Pharmacodynamics and pharmacokinetics
Is Macmiror an antibiotic or not?
Active ingredient from the group of nitrofurans . Shows antibacterial activity against gram-positive and -negative bacteria. It is also a good antifungal and antiprotozoal agent.
Inhibits the processes of division and reproduction of amoebas, lamblia and other protozoa , aerobic and anaerobic .
The following are sensitive to the drug: Papiliobacter , Enterococcus faecalis, Helicobacter pylori, Enterococcus faecium, Escherichia coli, Trichomonas vaginalis, Atopobium vaginae, Bacillus subtilis, Shigella flexneri, various strains of Salmonella, Enterobacter sph., Citrobacter spp., Staphylococcus aureus, Rettgerella spp., Budvicia aquatic, Poliindustria chimica.
The drug has the ability to be metabolized in the muscles and liver tissues, excreted in milk during breastfeeding, and pass the hemoplacental barrier. About half of nitrofuratel passes through the excretory system (mainly the kidneys).
Macmiror tablets
All instructions
Trade name: Macmiror International nonproprietary name: nifuratel Dosage form: film-coated tablets 115230, Moscow, Varshavskoe highway, 47, building 4, 14th floor tel./fax, https://cscpharma.ru
Compound
Active substance: nifuratel 200.00 mg;
Excipients (core): corn starch 60.00 mg, rice starch 5.00 mg, macrogol-6000 (polyethylene glycol-6000) 15.00 mg, talc 30.00 mg, magnesium stearate 2.50 mg, gelatin 2.30 mg, acacia gum (gum arabic) 2.30 mg; Excipients (shell): sucrose 150.00 mg, magnesium carbonate 33.00 mg, titanium dioxide 0.90 mg, wax 0.30 mg.
Description
Round, biconvex, white film-coated tablets. Pharmacotherapeutic group: antimicrobial and antiprotozoal agent - nitrofuran.
Pharmacotherapeutic group
antimicrobial and antiprotozoal agent - nitrofuran Code: G01AX05
Pharmacological properties
Pharmacodynamics
Nifuratel is an antimicrobial agent from the nitrofuran group; has antiprotozoal, antifungal and antibacterial effects.
Nifuratel has high efficiency and low toxicity, which determines a wide range of its clinical use.
Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms.
The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteridis, Klebsiella spp., Enterobacter sph., Serratia spp. , Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (Trichomonas, amoebas, Giardia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa.
It is the drug of choice for the treatment of salmonellosis, shigellosis and other acute intestinal bacterial infections.
Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.
Particularly effective against Helicobacter pylori strains resistant to metronidazole.
Pharmacokinetics
When taken orally, it is quickly absorbed from the gastrointestinal tract. Penetrates the blood-brain and hematoplacental barrier and is excreted in breast milk. Metabolized in the liver and muscle tissue. It is completely excreted from the body by the kidneys (30-50% unchanged), providing a strong antibacterial effect in the urinary tract.
Indications for use
Vulvovaginal infections caused by pathogens sensitive to the drug (pathogenic microorganisms, fungi of the genus Candida, Trichomonas, bacteria, chlamydia).
Pyelonephritis, urethritis, cystitis, pyelitis and other diseases of the urinary system.
Intestinal amebiasis and giardiasis.
Chronic inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pilory infection.
Contraindications for use
Hypersensitivity to the active substance or any component of the drug.
Sucrose/isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption.
Use during pregnancy and breastfeeding:
Nifuratel penetrates the hematoplacental barrier, so the use of the drug is possible only under strict indications, if the expected effect of therapy outweighs the potential risk to the fetus.
Nifuratel is excreted into breast milk, therefore, if it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.
Directions for use and dosage:
The drug is taken orally, following the recommendations.
Vaginal infections:
Adults: 1 tablet 3 times a day after meals for 7 days (both sexual partners should take the drug). Children: recommended dose of 10 mg/kg body weight daily for 10 days. The recommended dose should be taken in two divided doses.
Urinary tract infections:
Adults: depending on the severity of the disease, 1-2 tablets 3 times a day for 7-14 days. Children: recommended dose of 30-60 mg/kg body weight. The recommended dose should be taken in two divided doses.
On the recommendation of a doctor, the course of treatment for urinary tract infections can be extended or repeated.
