Lincomycin solution for intravenous and intramuscular administration 300 mg/ml 1 ml ampoule 10 pcs. in Kazan

From this article you will learn:

• What does Lincomycin help with?
• Lincomycin capsules – price 2021,
• how to use Lincomycin in dentistry and for the treatment of purulent-inflammatory diseases.

The article was written by a dentist with more than 19 years of experience.

Lincomycin is an antibiotic of the lincosamide group, which is quite outdated and does not have a wide spectrum of antimicrobial action. The advantages of this antibiotic are its low price, as well as its effectiveness in treating infection resistance to penicillin antibiotics. Remember that this is a prescription drug that should be used only as prescribed by a doctor, and in addition, lincomycin is strictly contraindicated for pregnant and lactating women, as well as children under 12 years of age.

The antibiotic Lincomycin in dentistry at one time found quite wide use, which was due to its relative affinity for bone tissue. However, it is unlikely that any sane dentist will now decide to prescribe lincomycin for dental implantation or gum inflammation. The range of indications for the use of Lincomycin in dentistry is, as a rule, limited to its purpose - either after a complex tooth extraction, or during tooth extraction due to inflammation, or with purulent periostitis of the jaw (i.e. gumboil).

Lincomycin capsules, ampoules –

If anyone is interested, the chemical formula of lincomycin is as follows: (2S, 4R)-N-[(1R, 2R)-2-hydroxy-1-[(2R, 3R, 4S, 5R, 6R)-3, 4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide. In this article we will talk about the optimal indications for the use of Lincomycin, as well as how to avoid the risk of developing a complication almost traditional for lincosamide antibiotics - antibiotic-associated diarrhea.

pharmachologic effect

An antimicrobial agent that belongs to the group of lincosamides. Its bacteriostatic effect is noted in relation to a wide range of microorganisms. If higher doses of the drug are used, it may produce a bactericidal effect.

The mechanism of the antimicrobial effect of the antibiotic is as follows: under its influence, protein synthesis is inhibited in the cells of microorganisms. It has pronounced activity against gram-positive anaerobic and aerobic microorganisms. Resistance to the influence of the drug is demonstrated by strains of Enterococcus faecalis, as well as viruses, fungi, and protozoa. Most gram-negative microorganisms are also resistant to it. Slow development of resistance to this drug has been noted. Cross-resistance of this substance with clindamycin has been noted.

Pharmacokinetics and pharmacodynamics

After oral administration, lincomycin hydrochloride is rapidly absorbed from the gastrointestinal tract. About 50% of the substance enters the systemic circulation. It is 75% bound to plasma proteins, the highest concentration is observed 2-4 hours after oral administration. The substance penetrates into fluids and organ tissues. The highest concentrations are observed in saliva, kidneys, genitals, liver, heart muscle, bone tissue, and bronchial secretions. Able to penetrate the blood-brain barrier, it is excreted in breast milk. Metabolism mainly occurs in the liver, it is excreted from the body in feces, a small amount is also excreted in the urine as metabolites and unchanged. The half-life from the body is 5-6 hours, it increases in people suffering from kidney disease.

Indications for use of Lincomycin

Lincomycin tablets and Lincomycin injections are prescribed for the following diseases:

• diseases of the bones and joints of an infectious nature, the development of which was provoked by microorganisms sensitive to the drug ( osteomyelitis , septic arthritis );
• infectious diseases of the ENT organs and respiratory tract, provoked by sensitive microorganisms (used for sore throat , sinusitis , otitis , bronchitis , pneumonia , tracheitis , etc.);
• diseases of the skin and soft tissues, which are provoked by microorganisms sensitive to the product ( abscess , purulent wounds , mastitis , furunculosis , erysipelas , etc.).
• Lincomycin-AKOS is used externally for inflammatory and purulent diseases of soft tissues and skin, which were caused by microorganisms sensitive to the active ingredient.

Lincomycin is used in dentistry to treat purulent and infectious processes that occur in the oral cavity. In particular, Lincomycin in dentistry can be prescribed for the treatment of periodontitis , periodontitis , gingivitis , purulent abscesses , etc. Whether there are indications for the use of Lincomycin is determined by the dentist individually.

