Valacyclovir tablet p/pl/o 500 mg N40 (Synthesis)

The drug Valacyclovir is taken regardless of food intake, the tablets should be washed down with water. Treatment of skin and mucous membrane infections caused by HSV, including newly diagnosed and recurrent genital herpes (Herpes genitalis), as well as labial herpes (Herpes labialis) Immunocompetent adults and adolescents aged 12 to 18 years. The recommended dose is 500 mg 2 times a day. In case of relapse, treatment should continue for 3 or 5 days. In the case of primary herpes, which can occur in a more severe form, treatment should begin as early as possible, and its duration should be increased from 5 to 10 days. In case of relapses of HSV, the most correct prescription of the drug Valaciclovir is considered to be in the prodromal period or immediately after the appearance of the first symptoms of the disease. The use of valacyclovir may prevent the development of lesions if it is given at the first signs and symptoms of relapse due to HSV. As an alternative treatment for labial herpes, the use of the drug Valacyclovir at a dose of 2000 mg 2 times a day for 1 day is effective. The second dose should be taken approximately 12 hours (but not earlier than 6 hours) after the first dose. When using this dosage regimen, the duration of treatment should not exceed 1 day, since exceeding the duration of this course of treatment does not lead to additional clinical benefit. Therapy should be started when the earliest symptoms of herpes labialis (ie, tingling, itching, burning) appear. Prevention (suppression) of recurrent infections of the skin and mucous membranes caused by HSV, including genital herpes, including in adults with immunodeficiency. Immunocompetent adults and adolescents aged 12 to 18 years. In immunocompetent patients, the recommended dose is 500 mg once daily. After 6-12 months of treatment, it is necessary to evaluate the effectiveness of therapy. Adults with immunodeficiency. In adult patients with immunodeficiency, the recommended dose is 500 mg 2 times a day. After 6-12 months of treatment, it is necessary to evaluate the effectiveness of therapy. Prevention of infections caused by HSV and diseases after solid organ transplantation. Adults and teenagers aged 12 to 18 years. The recommended dose is 2000 mg 4 times a day, prescribed as early as possible after transplantation. The dose should be reduced depending on creatinine clearance. The duration of treatment is usually 90 days, but in high-risk patients the course of treatment may be extended. Treatment of herpes zoster (Herpes zoster) and ophthalmic herpes zoster. Adults. The recommended dose is 1000 mg 3 times a day for 7 days. Special groups of patients. Children. The effectiveness of treatment with Valacyclovir in children has not been studied. Elderly patients. It is necessary to take into account the possible impairment of renal function in elderly patients, and the dose of Valaciclovir should be adjusted accordingly. It is necessary to maintain adequate water and electrolyte balance. Patients with impaired renal function. It is recommended to reduce the dose of Valaciclovir in patients with severe renal impairment (see dosage regimen in Table 2). In such patients, it is necessary to maintain adequate water and electrolyte balance. Dose adjustment of Valacyclovir for use in adults and adolescents aged 12 to 18 years with impaired renal function. Herpes zoster and ophthalmic herpes zoster in immunocompetent adults (treatment): at least 50 - 1000 mg 3 times a day, from 30 to 49 - 1000 mg 2 times a day, from 10 to 29 - 1000 mg 1 time a day, less than 10 - 500 mg 1 time per day. HSV (treatment). Immunocompetent adults and adolescents aged 12 to 18 years: at least 30-500 mg 2 times a day, less than 30-500 mg 1 time a day. Labial herpes in immunocompetent adults and adolescents aged 12 to 18 years (treatment): at least 50 - 2000 mg 2 times a day, from 30 to 49 - 1000 mg 2 times a day, from 10 to 29 - 500 mg 2 times per day, less than 10 - 500 mg 1 time per day. HSV (prevention (suppression)). Immunocompetent adults and adolescents aged 12 to 18 years: at least 30-500 mg once a day, less than 30-500 mg once every two days. Adults with immunodeficiency: at least 30-500 mg 2 times a day, less than 30-500 mg 1 time a day. Prevention of infections caused by CMV in adults and adolescents aged 12 to 18 years: at least 75 - 2000 mg 4 times a day, from 50 to 75 - 1500 mg 4 times a day, from 25 to 50 - 1500 mg 3 times per day, from 10 to 25 - 1500 mg 2 times a day, less than 10 or in patients on hemodialysis - 1500 mg 1 time per day. Additional information for indication: treatment of skin and mucous membrane infections caused by HSV, including newly diagnosed and recurrent genital herpes (Herpes genitalis), as well as labial herpes (Herpes labialis). There is no experience with the use of Valacyclovir in children with creatinine clearance values less than 50 ml/min/1.73 m2. Additional information for the indication: Prevention of CMV infections and morbidity after solid organ transplantation. Creatinine clearance should be determined frequently, especially during periods when renal function changes rapidly, such as immediately after transplantation or engraftment, and the dose of Valacyclovir is adjusted accordingly. with creatinine clearance indicators. Additional information for the indication: Treatment of herpes zoster and herpes zoster ophthalmicus Valacyclovir should be used after hemodialysis in patients undergoing intermittent hemodialysis. Patients with impaired liver function. Based on a study using a single dose of valaciclovir 1000 mg in adult patients with mild to moderate liver cirrhosis (with preserved synthetic liver function), no dose adjustment of valaciclovir is required. Pharmacokinetic data in adult patients with severe liver dysfunction (decompensated cirrhosis), impaired synthetic liver function and the presence of portacaval anastomoses also do not indicate the need for dose adjustment of Valacyclovir, however, clinical experience with these pathologies is limited. Information about doses greater than 4000 mg per day for patients with infections caused by HSV and CMV is listed in the section "Special Instructions."

