Elixir Codelac Broncho with thyme: instructions for use

Codelac Broncho elixir with thyme 100ml

A country

Russia
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Active substance

Ambroxol + Sodium glycyrrhizinate + Creeping thyme herb extract

Compound

Active ingredients: codeine phosphate hemihydrate - 4.5 mg, dry thermopsis extract - 10 mg, liquid thyme extract - 1000 mg, dry licorice extract - 165 mg.

pharmachologic effect

Cough remedy, contains components of plant origin. Combined drug. Codeine reduces the excitability of the cough center, reducing the intensity of the cough. In recommended therapeutic doses, it does not cause depression of the respiratory and cough centers, does not disrupt the function of the ciliated epithelium and does not reduce bronchial secretion. Thermopsis herb has an expectorant effect, manifested in increasing the secretory function of the bronchial glands, increasing the activity of the ciliated epithelium and accelerating the excretion of secretions, increasing the tone of smooth muscles bronchi due to the central vagotropic effect. Licorice root has an expectorant, anti-inflammatory and antispasmodic effect. Contains glycyrrhizin, which has an antiviral effect, and also potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, glycyrrhizin contributes to the most rapid relief of the infectious and inflammatory process in the respiratory tract. Thyme herb extract contains a mixture of essential oils that have expectorant, anti-inflammatory and bactericidal effects due to increased activity of the ciliated epithelium of the mucous membranes of the upper respiratory tract, increasing the amount of mucosal secretion membranes of the bronchi, diluting sputum, accelerating its evacuation and loosening inflammatory plaques. In addition, thyme has weak antispasmodic and reparative properties.

Indications for use

Symptomatic treatment of dry cough of any etiology in bronchopulmonary diseases.

Mode of application

Inside, during meals, with a small amount of water. Adults and children over 12 years old - 10 ml 4 times a day. Children from 2 to 6 years old - 2.5 ml 3 times a day, from 6 to 12 years old - 5 ml 3 times a day.

Interaction

Combined use with antitussive drugs leads to difficulty in sputum discharge.

Side effect

Allergic reactions, weakness, headache, diarrhea, dry mouth and respiratory tract, exanthema, rhinorrhea, constipation, dysuria. With long-term use in high doses - gastralgia, nausea, vomiting.

Contraindications

Hypersensitivity, pregnancy, lactation, children under 2 years of age. With caution: liver and/or kidney failure, gastric and duodenal ulcers, bronchial asthma.

Overdose

Symptoms: nausea, vomiting, diarrhea, dyspepsia. Treatment: symptomatic, gastric lavage is advisable in the first 1-2 hours after taking the drug.

special instructions

Do not combine with antitussives. Patients with diabetes can use the drug, taking into account the sorbitol content in the amount of 0.18 XE per 5 ml of elixir.

Dosage forms and composition

The drug is produced in two forms for oral administration:

• tablets: yellowish in color with visible small inclusions, flat-cylindrical, have a separating score, packaged in foil plates of 10 pieces, the package contains 1 or 2 blisters;
• liquid elixir with thyme: light brown syrup with a characteristic balsamic aroma, in glass bottles with screw caps from 50 to 200 ml, cardboard packaging equipped with a measuring spoon.

Codelac Broncho is a combination drug. It contains several active substances:

• ambroxol: 200 mg in tablets and 100 mg in syrup;
• extracted thermopsis: 100 mg;
• sodium glycyrrhizinate: 300 mg;
• in tablets - sodium bicarbonate: 200 mg;
• in syrup - extracted thyme: 500 mg.

Auxiliary compounds of tablets: starch, MCC, stearic acid, talc and others. The elixir also contains sorbitol, distilled water, napazole and nipagin. When storing in liquid medicine, slight sedimentation may occur. This does not affect the therapeutic properties.

What kind of cough do Codelac Broncho tablets and elixir help with?

The effect of both dosage forms of the drug is similar. These are mucolytics with a moderate anti-inflammatory effect. Designed to liquefy mucous secretions, improve the passage of accumulated clots from the bronchi and lungs. Increases cough productivity and helps cleanse the respiratory system.