Lincomycin ointment - application regimen

Lincomycin-AKOS ointment is produced pharmaceutically in Kurgan (Russia). The ointment is for external use only. The tube weighs 15 g. The indication for use is purulent inflammation of the skin and soft tissues, for example: pyoderma, phlegmon, furunculosis, erysipelas.

Scheme of use - lincomycin ointment - instructions for use recommends applying a thin layer to the affected areas of the skin 2-3 times a day. If there is no improvement within the first few days of use, it can be assumed that the infection is insensitive to lincosamides. In this case, you must urgently consult a doctor to replace the drug with another antibiotic.

Composition of the drug (per 100 g) –

→ Lincomycin ointment: official instructions (download in PDF)

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

• dysfunctions of the gastrointestinal tract ( vomiting , pain, nausea , stool disorders, increased activity of liver enzymes, esophagitis , hyperbilirubinemia );
• disorders of the hematopoietic process ( thrombocytopenia , agranulocytosis , neutropenia , pancytopenia );
• allergic processes ( skin itching , urticaria , rash , swelling erythema multiforme , anaphylactic shock );
• muscle weakness, headaches , arterial hypertension , dizziness .

If you experience any side effects, you should immediately tell your doctor about it.

Lincomycin capsules - dosage regimen, reviews

Lincomycin for oral administration is available in 250 mg capsules and is a prescription drug that should only be used as directed by a doctor. The regimen for use in children over 12 years of age and adults is 2 capsules 3-4 times a day (the duration of administration is determined by the doctor, but usually from 5 to 7 days). In younger children and pregnant and lactating women, taking the drug is prohibited.

The drug should be taken only on an empty stomach - approximately 1-1.5 hours before meals (below we will tell you what this is connected with). And this may be inconvenient, but according to the instructions - you should only take Lincomycin capsules with a full glass of water! Failure to comply with this rule will affect the effectiveness, as well as the already low safety of the drug.

Contents of one capsule of Lincomycin:

→ Lincomycin: official instructions for use (download in PDF)

Reviews of lincomycin capsules:

Most modern antibiotics have high bioavailability (absorbed from the intestines quickly and completely), which, for example, allows them to be taken after meals. Taking lincomycin capsules 1.5 hours before meals is associated with low bioavailability of the drug - even when taken on an empty stomach, no more than 30% of the active substance is absorbed from the intestines. At the same time, simultaneous food intake reduces the absorption of lincomycin in the intestine - only up to 5% of the active substance.

Those. simultaneous ingestion of food reduces the effectiveness of lincomycin by 4-5 times, and at the same time, the antibiotic that is not absorbed from the intestine continues to kill all beneficial microflora in the intestine. Poor bioavailability of lincomycin and the inability to combine its intake with food often cause the development of antibiotic-dependent diarrhea in patients. Therefore, a drug such as Lincomycin capsules should be taken only in parallel with taking probiotics.

How effective is Lincomycin as an antibiotic?

Scientific studies show that lincomycin shows good effectiveness only in 36.8% of cases, while in 63.2% of cases, pathogenic bacteria at the site of inflammation have only weak sensitivity to lincomycin. But if you have long-term inflammation (and especially if you have already taken courses of Lincomycin in the past), the effectiveness will be worse.

The same study showed that when it comes to long-term foci of inflammation in the area of ​​tooth roots (for example, in the presence of a fistula, granuloma/cyst), lincomycin will be effective only in 19% of cases. At the same time, in 47.6% of cases, Lincomycin demonstrates only weak effectiveness, and in the remaining 33.4% of cases, patients have complete resistance of the microflora in the inflammation site to lincomycin (it forms especially quickly in staphylococci).

Taking probiotics with Lincomycin:

Antibiotics of the lincosamide group are very often the cause of antibiotic-dependent diarrhea. If you have previously experienced diarrhea while taking antibiotics, or you have dysbiosis or other gastrointestinal diseases, in this case we do not recommend that you take antibiotics such as Lincomycin or Clindamycin. To reduce the risk of diarrhea, as well as reduce the negative impact of the antibiotic on the intestinal microflora, parallel intake of probiotics will help (these drugs contain bacteria beneficial to the intestines). For example, these could be Linex or Bifiform - they are the best, but also the most expensive. However, even simpler probiotics will provide benefits.

