Cholisal: instructions for using the gel

Pharmacology and pharmacodynamics

The gel helps fight inflammation, relieves pain and has an antimicrobial effect.

The active substance perfectly anesthetizes the area to which the gel was applied and eliminates inflammation. The analgesic effect lasts for 3-8 hours. Another active component has an antiseptic effect, killing harmful microorganisms.

The medicine has a certain structure, due to which it penetrates well into the tissue and remains on the oral mucosa for several hours. Almost does not enter the blood circulation.

Cholisal 10 g dental gel

Instructions for medical use of the drug CHOLISAL® Trade name Cholisal® International nonproprietary name No Dosage form Dental gel Composition 1 g of gel contains active substances: choline salicylate 87.10 mg, cetalkonium chloride 0.10 mg, excipients: hydroxyethylcellulose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, glycerol, oil anise, ethyl alcohol 96%, purified water to 1.0 g. Description Transparent, colorless, homogeneous mass with the smell of anise oil. Pharmacotherapeutic group Antimicrobial drugs for local treatment of oral diseases. Other. ATX code A01AB11 Pharmacological properties Pharmacokinetics Choline salicylate is rapidly absorbed from the mucous membranes (approximately 2 times faster than acetylsalicylic acid). Salicylates easily penetrate most tissues and body fluids. They exhibit high affinity for blood proteins and tissues, binding to blood plasma albumin in the range from 50 to 80%. The half-life of salicylates ranges from 2 to 4 hours. The biotransformation of salicylates to salicylic acid occurs in organs and tissues, mainly the liver, with the formation of salicylic acid, glucuronides, acetal, and gentisic acid. The resulting biotransformation products are excreted in the urine (75% is salicylic uric acid). About 10% of salicylates are excreted unchanged in the urine. Elimination is slow: about 50% of the dose is eliminated within 24 hours. Pharmacodynamics The drug uses the synergistic effect of the components: anti-inflammatory, analgesic and local disinfectant. The main active ingredient in the drug, choline salicylate, has a local anti-inflammatory and mild analgesic effect. The mechanism of the analgesic, antipyretic and anti-inflammatory action of salicylates is associated with inhibition of the activity of prostaglandin cyclooxygenase, as well as the activity of thromboxane synthetase. As a result of this action, the synthesis of prostanoids, primarily E and F, in inflammatory tissues, in the wall of the gastrointestinal tract and in the kidneys is inhibited. Applied topically, in normal doses the drug does not exhibit a general effect. Cetalkonium chloride is an antiseptic acting on bacteria, fungi, and viruses. The bacteriostatics included in the gel base, methylhydroxybenzoate and propylhydroxybenzoate, exhibit a disinfectant effect in concentrations of 0.15% and 0.08%, respectively. The analgesic effect is observed after 2-3 minutes, the duration of action is 2-8 hours. Indications for use - inflammatory processes of the oral mucosa - erosive and ulcerative lesions of the oral mucosa - gingivitis - periodontitis Method of administration and dosage A small amount of gel is squeezed onto a clean finger and rubbed with light massaging movements onto the affected area of ​​the oral mucosa. Use 2-3 times a day before meals and before bed. For periodontal diseases, the gel is injected into the pockets or applied in the form of compresses, or rubbed gently into the gums 1-2 times a day. The course of treatment is determined by the doctor. Side effects A brief, transient burning sensation and allergic reactions may occur at the site of application. Contraindications - hypersensitivity to salicylates and other components of the drug - third trimester of pregnancy, lactation period - children under 3 years of age Drug interactions When using the drug topically in accordance with the recommended dosage, there is no risk of interaction with other drugs. Only in case of a significant overdose and the development of symptoms of systemic action of choline salicylate, it should be taken into account that it acts synergistically with other anti-inflammatory, antipyretic and analgesic drugs. Special instructions No studies have been conducted to determine the duration and degree of absorption of choline salicylate into the body after topical application of the gel to the mucous membranes of the oral cavity. Pregnancy In the first and second trimesters of pregnancy, Cholisal® is used only in cases where the expected therapeutic effect for the mother exceeds the potential risk for the fetus. Effect on the ability to drive vehicles and maintain moving mechanisms No effect Overdose Theoretically, an overdose of the drug is impossible. Symptoms: increased sweating, tinnitus, nausea, vomiting, dizziness, skin manifestations (erythema or urticaria). These symptoms may appear in case of hypersensitivity to salicylates, after an overdose of the gel and the absorption of significant quantities of choline salicylate into the body. Treatment: the patient should rinse the mouth with plenty of water and, if necessary, induce vomiting. Release form and packaging 10 g or 15 g of the drug are placed in lithographed aluminum tubes, varnished inside. One tube, along with instructions for medical use in the state and Russian languages, is placed in a cardboard pack. Storage conditions Store at a temperature not exceeding 25 oC. Do not freeze! Keep out of the reach of children! Shelf life: 3 years Shelf life after first opening: 2 weeks. Do not use after the expiration date. Conditions for dispensing from pharmacies Without a prescription Manufacturer Jelfa Pharmaceutical Plant A.O. 58-500, Jelenia Gora, st. V.Polya, 21, Poland. Owner of the registration certificate OOO "Valeant", Russia Address of the organization that accepts claims from consumers regarding product quality in the territory of the Republic of Kazakhstan Representative office of OOO "Valeant" in the Republic of Kazakhstan Kazakhstan, 050059, Almaty, Al-Farabi Avenue, 17, Business - Block 4B, office 1104 Phone +7 727 3 111 516 Fax +7 727 3 111 517 Email

