Pentaxim vaccine, 1 pc., lyophilisate for preparing a suspension for intramuscular administration

"PENTAXIM" - vaccination against diphtheria, tetanus, whooping cough, polio, infection caused by Haemophilus influenzae type b

The vaccine is cell-free, contains purified Bordetella pertussis antigens, diphtheria and tetanus toxoids, inactivated polio viruses of three types and a vaccine against Haemophilus influenzae infection.

Manufacturer: Sanofi Pasteur S.A., France.

Protects against diseases: diphtheria and tetanus, whooping cough, polio and infection caused by Haemophilus influenzae type b.

Applicable: primary vaccination and revaccination of children from 3 months of age

Included in the national calendar of preventive vaccinations in Russia.

What diseases does Pentaxim protect against?

• Diphtheria is a severe bacterial infection that affects the mucous membranes of the nose and throat. The mortality rate from diphtheria, even in modern conditions, exceeds 10%.
• Whooping cough is a very dangerous disease for children under two years of age, and the mortality rate from it is also very high. At the same time, whooping cough is very contagious (even casual contact with a patient leads to infection in 100% of cases) and is relatively common.
• Tetanus is a serious infection that kills about 100,000 people worldwide every year. In countries where mass vaccination is carried out, the incidence of tetanus is 100 times lower.
• Poliomyelitis is infantile spinal paralysis, a disease that is currently rare, but highly contagious (very contagious).
• Haemophilus influenzae type B is the causative agent of 25% of pneumonia and sepsis, half of severe meningitis and 80% of epiglottitis in children under 5 years of age. This is why it is so important to vaccinate your child against this infection on time.

Vaccination for the whole family! About the vaccinations that adults and children need

Description of the drug

The Pentaxim vaccine is one of the most modern combined vaccines, which allows you to simultaneously protect a child from five dangerous infections. Pentaxim belongs to a new generation of acellular (cell-free) vaccines that replaced cellular (cellular) vaccines. Acellular vaccines are less reactogenic because are devoid of bacterial membrane lipopolysaccharides that cause reactions after vaccination. Pentaxim is a highly immunogenic vaccine, i.e. giving a high immune response of the body after vaccination.

Pentaxim is a combination vaccine containing adsorbed acellular pertussis-diphtheria-tetanus vaccine, inactivated polio vaccine and a vaccine for the prevention of Haemophilus influenzae type b. This allows one injection to immunize a child against whooping cough, diphtheria, tetanus, polio and diseases caused by Haemophilus influenzae (meningitis, sepsis, pneumonia, epiglottitis, etc.).

The presence of five components in one vaccine allows you to minimize the number of injections, thereby significantly reducing pain in the child.

At what age is it better to get the Pentaxim vaccine? How long does it take to do the second Pentax?

The Pentaxim vaccination schedule is as follows: according to the National Vaccination Calendar, it is carried out at 3 months, then at 4.5, then at 6 months. This is followed by revaccination one year after the third administration (approximately one and a half years).

• If the first vaccination took place after 6 months, then for the third vaccination and subsequent revaccination, when diluting Pentaxim, no component is added that protects against Haemophilus influenzae infection.
• If the first vaccination took place after 12 months, this component is not added for the second and all subsequent administrations.

Find out more about the vaccination calendar

Pharmacodynamics and pharmacokinetics

The Pentaxim vaccination is designed to vaccinate children against tetanus (Tetanus), diphtheria (Diphtheria), polio (Poliomyelitis), whooping cough (Pertussis) and diseases caused by Haemophilus influenzae (including against septicemia , meningitis , epiglotitis , pneumonia , etc.) . If the timing of revaccination is observed, the vaccinated child develops lasting immunity to these diseases.

The manufacturer of Pentaxim did not provide data regarding the pharmacokinetics of the drug.

Pentaxim is well tolerated and is recommended for use in children over three months of age.

It must be taken into account that the drug does not contribute to the formation of immunity against diseases caused by other serotypes of Haemophilus influenzae (A, C, D, E and F) , as well as immunity to meningitis provoked by other pathogenic microflora .

Compatibility and revaccination

• Is it possible to do Pentaxim after DTP? Is it possible to do regular DTP after Pentaxim?