Probiotic Bifiform (30 capsules) –

Summary: all this makes the prescription of lincomycin acceptable, for example, when opening a purulent abscess on the gum (flux), as well as when removing a tooth with a purulent granuloma at the root apex. Acceptable simply because in these cases we drain the purulent focus and allow the outflow of pus, and antibiotic therapy in these situations is of secondary importance. But the prescription of lincomycin in the process of treating an exacerbation of chronic periodontitis, or to simply suppress inflammation - all this is ineffective and harmful.

Instructions for use of Lincomycin (Method and dosage)

If the patient has been prescribed Lincomycin injections, the instructions for use must be carefully followed during the treatment process. The drug in ampoules can be administered intravenously and intramuscularly. The daily dose of the drug for an adult patient should be no more than 1.8 g; if the disease is severe, the doctor can increase it to 2.4 g. The drug is administered three times a day, with the interval between injections being 8 hours. For children, the drug should be administered at a dose of 10-20 mg per 1 kg of body weight per day. Lincomycin is administered intravenously by drip; before administration, the solution is diluted with an isotonic sodium chloride solution.

For infectious diseases, Lincomycin capsules are also prescribed. The instructions for use recommend taking the drug in capsules for sore throat, as well as for sinusitis, either 1 hour before a meal, or 2 hours after taking it. The tablets cannot be chewed, they must be swallowed whole with plenty of liquid. The drug in tablets should be taken at regular intervals, dividing its daily dose. For children whose body weight exceeds 25 kg, the daily dose should be determined at the rate of 30 mg of the drug per 1 kg of weight.

When using the medicine in dentistry, as well as in the treatment of other infectious diseases, as a rule, Lincomycin is prescribed 500 mg three times a day. For severe symptoms, the dose can be increased to 500 mg of the drug four times a day. As a rule, the course of treatment lasts from 1 to 2 weeks. Sometimes the duration of treatment is up to 3 weeks (for example, with osteomyelitis ). If the patient has liver or kidney dysfunction, the dose should be adjusted individually.

Lincomycin ointment is prescribed externally. The instructions for use indicate that Lincomycin-AKOS ointment should be applied directly to the affected area in a thin layer. This procedure must be done 2-3 times a day.

Lincomycin 30% 1ml No. 10 Solution for Injection

LINCOMYCIN

The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.

pharmachologic effect

Antibiotic of the lincosamide group. In therapeutic doses it acts bacteriostatically. At higher concentrations it has a bactericidal effect. Suppresses protein synthesis in microbial cells.

Active primarily against aerobic gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae /except Enterococcus faecalis/), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomycin is also active against Mycoplasma spp.

Most gram-negative bacteria, fungi, viruses, and protozoa are resistant to lincomycin. Resilience is developed slowly.

Cross-resistance exists between lincomycin and clindamycin.

Pharmacokinetics

After oral administration, 30-40% is absorbed from the gastrointestinal tract. Eating slows down the rate and extent of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver. T1/2 is about 5 hours. It is excreted unchanged and in the form of metabolites in urine, bile and feces.

Indications

Severe infectious and inflammatory diseases caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection. As a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics.

For external use: purulent-inflammatory skin diseases.

ICD-10 codes

Dosage regimen

When taken orally by adults - 500 mg 3-4 times / day or intramuscularly - 600 mg 1-2 times / day. 600 mg is administered intravenously in 250 ml of isotonic sodium chloride or glucose solution 2-3 times a day.

Children aged 1 month to 14 years orally - 30-60 mg/kg/day; administered intravenously at a dose of 10-20 mg/kg every 8-12 hours.

For external use, apply a thin layer to the affected areas of the skin.

Side effect

From the digestive system: nausea, vomiting, epigastric pain, diarrhea, glossitis, stomatitis; transient increase in the level of liver transaminases and bilirubin in the blood plasma; with long-term use in high doses, the development of pseudomembranous colitis is possible.