Intestinal amoebiasis:
Adults: 2 tablets 2-3 times a day for 10 days. Children: recommended dose of 10 mg/kg body weight 3 times a day.
Giardiasis:
Adults: 2 tablets 2-3 times a day for 7 days. Children: recommended dose of 15 mg/kg body weight 2 times a day for 7 days.
Inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pylori:
Adults: 2 tablets 2-3 times a day for 7 days. Children: recommended dose of 15 mg/kg body weight 2 times a day for 7 days.
Overdose
There have been no cases of overdose.
Side effect
Dyspeptic disorders: nausea, vomiting, bitterness in the mouth, diarrhea, heartburn. Allergic reactions: skin rash, itching.
Interaction with other drugs
Strengthens the antifungal effect of nystatin.
special instructions
When treating vaginal infections only with oral therapy with Macmiror, it is recommended to increase the daily dosage of the drug to 4-6 tablets.
During the treatment period you should abstain from sexual intercourse.
Impact on the ability to drive vehicles and machinery
The drug does not affect the ability to drive vehicles or engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form
Film-coated tablets 200 mg.
10 tablets per blister made of PVC / aluminum foil.
2 blisters with instructions for use are placed in a cardboard box.
Storage conditions
In a place protected from light, at a temperature not exceeding 25 ° C.
Keep out of the reach of children!
Best before date
5 years.
Do not use after expiration date.
, Italy / Polichem Srl, Italy
Address: Via G. Marcora, 11 - 20121 Milan, Italy / Via G. Magsoga, 11 - 20121 Milan, Italy
Organization receiving complaints
JSC "SSC LTD"
115230, Moscow, Varshavskoe highway, 47, building 4, 14th floor tel./fax, https://www. cscpharma.ru
Instructions for Macmiror (Method and dosage)
The duration of treatment and the required dosage should be prescribed by a doctor.
According to the instructions for use of Macmiror:
Gastrointestinal diseases : Adults are prescribed 2-3 tablets 2-3 times a day, the course of treatment is from 7 to 10 days, depending on the disease.
For children, the daily dose is 15 mg per kg of weight. It is divided into 2-3 doses. Course – 7-10 days.
Urinary tract infections : Daily dosage for adults – 0.3-0.4 g per day, after meals. The course of treatment is from 7 to 14 days. Children over 6 years old – 15 mg per kg of body weight.
For vulvovaginitis and PPIs, adults are prescribed 3 tablets per day, divided into 3 doses. For complex treatment, a special cream for men and women is additionally prescribed.
For children over 10 years of age, the daily dose is calculated on the principle of 0.01 grams per kg of body weight and is divided into 2 doses per day.
Macmiror 200 mg 20 pcs. doppel farmaceutici film-coated tablets
pharmachologic effect
Antimicrobial and antiprotozoal agent - nitrofuran.
Composition and release form Macmiror 200 mg 20 pcs. doppel farmaceutici film-coated tablets
Tablets - 1 tablet:
- Active substance: nifuratel 200.00 mg;
- Excipients (core): corn starch 60.00 mg, rice starch 5.00 mg, macrogol-6000 (polyethylene glycol-6000) 15.00 mg, talc 30.00 mg, magnesium stearate 2.50 mg, gelatin 2.30 mg, acacia gum (gum arabic) 2.30 mg;
- Excipients (shell): sucrose 150.00 mg, magnesium carbonate 33.00 mg, titanium dioxide 0.90 mg, wax 0.30 mg.
10 tablets per blister made of PVC / aluminum foil.
2 blisters with instructions for use are placed in a cardboard box.
Description of the dosage form
Round, biconvex, white film-coated tablets.
Characteristic
Belongs to the group of nitrofurans.
Directions for use and doses
The drug is taken orally following the recommendations.
Vaginal infections:
- Adults: 1 tablet 3 times a day after meals for 7 days (both sexual partners should take the drug).
- Children: recommended dose of 10 mg/kg body weight daily for 10 days.
The recommended dose should be taken in two divided doses.
Urinary tract infections:
- Adults: depending on the severity of the disease, 1-2 tablets 3 times a day for 7-14 days.
- Children: recommended dose of 30-60 mg/kg body weight. The recommended dose should be taken in two divided doses.
On the recommendation of a doctor, the course of treatment for urinary tract infections can be extended or repeated.
Intestinal amoebiasis:
- Adults: 2 tablets 2-3 times a day for 10 days.
