Pharmacological properties of the drug Tizin
Pharmacodynamics. Tetrizoline hydrochloride is a sympathomimetic that stimulates α-adrenergic receptors of the sympathetic nervous system and has virtually no effect on β-adrenergic receptors. When applied to the mucous membrane of the nasal cavity as a sympathomimetic amine, it has a vasoconstrictor and anti-edema effect, leading to a narrowing of small arterioles, a decrease in swelling of the mucous membrane of the nasal passages and a decrease in secretion. Pharmacokinetics. The vasoconstrictor effect of tetrizoline and the reduction in swelling of the nasal mucosa under its influence begins approximately 1 minute after application and lasts for 4–8 hours. When applied topically in recommended doses, tetrizoline is practically not absorbed from the mucous membrane, but the possibility of systemic absorption in patients cannot be ruled out with damage to the epithelium of the mucous membrane.
Use of the drug Tizin
0.1% Tizin solution is instilled into adults and children over 6 years of age, 2–4 drops into each nasal passage. 0.05% Tizin solution for children is instilled into children aged 2–6 years, 2–3 drops. Use Tizin as needed, but not more than once every 4 hours. Tizin drops are used at large intervals (up to 8 hours). The use of drops before bedtime does not cause insomnia due to the lack of central action. Tizin should not be used for 5 days; re-use is possible only after a few days.
Tizin Classic nasal spray 0.1% 10ml
Tizin Classic nasal spray 0.1% 10ml
Tizin® preparations are modern sprays for the treatment of runny nose(1). Thanks to the xylometazoline contained in the composition, the use of Tizin® sprays helps reduce swelling and clear the nasal sinuses. The drug can be used for complications of rhinitis such as sinusitis and otitis. The drug is approved for use in children over 6 years of age and adults.
Spray Tizin® Classic is an affordable(2) and effective remedy against nasal congestion and runny nose. Tizin® Classic dosed nasal spray has a high safety profile and allows you to accurately control the dose of the drug, which reduces the risk of overdose.
Main advantages
Helps restore nasal breathing: Tizin® Classic reduces swelling of the nasal mucosa and helps clear the sinuses.
It acts on the problem in a complex way: Tizin® Classic treats a runny nose(1) and fights the feeling of heaviness in the head!(3)
Ease of use:
The spray format is convenient to use for children over 6 years old and adults.
Wide spray area:
spray for runny nose Tizin® evenly delivers the product to the mucous membrane, and the active substance does not flow down the throat.
High safety profile:
Tizin® has a gentle effect on the nasal mucosa.
Remedy for runny nose at an affordable price(2) – a budget option for nasal congestion spray in the Tizin® line.
TIZIN® lines against runny nose:
Tizin® Expert and Tizin® Classic are used to treat colds (1). For the treatment of adults, a 0.1% solution is used, for children from 2 to 6 years old - 0.05%.
Tizin® Alergy is suitable for the treatment of allergic rhinitis in adults and children from 6 years of age.
1. Symptomatic treatment for rhinitis. 2. Among the line of drugs TIZIN®. 3. A feeling of heaviness caused by swelling of the nasal mucosa.
Composition per 1 ml of solution contains:
Active ingredient: xylometazoline hydrochloride 1.0 mg (0.1%); the amount of active ingredient in one dose for 0.1% is 0.14 mg of xylometazoline hydrochloride;
Excipients: benzalkonium chloride – 0.2 mg, sorbitol 70% – 20.0 mg, sodium chloride – 4.16 mg, sodium dihydrogen phosphate dihydrate – 3.38 mg, disodium hydrogen phosphate dihydrate – 2.08 mg, disodium edetate – 1 .0 mg, purified water – sufficient amount.
Indications for use: to reduce swelling of the mucous membrane of the nasopharynx and discharge in acute allergic rhinitis, acute respiratory infections with symptoms of rhinitis, sinusitis, hay fever, otitis media.
