How to take Zyrtec drops
The optimal dose of the drug depends on the age category of the patient:
- from 6 years of age and adults can be given initially 10 drops, and depending on the condition, can be gradually increased to 20 drops;
- at the age of 2-6 years, 5 drops are prescribed 2 times a day, or you can combine them in one dose;
- from 1 to 2 years, no more than 5 drops are prescribed 1-2 times a day;
- from 6 to 12 months you can give 5 drops 1 time per day.
If the medicine is given to children, then the dosage may also be affected not only by age, but also by body weight.
For people with kidney disease, the dosage is determined individually.
Zyrtec 10 mg, 30 film-coated tablets
Registration Certificate Holder
UCB FARCHIM (Switzerland)
Dosage form
Medicine - Zyrtec®
Description
Film-coated tablets
white, oblong, with biconvex surfaces, with one-sided score and “Y” engraving on both sides of the score.
1 tab.
Cetirizine dihydrochloride 10 mg
Excipients
: microcrystalline cellulose, lactose monohydrate, colloidal silicon dioxide, magnesium stearate; Opadry® Y-1-7000 (hypromellose (E464), titanium dioxide (E171), macrogol 400).
7 pcs. - blisters (1) - cardboard packs. 10 pieces. - blisters (1) - cardboard packs. 10 pieces. - blisters (2) - cardboard packs.
Indications
- treatment of symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia;
- hay fever (hay fever);
- urticaria (including chronic idiopathic urticaria);
- Quincke's edema;
- other allergic dermatoses (including atopic dermatitis), accompanied by itching and rashes.
Contraindications for use
- end-stage renal failure (CC < 10 ml/min);
- pregnancy;
- lactation period (breastfeeding);
- hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
- children under 6 years of age (for tablets);
- children up to 6 months (for drops);
- hypersensitivity to the components of the drug;
- hypersensitivity to hydroxyzine.
Carefully
The drug should be prescribed for chronic renal failure (correction of the dosage regimen is required), for chronic liver diseases, and for elderly patients (due to a possible decrease in glomerular filtration).
pharmachologic effect
Antiallergic drug. Histamine H1 receptor blocker, competitive histamine antagonist, hydroxyzine metabolite. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects.
Affects the early histamine-dependent stage of allergic reactions, limits the release of inflammatory mediators at the late stage of the allergic reaction, reduces the migration of eosinophils, neutrophils and basophils, stabilizes mast cell membranes. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates skin reactions to the introduction of histamine, specific allergens, as well as to cooling (with “cold” urticaria). Reduces histamine-induced bronchoconstriction in mild bronchial asthma.
It has virtually no anticholinergic and antiserotonin effects. In therapeutic doses it has virtually no sedative effect.
After a single dose of cetirizine at a dose of 10 mg, the onset of effect is observed after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), the effect lasts more than 24 hours. During a course of treatment, tolerance to the antihistamine effect of cetirizine does not develop. After stopping treatment, the effect lasts up to 3 days.
Drug interactions
When studying the drug interactions of cetirizine with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide and diazepam, no clinically significant adverse interactions were identified.
When administered simultaneously with theophylline (400 mg/day), the total clearance of cetirizine is reduced by 16% (the kinetics of theophylline does not change).
When administered simultaneously with macrolides and ketoconazole, no changes were noted on the ECG.
When using the drug in therapeutic doses, no data on interaction with alcohol (at a blood alcohol concentration of 0.5 g/l) were obtained. However, the patient should refrain from drinking alcohol during drug therapy to avoid depression of the central nervous system.
Dosage regimen
The drug is prescribed orally.
Adults and children over 6 years old
prescribed at a dose of 10 mg (1 tablet or 20 drops)/day. Adults - 10 mg 1 time/day; children - 5 mg 2 times / day or 10 mg 1 time / day. Sometimes an initial dose of 5 mg may be sufficient to achieve a therapeutic effect.
Children aged 2 to 6 years
prescribed 2.5 mg (5 drops) 2 times/day or 5 mg (10 drops) 1 time/day.
Children aged 1 to 2 years
Prescribe 2.5 mg (5 drops) up to 2 times a day.
