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Manufacturers: Cadila Healthcare
Active ingredients
- Acyclovir
Disease class
- Anogenital herpetic viral infection
- Herpes simplex virus infections
- Herpetic gingivostomatitis and pharyngotonsillitis
- Shingles
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antiviral
- Antiherpetic
Pharmacological group
- Antiviral (except HIV) drugs
Pharmacodynamics and pharmacokinetics
The drug is an antiviral synthetic drug. The active substance, through interaction with the enzymes of cells affected by the virus, stops the replication of the virus. By its nature, it has a chemical structural similarity to deoxyguanidine from DNA and selectively interacts with DNA synthesis of viruses. In general, it is active against the following viruses:
- cytomegaloviruses;
- chicken pox Varicella zoster;
- herpes simplex, types 1 and 2 (Herpes simplex)
- Epstein-Barr virus .
The absorption of the drug occurs partially from the gastrointestinal tract and the bioavailability is 20%. The maximum concentration is observed after 1–2 hours. Once in the bloodstream, it binds to proteins by approximately 12–15% and can penetrate the BBB.
Compound
Active ingredients: Alpha-glutamyl-tryptophan sodium [Thymogen sodium] (in terms of alpha-glutamyl-tryptophan) 0.15 mg Ascorbic acid 12 mg Bendazole hydrochloride (dibazol) 1.25 mg Excipients: Sucrose 800.0 mg Purified water up to 1 ml
Description:
The syrup is colorless to yellow.
Pharmacotherapeutic group:
Immunostimulating agent.
ATX code: L03AX
Pharmachologic effect:
Pharmacodynamics:
the drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B pathogens, as well as other viruses that cause acute respiratory diseases. Reduces the severity of the main clinical symptoms of influenza and ARVI, and also shortens the duration of the disease and promotes its uncomplicated course. In in vitro studies, the drug specifically suppresses (inhibits) the reproduction (replication) of the SARS-CoV-2 virus, which is the causative agent of the new coronavirus infection (COVID-19). Increases the content of secretory immunoglobulin A (slgA) in the mucous membrane of the nasopharynx - the entrance gate of infection, increasing the local immunoresistance of the body to respiratory infections of a viral and bacterial nature. With a preventive effect, the drug increases the potential metabolic activity of innate immune cells (neutrophil granulocytes and monocytes), which, in the event of infection, increases their ability to absorb and destroy bacterial and viral agents due to increased enzymatic (oxidative) activity, synthesis of cationic proteins and increased number of phagocytic cells. In this case, the initial state of metabolic activity of innate immune cells, in the absence of infectious agents, does not change, being within normal values. Bendazole induces the body's production of endogenous interferon and has an immunomodulatory effect (normalizes the body's immune response). Enzymes, the production of which is induced by interferon in the cells of various organs, inhibit viral replication. Alpha-glutamyl-tryptophan (thymogen) is a synergist for the immunomodulatory effect of bendazole, normalizing the T-cell component of immunity. Ascorbic acid activates the humoral component of the immune system, normalizes capillary permeability, thereby reducing inflammation, and exhibits antioxidant properties, neutralizing oxygen radicals that accompany the inflammatory process, and increases the body's resistance to infection.
Pharmacokinetics:
When taken orally, the drug is completely absorbed from the gastrointestinal tract. The bioavailability of bendazole is about 80%, alpha-glutamyl tryptophan is no more than 15%, ascorbic acid is up to 70%. Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum). Communication with plasma proteins – 25%. TCmax after oral administration – 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues, penetrates the placenta. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, intestinal motility disorders, helminthic infestation, giardiasis), consumption of vegetable and fruit juices, and alkaline drinking reduce the binding of ascorbic acid in the intestine. Ascorbic acid is metabolized primarily in the liver into deoxyascorbic acid, then into oxaloacetic and diketogulonic acids. It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites. The products of bendazole biotransformation in the blood are two conjugates formed as a result of methylation and carboethoxylation of the imino group of the imidazole ring of bendazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alphaglutamyl-tryptophan, under the influence of petidases, is broken down into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.
Indications for use:
Prevention and complex therapy of influenza and acute respiratory viral infections in children over one year of age.
Contraindications:
hypersensitivity to the components of the drug, diabetes mellitus, pregnancy, children under 1 year of age. If necessary, please consult your doctor before taking the drug.
Precautions for use.
Consult your doctor before taking the drug if you have hypotension.
Use during pregnancy and breastfeeding:
During pregnancy, taking the drug is not recommended due to insufficient clinical data. During breastfeeding, use is possible if the expected benefit to the mother outweighs the potential risk to the child. If you need to take the drug during breastfeeding, please consult your doctor.