- Children: recommended dose of 10 mg/kg body weight 3 times a day.
Giardiasis:
- Adults: 2 tablets 2-3 times a day for 7 days.
- Children: recommended dose of 15 mg/kg body weight 2 times a day for 7 days.
Inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pylori:
- Adults: 2 tablets 2-3 times a day for 7 days.
- Children: recommended dose of 15 mg/kg body weight 2 times a day for 7 days.
Pharmacodynamics
Nifuratel is an antimicrobial agent from the nitrofuran group; has antiprotozoal, antifungal and antibacterial effects.
Nifuratel has high efficiency and low toxicity, which determines a wide range of its clinical use.
Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms.
The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteridis, Klebsiella spp., Enterobacter sph., Serratia spp. , Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (Trichomonas, amoebas, Giardia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa.
It is the drug of choice for the treatment of salmonellosis, shigellosis and other acute intestinal bacterial infections.
Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.
Particularly effective against Helicobacter pylori strains resistant to metronidazole.
Pharmacokinetics
When taken orally, it is quickly absorbed from the gastrointestinal tract. Penetrates the blood-brain and hematoplacental barrier and is excreted in breast milk. Metabolized in the liver and muscle tissue. Completely excreted from the body by the kidneys (30-50% unchanged), providing a strong antibacterial effect in the urinary tract.
Indications for use Macmiror 200 mg 20 pcs. doppel farmaceutici film-coated tablets
Vulvovaginal infections caused by pathogens sensitive to the drug (pathogenic microorganisms, Candida fungi, Trichomonas, bacteria, chlamydia).
Pyelonephritis, urethritis, cystitis, pyelitis and other diseases of the urinary system.
Intestinal amebiasis and giardiasis.
Chronic inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pilory infection.
Contraindications
Hypersensitivity to the active substance or any component of the drug.
Sucrose/isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption.
Application Macmiror 200 mg 20 pcs. doppel farmaceutici film-coated tablets during pregnancy and breastfeeding
Nifuratel penetrates the hematoplacental barrier, so the use of the drug is possible only under strict indications, if the expected effect of therapy outweighs the potential risk to the fetus.
Nifuratel is excreted into breast milk, therefore, if it is necessary to prescribe the drug during lactation, the issue of stopping breastfeeding should be decided.
special instructions
When treating vaginal infections only with oral therapy with Macmiror, it is recommended to increase the daily dosage of the drug to 4-6 tablets.
During the treatment period you should abstain from sexual intercourse.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect the ability to drive vehicles or engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Overdose
There have been no cases of overdose.
Side effects Macmiror 200 mg 20 pcs. doppel farmaceutici film-coated tablets
Dyspeptic disorders: nausea, vomiting, bitterness in the mouth, diarrhea, heartburn.
Allergic reactions: skin rash, itching.
Drug interactions
Strengthens the antifungal effect of nystatin.
Macmiror's analogues
Level 4 ATC code matches: Acylact
Iodoxide
Furazolidone
Kolposeptin
Lactonorm
Hexicon
Ecofemin
Lactozhinal
Depanthol
Dafnedjin
Analogue in tablets: furazolidone .
Analogues, ointments and suppositories: Macmiror Complex, Vokadin, Hexicon, Osarbon, Chlorhexidine, Betadine, Ecovag, Iodoxide .
Often the price of analogs is very different from the original.
Reviews about McMiror
Reviews on the forums are mostly good. It helps well against PPIs , does not cause complications on the liver, and side effects are rare. Many people write that the medicine is miraculous and helps in cases where there are liver diseases and it is difficult to take other medications.
Reviews of tablets for giardiasis are also positive, although there are complaints of headache and nausea. Doctors often prescribe medication for Giardia to children. Parents note its effectiveness.
McMirror price (where to buy)
The average price of Macmiror tablets in Russia is 539 rubles for 10 tablets of 400 mg. The cost of the medicine in Novosibirsk is 520 rubles for 20 pieces. You can buy tablets in Moscow for 600 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
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Macmiror vaginal capsules
All instructions
Trade name: Macmiror Complex International nonproprietary name: Nystatin + Nifuratel Dosage form: vaginal capsules
Compound
Active ingredients: nystatin 200,000 IU + nifuratel 500.0 mg
Excipients: dimethylpolysiloxane AK1000 (Dimethicone) 960.0 mg
Shell composition: gelatin 351.0 mg, glycerin (glycerol) 171.0 mg, sodium ethyl parahydroxybenzoate 1.8 mg, sodium iropyl parahydroxybenzoate 1.0 mg, titanium dioxide 0.4 mg, iron dye yellow oxide 2.4 mg
Description
soft gelatin capsules, egg-shaped, yellow with a brown tint, containing a yellow oily suspension.