Children aged 6 months to 12 months
prescribed 2.5 mg (5 drops) 1 time/day.
For renal failure
and in elderly patients, the dose of the drug should be adjusted depending on the value of CC.
CC can be calculated based on serum creatinine concentration using the following formula:
For men: CC (ml/min) = [140 - age (years)] x body weight (kg)/72 x serum creatinine (mg/dl);
CC for women can be calculated by multiplying the resulting value by a coefficient of 0.85.
Adult patients with renal and hepatic insufficiency
The dose is set according to the following table.
Renal failure KK (ml/min) Dosage regimen
Norm≥8010 mg/day Mild50-7910 mg/dayModerate30-495 mg/daySevere<305 mg every other dayTerminal stage - patients on dialysis<10 The drug is contraindicated
Patients with impaired liver function only
no dosage adjustment is required.
Overdose
Symptoms:
When taking the drug once in a dose of more than 50 mg, confusion, diarrhea, dizziness, increased fatigue, headache, malaise, mydriasis, itching, weakness, sedation, drowsiness, stupor, tachycardia, tremor, urinary retention are possible.
Treatment:
Immediately after taking the drug, you should perform gastric lavage or artificially induce vomiting. It is recommended to prescribe activated carbon and carry out symptomatic and supportive therapy. There is no specific antidote. Hemodialysis is ineffective.
Side effect
From the hematopoietic system:
thrombocytopenia.
From the nervous system:
drowsiness, dizziness, headache, aggression, agitation, confusion, depression, hallucinations, insomnia, tic, convulsions, dyskinesia, dystonia, paresthesia, fainting, tremor.
From the side of the organ of vision:
disturbance of accommodation, blurred vision, nystagmus.
From the cardiovascular system:
tachycardia.
From the respiratory system:
rhinitis, pharyngitis.
From the digestive system:
dry mouth, nausea, abdominal pain, diarrhea, liver dysfunction (increased levels of transaminases, alkaline phosphatase, GGT, bilirubin).
From the urinary system:
urination disorder, enuresis.
Allergic reactions:
itching, rash, urticaria, angioedema, increased sensitivity, up to the development of anaphylactic shock.
From the side of metabolism:
increase in body weight.
Other:
fatigue, asthenia, malaise, swelling.
Side effects occur in very rare cases.
special instructions
Children aged 6 months to 6 years
Zyrtec® is prescribed in the dosage form of drops for oral administration at 10 mg/ml.
Effect on the ability to drive vehicles and operate machinery.
An objective assessment of the ability to drive vehicles and operate machinery did not reliably reveal any adverse reactions when taking the drug at the recommended dose. But, nevertheless, during the period of taking the drug, it is advisable to refrain from engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Storage conditions
Tablets should be stored in their original packaging at a temperature not exceeding 30°C. Drops for oral administration should be stored at a temperature not exceeding 25°C.
Best before date
The shelf life of the drug is 5 years.
The drug should be stored out of the reach of children.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated.
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Use for renal impairment
Restrictions for impaired renal function - With caution.
Carefully _
the drug should be prescribed for chronic renal failure (moderate or severe), as well as for elderly patients (due to a possible decrease in glomerular filtration).
In case of renal failure, the dose is reduced depending on the QC.
Contraindicated in end-stage renal failure (CC < 10 ml/min).
Use in elderly patients
Restrictions for elderly patients - Use with caution.
Carefully _
the drug should be prescribed to elderly patients (due to a possible decrease in glomerular filtration).
Use in children
Restrictions for children - Contraindicated. Contraindicated in children under 6 years of age (for tablets), in children under 6 months of age (for drops).
Terms of sale
The drug is approved for use as a means of OTC.
Contacts for inquiries
YUSB PHARMA S.A. (Belgium)
YUSB Pharma LLC
105082 Moscow, Perevedenovsky per. 13, p. 21 Tel.; Fax
Contraindications
You should stop taking the drug in the following cases:
- increased susceptibility to any component of the drug;
- kidney disease;
- period of bearing a child;
- lactation period;
- children under 6 months.
Can be used with caution when:
- epilepsy;
- elderly people;
- chronic renal failure;
- tendency to urinary retention.
