Tenoten is a sedative, which, according to information from the official website of the drug, is indicated for all people with symptoms of anxiety. Everything about it is good: it relieves irritability, has no side effects, is not capable of overdose, does not make you sleepy and does not slow down the brain. True, there is no molecule of the active substance in it - homeopathy after all.
It is produced by the Materia Medica holding, which is managed by meme scientist Oleg Epstein. He changed the packaging of homeopathic medicines and called them “release-active” (without changing the preparation method, btw). This development in 2021 received an anti-award “For the most harmful pseudoscientific project” from the Ministry of Education and Science of the Russian Federation. And in 2019, the Russian Academy of Sciences stated that the idea of release activity contradicts biological, physical and chemical fundamental laws.
But things are getting muddy, money is swirling, so Materia Medica produces homeopathy (Tenoten, Anaferon, Ergoferon, Impaza, Rengalin and others), which millions of Russians are taking advantage of. Although the placebo effect was not canceled.
What is inside
Tenoten is prescribed for anxiety disorders, neuroses, phobias, personality and behavioral disorders caused by brain injuries (wow, they swung), and other mental health disorders.
The main stress relievers in Tenoten are antibodies to the brain-specific protein S100. Sounds solid, let's figure it out. S100 is a family of proteins that do many different things inside and outside the cell. For example, they support calcium metabolism and participate in cell growth and specialization. Some members of the family may be a nonspecific marker of tumor (melanoma, neurofibroma, sarcoma) and inflammatory diseases (psoriasis). Brain-specific means that these family members are synthesized by nerve cells in the brain. But why them? Are there studies that support the involvement of the brain-specific S100 protein in the stress response? Nope. In general, it looks like they took a random protein.
Antibodies are also proteins that protect the body from colonization by pathogens themselves or press an alarm button that activates other pathways of the immune response. That is, antibodies to the brain-specific protein S100 should kill this very protein. But he’s such a good guy, why??? Idk. We did not find any justification for choosing this particular protein to reduce stress and “even out mood.”
Tenoten tab d/rassas No. 40
Manufacturer
Materia Medica Holding (Russia)
Shelf life
3 years
Storage conditions
At a temperature not exceeding 25 °C
Registration certificate number
LS-000542 dated 11/18/2009
Compound
| Lozenges | 1 table |
| active substance: | |
| antibodies to brain-specific protein S-100, affinity purified* | 0.003 g |
| excipients: lactose monohydrate (lactose) 0.267 g; MCC - 0.03 g; magnesium stearate - 0.003 g | |
| *Applied to lactose in the form of a water-alcohol mixture containing no more than 10−15 ng/g of the active form of the active substance |
Characteristic
| Lozenges | 1 table |
| active substance: | |
| antibodies to brain-specific protein S-100, affinity purified* | 0.003 g |
| excipients: lactose monohydrate (lactose) 0.267 g; MCC - 0.03 g; magnesium stearate - 0.003 g | |
| *Applied to lactose in the form of a water-alcohol mixture containing no more than 10−15 ng/g of the active form of the active substance |
Description of the dosage form
Tablets are flat-cylindrical in shape, scored and chamfered, from white to almost white.
On the flat side with a notch there is the inscription “MATERIA MEDICA”, on the other flat side there is the inscription “TENOTEN”.
Pharmacodynamics
It has a calming, anti-anxiety (anxiolytic) effect without causing unwanted hypnogenic and muscle relaxant effects. Improves tolerance to psycho-emotional stress. It has stress-protective, nootropic, antiamnestic, antihypoxic, neuroprotective, antiasthenic, antidepressant effects.
In conditions of intoxication, hypoxia, and after an acute cerebrovascular accident, it has a neuroprotective effect, limits the area of damage, and normalizes learning and memory processes in the central nervous system.
Inhibits lipid peroxidation processes.
Modifies the functional activity of the S-100 protein, which carries out the coupling of synaptic (information) and metabolic processes in the brain. Providing a GABA-mimetic and neurotrophic effect, it increases the activity of stress-limiting systems and helps restore the processes of neuronal plasticity.
Contraindications
increased individual sensitivity to the components of the drug;
children under 18 years of age (children and persons under 18 years of age are advised to use the drug Tenoten for children).
Use during pregnancy and breastfeeding
The safety of Tenoten during pregnancy and lactation has not been studied. If it is necessary to take the drug, the risk/benefit ratio should be taken into account.
Directions for use and doses
Inside,
not during meals. 1-2 tables each. for one dose (keep in mouth until completely dissolved). Take 2 times a day; if necessary - up to 4 doses per day. The course of treatment is 1–3 months; if necessary, the course of treatment can be extended to 6 months or repeated after 1–2 months.
If there is no sustained improvement in your condition within 3-4 weeks after starting treatment, you should consult a doctor.
Side effects
Reactions of increased individual sensitivity to the components of the drug are possible.
Interaction
No cases of incompatibility with other drugs have been registered to date.
Overdose
In case of accidental overdose, dyspepsia may occur due to the excipients included in the drug.
special instructions
The drug contains lactose, and therefore it is not recommended for use in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or congenital lactase deficiency.
Due to the presence of activating properties in the action of the drug Tenoten, the last dose of the drug should be taken no later than 2 hours before bedtime.
Impact on the ability to drive vehicles.
No negative effect of the drug Tenoten on the ability to drive vehicles and other potentially dangerous mechanisms has been identified.
Conditions for dispensing from pharmacies
Over the counter.
