Registration number: P N001049/03 Trade name: CYCLOFERON® Group name: Meglumina acridone acetate Dosage form: solution for intravenous and intramuscular administration
Composition of the drug Pharmacological properties Indications for use Contraindications
Directions for use and dosage Side effects Interaction with other drugs
Pharmacological properties
Pharmacodynamics
CYCLOFERON® is a low-molecular-weight interferon inducer, which determines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory, etc.).
The main interferon-producing cells after administration of the drug CYCLOFERON® are macrophages, T- and B-lymphocytes. Depending on the type of infection, the activity of one or another part of the immune system predominates. The drug induces high interferon titers in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes. CYCLOFERON® activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Enhances the activity of α-interferons. CYCLOFERON® demonstrates antiviral activity against pathogens of tick-borne encephalitis, influenza, herpes, cytomegalovirus, papilloma virus and other viruses. Preclinical studies have shown that the use of Cycloferon in the early stages of the infectious process leads to a decrease in the viral load (virus titer) in lung tissue. Increases the body's nonspecific resistance to viral and bacterial infections. The drug has been found to be highly effective in complex therapy of acute and chronic bacterial infections (neuroinfections, chlamydia) as a component of immunotherapy. Pharmacokinetics
When the maximum permissible dose is administered, the maximum concentration in the blood is reached after 1–2 hours; after 24 hours the drug is detected in trace amounts. Crosses the blood-brain barrier. The half-life is 4–5 hours. CYCLOFERON® does not have cumulative properties. Does not accumulate in tissues with prolonged use.
Compound
Cycloferon tablets contain acridone acetic acid as an active ingredient.
They also contain inactive components: calcium stearate, methylcellulose. acridone acetic acid as an active ingredient ; the solution also contains auxiliary substances: a stabilizing and salt-forming additive, water for injection.
Liniment Cycloferon contains as an active component acridone acetic acid in the form of N-methylglucamine salt , as well as auxiliary ingredients 1,2-propylene glycol up to 100%, 0.1% catapol.
Directions for use and doses
In adults
CYCLOFERON® is used intravenously or intramuscularly. For herpes and cytomegalovirus infection, the course of treatment consists of 10 injections of the drug, 250 mg each, with an interval between injections of 48 hours (every other day). A single dose is 250 mg (1 ampoule). The course dose is 2.5 g. Treatment is most effective at the beginning of an exacerbation of the disease.
For neuroinfections, the course of treatment consists of 12 injections of the drug, 250–500 mg each, with an interval between injections of 48 hours (every other day) in combination with etiotropic therapy. A single dose is 250–500 mg (1–2 ampoules). The course dose is 3.0–6.0 g. Repeated courses are carried out as needed. For immunodeficiency conditions, the course of treatment consists of 10 intramuscular injections of the drug, 250 mg each, with an interval between injections of 48 hours (every other day). A single dose is 250 mg (1 ampoule). The course dose is 2.5 g. A repeat course is carried out after 6–12 months.
For chlamydial infection, the course of treatment consists of 10 injections of the drug, 250 mg each, with an interval between injections of 48 hours (every other day). A single dose is 250 mg (1 ampoule). The course dose is 2.5 g. A second course of treatment is carried out after 10–14 days. It is advisable to combine the drug CYCLOFERON® with antibiotics.
In children over 4 years old
CYCLOFERON® is used intramuscularly or intravenously. A single dose is 6–10 mg per 1 kg of body weight.
For herpes infection, the course of treatment consists of 10 injections of the drug with an interval between injections of 48 hours (every other day). If the replicative activity of the virus is maintained, the course of treatment is continued according to the maintenance regimen - administration of the drug once every three days for four weeks.
Contraindications
The annotation for the drug contains the following contraindications for its use:
- liver cirrhosis (decompensation stage);
- high sensitivity to the components of the product;
- pregnancy , breastfeeding ;
- the child is under 4 years of age (due to imperfect swallowing).
Also, certain contraindications exist if patients have diseases of the digestive system during the acute phase. Cycloferon should be used with caution if you have of allergic reactions .
Side effect
According to the World Health Organization, undesirable effects are classified according to the frequency of their development as follows: – very common (≥ 1/10); – common (≥ 1/100 – – uncommon (≥ 1/1000 – – rare (≥ 1/10000 – – very rare ( – frequency unknown (cannot be determined from available data). General disorders and administration site conditions: very rarely - chills, fever, pain and redness at the injection site Disorders of the skin and subcutaneous tissues: very rarely - rash, urticaria If any of the undesirable effects indicated in the instructions worsen or you notice any other undesirable effects not listed in the instructions, tell your doctor about this.
special instructions
If the patient has aggravated diseases of the digestive system , and also experienced allergic reactions , before taking Cycloferon, you must tell your doctor about this.
