How does Melaxen work?
The instructions say that the drug effectively combats disturbed sleep. After taking it, the following positive changes are noted:
- sleep quality improves;
- the frequency of getting up for no reason in the middle of the night decreases;
- the general condition after getting up in the morning improves noticeably;
- The feeling of drowsiness and weakness disappears when waking up early.
The drug can also be taken by people who have meteosensitivity, a tendency to depression and increased fatigue. The drug has no age restrictions and can be used by older people.
What does Melaxen help with?
The instructions say that Melaxen is a sedative medication. It is used to improve and correct existing deviations from the circadian rhythm. Usually the drug is prescribed to be taken in the following cases:
- sleep problems;
- if the work involves night shifts or rotational work;
- disturbance of biological rhythms, which is associated with age;
- sleep disturbance caused by somatic diseases.
Buy Melaxen film-coated tablets 3 mg No. 12 in pharmacies
Instructions for use Melaxen Dosage forms tablets 3 mg Synonyms Circadin Group Adaptogenic agents International nonproprietary name Melatonin Composition Active substance - melatonin. Manufacturers Melavit (United States of America), Unipharm Inc (United States of America) Pharmacological action Adaptogenic, hypnotic, antioxidant. Inhibits the secretion of gonadotropins, and to a lesser extent, other hormones of the adenohypophysis - corticotropin, thyrotropin, somatotropin. Normalizes circadian rhythms. Increases the concentration of GABA in the central nervous system and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase, which is involved in the synthesis of GABA, dopamine and serotonin. Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the intellectual and mnestic functions of the brain, the emotional and personal sphere. Helps organize biological rhythm and normalize night sleep. Improves sleep quality, reduces the frequency of headaches and dizziness, and improves mood. Accelerates falling asleep, reduces the number of night awakenings, improves well-being after waking up in the morning, and does not cause a feeling of lethargy, weakness and fatigue when waking up. Makes dreams more vivid and emotionally rich. Adapts the body to rapid changes in time zones, reduces stress reactions, and regulates neuroendocrine functions. It has immunostimulating and antioxidant properties, prevents the development of atherosclerosis and neoplasms. It has the most pronounced effect in cases of long-term severe sleep disturbances. Pharmacokinetics. When taken orally, it is quickly and completely absorbed and easily passes histohematic barriers, including the BBB. It has a short half-life and is quickly eliminated from the body. Side effects Allergic reactions to the components of the drug are possible. Headache, nausea, vomiting, diarrhea, morning drowsiness, swelling. Indications for use Prevention and course treatment: desynchronosis (disturbance of the normal circadian rhythm): due to rapid movement between time zones of the Earth; in case of violation of the light regime, including for people engaged in shift work or rotational work; when biological rhythms are disturbed in older people (age-related desynchronosis), against the background of somatic diseases (arterial hypertension); weather sensitivity; fatigue, sleep disturbances (including in elderly patients); depressive syndrome. Contraindications Hypersensitivity, allergic diseases, autoimmune diseases, lymphogranulomatosis, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, chronic renal failure (CRF), pregnancy, lactation, childhood (due to lack of data). Directions for use and dosage : Inside. Adults: 1 tablet 30-40 minutes before bedtime, once a day, long-term, the recommended course of administration is 6-8 weeks. Course intake 2-3 times a year for 6-8 weeks (spring and autumn). Overdose In case of accidental overdose: gastric lavage, symptomatic therapy. Interaction Strengthens the effect (mutually) of drugs that depress the central nervous system and beta-blockers. It is not recommended to take it together with non-steroidal anti-inflammatory drugs (NSAIDs). Incompatible with MAO inhibitors, glucocorticoids, cyclosporine. Special instructions During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Avoid bright lighting. It is necessary to inform women who want to become pregnant that the drug has a weak contraceptive effect. Storage conditions: In a dry place, protected from light, at a temperature of 10-30 C.