From the hematopoietic system: reversible leukopenia, neutropenia, thrombocytopenia.

Allergic reactions: urticaria, exfoliative dermatitis, Quincke's edema, anaphylactic shock.

Effects due to chemotherapy: candidiasis.

Local reactions: phlebitis (with intravenous administration).

With rapid intravenous administration: decreased blood pressure, dizziness, general weakness, relaxation of skeletal muscles.

Contraindications for use

Severe liver and/or kidney dysfunction, pregnancy, lactation, hypersensitivity to lincomycin and clindamycin.

Use during pregnancy and breastfeeding

Lincomycin crosses the placental barrier and is excreted in breast milk. Use during pregnancy is contraindicated. If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Use for liver dysfunction

Contraindicated in cases of severe liver dysfunction.

If liver function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of liver function is necessary.

Use for renal impairment

Contraindicated in cases of severe renal impairment.

If renal function is impaired, the single dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between doses should be increased. With long-term use, systematic monitoring of renal function is necessary.

Use in children

Children aged 1 month to 14 years orally - 30-60 mg/kg/day; administered intravenously at a dose of 10-20 mg/kg every 8-12 hours.

Interaction

If an antibiotic is used at the same time as non-steroidal anti-inflammatory drugs, the patient is more likely to develop respiratory failure and may experience respiratory arrest.

Taking Lincomycin and antidiarrheals simultaneously increases the likelihood of developing pseudomembranous colitis.

You cannot treat with the drug at the same time as using muscle relaxants and inhalational anesthetics.

Antibiotic absorption is reduced when taking adsorbent drugs simultaneously.

Lincomycin reduces the severity of the action of neostigmine , pyridostigmine , ambenonium .

The bacteriostatic effect of the antibiotic is reduced by simultaneous administration of Erythromycin and chloramphenicol .

Pharmaceutical incompatibility with kanamycin , novobiocin , and ampicillin .

Side effects and contraindications –

Lincomycin cannot be used during pregnancy, because the drug has a toxic effect on the fetus. In addition, it penetrates well through the placenta (the concentration in the fetal blood will be about 25% of the concentration in the maternal blood serum). Therefore, pregnant and lactating women should not use any form of lincomycin, including ointment.

You should also not take the drug if you have intestinal diseases (colitis, enteritis, ulcerative colitis), or if you have allergic reactions to lincosamides or doxorubicin. If symptoms of pseudomembranous colitis (diarrhea) develop while taking lincomycin, it is necessary to urgently discontinue the drug and begin specific treatment. The latter may include prescribing a tablet. Metronidazole or Vancomycin.

Our portal has a separate article devoted to the use of antibiotics in dentistry. A detailed list of the most effective drugs for inflammation of teeth and gums can be seen at this link.

Lincomycin: drug analogues

A semisynthetic analogue of lincomycin is another antibiotic of the lincosamide group - the drug Clindamycin. It should be noted that this drug also has a fairly narrow spectrum of antimicrobial action, but its effectiveness against some types of microorganisms will be 2-10 times higher - compared to lincomycin. Another advantage of this drug is that its absorption in the intestine does not depend on food intake (lincomycin can only be taken on an empty stomach, 1-1.5 hours before meals).

The price of Clindamycin starts from 150 rubles (for a package of 16 capsules of 150 mg). Dosage regimen: 1 capsule 4 times a day, duration of administration is determined by the doctor. To summarize, the effectiveness of clindamycin will be only slightly higher, but taking the drug will be much more convenient. However, the risk of developing pseudomembranous colitis when taking clindamycin will be higher than when taking lincomycin. And remember that antibiotics should not be taken without a doctor's prescription. We hope that our article was useful to you!

Sources:

1. Dental education of the author of the article, 2. Personal experience as a maxillofacial surgeon, dental surgeon, 3. American Academy of Periodontology (USA), 4. “Antibiotics and chemotherapeutic drugs: a textbook” (Sizentsov, Misetov), ​​5. “ Sensitivity of microbial associations of periodontal pocket exudate and odontogenic lesion to antibacterial drugs” (Makeeva I.M.).

special instructions

If the patient has impaired renal or liver function, the single dose of the drug is reduced by 1/3-1/2, and the interval between administration is increased. With prolonged antibiotic treatment, the condition of the liver and kidneys must be monitored.