Directions for use and dosage:
Orally 30 minutes before meals. For treatment:
Children aged 1 to 3 years – 2 ml 3 times a day;
children aged 3 to 6 years – 4 ml 3 times a day; children aged 6 to 10 years – 8 ml 3 times a day; children over 10 years of age – 12 ml 3 times a day. Course of application – 4 days. If after 3 days of treatment there is no improvement or the symptoms worsen or new symptoms appear, you should consult your doctor. For prevention:
- in direct contact with a patient with influenza and other acute respiratory viral infections: Children aged 1 to 3 years - 2 ml 3 times a day; children aged 3 to 6 years – 4 ml 3 times a day; children aged 6 to 10 years – 8 ml 3 times a day; children over 10 years of age – 12 ml 3 times a day. Course of application – 4 days. Preventive courses, if necessary, are repeated after 3 weeks (until the epidemic situation normalizes).
Side effect:
a short-term decrease in blood pressure is possible. Possible allergic reactions: urticaria. In these cases, the use of the drug is stopped and symptomatic treatment and antihistamines are prescribed. Consult your doctor if you experience any of the side effects mentioned or other side effects not listed in the instructions. If the side effects listed in the instructions get worse, tell your doctor.
Overdose:
Cases of overdose have not been described.
Interaction with other drugs:
No interaction of alpha-glutamyl-tryptophan with drugs has been identified. Bendazole prevents the increase in total peripheral vascular resistance caused by the use of non-selective beta-blockers. Strengthens the hypotensive (lowering blood pressure) effect of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole. Ascorbic acid increases the concentration in the blood of antibacterial drugs of the tetracycline series and benzylpenicillin. Improves the absorption of iron (Fe) preparations in the intestine. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce its absorption and absorption. When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%. Ascorbic acid increases the risk of developing crystalluria when using drugs containing acetylsalicylic acid (ASA) and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration in the blood of oral contraceptives. When used simultaneously, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Possible simultaneous use with antiviral drugs and symptomatic treatment of influenza and ARVI. Consult your doctor if you are taking the medications listed in this section or other medications.
Special instructions:
After a repeated course, monitoring of blood glucose concentrations is recommended.
Impact on the ability to drive vehicles and machinery:
the drug does not affect the ability to drive vehicles, operate moving machinery, or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form:
Syrup [for children]. 50 ml in a dark glass bottle. The bottle is sealed with a plastic cap with tamper evident or a plastic cap with tamper evident and childproof. One bottle is placed in a cardboard pack. Instructions for use are placed in a pack or in the form of a folded sheet placed under the opening part of the label. A dosing device is placed in the pack: a measuring cup or a dosing spoon, or a dosing pipette.
Storage conditions:
Store at a temperature not exceeding 25 Сo. Keep out of the reach of children.
Best before date:
2 years. Do not use after the expiration date stated on the packaging.
Vacation conditions:
available without a prescription.
Manufacturer / legal entity in whose name the registration certificate was issued / organization receiving complaints regarding the quality of the drug: Joint Stock Company Medical-Biological Research and Production Complex Cytomed (JSC MBNPK Cytomed). Address: Russia, 194356, St. Petersburg, Orlovo-Denisovsky prospect, building 14, building 1, tel., cytomed.ru Production site address: Russia, St. Petersburg, Orlovo-Denisovsky prospect, building 14, building 1.
General Director A.N. Khromov JSC Medical-Biological Research and Production Complex Cytomed
Instructions for use of Ciclovir (Method and dosage)
Ciclovir tablets, instructions for use: take orally for a standard five-day course or for shingles - three days. Adults and children over 5 years old:
- dose for infections caused by the herpes simplex virus - 1000 mg 5 times a day, as a prophylactic 800 mg 4 times a day;
- for herpes zoster - 4000 mg 5 times a day (children under 2 years old should take 0.5 adult doses);
- For organ transplants and other diseases, for the purpose of prevention, treatment is prescribed during the period of risk - usually for 6 weeks.
Instructions for use of Ciclovir ointment: cutaneously, treat the affected surface up to 5 times a day, maintaining an interval of 4 hours. The standard course is from 5 to 10 days.
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- Viru-Merz serol Aerosol
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- Antiherpes (Antiherpes) Homeopathic granules
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Ciclovir, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Ciclovir is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Analogs
Level 4 ATC code matches: Herperax
Vivorax
Vairova
Acyclostad
Geviran
Walcyte
Valavir
Ribavirin
Valtrex
Valvir
Rebetol
Famciclovir Teva
Famvir
Valaciclovir
Most names of analogues begin with the prefix “Acyclovir” and differ in the content of the active substance, release form and manufacturer. The most affordable options are: Acyclovir-Farmak , Acyclovir-Vishfa , etc.
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