Pharmgroups
Anxiolytics; nootropics (Anxiolytics)
Pharmaceutical actions
anxiolytic, antidepressant, nootropic, antiasthenic, antihypoxic, neuroprotective, antistress, antiamnestic
Why should it work?
This is what is written about the mechanism on the official website: “The effect is realized by stabilizing the physiological mechanisms of brain functioning, optimizing metabolic processes and transmitting nerve impulses.” Has it become clearer? And also: “modifies the functional activity of the S100 protein” (what kind of modifications does the killer antibody carry out?), “increases the activity of stress-limiting systems,” “promotes the restoration of neuronal plasticity processes.”
Okay, it's all blah blah. How does he do it? Guys, you are going to die. In the instructions in the “Pharmacokinetics” section, which should describe what happens to the substance in the body, there is the following:
“The sensitivity of modern physicochemical methods of analysis does not allow us to assess the content of the active substance of the drug Tenoten in biological fluids, organs and tissues due to the specific composition of the drug, which makes it technically impossible to study pharmacokinetics.”
That is, the instructions say that the manufacturer does not know what happens to Tenoten in the body, how it is excreted, what systems it enters, and therefore how it works.
Tenoten for children: who is it indicated for?
Tenoten for children is intended for teenagers and preschoolers aged 3 years and older. Direct indications are:
- neuroses;
- hyperactivity;
- attention deficit disorder;
- severe anxiety in the presence of strangers;
- obvious irritability;
- nervous excitability.
A special course is intended for children planning to attend a preschool institution, or any other institution that does not involve being with a parent at the same time. Tenoten helps the child adapt to a new team, to the environment, to the rules and daily routine. Children in the first month of attending preschool may, due to nervous shock, begin to urinate in their pants. This is due to neurosis, due to which the child’s brain loses connection with the bladder sphincter. Evacuation begins without the child's knowledge. You can’t scold someone for dirty pants in such a situation. We need to help the baby get used to the new environment, which is radically different from home.
Neurologists recommend starting to take the drug a week before the first visit to a new environment. They continue the course, as a rule, during the first month of their stay in the team. If a child experiences bowel irregularities, morning tearfulness, or irritability, it makes sense to discuss additional therapy or dose adjustment of Tenoten with the attending physician.
For high school students who experience constant nervous tension due to upcoming exams, Tenoten for children is necessary to restore their performance. The drug will reduce anxiety, help improve rational thinking, and speed up memory processes.
A child who has suffered a minor traumatic brain injury is prescribed Tenoten as a safe nootropic that improves blood circulation. This allows you to reduce the risk of complications and prevent the manifestation of unwanted symptoms after a head injury. Serious head injuries accompanied by nausea, dizziness and loss of consciousness should be treated under the supervision of a specialist.
Why does not it work
Well, patamushta. This is homeopathy and, according to Zhukov’s precepts, “homeopathy cannot have evidence of effectiveness.”
Marketers, of course, are cunning: they don’t write anywhere that this is a homeopathic or at least a release-active drug. But let’s look at the composition: the active ingredient is affinity-purified antibodies to the brain-specific protein S100. The content per tablet is 0.003 grams. And then an awkward asterisk explaining that these 0.003 grams are applied to lactose in the form of a water-alcohol mixture containing no more than 10-15 ng/g of the active form of the active substance. Ng is a nanogram, or one billionth of a gram.
This means that in one tablet there are 3 × 10-27, or 0.0000000000000000000000000003 grams of active substance. In short, all these zeros here mean that there is not even a single seedy atom of this substance in the tablet. All that remains is sugar, onto which the magic mixture (aka water) has been dripped.
You know what else it's all about... Antibodies are large proteins that, ahem kek lol, do not pass through the blood-brain barrier, a kind of fence between the circulatory and nervous systems of the brain, the task of which is not to let any crap through (because the brain is a particularly valuable organ) . So even if the developers were worthy of providing at least one molecule per tablet, it simply would not reach these brain-specific proteins. That's it, curtain.
Tenoten for children: instructions for use
Each tablet contains a score in the center. But it is not applied to divide the dose in half. The tablets are taken orally. They are not intended to be washed down with water. Each dose must be dissolved on the tongue. If the child’s age does not allow him to dissolve medications, which is important for children under 4 years of age and those who have disorders of the pharyngeal muscles, you can dissolve the tablet in half a glass of drinking water, and give the solution to the patient to drink.
As a preventive measure for nervous disorders, especially during the period of preparation for adaptation associated with visiting children's institutions or with any other radical change of environment, 1-2 tablets per day are prescribed.
If neuralgia has already developed, take 1 tablet three times a day. The course should not last less than two months. The recommended period is three months. After which you should see a doctor, who, based on the patient’s condition, will decide to extend therapy for another 3 months or discontinue the drug. Prolongation involves reducing the dose to 2 tablets per day for a period of up to 6 months of therapy.
You can repeat the course after a break, which should be no shorter than a month.
When a child has attention deficit disorder, give 1 tablet in the morning and before bed for 2 months. If after 4 months of any therapy there is no obvious improvement in the condition, you should stop taking Tenoten and consult a specialist for advice.
High school students are recommended to take the drug a month before the start of exam time. One tablet twice a day is the optimal dose to help you concentrate on your studies, reduce anxiety and gain confidence in your abilities. There is no need to stop admission until the last exam is completed. The total duration of the course is in this case two months: a month before the start of the session and the period during the entire examination month.