If the patient has renal or liver failure, the drug is contraindicated, for which Lincomycin can be prescribed exclusively for health reasons.

If a patient is prescribed Lincomycin tablets, which subsequently develops pseudomembranous colitis as a side effect, the drug is discontinued and Bacitracin or Vancomycin .

Externally, the ointment is carefully prescribed for dermatomycosis .

The solution should not be administered rapidly intravenously

Lincomycin

When using lincomycin, official national recommendations on the appropriate use of antibacterial drugs, as well as the sensitivity of pathogenic microorganisms in a particular country, should be taken into account.

Lincomycin should be prescribed with caution to patients with a history of gastrointestinal diseases, especially colitis.

Cases of pseudomembranous colitis have been reported that developed 2 months after taking antibacterial drugs that require the administration of ion exchange resins (cholestyramine); in severe cases, replacement of fluid, electrolyte and protein losses is indicated, vancomycin - orally, in a daily dose of 0.5-2 g ( in 3-4 doses) for 10 days or bacitracin. The use of drugs that inhibit intestinal motility is contraindicated.

Lincomycin is not indicated for the treatment of meningitis because its concentration in the cerebrospinal fluid is insufficient to treat meningitis.

The use of lincomycin in patients with diabetes mellitus is not recommended unless alternative treatment is available, as there are no adequate data on the treatment of patients with endocrine or metabolic diseases.

The half-life of lincomycin may be increased in patients with hepatic or renal impairment, so caution should be exercised when prescribing lincomycin to patients with moderate hepatic/renal impairment and monitor lincomycin blood concentrations during high-dose lincomycin therapy. In such patients, the possibility of reducing the frequency of drug administration should be considered.

Use in severe liver/renal impairment is contraindicated.

As with the use of other antimicrobial drugs, when using lincomycin, especially long-term, it is possible to develop a secondary infection associated with the growth of drug-resistant microorganisms (especially fungi), to exclude and confirm which the patient’s condition should be re-evaluated. If a secondary infection occurs during therapy, the necessary measures should be taken to treat it.

Lincomycin should be used with caution in patients with existing fungal diseases, and such patients should also be prescribed antifungal therapy.

Severe bullous reactions such as Stevens-Johnson syndrome have been reported with the use of lincomycin. Patients should be informed that if skin reactions and/or lesions of the mucous membranes develop, they should immediately consult a doctor before continuing treatment with lincomycin.

Allergic reactions have been reported with the use of lincomycin, which can progress to a life-threatening condition. In these cases, the use of lincomycin should be discontinued and appropriate treatment should be initiated.

Lincomycin has neuromuscular blocking activity and may increase muscle weakness in patients with myasthenia gravis. The use of lincomycin in patients with an established diagnosis of pseudoparalytic myasthenia gravis is not recommended.

Cases of neutropenia and/or leukopenia have been reported during treatment with lincomycin, so periodic monitoring of blood tests is recommended during therapy.

During long-term treatment, periodic monitoring of the activity of liver transaminases and kidney function is necessary. If violations are detected, the possibility of discontinuing the drug should be considered.

To avoid the development of aseptic necrosis, it is better to administer deeply intramuscularly. It cannot be administered intravenously without prior dilution.

Analogs

Level 4 ATC code matches:
Clindamycin

Lincomycin Hydrochloride

Analogues of the antibiotic Lincomycin are the drugs Lincomycin hydrochloride , Linkocin Clindamycin , Dalatsin C , Clindamycin-Norton , etc.

The use of other drugs by patients prescribed Lincomycin without the prior approval of a physician is strictly prohibited.

With alcohol

When discussing the compatibility of this antibiotic with alcohol, it should be noted that alcohol should not be consumed while being treated with this medicine. This combination will disrupt the absorption of the active substance of the drug in the gastrointestinal tract; under the influence of alcohol on the liver, an acceleration of the half-life of the active substance is observed. Consequently, the concentration of the drug in the body decreases, and its effectiveness decreases.

In addition, if a patient combines Lincomycin and alcohol, the consequences can be negative, as the likelihood of side effects increases.