How to take Melaxen correctly
The medicine is intended for oral administration. The tablet must be swallowed whole and cannot be chewed or sucked. It is best to drink the medicine after meals, half an hour before bedtime. Single dose – 1 tablet. On average, the treatment course lasts 3 weeks. It is enough for an adult to take 1 tablet per day. In some cases, half a tablet per day may be enough. There can be no more than 3 therapeutic courses per year.
If there is a need to simplify the process of adaptation of the body as a result of a sudden change in time zone or for the purpose of acclimatization, the drug is taken as follows:
- 24 hours before the planned flight, a person needs to take 1 tablet;
- to adjust your sleep pattern, take 1 tablet half an hour before bedtime;
- the course lasts 3 days.
After this, the drug can be taken for preventive purposes. But before this, you should definitely consult with your doctor to prevent unwanted reactions. In case of urgent need, the daily dosage can be increased to 2 tablets.
Instructions for use
Registration number: P-8-242 No. 015325/01 dated 08.29.08
Trade name of the drug: MELAXEN
INN: melatonin
Dosage form: film-coated tablets 3 mg.
Composition: Active ingredient -
Melatonin, 3 mg; excipients: calcium hydrogen phosphate, microcrystalline cellulose, magnesium stearate; shell: talc, shellac, isopropanol.
Description
: round, biconvex, white to yellowish-white film-coated tablets, with a scored line on one side of the tablet.
PHARMACOTHERAPEUTIC GROUP
. Adaptogenic agent.
ATX CODE
: N05CM17
Characteristics of the drug
:
Melaxen is a chemical analogue of the biogenic amine Melatonin. Chemical formula N-acetyl-5-methoxytryptamine. Molecular weight 232. Dissolves in water, alcohol, lipids. Penetrates well through the blood-brain barrier. Synthesized from amino acids of plant origin.
PHARMACOLOGICAL PROPERTIES
It is a synthetic analogue of the pineal gland hormone. Normalizes circadian rhythms. Regulates the sleep-wake cycle, daily changes in locomotive activity and body temperature. Helps normalize night sleep (accelerates falling asleep, reduces the number of night awakenings, improves well-being after waking up in the morning, does not cause a feeling of lethargy, weakness and fatigue when waking up, dreams become more vivid and emotionally rich).
Adapts the body to rapid changes in time zones, reduces stress reactions.
Shows immunostimulating and pronounced antioxidant properties.
Inhibits the secretion of gonadotropins, and to a lesser extent, other hormones of the adenohypophysis - corticotropin, thyrotropin and somatotropin.
Does not cause addiction or dependence.
Pharmacokinetics
When taken orally, it is quickly and completely adsorbed and easily passes histohematic barriers, including the blood-brain barrier. Has a short half-life.
Indications
As a sleeping pill.
As an adaptogen to normalize biological rhythms.
Contraindications
Hypersensitivity, severe renal impairment, autoimmune diseases, leukemia, lymphoma. Allergic reactions, lymphogranulomatosis, myeloma, epilepsy, diabetes mellitus, chronic renal failure, pregnancy and lactation.
Directions for use and doses
Inside. Adults take ½-1 tablet 30-40 minutes before bedtime once a day. As an adaptogen when changing time zones: 1 day before the flight and in the next 2-5 days, 1 tablet 30-40 minutes before bedtime. The maximum daily dose is up to 2 tablets per day.
SIDE EFFECT
Allergic reactions to the components of the drug and swelling are possible in the first week of use. Headache, nausea, vomiting, diarrhea, morning drowsiness.
OVERDOSE
In case of accidental overdose: gastric lavage, symptomatic therapy. Increased severity of side effects.
INTERACTIONS WITH OTHER MEDICINES
Enhances the effect of drugs that depress the central nervous system and beta blockers. It is not recommended to take together with hormonal medications.
Incompatible with MAO inhibitors, glucocorticosteroids and cyclosporine.
SPECIAL INSTRUCTIONS
During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. It is necessary to inform women who want to become pregnant that the drug has a weak contraceptive effect.
Release form
12 or 24 tablets in an aluminum foil/PVC blister. One or two blisters along with instructions for use will be placed in a cardboard box.
