Pharmacodynamics and pharmacokinetics
The main component of the drug, hexetidine , is an antiviral, fungicidal and antibacterial agent. It also has a slight anesthetic and enveloping effect. Hexetidine replaces thiamine , which promotes the growth of bacterial flora, which determines the antibacterial effect of the drug. In addition, this active component prevents the synthesis of substances that create the protective shell of fungi.
Methyl salicylate reduces the effect of the enzyme cyclooxygenase , stimulating blood to diseased areas and accelerating their recovery, as well as providing a local irritant and anti-inflammatory effect on the mucous membranes.
The combination of essential oils of the drug has a mild antibacterial and anti-inflammatory effect, and also reduces the feeling of discomfort when coughing.
The effect of the medicine lasts about 11 hours. All components are excreted with saliva . They do not enter the general bloodstream and are evenly distributed on the mucous membrane of the pharynx and mouth.
Experience with the use of the drug stopangin in the treatment of inflammatory diseases of the pharynx in children
Chronic tonsillitis, which is a long-term inflammatory process in the palatine tonsils, is one of the most pressing problems in pediatric otorhinolaryngology. This is due to the extremely important role of the tonsils in the formation of mechanisms of specific and nonspecific defense of the child’s body during its growth. Chronic tonsillitis accounts for 4 to 9% of all diseases in children [1]. In the group of frequently ill children, chronic tonsillitis accounts for 43% [2]. The disease is manifested by frequent sore throats in combination with general toxic-allergic phenomena: periodic rise in temperature, tonsillogenic intoxication, accompanied by weakness, as well as periodic pain in the joints and heart. Among the complications of chronic tonsillitis, it is necessary to highlight lateral and retropharyngeal abscesses, as well as rheumatism, diseases of the urinary system, prostate gland, and meninges [3]. Thus, chronic tonsillitis must be considered as a focal infection, the elimination of which is an extremely important part of the task of maintaining the health of the child as a whole, as well as preventing diseases associated with chronic tonsillitis [4].
Due to the empirical nature of prescribing antibacterial therapy and the widespread prevalence of resistant strains of the main pathogens, recently increasing importance has been given to the inclusion of locally active drugs in the treatment regimen. One of the promising areas is the prescription of drugs that combine antiseptic, anti-inflammatory and analgesic effects. The Ivex drug Stopangin meets these requirements.
Stopangin is a combination drug that contains three main components: hexetidine, methyl salicylate and a complex of essential oils. The main active ingredient, hexetidine, has a wide range of pharmacological properties. Hexetidine has a bactericidal and bacteriostatic effect, and has an antifungal and antiviral effect. The drug is active against S. aureus, S.pyogenes, S.epidermidis, Clostridium perfringens, Mycobacterium tuberculosis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Candida spp., Actinomyces spp., Trichophyton spp., Histoplasma capsulatum, etc. [5] . It is reported that strains with acquired resistance to antibiotics do not develop cross-resistance to hexetidine, even with prolonged treatment with this drug for 5 months. In addition to its antimicrobial properties, hexetidine has a hemostatic and analgesic effect, which justifies its use after tonsillectomy [5]. Unlike chlorhexidine, it is low-toxic and can therefore be prescribed to children. Methyl salicylate has analgesic and anti-inflammatory effects. Stopangin is available in the form of a spray and a solution for gargling. stopangin contains a complex of essential oils: anise, eucalyptus, sassafras, clove, peppermint oil. They have not only softening, but also antiseptic effects.
In the Department of Ear, Nose and Throat Diseases of the Federal State Institution MNIIPiDH Roszdrav, a study was conducted on the effectiveness of the drug stopangin in the treatment of chronic compensated tonsillitis (CCT) and chronic decompensated tonsillitis (CDT) in children in comparison with traditional therapy. During the study, the following tasks were solved: assessment of the anti-inflammatory and analgesic properties of the drug, both in the conservative treatment of chronic tonsillitis and after tonsillectomy, as well as the effect of stopangin on the pathogenic microflora of the pharynx before and after treatment.