Ambroxol in combination with thermopsis extract reduces the viscosity of mucus, stimulating its elimination. Sodium bicarbonate improves the motility of bronchioles and epithelial villi on the walls of the bronchi. Glycyrrhizinate has an antimicrobial effect and neutralizes the damaging effects of oxidation products. Thyme complements the activity of other components of the elixir, helps to expectorate mucus more easily, helps relieve microspasms and makes breathing easier.

Positive dynamics are usually observed from the second day of therapy. The effect of the medicine increases gradually: the cough becomes less intrusive, the mucus leaves in a larger volume, and relief comes faster.

Side effects

During treatment, the following are rarely possible:

• the appearance of physical weakness, dizziness;
• dryness, unpleasant taste in the mouth, loss of appetite;
• abdominal cramps, stool upset, constipation;
• irritation of the mucous membrane of the nasopharynx, trachea;
• the appearance of a runny nose.

After taking large doses, intoxication may occur. Possible vomiting, severe abdominal pain, diarrhea. In such cases, it is necessary to lavage the stomach and take enterosorbents.

Compound

When to take Codelac Broncho

The drug is taken when signs of respiratory inflammation or symptoms of exacerbation of chronic conditions develop. It is recommended to start the course of treatment from the first minutes of discomfort: sore throat, hoarseness and coughing.

General indications:

• accumulation of sputum in acute and chronic forms of bronchitis;
• chronic pulmonary obstruction;
• bronchiectasis;
• viral or bacterial pneumonia;
• signs of ARVI, accompanied by cough.

Pharmacodynamics

A combined drug for the treatment of cough, it has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The effect of the Codelac® Broncho elixir with thyme is due to the pharmacological properties of its components.

Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of serous and mucous components of sputum, and increases the secretion of surfactant in the alveoli. Reduces the viscosity of sputum and promotes its removal.

Glycyrrhat (glycyrrhizic acid and its salts) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous corticosteroids, providing anti-inflammatory and antiallergic effects. Due to its pronounced anti-inflammatory activity, it helps reduce the inflammatory process in the respiratory tract.

Thyme herb extract contains a mixture of essential oils that have an expectorant and anti-inflammatory effect. In addition, thyme herb extract has weak antispasmodic and reparative properties.

Contraindications

The drug in tablets is prohibited for use by children under 12 years of age. Elixir - for infants and children up to 2 years old. Contraindications also include:

• pregnancy, breastfeeding period;
• individual intolerance to the active or auxiliary components of the drug;
• period of exacerbation of stomach ulcers, duodenal ulcers, and some forms of gastritis;
• diseases with a high risk of internal bleeding;
• severe renal failure or liver dysfunction.

Patients with diabetes should be careful when treating with the elixir, as it contains the carbohydrate sorbitol. Those suffering from bronchial asthma, chronic liver and kidney diseases also need to monitor their well-being while using the drug.

Codelac Broncho: instructions for use

CODELAC® BRONCHO is a series of specialized medications intended for the treatment of respiratory tract diseases, incl. colds, accompanied by a cough with difficult sputum discharge. This cough is often called “wet” or “productive.”

Where can I buy

A distinctive feature of the KODELAK® BRONXO series drugs is a unique combined composition that has no analogues in Russia1.

Thanks to the combined composition, CODELAC® BRONCHO preparations provide a comprehensive therapeutic effect for wet coughs with sputum (“productive” and “unproductive”), helping to shorten the cough period and resolve the cough.

Where can I buy

The combination of ingredients in the antitussive drugs KODELAK® BRONCHO successfully combines both the developments of modern pharmacology and the centuries-old traditions of traditional medicine, based on knowledge of the healing properties of medicinal herbs and plants. In addition to medically synthesized molecules, CODELAC® BRONCHO preparations contain natural plant components:

• thermopsis extract – in KODELAK® BRONCHO tablets;
• thyme herb extract – as part of the elixir KODELAK® BRONCHO with thyme;
• licorice root extract (glycyrrate and its salts) - in both preparations - tablets and elixir.

The very idea of ​​herbal medicine is widely supported by the World Health Organization (WHO).

Based on an analysis of vast global experience, WHO recognized the need for the rapid integration of traditional medicine methods into the health care system of all countries2.

The effect of CODELAC® BRONCHO preparations is due to the pharmacological properties of their constituent components. The action of all components is aimed at mutually enhancing the properties of each of them.