The medicine in tablet form is also contraindicated in case of galactose allergy and in children under 6 years of age.
Negative manifestations and overdose
The most common adverse reactions are:
- headache;
- fatigue;
- dizziness;
- fast fatiguability;
- gagging;
- feeling of dry mouth.
No less common adverse reactions include:
- stomach upset;
- excited state;
- allergies in the form of skin rash;
- abnormal heartbeat;
- weight gain;
- aggressive or depressive behavior;
- disturbed sleep.
The following reactions occur much less frequently:
- taste disturbance;
- tremor;
- fainting;
- deterioration of visual acuity.
An overdose may occur, which is characterized by the above negative reactions in a more pronounced form. With such signs, it is necessary to induce vomiting or rinse the stomach. It is also worth starting treatment based on symptoms
Adverse reactions and overdose
Common negative side effects from taking the drug include:
- headache;
- lethargy;
- dizziness;
- excessive fatigue;
- vomiting, nausea;
- feeling of dryness in the mouth.
Slightly less common:
- stomach upset;
- nervous state;
- allergic skin reaction.
- peripheral edema;
- hives;
- abnormal heart rhythm;
- weight gain;
- aggressive or depressive state;
- disturbed sleep;
- convulsions.
It is extremely rare:
- taste disturbance;
- tremor;
- fainting;
- blurred vision.
There may be cases of overdose, manifested by the adverse reactions described above. In this condition, you need to induce vomiting or rinse the stomach. You can also start symptomatic therapy.
Can I take Zyrtec during pregnancy?
Medical research on the effect of the drug on the body during pregnancy was carried out exclusively on animals. Their results deny the possibility of a negative impact on the developing fetus and the condition of the expectant mother. Due to the lack of necessary data, the medication can be used only after examination by a doctor.
The active ingredient may pass into breast milk. Therefore, if there is a need to take the drug, you should temporarily switch to artificial feeding.
special instructions
The medicine can be stored for 5 years from the date of its release. It should be stored in a dry and dark place away from children, at a temperature of +8...+15 degrees.
It should not be taken in parallel with alcohol, as alcohol-containing drinks increase the risk of negative effects on the central nervous system.
If the patient has serious spinal cord injuries, then before taking it you should consult a specialist, since the use of the medicine may worsen the situation.
In the first couple of hours after using the medication, you should not drive a car or operate other dangerous mechanisms.
Zyrtec drops for oral administration 10 mg/ml 20 ml 1 piece
In patients with spinal cord injury, prostatic hyperplasia, as well as in the presence of other factors predisposing to urinary retention, caution is required, because Cetirizine may increase the risk of urinary retention.
It is recommended to be careful when using cetirizine concomitantly with alcohol, although at therapeutic doses no clinically significant interaction with ethanol was observed (at a blood ethanol concentration of 0.5 g/l).
Caution should be observed in patients with epilepsy and increased convulsive readiness.
Before prescribing allergy tests, a three-day “washing out” period is recommended due to the fact that histamine H1 receptor blockers inhibit the development of skin allergic reactions.
Use in pediatrics
Due to the potential depressant effect on the central nervous system, caution should be exercised when prescribing Zodak to children under 1 year of age who have the following risk factors for sudden infant death syndrome, such as (but not limited to):
sleep apnea syndrome or sudden infant death syndrome in a brother or sister,
maternal drug abuse or smoking during pregnancy,
young mother's age (19 years and younger),
Smoking abuse by a nanny caring for a child (1 pack of cigarettes per day or more),
Children who regularly fall asleep face down and are not placed on their back
premature (gestational age less than 37 weeks) or low birth weight (below the 10th percentile of gestational age) children,
when taking drugs together that have a depressant effect on the central nervous system.
The drug contains excipients methylparabenzene and propylparabenzene, which can cause allergic reactions, incl. slow type.
Impact on the ability to drive vehicles and machinery
An objective assessment of the ability to drive vehicles and operate machinery did not reliably reveal any adverse events when using the drug Zodak in recommended doses. However, for patients with symptoms of drowsiness while taking the drug during the treatment period, it is advisable to refrain from driving a car, engaging in potentially hazardous activities, or operating machinery that requires increased concentration and speed of psychomotor reactions.