When to use

The gel is prescribed in the following cases:

• stomatitis;
• cheilitis;
• damage to the integrity of the mucosa due to the use of prostheses or as a result of mechanical impact;
• pain relief after dental surgery;
• when teething in babies;
• other damage and inflammatory processes in the oral mucosa.

What does Cholisal help with?

The gel is able to cope with inflammatory processes occurring in the oral cavity and various injuries. The drug should be taken for the following conditions:

• stomatitis;
• mechanical injuries and other damage resulting from wearing prostheses;
• for severe pain, as well as for prophylactic purposes after dental surgery;
• teething in babies;
• gingivitis.

Adverse reactions and overdose

In rare cases, side effects may occur. A tingling or burning sensation may be felt at the sites where the ointment is applied. This reaction usually disappears after a few minutes. Various allergies may also appear.

No cases of overdose have been identified to date. The gel does not need to be swallowed, only used topically. If there is a lot of ointment on the mucous membrane, then you need to rinse your mouth well. If the composition gets into the gastrointestinal tract, you need to rinse the stomach. Treatment is carried out taking into account the existing symptoms.

Pharmacological properties of the drug Cholisal

The drug uses the synergistic effect of components: anti-inflammatory, analgesic and antiseptic. The main active ingredient of the drug, choline salicylate, has a local anti-inflammatory and mild analgesic effect. The mechanism of the analgesic, antipyretic and anti-inflammatory action of salicylates is associated with inhibition of COX activity, as well as thromboxane synthetase activity. As a result, the synthesis of prostaglandins is inhibited, primarily prostaglandins E and F in tissues altered by inflammation, in the wall of the gastrointestinal tract and kidneys. Applied topically, in normal doses it does not have a systemic effect. Cetalkonium chloride enhances the analgesic and anti-inflammatory effects. The antiseptics included in the gel base, methyl parahydroxybenzoate and propyl parahydroxybenzoate (in concentrations of 0.15 and 0.08%, respectively), have an antibacterial effect. Choline salicylate quickly penetrates the mucous membranes (approximately 2 times faster than acetylsalicylic acid). Salicylates easily penetrate most tissues and body fluids. They have a high affinity for blood proteins and tissues, binding (50–80%) to blood plasma albumins. The half-life of salicylates is 2–4 hours. The biotransformation of salicylates occurs in tissues, mainly in the liver to salicylic acid, from which salicylamic acid, glucuronides, acetal, and gentisic acid are formed. Biotransformation products are excreted in the urine (75% is salicylic uric acid). Approximately 10% of salicylates are excreted unchanged in the urine. Excretion occurs slowly, approximately 50% of the dose is eliminated within 24 hours.