X
AMBROXOL: thins mucus, reduces viscosity and promotes its removal from the bronchi.
Today, ambroxol is the most popular and sought-after molecule in Russia for the treatment of wet cough3. Among other things, ambroxol is also one of the most widely studied cough remedies. The international database of specialized medical publications Pubmed contains more than 700 studies using ambroxol. X
GLYCIRRATE (glycyrrhizic acid and its salts): has anti-inflammatory and antiviral effects;
has a corticosteroid-like effect, helps reduce the inflammatory process in the respiratory tract, including the bronchi. Additionally, it has a moderate protective effect on cells (=cytoprotection), due to its antioxidant and membrane-stabilizing activity. X
SODIUM HYDROCARBONATE: reduces the viscosity of sputum, stimulates its excretion by enhancing the motor function of the ciliated epithelium of the bronchi and bronchioles.
X
THYME HERB EXTRACT: has an expectorant, anti-inflammatory and antimicrobial effect, has a healing effect on the mucous membrane damaged by the action of microbes and cough impulses.
WHO experts, the European Commission, as well as the European Scientific Cooperative on Phytotherapy (ESCOP) give a positive assessment to medications containing thyme (thyme) and approve their use, for example, for acute and chronic bronchitis, including in children .4.5 X
THERMOPSIS EXTRACT: has an expectorant effect, helps thin mucus by enhancing additional secretion of the bronchial glands.
When taking drugs containing thermopsis, both bronchial secretion and the initial parts of the cough reflex are stimulated (the frequency and intensity of cough increases). Slight differences in the compositions of KODELAK® BRONCHO tablets and KODELAK® BRONXO elixir with thyme are due to the technology of their industrial production.

The combined composition and complex action of KODELAK® BRONCHO preparations is aimed at all the main factors that predetermine the appearance of a wet cough during a cold:

1. against viruses and germs:

• antiviral properties are due to the presence of glycyrrhizic acid in the composition; its activity against a number of viruses has been demonstrated in vitro, as well as in an in vivo model of influenza6,7
• antimicrobial properties are due to thyme - the flavonoids thymol and carvacrol contained in it have a bactericidal effect on coccal pathogenic flora, a bacteriostatic effect on gram-negative microorganisms, as well as high antimycotic activity against pathogenic fungi8.

2. against inflammation in the bronchi:

• help reduce inflammation in the walls of the bronchi;
• favor the restoration and healing of mucous membranes damaged by microbes, inflammation and intense coughing attacks.

3. against phlegm:

• reduce the viscosity of thick sputum, diluting it, changing rheological properties and improving glide;
• promote the removal of phlegm from the lungs and bronchi, stimulating the evacuation function of the ciliated epithelium;
• create conditions for the release of phlegm from even the smallest and narrowest bronchi, thanks to a moderate antispasmodic effect.

The complex therapeutic effect due to the combined composition is a distinctive feature of the CODELAC® BRONCHO series of drugs. This fundamentally distinguishes CODELAC® BRONCHO preparations from single-component drugs based on ambroxol and/or acetylcysteine, which are well known and widely used in the treatment of wet cough due to advertising.

In particular, the advantage of CODELAC® BRONCHO for cough with sputum in comparison with monocomponent ambroxol preparations is confirmed by the results of observational clinical studies:

1. KODELAK® BRONCHO acts 2 times more powerfully, significantly improving sputum discharge and more significantly reducing the severity of cough9;
2. KODELAK® BRONCHO quickly converts a non-productive cough into a productive one, while taking it, a shorter duration of the cough period was noted10-11;
3. CODELAC® BRONCHO helps to significantly reduce the severity of bronchial inflammation in the lungs11;
4. CODELAC® BRONCHO has a higher subjective assessment from patients who were treated for cough10-11.

works 2 times more powerfully

characterized by shorter duration of cough

significantly reduces bronchial inflammation

has a higher patient rating

The following features are characteristic of the preparations of the CODELAC® BRONCHO series:

• readiness for action within 30 minutes after administration12,13;
• duration of action is 6-8 hours after a single dose14;
• favorable safety profile9-11;
• absence of any components that form dependence and/or addiction.

CODELAC® BRONCHO preparations are produced in 2 dosage forms, which provide a choice of products for people of different age groups:

• elixir – for children over 2 years of age and adults;
• tablets – for adults and children over 12 years of age.

