin itching, skin rash, erythema, eczema; skin pigmentation, photosensitivity (more often in HIV-infected patients); When taking the drug Negrustin® on areas of the skin exposed to intense sunlight, due to photosensitization, skin reactions similar to sunburn may develop (mainly in fair-skinned patients).
Gastrointestinal disorders: nausea, abdominal pain (including in the epigastric region), dry mouth, flatulence, diarrhea or constipation, anorexia.
Nervous system disorders: anxiety, fatigue, headache.
Blood and lymphatic system disorders: iron deficiency anemia.
Other: increased sensitization to animal fur.
Instructions for use of Negrustin (Method and dosage)
The instructions for Negrustin include oral administration of capsules and solution. The patient is prescribed to take one capsule or 1 ml of solution three times a day.
Adolescents aged 12 to 16 years are prescribed 1 or 2 capsules per day. Instructions for use of Negrustin stipulate that a maximum of 6 capsules or 6 ml of Negrustin solution can be taken per day.
It is advisable to take the drug while eating. The capsules should not be chewed; they should be taken with a small amount of water. The course of treatment should last at least 4 weeks, maximum treatment can last for two months. If there is such a need, the patient may be prescribed an additional course of treatment again.
Directions for use and dosage
Inside.
Capsules should be taken without chewing with sufficient liquid (preferably 1 glass of water).
Adults and adolescents over 12 years of age: 1 capsule 1-2 times a day, regularly at the same time. When taken 2 times a day, the drug should be taken in the morning and evening.
The course of treatment is usually 4-6 weeks. If symptoms persist or worsen within 4 weeks of starting treatment, you should consult your doctor.
If you miss one dose of Negrustin®, you should take the drug as soon as possible. If it is time for the next dose of the drug, you should not take an additional dose of the drug to make up for the missed dose. You should not take two doses of the drug at the same time.
Interaction
There is a weakening of the effect of Negrustin when taken simultaneously with indinavir , protease inhibitors, Digoxin , Cyclosporine , indirect anticoagulants, Amitriptyline , Theophylline , Nortriptyline .
If the patient takes Negrustin with other antidepressant drugs , there may be an increase in side effects, in particular psychomotor agitation, a feeling of fear, nausea and vomiting.
When Negrustin and photosensitizing drugs , increased photosensitivity may be observed.
Simultaneous treatment with Negrustin and the use of oral contraceptives may cause bleeding.
Negrustin®
St. John's wort extract activates microsomal oxidation (cytochrome P450), therefore, when used simultaneously, it reduces plasma concentrations of the following drugs: digoxyntheophylline; midazolam; tacrolimus; cyclosporine, irinotecan, imatinib and other cytostatics; indirect coumarin anticoagulants (warfarin, phenprocoumon); amitriptyline, nortriptyline, indinavir and other HIV protease inhibitors.
The use of dry extract of St. John's wort may lead to a decrease and/or shortening of the duration of the effect of drugs (for example, fexofenadine, benzodiazepine and its derivatives, methadone, simvastatin, finasteride), the metabolism of which involves cytochrome P450 isoenzymes CYP3A4, CYP2C9, CYP2C19 or P-glycoprotein . Increased enzymatic activity is usually restored within 1 week after stopping the use of dry St. John's wort extract. Increases the antidepressant effect of MAO inhibitors, while increasing the risk of their side effects. The interval between taking Negrustin® and the MAO inhibitor should be at least 14 days.
When used simultaneously with selective serotonin reuptake inhibitors (including fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram), nefazodone, buspirone or triptans, St. John's wort extract may potentiate the effect of these drugs, including the incidence of side effects (serotonergic effects) such as nausea, vomiting, anxiety, agitation and confusion (serotonin syndrome).
Reduces the hypotensive effect of reserpine.
Concomitant use with oral contraceptives may weaken their effect and lead to intermenstrual bleeding.
Concomitant use of photosensitizing agents may lead to increased phototoxic effects.
May enhance the effect of general anesthesia and narcotic analgesics. Before surgery, the potential for interaction with drugs used for local or general anesthesia should be assessed. If necessary, you should stop taking dry St. John's wort extract.
If it is necessary to prescribe other medications simultaneously, you should inform your doctor about your use of St. John's wort extract.
special instructions
During treatment with the drug, you should not stay in sunlight for a long time. This warning primarily applies to people with fair skin.
There is no need to allow simultaneous use of other drugs that cause photosensitivity .
sorbitol in Negrustin, of sorbitol enters the body .
If the solution is prescribed to people with diabetes , it must be taken into account that 1 ml of solution corresponds to 0.01 XE.
Prescribed with caution to those diagnosed with fructose intolerance .
There may be an effect of the drug on the ability to drive vehicles and operate precision machinery, especially if Negrustin was taken simultaneously with alcohol.
Analogs
Level 4 ATC code matches:
Pipofezin
Bethol
Incazan
Melitor
Azafen
Miaser
Velafax
Mirtazonal
Venlaxor
Remeron
Venlafaxine
Lerivon
Mirtazapine
Cymbalta
Velaxin
Coaxil
Pyrazidol
Deprim
Gelarium Hypericum
Trittico
Analogs of the drug Negrustin are products containing a similar active substance. Today, the following analogues can be purchased in pharmacies: Deprim , Gelarium Hypericum , Deprim Forte , Herbion Hypericum , Nervotonic , Novoimanin , Life 600 , St. John 's wort extract , Life 900 , Turinervin , Hypericin , dry extract of St. John's wort . Before replacing Negrustin with another drug, you should consult a specialist.
Overdose
To date, no cases of drug overdose have been reported.
When using the drug in doses exceeding the recommended ones, the severity of dose-dependent side effects may increase (see section “Side Effects”).
Seizures and confusion have been reported after taking up to 4.5 g of dry extract per day for 2 weeks and an additional 15 g of dry extract immediately before hospitalization. With significant overdoses, phototoxic reactions may develop.
Treatment: symptomatic; Sun exposure and UV exposure should be avoided for 1-2 weeks. Outdoor activities should be limited and sun protection products and/or clothing should be used.
Reviews for Negrustin
Reviews about Negrustin on forums and websites are often left by people who have undergone a long course of treatment with the drug. There are both positive reviews and negative opinions regarding the lack of effect of therapy with this drug. There are a number of reviews indicating that Negrustin has a positive effect on mood and helps overcome anxiety. When starting to take Negrustin, doctors' reviews should also be taken into account. Experts on the network strongly recommend not to practice such treatment without prior appointment, since there are many cases of uncontrolled use of the drug.