The answer to both questions is yes, you can. If you only have DTP at your disposal, it is better not to wait for an imported vaccine to appear, but to get vaccinated on time. Discuss your polio and hemophilus influenzae vaccination schedule with your pediatrician, as these components are not included in the DPT vaccine.

• Is it possible to do Infanrix Hexa after Pentaxim?

The Infanrix Hexa vaccine can replace Pentaxim for the first, second and third vaccinations, and vice versa. But with one caveat: the Pentaxim vaccine does not have a component that protects against hepatitis B, but Infanrix Hexa does. Therefore, if you are switching from one vaccine to another, ask your pediatrician to create an individual hepatitis B vaccination schedule for you. It is also worth remembering that the timing of administration of the Infanrix Hexa vaccine is up to 36 months, that is, up to 3 years.

• How do Pentaxim and the polio vaccine work together? Is it possible to take Pentaxim after polio?

Pentaxim contains an acellular polio vaccine. You can replace some of the polio vaccinations with the Pentaxim vaccine, and also continue the polio vaccination with Pentaxim.

However, if you have previously been vaccinated with a live polio vaccine, you need to wait at least a month with Pentaxim, as after any vaccine.

• Is it possible to do Pentaxim after Mantoux?

Yes, you can. You can get vaccinated with Pentaxim on the day of the Mantoux test.

• Is it possible to take Prevenar and Pentaxim at the same time? Is it possible to use Pentaxim and hepatitis at the same time?

Yes, you can. If the time has come for vaccination, any number of vaccines can be administered simultaneously, provided they are compatible. It has been proven that the frequency and severity of reactions to vaccination (and even more so, rare complications) do not depend on the number of vaccines administered at one time. Generally, vaccines work well together. There are rare exceptions, such as BCG.

• Is it possible to take Pentaxim if you have a runny nose? Is it possible to do Pentaxim if teething?

Yes, you can. Neither colic, nor an umbilical hernia, nor small residual cysts in the baby’s brain, nor a runny nose without fever will in any way affect the child’s condition after vaccination. Such challenges have no medical basis. Unfortunately, most cases of severe childhood infections are detected in children whose parents decided to “just wait a little.”

Meet our team of pediatricians who administer vaccinations

How is vaccination carried out?

Vaccination is carried out in a vaccination room, in compliance with all sanitary requirements. All drugs are certified. A certificate for the drug is provided upon request.

Without reminders, before vaccination, the medical worker must show the drug and the expiration date of the vaccine.

Only sterile and disposable instruments are used. The vaccination must be carried out using disposable medical gloves.

On the day of vaccination, the child is examined by a pediatrician and the temperature is measured. In the absence of contraindications, vaccination is carried out. Information about the vaccination performed is entered into the card, vaccination certificate, and detailed recommendations for caring for the child in the post-vaccination period are given.

Before vaccination, the doctor will answer all your questions. Be sure to bring information about previous vaccinations to your appointment!

Please note that vaccination of a child, Mantoux test, Diaskintest can only be carried out in the presence of parents or legal representatives of the child (guardians), or if the accompanying person has a NOTARIZED power of attorney to carry out the manipulation (indicating the drug planned for administration) . Otherwise, vaccination will be denied. We comply with the laws of the Russian Federation.

Only here!

Contraindications to the administration of Pentaxim

• Progressive severe encephalopathy;
• Encephalopathy that developed within a week after administration of any vaccine containing a pertussis component (Bordetella pertussis antigens);
• A severe reaction (fever up to 40 degrees, convulsions, decreased blood pressure) that develops within 48 hours after administration of any vaccine containing a pertussis component;
• Allergic reactions to previous administrations of any vaccines containing components against diphtheria, tetanus, whooping cough, polio and Hib infection;
• Any disease that occurs with elevated body temperature (you can start vaccinating the child 5 days after the temperature has returned to normal, regardless of residual cough and runny nose).

Release form

Pentaxim vaccine for immunization against diphtheria (Diphtheria) and tetanus (Tetanus), adsorbed, pertussis (Pertussis), acellular, and polio (Poliomyelitis), inactivated, is a cloudy, whitish suspension. Intended for intramuscular administration, it is available in 0.5 ml doses in 1 ml glass syringes (the syringe can come with or without a fixed needle).

The vaccine for the prevention of diseases caused by HIB is a homogeneous, white, lyophilized mass for the preparation of a suspension for intramuscular administration. Available in glass bottles, 1 dose per bottle.