Preparing the patient for diagnostic manipulations in the nasal passages.
Directions for use and doses
Adults and school-age children (over 6 years old)
— 3 times a day, one dose of Tizin® Classic is administered in the form of a 0.1% nasal spray dosed into each nostril. The dose depends on the individual sensitivity of the patient and the clinical effect.
Xylometazoline nasal metered spray should not be used for more than 5–7 days, unless your doctor recommends a different duration of treatment.
After completion of therapy, the drug can be re-administered only after a few days.
Always consult your doctor regarding the duration of use in children.
General recommendations for administration
Remove the protective cap. Before first use, press the spray nozzle several times (Fig. 1) until a uniform cloud of “fog” appears. The bottle is ready for further use. When using, press once (Fig. 2). Inhale the drug through the nose. If possible, keep the spray bottle vertical. Do not spray horizontally or downward. After use, close the bottle with a cap.
Contraindications
Hypersensitivity to any of the components of the drug, concomitant use of monoamine oxidase inhibitors (MAO) or other drugs that can cause an increase in blood pressure; arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, atrophic rhinitis, surgical interventions on the meninges (history), childhood (up to 6 years - for a dosage of 0.1%, up to 2 years - for a dosage of 0.05%).
Side effect
Tizin® Classic may cause transient mild nasal irritation (burning), paresthesia, sneezing and hypersecretion in susceptible individuals.
In some cases, after using the drug, increased swelling of the nasal mucosa (reactive hyperemia) may be observed.
Long-term or frequent use of xylometazoline or its use in high doses can lead to a burning sensation in the nose or dry mucous membrane, as well as reactive congestion with the development of drug-induced rhinitis. This effect can be observed even 5-7 days after completion of treatment, and with prolonged use it can cause irreversible damage to the mucous membrane with the formation of crusts (rhinitis sicca).
In very rare cases, headache, insomnia or fatigue, and depression may occur (with long-term use in high doses).
In isolated cases, local intranasal use of sympathomimetics may be accompanied by systemic effects, such as palpitations, tachycardia, arrhythmias, increased blood pressure, and blurred vision.
Overdose
Symptoms of intoxication
Overdose or accidental ingestion of the drug can lead to the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmias, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.
In addition, the following symptoms may be observed: suppression of central nervous system function, accompanied by drowsiness, decreased body temperature, bradycardia, shock-like hypotension, apnea and coma.
Treatment of intoxication
The use of activated carbon, gastric lavage, artificial respiration with the introduction of oxygen. To lower blood pressure, use phentolamine 5 mg in saline solution intravenously slowly or 100 mg orally.
Vasopressor drugs are contraindicated. If necessary, antipyretic and anticonvulsant drugs are used.
Interaction with other drugs
Concomitant use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants may lead to an increase in blood pressure due to the cardiovascular effects of these substances.
special instructions
Long-term use and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa.
The rebound phenomenon can cause airway obstruction, which leads to the patient using the drug repeatedly or even continuously. This can lead to chronic swelling (rhinitis medicamentosa), and eventually even to atrophy of the nasal mucosa (ozena).
In case of chronic rhinitis, Tizin® Classic 0.05% and 0.1% can only be used under the supervision of a physician, taking into account the risk of atrophy of the nasal mucosa.
Tizin® Classic should not be used if you are hypersensitive to benzalkonium chloride, which is included in the drug as a preservative.
Do not exceed recommended doses, especially in children and the elderly.
Vacation:
over the counter
Expiration date, days:
1080
Age:
from 6 years old
Precautionary measures
Keep out of the reach of children.
Storage conditions
Store at a temperature not exceeding 25°C. Keep out of the reach of children.