Reviews

Regarding the use of the gel during teething, you can find mostly positive reviews. The drug quickly and effectively copes with inflammatory processes, relieves pain and cools the affected area. If you use the product the night before going to bed, its effect will last almost until the morning. It also has an antipyretic effect. For many, it is a plus that the composition does not contain lidocaine, since it can provoke various and severe allergies.

There are also many positive reviews when using ointment for stomatitis. Within 3-5 minutes you can notice a significant improvement in your condition, pain and discomfort disappear. Inflammation disappears 15-20 minutes after application. If you apply compresses before going to bed, you can quickly get rid of the problem and its symptoms.

How to use Cholisal gel

The instructions indicate that the ointment is for external use only. It should be applied exclusively to the affected area of ​​the mouth.

The product should be applied 20 minutes before or after meals. You can also rub the ointment in before going to bed. The procedure can be repeated up to 3 times a day. It will be enough for a child to use 0.5 cm, and for an adult – 1 cm.

If a person suffers from periodontal disease, then the ointment can be placed in the gum pockets that appear or effective compresses can be made.

special instructions

Despite the many advantages and high safety of the drug, dentists all recommend adhering to several rules:

1. Gel in large doses can enhance the effect of antipyretics, analgesics and anti-inflammatory drugs, so it is especially important to monitor the dose of the gel used if you take such drugs.
2. Women during lactation and pregnancy, as well as children under 1 year of age, are advised to use the gel with caution.

Holisal: reviews from specialists and patients

What can you say about Holisal?

Only good. All specialists from the dental industry speak only positively about the drug. Negative reviews are extremely rare, and, as a rule, they are from patients who made mistakes in trying to self-medicate. For example, some patients begin to use the product without first consulting a dentist, completely forgetting that inflammation in the mouth always has a cause. In such cases, using Cholisal alone is not enough, since the treatment will be ineffective and short-term. Therefore, it is necessary to discover the cause and carry out full therapy to avoid relapse of the disease.

What benefits do doctors and patients notice?

1. Versatility of use. Cholisal is available in one form, which allows it to be used by both adults and children. There are no age restrictions, the gel is safe and effective for everyone.
2. In normal doses, the drug is inert and does not react with other drugs, which makes it possible to include it in combination therapy.
3. No risk of overdose.
4. No sugar in the composition.
5. The drug penetrates deeply into tissues, providing a stronger and longer-lasting therapeutic effect.
6. Quickly relieves pain.
7. Cholisal gel does not affect the psychomotor state of the patient, so it can be used while driving a vehicle or when working with complex mechanisms.
8. The gel is applied topically, which eliminates a number of side effects that can usually occur with oral medications.
9. Availability and popularity. Cholisal is sold without a prescription, so you can easily purchase it at any pharmacy.

Comparison with other drugs

As we can see, the choice of drugs for the treatment of the oral mucosa is considerable, but all these drugs have mainly a superficial and narrow therapeutic effect. For example, today there is a large selection of dental drugs that have only an antibacterial effect. Such products most often include antibiotics and antiseptic components (chlorhexidine, metronidazole). Such drugs include Asepta-balsam, Metrogyl Denta, Faringosept and others.

There are also dental products on the market that have only an anti-inflammatory effect (for example, “Parodontocide”) or an analgesic effect (for example, “Kamistad”, “Dentol”).

Therefore, we can say that the composition of Cholisal is unique in its kind. It simultaneously has anti-inflammatory, antibacterial, antimycotic and analgesic effects, which most other dental products cannot boast of.