Each cardboard package is equipped with one bottle of lyophilisate and one glass syringe with a suspension, placed in a closed cell packaging.

In the case when the syringe comes without a needle, the delivery set additionally includes 2 separate sterile needles, sealed in cell packaging.

What might be the reaction to the Pentaxim vaccine?

Pentaxim is usually easily tolerated. Possible reactions: pain and hardness at the injection site; redness of the injection site; increased body temperature, irritability, sleep disturbances or drowsiness. Post-vaccination reactions requiring medical attention develop in only 0.6% of vaccinated children.

The older the child, the more pronounced the reactions to vaccinations are, precisely because of the “ripe” immunity. This in itself is not scary, but redness and pain at the injection site, high fever and other reactions are much more common in children with delayed vaccinations, and are not typical for infants.

How to prepare your child for vaccination

Before vaccination, it is advisable not to feed the child, but to offer plenty of fluids. At the clinic, you need to make sure that the child is not sweating. If this does happen, you need to wait until the child cools down and only then go for vaccination. After vaccination, it is advisable not to give food to the child for 1-2 hours, limiting yourself to drinking. If the child is hungry, then offer him dietary food, excluding fatty and sweet foods, as this may worsen the tolerability of the vaccine.

If the temperature has increased, be sure to give an antipyretic containing paracetamol, nimesulide or ibuprofen. If any atypical symptoms appear, you should promptly consult a doctor.

Publication date: 12/13/2018 17:05:16

Comparative table of different vaccines

*Only the first two vaccinations are given free of charge (the third vaccination and revaccination are paid) **Although the age is not limited, in practice it is done up to 6 years

Even more articles about vaccination:

• Vaccination in questions and answers
• The Gardasil vaccine, or how to protect yourself from the human papillomavirus

Benefits of the Pentaxim vaccine

• Vaccination with the Pentaxim vaccine guarantees a high degree of protection against five infections simultaneously.
• The introduction of the Pentaxim vaccine results in a low incidence of local reactions compared to other vaccines.
• Reducing the injection load on the child - one injection instead of three.
• Easy tolerability of vaccination due to the content of acellular pertussis component.
• There is no risk of developing vaccine-associated polio, because The vaccine contains an inactivated (killed) virus.
• The Hib component provides a high level of protection against frequent acute respiratory infections, sinusitis, meningitis, pneumonia, and otitis caused by this infection at a very early age.
• Pentaxim corresponds to the Russian preventive vaccination calendar in 4 components and effectively complements the Hib component.

Is it possible to use polio drops after Pentaxim?

The Russian vaccination calendar provides for exactly this sequence in the combined use of the inactivated biological product Pentaxim and live polio vaccine.

The use of killed polioviruses in the first two stages of immunoprophylaxis eliminates the possibility of a child developing vaccine-associated paralytic poliomyelitis, which may be caused by a live mutated pathogen.

Analogs

Level 4 ATX code matches:
Tetraxim

Infanrix Hexa

Infanrix

The same pharmacological group with the Pentaxim vaccine includes the drugs Bubo-Kok , Bubo-M , DTP vaccine , DTP-M , DPT-Hep-B vaccine , Infanrix , Infanrix Hexa , Tetraxim , Infanrix Penta .

DTP or Pentaxim - which is better?

The drug Pentaxim contains antigens of tetanus and diphtheria toxoids , components of the cell walls of Bordetella pertussis (the causative agent of whooping cough ), inactivated polio virus types 1-3 and capsular polysaccharides HIB (Haemophilus influenzae serotype b).

The main difference between Pentaxim and the whole-cell DTP vaccine is the method of its preparation, due to which the vaccine is characterized by lower reactogenicity in comparison with its analogue.

Which is better - DTP or Pentaxim?

To this question, doctor Komarovsky E.O. answers that the acellular pertussis component of the Pentaxim vaccine allows the baby to more easily endure the post-vaccination period, while the child suffers much less often from pain at the injection site and fever.

Another “advantage” of Pentaxim is that this vaccine makes it possible to immunize a child against 5 diseases in 4 injections.

Pentaxim or Infanrix - which is better?

Which is better - Pentaxim or Infanrix ? Which is better Pentaxim or Infanrix Hexa ? Such questions worry almost all young parents who are faced with vaccination for the first time.