ELIXIR: for children over 2 years old and adults

Where can I buy

elixir KODELAK® BRONCHO instructions

TABLETS: for adults and children over 12 years of age

Where can I buy

KODELAK® BRONCHO tablets instructions

Taking into account the frequency of doses given in the instructions for medical use of CODELAK® BRONCHO drugs, as well as the duration of the course of treatment, below are recommendations for the optimal choice of dosage forms for consumers of different ages:

elixir, 100 ml

elixir, 200 ml

pills

children from 2 years old

adults and children over 12 years old

Each of the release forms of KODELAK® BRONCHO ensures maximum ease of use of the drug:

ELIXIR:

• the convenience of a liquid dosage form, providing parents with comfortable use of the drug, and ease of administration and swallowing for children;
• convenience and accuracy of dosing - the drug packaging is equipped with a convenient double-sided measuring spoon, for 2.5 and 5 ml, respectively
• absence of alcohol, sugar and dyes
• two volume options: 100 ml (for children) and 200 ml (for adults)

PILLS:

• small tablet size, facilitating the process of taking and swallowing the drug;
• 2 packaging options - 10 and 20 tablets per package.

Method of use of antitussive drugs KODELAK® BRONCHO.

How to take CODELAC® BRONCHO?

The table below can help you understand this issue...

Based on the standard recommended course of administration for 3-5 days, taking into account the optimal volumes and consumption of drugs when taken in accordance with the instructions for medical use.

Bibliography:

1. Based on drug register data as of April 2021.
2. Karpeev A.A., Kiseleva T.L. Herbal medicine: Methodological recommendations of the Ministry of Health of the Russian Federation 2000/63/. M.: Publishing house FNKETS TMDL Roszdrav, 2006. - P. 9-42.
3. Based on IMS Health data, retail audit, April 2017.
4. World Health Organization (2010) WHO monographs on medicinal plants widely used in the Newly Independent States (NIS)
5. ESCOP Monograph, Thimi herba (Thyme). European Scientific Cooperation on Phytomedicine, Elburg (2003) // Monograph European Scientific Association for Herbal Medicine - monograph “Thyme Herb” (Thyme), Elburg, 2003.
6. V.V. Zarubaev, V.B. Anikin, V.S. Smirnov. ANTI-VIRAL ACTIVITY OF GLYCERRETIC AND GLYCYRRHIZIC ACIDS. Infection and immunity 2021, Vol. 6, No. 3, p. 199–206
7. A. Wolkerstorfer, H. Kurz. Glycyrrhizin inhibits influenza A virus uptake into the cell. Antiviral Research 83 (2009) 171–178.// A. Wolkerstorfer, H. Kurz, Glycyrrhizic acid: blocking the penetration of influenza A viruses into cells. Antiviral Research 83 (2009) 171-178.
8. Sokolov S.Ya. Herbal medicine and phytopharmacology: A guide for doctors. M.: Medical Information Agency, 2000. 976 pp.
9. Codelac Broncho is 2.6 times more effective in reducing the intensity of wet cough compared to ambroxol in children from 2 to 6 years of age (from the 3rd to the 10th day of therapy). Mizernitsky Yu.L. Clinical effectiveness of combined mucoactive expectorant therapy in children with acute respiratory infections of the lower respiratory tract. Pediatrics 3, 2011, Consilium medicum supplement, p. 16-21.
10. Snegotskaya M.N. New drugs in the treatment of cough in children. Pediatrics. 5/2012, p. 24-29.
11. Princely N.P. Combined expectorants in the practice of an internist. Features of the preparations CODELAC® BRONCHO and CODELAC® BRONCHO with thyme. Directory of polyclinic doctor No. 11, 2012, pp. 45-49.
12. Thermopsis extract has an expectorant effect, the maximum effect develops after 30-60 minutes. Instructions for medical use of the drug KODELAK® BRONCHO.
13. Ambroxol begins to act 30 minutes after application. Kirilina S.A. “Pediatrician Practice”, September 2012, p. 11-13.
14. Based on the recommended frequency of use of CODELAC BRONCHO and CODELAC BRONCHO with THYME, presented in the instructions for medical use of the drugs