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug inhibits the activity of DNA polymerase herpes viruses , prevents the synthesis of viral DNA and inhibits replication processes.

After entering the body, valacyclovir is transformed into acyclovir and L-valine , then phosphorylation and acyclovir is converted into acyclovir triphosphate . The resulting compound is capable of inhibiting the DNA polymerase of a harmful agent (virus) through a competitive mechanism.

Phosphorylation usually occurs in two stages. In the first, the reaction is catalyzed by the enzyme thymidine kinase . The drug exhibits particular activity against Herpes simplex; it is less sensitive to Varicella zoster. The substance is excreted by the kidneys or feces; the half-life is approximately three hours.

Valacyclovir price

The price of Valaciclovir tablets in Russia is approximately 600 rubles for 10 pieces.

Together with tablets, as a rule, an ointment containing valacyclovir is used.

The price of Valacyclovir in Ukraine is slightly higher. You can buy the drug for 360 UAH (10 tablets).

Online pharmacies in RussiaRussia

ZdravCity

Valacyclovir Canon tablets p.p.o.
500 mg 10 pcs. JSC Kanonpharma Production 365 rub. order
Valaciclovir tablets p.p.o. 0.5g 50pcs Izvarino Pharma LLC
2650 rub. order
Valaciclovir tablets p.p.o. 500 mg 10 pcs. Izvarino Pharma LLC
RUB 854 order
Valaciclovir tablets p.p.o. 500mg 10pcsOzon LLC
RUR 504 order
Valaciclovir-AKOS tab. p/o captivity. 500 mg No. 40 JSC Sintez
RUB 1,671 order

Interaction

There were no clinically significant cases of interaction between tablets and other drugs.

However, the active substance is excreted from the body through the kidneys by tubular secretion . Any medications that are prescribed simultaneously with Valacyclovir will interfere with its normal elimination from the body. This primarily applies to Cimetidine and other drugs that block the mechanism of tubular secretion.

When combined with Mycophenolate , the concentration of acyclovir in the blood plasma increases.

When the drug is combined with Cyclosporine , Tacrolimus and drugs that interfere with the normal functioning of the kidneys, the load on these organs increases.

Side effects

The drug has been well researched. As a result of laboratory studies and observations of patients with herpes zoster and herpes virus (including those with concomitant immunodeficiency ) taking valacyclovir , almost all possible adverse reactions were identified.

Possible:

nausea, pain in the epigastric region, vomiting, anorexia and diarrhea , increased activity of liver enzymes, hepatitis ;
impaired renal function, photosensitivity , shortness of breath, thrombocytopenia ;
headaches, dizziness , hallucinations , depression , agitation , ataxia , psychosis , dysarthria , disturbances of consciousness and coma ;
rash , itching , anaphylaxis , urticaria , Quincke's edema ;
neutropenia , aplastic anemia , vasculitis , thrombocytopenia ;
nasopharyngitis , facial swelling , tachycardia , increased blood pressure , increased fatigue;
rhinorrhea , fever and dehydration .

Valacyclovir analogs

Level 4 ATC code matches:
Herperax

Vivorax

Vairova

Acyclostad

Geviran

Walcyte

Valavir

Ribavirin

Valtrex

Valvir

Rebetol

Cyclovir

Famciclovir Teva

Famvir

The closest analogues: Vayora, Valaciclovir Canon, Valaciclovir hydrochloride, Valogard, Valcicon, Virdel, Valavir, Valvir, Valtrex, Vacirex .

Which is better: Valaciclovir or Valtrex?

Valtrex is an imported analogue with the same active ingredient. In terms of effectiveness and frequency of adverse reactions, the drugs are identical. However, the cost of Valtrex is significantly higher than Valaciclovir.