Reviews about Lincomycin

Reviews of Lincomycin that users leave online indicate that this drug has a pronounced antimicrobial effect and allows you to quickly get rid of the unpleasant symptoms of infectious diseases. Those who have used Lincomycin injections also leave mostly positive reviews.

Both when administered intravenously and intramuscularly, the solution acts quickly and reduces the severity of symptoms. Reviews about the use of the product in dentistry often contain information that the drug helped to quickly get rid of purulent and inflammatory diseases.

Lincomycin price, where to buy

The price of Lincomycin in ampoules averages from 40 rubles for 10 ampoules of 1 ml.

The price of Lincomycin tablets ranges from 60 to 90 rubles for 20 pieces. You can buy the drug in capsules in Ukraine for an average of 25 UAH. (30 pcs.).

Lincomycin-AKOS ointment can be purchased at a price of 27 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Lincomycin capsules 250 mg 20 pcs. Ozon LLC
  127 rub. order
• Lincomycin capsules 250 mg 20 pcs. BelmedpreparatyRUUE Belmedpreparaty

  73 rub. order

• Lincomycin capsules 250 mg 20 pcs. Medicine production LLC

  85 rub. order

• Lincomycin hydrochloride solution for injection. 30% 1ml 10 pcs. JSC Dalkhimfarm

  116 RUR order

• Lincomycin caps. 0.25g 20pcsOzon LLC

  RUB 142 order

Pharmacy Dialogue

• Lincomycin h/x (caps. 250 mg No. 20)Production of medicines

  78 RUR order

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) Belmedpreparaty

  80 rub. order

• Lincomycin (caps. 250 mg No. 20) Belmedpreparaty

  64 RUR order

• Lincomycin (caps. 250 mg No. 20) Ozon LLC

  114 RUR order

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) DHF JSC

  88 rub. order

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Pharmacy24

• Lincomycin-Darnitsa 30% 1 ml No. 10 solution
  37 UAH. order
• Lincomycin KMP 250 mg N30 capsules PAT "Kievmedpreparat", Ukraine

  35 UAH order

• Lincomycin-Darnitsa 30% 2 ml No. 10 solution for injection

  54 UAH order

• Lincomycin 300 mg/ml 1 ml No. 10 solution TOV" Pharmaceutical company "Zdorovya", Kharkiv, Ukraine

  34 UAH order

• Lincomycin 0.25 N20 capsules PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine

  32 UAH order

PaniPharmacy

• Lincomycin capsule Lincomycin capsules 0.25g No. 30 Ukraine, Kievmedpreparat OJSC

  42 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Health LLC

  35 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Darnitsa ChAO

  41 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Health LLC

  53 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Darnitsa ChAO

  56 UAH order

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Lincomycin - price, release forms

The antibiotic lincomycin has 3 release forms (capsules, ampoules and ointment), but in any case you will find this drug in pharmacies only from a Russian or Belarusian manufacturer. Moreover, not only Lincomycin is available by prescription in capsules or ampoules, but even in ointment forms. The cost of all drugs is lower - indicated for 2021.

• Lincomycin capsules - each capsule contains 250 mg of the active substance “lincomycin”. For Lincomycin capsules, the price starts from 75 rubles (the package contains 2 blisters of 10 capsules each). If we take into account the standard regimen of use for an adult, 1 package is only enough for 3 days of use, which makes this drug even more expensive than the antibiotic Tsiprolet (from the group of fluoroquinolones).

• Lincomycin in ampoules - each package contains 10 ampoules of 1.0 ml. Each ampoule contains 300 mg of lincomycin hydrochloride, which in percentage terms is a 30% concentration. If we take into account the standard dosage regimen for adults, 1 package is enough for only 2.5 days of antibiotic therapy. The cost of 1 package will be from 90 to 130 rubles (for a short 5-day course of treatment, 2 packages will be required).

• Lincomycin ointment 2% - intended for external use only, used for purulent inflammation of the skin. The ointment is available in tubes of 15 g - with a concentration of the active substance of 2%. The ointment is produced in Kurgan, and its cost will be from 150 rubles.