Pharmacotherapeutic group
antimicrobial combination agent (antimicrobial and antiprotozoal agent + antifungal agent) Code: G01AX
Pharmacological properties
Pharmacodynamics
Antimicrobial drug for topical use. It has antiprotozoal, antifungal and antibacterial effects.
Nifuratel, a derivative of nitrofuran. Highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis).
Nystatin is an antifungal antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to cell death.
Highly active against Candida albicans. The combination of nifuratel and nystatin allows one to achieve a more pronounced antifungal effect and significantly expand the spectrum of antimicrobial action.
The high efficiency and low toxicity of the components of the drug determine a wide range of its clinical use in the treatment of vaginitis of mixed etiology, in particular, use for the prevention of mycoses caused by the specific treatment of trichomoniasis.
Macmiror Complex does not disturb the physiological flora, which allows you to avoid the development of dysbacteriosis and quickly restore vaginal normocenosis.
Pharmacokinetics
Conducted studies confirm that when used vaginally in animals (rabbits and dogs) with repeated administration of a daily dose, which is 30 times higher than the therapeutic dose, the substances included in the drug do not have a systemic effect.
Studies of the pharmacokinetics of the drug in humans also confirm that when used intravaginally, the drug is practically not absorbed from the surface of the vaginal mucosa and does not have a systemic effect.
The concentration of nifuratel in blood plasma is below the limit of quantitation. Maximum concentration (Cmax) 4.54 ng/ml; time to reach maximum concentration (Tmax) 8.0 hours; integral area under the pharmacokinetic concentration-time curve (AUC) 10.27 ng ml'1 h.
Nystatin is not absorbed through the skin and mucous membranes when applied topically.
Indications for use
Vulvovaginal infections caused by pathogens sensitive to the drug, including: bacterial vaginitis, vaginal trichomoniasis; vaginitis caused by fungi of the genus Candida, mixed vaginitis.
Contraindications for use
Hypersensitivity to nifuratel, nystatin or any excipient of the drug.
Children under 18 years of age.
Use during pregnancy and breastfeeding:
The use of the drug during pregnancy is possible if the potential benefit to the mother outweighs the risk to the fetus or child.
Directions for use and dosage:
Intravaginally: 1 vaginal capsule is administered daily in the evening before bed for 8 days or as recommended by a doctor. If necessary, treatment can be repeated after menstruation.
To achieve maximum effect, insert the capsule deep into the vagina.
Overdose
No cases of overdose have been reported.
Side effect
Allergic reactions in the form of skin rash or itching are possible. If allergic reactions develop, use of the drug must be discontinued.
Interaction with other drugs
No clinically significant interaction of the drug Macmiror Complex with other drugs has been established.
special instructions
It is necessary to simultaneously treat the sexual partner due to the risk of re-infection. During treatment with the drug, sexual contact should be avoided.
Vaginal capsules are not used for treatment in children; if it is necessary to use the drug in this category of patients, it is recommended to use the drug Macmiror Complex in the dosage form of a vaginal cream complete with an applicator (graduated syringe). The presence of a special nozzle allows you to introduce the cream without damaging the hymen.
Impact on the ability to drive vehicles and machinery
The use of the drug does not affect the ability to drive vehicles or other activities that require increased attention.
Release form
8 or 12 capsules per blister made of Al/PVC/PVDC.
1 blister along with instructions for use in a cardboard box.
Storage conditions
In a dry place at a temperature not exceeding 25 °C.
Keep out of the reach of children!
Best before date
3 years.
Do not use after expiration date.
Registration Certificate Holder
"Polichem S.r.l.", Italy / "Polichem Srl", Italy.
Address: Via G. Marcora, 11, 20121. Milan, Italy /
Via Giuseppe Marcora, 11 - 20121, Milano, Italy.
, Italy / Doppel Farmaceutici Srl, Italy.
Address: Via Martiri delle Foibe, 1 - 29016 Cortemaggiore (Piacenza), Italy /
