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Manufacturers: Sagmel, Inc. (USA)
Active ingredients
- Miconazole
Disease class
- Not indicated. See instructions
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antifungal
Pharmacological group
- Antifungal agents
Pharmacodynamics and pharmacokinetics
The active component has a detrimental effect on yeast fungi and dermatophytes . Antimicrobial activity is observed against gram-positive flora.
The basic principle of the action of miconazole is based on inhibition (inhibition) of the process of synthesis of the enzyme ergosterol in the cell membrane. Ginezol cream does not affect the vaginal pH and the composition of the microflora. The drug can quickly eliminate vaginal itching that occurs due to fungal pathology.
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Contraindications
Instructions for use of Ginezol do not recommend prescribing the medication for pathology of the renal system, or for individual intolerance to miconazole.
Ginesol during pregnancy is contraindicated in the form of suppositories and capsules (in the 2nd and 3rd trimesters).
If microcirculation or diabetes mellitus is diagnosed, the drug is prescribed with caution, assessing the possible risks during treatment.
Vaginal cream Gynezol 7 (Gynezol 7)
Instructions for medical use of the drug
Description of pharmacological action
Miconazole combines antifungal action against dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast (Candida albicans, Candida glabrata and other Candida species) and various other fungi (Malassezia furtur, Aspergilus niger, Penicillium crustaceum ) with antibacterial action against certain gram-positive bacteria. Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to necrosis of fungal cells. Miconazole very quickly eliminates the itching that often accompanies infections caused by yeasts and dermatophytes. Does not change the composition of microflora and vaginal pH.
Indications for use
Externally - ringworm caused by fungi sensitive to the drug (including secondary infection with gram-positive microorganisms); onychomycosis. Locally - vaginal and vulvovaginal candidiasis, superinfection caused by gram-positive microorganisms; fungal balanitis.
Release form
vaginal cream 2%; plastic tube 45 g with applicator cardboard pack 1;
Pharmacokinetics
After introducing the cream into the vagina, an active suspension is released. Systemic absorption after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.
Use during pregnancy
The drug is contraindicated for use in the first trimester of pregnancy. In the second and third trimesters of pregnancy, the drug can be used only in cases where, in the opinion of the doctor, the expected benefit to the woman outweighs the potential risk to the fetus. When used during lactation, breastfeeding should be discontinued.
Contraindications for use
- individual hypersensitivity to imidazoles or other components of the drug; - children under 12 years of age; - pregnancy (first trimester). During lactation, it is necessary to resolve the issue of stopping breastfeeding. With caution: diabetes mellitus, microcirculation disorders, pregnancy (II and III trimester).
Side effects
Adverse reactions occur rarely and in most cases are mild. Allergic reactions are possible (local irritation, itching, burning sensation, especially at the beginning of treatment).
Directions for use and doses
Intravaginally, suppositories are inserted deep into the vagina, before bedtime - 1 suppository. within 6–7 days. Externally, a small amount of cream is applied to the mucous membranes of the external genitalia and/or inserted into the vagina using an applicator once a day at night for 6–7 days.
Special instructions for use
If an allergic reaction occurs, treatment should be stopped. If necessary, the drug can be removed by rinsing the vagina with boiled water. To prevent reinfection, hygiene rules should be observed. If a sexual partner has an infection, he should also be given appropriate treatment.
Storage conditions
In a dry place, protected from light, at a temperature of 15–30 °C.
Best before date
24 months
ATX classification:
G Genitourinary system and sex hormones
G01 Antiseptics and antimicrobials for the treatment of gynecological diseases
G01A Antiseptics and antimicrobials for the treatment of gynecological diseases (excluding combinations with corticosteroids)
G01AF Imidazole derivatives
G01AF04 Miconazole
Instructions for use Ginezol 7 (Method and dosage)
Ginezol 7 suppositories, instructions for use
One vaginal suppository is prescribed locally until the symptoms of the fungal infection completely disappear. Ginezol suppositories must be inserted deep into the vagina before bed (dosage 100-200 mg). The course lasts 14 days.
Instructions for the cream
Ginezol cream is applied twice a day to the skin affected by a fungal infection (you can rub the drug in with light, circular movements).
During treatment, mycological monitoring , the results of which determine the effectiveness of antifungal therapy with Ginezol 7. The average duration of treatment for fungal diseases is 2-6 weeks.
Therapy for onychomycosis is designed for 3 months of continuous treatment.
Ginesol for thrush is prescribed according to the regimen prescribed by the treating doctor.
Ginesol 7 vaginal suppositories 100 mg No. 7x1
Description
Large, white or whitish opaque suppository, ovoid in shape with a rounded end.
Main active ingredient
Miconazole
Release form
Suppositories
Dosage
100 mg
Pharmacological properties
Miconazole is an imidazole derivative. Active against most Candida spp; Aspergillus spp; Dimorphons fungi; Cryptococcus neoformans; Pityrosporum sp; Topulopsis glabrata. Miconazole inhibits the biosynthesis of ergosterol and changes the lipid composition of the membrane, causing the death of the fungal cell. Also active against some gram-positive microorganisms.