Most often, doctors suggest vaccinating a child with DTP , or Pentaxim, or Infanrix. These preparations differ from each other in the number of components and the degree of their purification.

The DTP vaccine allows a child to develop immunity to whooping cough , tetanus and diphtheria (it contains a suspension of dead microbes Bordetella pertussis, as well as purified tetanus and pertussis toxoids ). The DTP-Hep-B vaccine is a four-component drug that promotes the development of immunity to whooping cough , tetanus , diphtheria and hepatitis B.

The Infanrix vaccine comes in three-, four-, five- and six-component versions: the Infanrix three-component suspension is used to prevent diphtheria , whooping cough and tetanus ; the four-component suspension Infanrix IPV allows the child to additionally develop immunity to polio ; The five-component Infanrix Penta is used to prevent 3 of these diseases, polio and hepatitis B ; Infanrix Hexa - for the prevention of 3 specified diseases, polio, hepatitis B and HIB infections .

Unlike the whole-cell vaccine DTP , Pentaxim and Infanrix are acellular drugs that contain only fragments of disease antigens. Comparing reviews from parents whose children were immunized with DPT and acellular vaccines , we can conclude that the latter are much better tolerated and cause fewer side effects.

To the question “Which is better - Pentaxim or Infanrix ?”, Komarovsky E.O. answers that both vaccines are high-quality products with highly purified components.

Infanrix wins here , since the pertussis component is present in it in the most split form. This has an impact on the effectiveness of vaccination, but it can significantly reduce not only the severity, but also the likelihood of adverse reactions.

Pentaxim or Tetraxim?

The drugs Tetraxim and Pentaxim are produced by the same manufacturer. Tetraxim vaccine and Pentaxim is the absence of the HIB component.

In cases where parents, in accordance with the individual vaccination schedule, do not need to vaccinate their child against hemophilus influenzae , the use of the Tetraxim vaccine allows them not to overpay for the unused hemophilus influenzae component.

special instructions

To prevent possible adverse reactions (including hypersensitivity reactions), the doctor must assess the child’s health and medical history, check the medical history of his immediate family (including allergy) and immunization history, and clarify cases of side effects after previous immunization.

When conducting vaccinations, the doctor is required to have tools and medications that may be necessary in the event of an allergic reaction .

For children taking immunosuppressants , vaccination should be postponed until the end of treatment or remission of the disease. for parents of children with chronic immunodeficiency , even though the immune system may be weak.

Pentaxim price

The price of the Pentaxim vaccine in Ukrainian pharmacies is 550-556 UAH. The price of vaccination in Russian pharmacies is 1260 rubles.

You can buy Pentaxim in Moscow and other large cities in a regular pharmacy, or through online pharmacies. However, in this case, the conditions for transportation and storage of the drug may be violated (failure to comply with the cold chain is detrimental to the vaccine).

For this reason, in treatment rooms, to eliminate the possibility of side effects, doctors refuse to vaccinate children with drugs brought by their parents if they are not available and advise them to go to commercial vaccination centers.

Reviews of Pentaxim

Reviews about the Pentaxim vaccine are overwhelmingly positive. Reviews from doctors indicate that the drug is well tolerated by children, causes adverse reactions DTP

Commenting on the rare negative reviews about Pentaxim, doctors emphasize that each child’s body is individual, and it is impossible to predict its reaction to the vaccine. The guarantee that immunization will be easy for a child is the quality of the vaccine preparation, the child’s health condition and the conditions of vaccination.

Komarovsky E.O. in his blog he writes that vaccination is well tolerated by healthy children who lead a normal lifestyle, that is, children who walk enough, do not overeat, receive complementary foods in a timely manner (not too early), etc. In the case where parents violate the basic principles of care, vaccination can be a blow to a weakened immune system , and the child’s body reacts violently to it.

For parents who vaccinated their children with the Pentaxim vaccine, the main advantages of the drug are its effectiveness, excellent tolerability (in most cases, the post-vaccination period is asymptomatic), the ability not to give unnecessary injections, and in 4 injections to immunize simultaneously against 5 infections (for comparison, Infanrix, which is also well tolerated by children, allows you to develop immunity to only 3 diseases).

The disadvantages of the drug, according to most mothers, are its high price and the frequent lack of vaccine in many pharmacies and vaccination centers.