Contraindications to the use of the drug Tizin
Hypersensitivity to tetrizoline or other components of the drug, dry rhinitis. Tizin drops 0.1% are not prescribed to children under 6 years of age. Tizin drops 0.05% are not prescribed to children under 2 years of age. Tizin should not be prescribed for severe forms of cardiovascular diseases (coronary heart disease, hypertension (arterial hypertension), pheochromocytoma), with metabolic disorders (hyperterosis, diabetes), as well as for patients receiving treatment with MAO inhibitors and other drugs that can increase blood pressure; patients with glaucoma.
Features of the drug
Tizin spray belongs to the group of topical nasal preparations. The active component in the drug is xylometazoline. This substance has vasoconstrictor properties. It quickly reduces tissue swelling and mucus secretion. When treating rhinitis, it is possible to quickly remove nasal congestion and restore nasal breathing.
Tizin nasal spray is a very convenient form of release of a remedy for the runny nose. Manufacturers produce the drug containing 0.1% and 0.05% of the active substance.
When using a spray, which is a clear liquid with a slight specific odor, maximum comfort is guaranteed. The drug can be used in any position and, if necessary, even during movement. In addition, its use has a targeted effect on the inflamed areas of the mucous membrane.
Tizin spray is equipped with a special sprayer that provides precise dosage with fine spraying. Its design guarantees coverage of a wide area of the mucous membrane.
Side effects of the drug Tizin
Reactive hyperemia and swelling of the mucous membrane, burning sensation or dryness of the mucous membrane, chronic swelling during long-term therapy. Sometimes systemic side effects are observed (tachycardia, headache, tremor, general weakness, sweating, increased blood pressure). Frequent use of the drug in high doses can cause a burning sensation and dryness in the nasal cavity, as well as the development of drug-induced rhinitis. Long-term use of imidazole derivatives can cause damage to the epithelium of the nasal cavity with the development of dry rhinitis.
Special instructions for the use of the drug Tizin
The drug should be prescribed with extreme caution and after assessing the degree of possible risk to patients with severe forms of cardiovascular diseases (coronary artery disease, hypertension (arterial hypertension)), metabolic disorders (hyperthyroidism, diabetes mellitus). In patients with glaucoma (especially angle-closure) it is used with caution and only under medical supervision. During pregnancy and breastfeeding. Since there is a possibility of developing systemic side effects, the use of the drug during pregnancy and lactation is possible only after careful comparison of the possible benefits to the mother and the risk to the fetus or infant. Ability to drive vehicles and operate machinery. Caution should be exercised with long-term use of the drug, since systemic effects from the cardiovascular system may develop, which have a negative impact on the ability to drive vehicles or work with potentially dangerous mechanisms.
Indications
The main indication for the use of Tizin spray is the symptomatic treatment of nasal congestion. It is prescribed for a runny nose, which often accompanies seasonal ARVI. It can also be used in cases of allergic rhinitis, including hay fever, which occurs due to an allergy to pollen.
Doctors recommend buying a spray for the treatment of sinusitis, which is characterized by inflammation of the nasal sinuses. During an exacerbation, the disease is characterized by copious discharge from the nose of a yellowish-green hue. In addition, symptoms of intoxication of the body are observed.
Overdose of the drug Tizin, symptoms and treatment
Manifested by mydriasis, nausea, cyanosis, fever, fasciculation, tachycardia, arrhythmia, asystole, hypertension (arterial hypertension), pulmonary edema, respiratory disorders, mental disorders. In some cases, the absorption of imidazole derivatives with α-sympathomimetic activity may be accompanied by CNS depression, which is manifested by drowsiness, hypothermia, bradycardia, collapse, apnea and coma. There is no specific antidote for tetrizoline. The use of stimulant drugs is contraindicated. Although the symptoms of a Tizin overdose are quite alarming, they usually disappear quickly. If necessary, oxygen therapy is carried out and anticonvulsants are used. To reduce blood pressure, 5 mg of phentolamine is administered in an isotonic saline solution intravenously slowly or prescribed at a dose of 100 mg orally. In case of arterial hypotension, vasoconstrictor drugs are contraindicated. When anticholinergic symptoms develop, physostigmine is used as an antidote.