Pharmacokinetics
After inserting the suppository into the vagina, the active substance is released. Systemic absorption after intravaginal use is limited. 8 hours after using the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.
Indications for use
Vaginal and vulvovaginal candidiasis; superinfection caused by gram-positive microorganisms.
Directions for use and doses
1 suppository is inserted deep into the vagina 1 time per day before bedtime for 7 days. The course of treatment should not be interrupted.
Use during pregnancy and lactation
In the second and third trimester of pregnancy, the drug can be used only in cases where, in the opinion of the doctor, the expected benefit to the woman outweighs the potential risk to the fetus. It is not known whether miconazole passes into breast milk; however, the drug should be used with caution during breastfeeding.
Precautionary measures
Solid fat can break down the latex of condoms and diaphragms. Condoms and diaphragms should not be relied upon to prevent pregnancy or protect against sexually transmitted diseases. You should not use tampons while using suppositories. If a sexual partner has an infection, he should also be given appropriate treatment.
Interaction with other drugs
The simultaneous use of vaginal suppositories containing miconazole and indirect coumarin anticoagulants (for example, warfarin) may lead to an increase in the concentration of indirect anticoagulants in the blood plasma. It is necessary to monitor the appearance of symptoms such as bleeding, spontaneous bruising, and monitor the international normalized ratio (INR).
Contraindications
Increased individual sensitivity to imidazoles or other components of the drug. Children's age up to 12 years. Pregnancy period (first trimester). With caution - diabetes mellitus, microcirculation disorders.
Compound
Active ingredient: miconazole nitrate 100 mg. Excipient: solid fat 2400 mg.
Overdose
There are no data on overdose of miconazole nitrate in humans.
Side effect
When using suppositories, local reactions are possible, especially at the beginning of treatment: irritation, itching, burning sensation in the vulva and vagina.
Storage conditions
At a temperature not exceeding 30 °C, out of the reach of children.
Buy Ginezol 7 supp.vagin.100mg in blister pack No. 7x1 in the pharmacy
Price for Ginesol 7 sup.vagin.100mg in blister pack No. 7x1
Instructions for use for Ginezol 7 sup.vagin.100mg in blister pack No. 7x1
Ginesol's analogs
Level 4 ATC code matches: Gaynomax
Sertaconazole
Ornisis
Metrogil Plus
Livarol
Flagyl
Ginofort
Zalain
Ketoconazole
Candide B6
Candide
Gyno-Travogen Ovulum
Kanizon
Metromicon-Neo
Lomexin
Klion-D 100
Neo-Penotran
Gyno-Pevaril
Antifungol
Analogs of the drug: Mikozon , Daktanol , Daktarin , Gino-Daktanol .
Naftifine 1% cream for external use, 30g (Tula pharmaceutical factory)
Registration Certificate Holder
TULA PHARMACEUTICAL FACTORY (Russia)
Dosage form
Medicine - Naftifin
Description
Cream for external use 1%
white, uniform, shiny, with a weak characteristic odor.
1 g
naftifine hydrochloride 10 mg
Excipients
: sodium hydroxide - 1.2 mg, benzyl alcohol - 10 mg, sorbitan stearate - 19 mg, cetyl palmitate - 20 mg, cetyl alcohol - 40 mg, stearyl alcohol - 40 mg, polysorbate 60 - 61 mg, isopropyl myristate - 80 mg, purified water - up to 1000 mg.
10 g - aluminum tubes (1) - cardboard packs. 15 g - aluminum tubes (1) - cardboard packs. 20 g - aluminum tubes (1) - cardboard packs. 25 g - aluminum tubes (1) - cardboard packs. 30 g - aluminum tubes (1) - cardboard packs. 40 g - aluminum tubes (1) - cardboard packs. 50 g - aluminum tubes (1) - cardboard packs. 60 g - aluminum tubes (1) - cardboard packs. 70 g - aluminum tubes (1) - cardboard packs. 80 g - aluminum tubes (1) - cardboard packs. 90 g - aluminum tubes (1) - cardboard packs. 100 g - aluminum tubes (1) - cardboard packs.
Indications
Onychomycosis, pityriasis versicolor, epidermophytosis of large skin folds and feet, rubromycosis, trichophytosis, microsporia, skin candidiasis, mycoses with secondary bacterial infection.
Contraindications for use
Hypersensitivity to naftifine.
pharmachologic effect
Antifungal agent, belongs to allylamines. The mechanism of action is associated with inhibition of ergosterol biosynthesis, which leads to disruption of the synthesis of the pathogen cell wall. It has a fungicidal effect on dermatophytes, molds, and sporotrichosis pathogens. It has a fungicidal or fungistatic effect on yeast fungi, depending on the specific strain. It has antimicrobial activity against various gram-positive and gram-negative microorganisms, which are often combined with fungi. Has an anti-inflammatory effect, reduces itching. It is characterized by a prolonged action (up to 24 hours).
Dosage regimen
Individual, applied externally 1-2 times/day, duration of treatment varies from 2 weeks to 6 months.
Side effect
In some cases:
at the site of application, dryness and redness of the skin, a burning sensation.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - With caution.
Use during pregnancy in recommended doses does not have an adverse effect on the fetus.