Patients suffering from thyroid diseases should use this drug only with constant monitoring of their health by an endocrinologist. How often you can take pills in this case is also determined by a specialist.
If the dosage regimen was disrupted due to a missed dose, you should continue the regimen at the first opportunity by taking the next dose.
If there is no positive effect during the treatment process, you should definitely consult a specialist.
Taking the drug does not affect the ability to drive vehicles and operate complex machinery.
Often patients have a question about whether it is an antibiotic or not. It should be clearly understood that Cycloferon is not an antibiotic and cannot replace antibacterial drugs if necessary.
Cycloferon for cats and other animals can only be used as directed by a veterinarian and according to the regimen prescribed by him.
Release form
Solution for intravenous and intramuscular administration 125 mg/ml. 2 ml in brown glass ampoules. A self-adhesive label is placed on the ampoule. 5 ampoules are placed in a blister pack made of polymer film. The contour blister packaging is heat-sealed with a cover film or left open. 1 blister pack together with instructions for medical use are placed in a cardboard box. To control the first opening, the side flaps of the package can be sealed with labels.
Analogs of Cycloferon
Level 4 ATX code matches:
Estifan
Septilin
Sodium nucleinate
Gepon
Imudon
Immunal
Wobenzym
Respibron
Ruzam
Phlogenzyme
Glutoxim
Histamine dihydrochloride
Pyrogenal
Timalin
Uro-Vaxom
Engystol
Imunofan
Imunorix
Kipferon
Tsitovir-3
Analogues of Cycloferon are drugs that have a similar effect on the body. These are the drugs Immunin , Amiksin , Inflamafertin , Anaferon , Galavit , Maximun , Thymogen , Protfenolozide , Oscillococinum .
Reviews about Cycloferon
Reviews about Cycloferon on the Internet are varied. As a rule, reviews of Cycloferon tablets indicate that the drug does not provoke side effects. With proper use of the drug, both adults and children, after a course of treatment, there is a marked improvement in the condition of many diseases.
Reviews from doctors about Cycloferon injections are often positive, but experts advise using this remedy only when indicated and strictly according to the described scheme. The injections should not be used on children under four years of age. Also, experts do not recommend drinking alcohol at the same time, since the effectiveness of treatment in this case is sharply reduced.
Using liniment, patients note its effectiveness against herpes, as well as infectious diseases of the genitourinary system. In this case, a tangible result appears only if the ointment is used regularly.
Cycloferon price, where to buy
The average price of Cycloferon No. 10 tablets is 150 rubles.
The price of Cycloferon in ampoules is on average 300 rubles per pack of 5 ampoules. The price of Cycloferon injections in Ukraine (Kyiv, Kharkov and other cities) is from 150 to 160 hryvnia for 5 ampoules. You can buy ampoules at a lower price by ordering online. How much an injection solution or tablet costs should be found in a specific pharmacy chain.
The price of Cycloferon ointment is on average 270 rubles per 30 ml. Liniment can also be bought in Ukraine, its cost is from 100 to 120 hryvnia per 30 ml.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Cycloferon tablets p.p.o.
enteric solution 150 mg 20 pcs. LLC NTFF POLYSAN 392 rub. order - Cycloferon tablets p.p.o. enteric solution 150 mg 10 pcs. LLC NTFF POLYSAN
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Pharmacy Dialogue
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- Cycloferon tablets 150 mg No. 10Polysan NTFF
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- Cycloferon tablets 150 mg No. 20Polysan NTFF
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- Cycloferon tablets 150 mg No. 50Polysan NTFF
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- Cycloferon liniment 5% 5mlPolysan NTFF
RUB 178 order
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Pharmacy24
- Cycloferon 2 ml N5 solution TOV NTFF Polisan, Russian Federation
239 UAH order - Cycloferon 150 mg No. 10 tablets TOV NTFF Polisan, Russian Federation
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452 UAH order
PaniPharmacy
- Cycloferon tablets Cycloferon tablets. 150 mg No. 10 Russia, Polisan
120 UAH order
- Cycloferon ampoule Cycloferon injection solution 12.5% 2ml ampoules No. 5 Russia, Polisan
299 UAH order
- Cycloferon tablets Cycloferon tablets. 150 mg No. 50 Russia, Polisan
484 UAH order
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