Storage conditions
At a temperature of 10-30°C, in a dry place, protected from light. Keep out of the reach of children.
BEST BEFORE DATE
4 years. Do not use after expiration date.
Release from pharmacies
Without a doctor's prescription.
Contraindications
The American drug has a large list of contraindications. It should not be taken if you have existing pathologies: diabetes, epilepsy, myeloma, autoimmune diseases. In addition, the following conditions are considered contraindications:
- serious disturbances in kidney function;
- allergy to constituent substances;
- excessive sensitivity to melatonin;
- hereditary lactose intolerance;
- period of bearing a child.
Adverse reactions and overdose
Melaxen cannot be considered an absolutely harmless drug. During administration, undesirable reactions may occur:
- headache;
- difficult awakening;
- vomiting, nausea, upset stomach;
- swelling of the lower extremities during the first time of taking the medicine.
If the body does not tolerate any of the constituent components, an allergic reaction may occur.
There may be cases of drug overdose, which is manifested by more pronounced adverse reactions. Short-term episodic memory loss and confused thinking may also occur.
special instructions
The drug has its own characteristics that must be taken into account before taking it. Women who are planning to conceive a child in the near future should also refrain from taking the drug, since Melaxen has a mild contraceptive effect.
At the time of therapy, it is better to avoid sunbathing, since the active substances tend to disintegrate under the influence of solar radiation.
Also, during the treatment process, you should not drive a vehicle or operate other dangerous mechanisms.
In the course of the studies, it was found that the medicine can enhance the effect of sedative medications. Interactions with drugs affecting the central nervous system have not been established. But still, when they are taken in parallel, a feeling of anxiety and problems with perceiving what is happening around may appear.
Melaxen
Melaxen (melatonin) is an adaptagen and mild hypnotic. In recent years, the role of melatonin in medicine has increased significantly. Based on it, a number of antidepressants and hypnotics (hypnotics) that act on melatonin receptors in the brain have been created. Melatonin is a natural hormone in the body, synthesized in the pineal gland from tryptophan. This is a multifunctional hormone involved in many biochemical processes. With the onset of darkness, a person's melatonin level increases, which leads to a decrease in body temperature, elimination of psycho-emotional stress, and induction of sleep. Melatonin is a powerful antioxidant that protects the DNA of brain cells from free radical damage. It has a wide range of proven pharmacological effects, including hypnotic, immunomodulatory, antioxidant, antidepressant, adaptogenic, and anti-stress. Melatonin, used as the active ingredient of the drug Melaxen, is produced from amino acids obtained from medicinal plant materials and is an analogue of natural melatonin produced by the pineal gland. Normalizes circadian rhythms. Improves the quality of night sleep: reduces the period of falling asleep, minimizes the number of episodes of night awakenings, promotes good health and mood in the morning, improves the emotional coloring of dreams, making them more vivid, ensures the absence of lethargy, lethargy, and loss of strength after waking up in the morning.
Helps the body better tolerate jet lag. Reduces stress load. Strengthens immune status. Interferes with the release of gonadotropins. Does not cause tolerance, addiction or drug dependence. When taken orally, it is quickly and completely absorbed from the gastrointestinal tract. Easily penetrates blood-parenchymal barriers, including the blood-brain barrier. Has a short half-life. Adults take half a tablet or a whole tablet once a day half an hour before going to bed. If the drug is used to adapt to time zone changes, then the first dose is taken one day before the flight, and then for the next 2-5 days - half an hour before bedtime. You should not take more than two Melaxen tablets per day. Possible side effects: drowsiness after waking up in the morning, headaches, dyspepsia, allergic reactions. The drug has a weak contraceptive effect, which should be kept in mind when prescribing it to women trying to become pregnant. The drug increases sensitivity to ultraviolet radiation, so when taking Melaxen you should avoid prolonged exposure to direct sunlight. During the period of taking the drug, it is recommended to refrain from work related to mechanisms that require attention and concentration. Melaxen potentiates the effects of other hypnotics.