The study involved 51 patients aged 5 to 17 years: 31 of them with CCT and 20 patients with CDT after tonsillectomy. All children underwent a course of antibacterial therapy before hospitalization, some twice. The patient examination plan included a daily examination with an assessment of the dynamics of the condition of the pharyngeal mucosa and taking into account the patient’s subjective assessment of the severity of the pain syndrome on a visual analogue scale. All patients had their pharyngeal microflora examined before and after treatment.
All patients were divided into two groups (Table). Patients of the main group received treatment with Stopangin: the lacunae of the tonsils were washed with a solution of the drug 2 times a day (in patients after tonsillectomy, the oropharynx was rinsed), as well as the pharynx was irrigated with Stopangin spray 3 times a day. Patients in the control group received traditional therapy: washing the lacunae of the tonsils, rinsing the oropharynx with a solution of furatsilin or saline with the addition of eucalyptus tincture (1:10) and lubricating the pharynx with Lugol's solution. Children with HDT after tonsillectomy additionally had their throats irrigated with Cameton aerosol 3 times a day. The course of treatment was 7–8 days.
All patients initially complained of sore and dry throat and pain when swallowing. 50% of children had symptoms of intoxication: weakness, fatigue, increased sweating, periodic rise in temperature to low-grade levels, “flying” pain in the joints. Pharyngoscopy revealed in most children severe hyperemia of the anterior palatine arches and hypertrophy of the tonsils from grades I to III, usually with purulent plugs in the lacunae. With pharyngitis, the clinical picture was complemented by thickening of the lateral ridges of the pharynx or the presence of lymphoid granules on the posterior wall of the pharynx. With tonsillomycosis, there was a characteristic white coating on the surface of the tonsils.
All patients underwent a study of the pharyngeal microflora before starting treatment. In the first group, monoflora was sown in 4 patients; in the remaining 17, microorganisms were sown in association. In the second group, a monoculture was sown in 1 patient and an association of microorganisms was sown in 10 patients.
The study demonstrated a higher therapeutic effectiveness of the drug Stopangin compared to traditional therapy. In patients with CCT who received stopangin, by the 2–3rd day of treatment, the disappearance of pain and discomfort in the throat was noted; on the 3–4th day, hyperemia of the pharynx mucosa disappeared and the lymphoid tissue of the tonsils was significantly reduced. A decrease or disappearance of plaque on the tonsils with tonsillomycosis was observed on days 5–6. In the control group of children with CCT, the above symptoms resolved 2–3 days later.
In children with HDT (after tonsillectomy) with the use of stopangin, the pain syndrome resolved on the 3rd–4th day, by which time the hyperemia of the mucous membrane and swelling of the arches and uvula of the soft palate also disappeared. On the 4th–5th day, the almond niches were cleared of plaque. None of the patients in this group had trismus of the masticatory muscles or tenderness of the submandibular lymph nodes. In the control group, after tonsillectomy, pain when swallowing persisted until the 5th–7th day; the tonsil niches were cleared of plaque by the 7th–9th day. In 4 out of 10 patients, trismus of the masticatory muscles and the phenomenon of submandibular lymphadenitis of varying severity were noted.
Analysis of the microbial flora after treatment revealed the antibacterial effect of stopangin: in 70% of patients after a course of treatment with the drug, normal flora was noted in throat smears, while in the group receiving traditional therapy, pathogenic bacteria were not detected in 55% of patients.
No side effects were identified in the stopangin treatment group. Most children noted the pleasant taste of the drug.
The results of the study indicate the beneficial complex effect of the drug stopangin on children with chronic tonsillitis and after tonsillectomy.
- The use of the drug stopangin in children with chronic tonsillitis leads to a reduction in treatment time compared to traditional therapy due to the antiseptic and anti-inflammatory properties of the drug.
- The antimicrobial and antimycotic properties of the drug lead to faster disappearance of plaque and more effective sanitation of the oropharyngeal mucosa compared to traditional therapy.
- The use of stopangin can reduce the severity of pain in patients with chronic tonsillitis and children after tonsillectomy.
Literature
- Garashchenko T. I., Bogomilsky M. R., Shishmareva E. V. New approaches to the treatment of exacerbations of chronic tonsillitis in children // Children's infections. 2004. No. 1.
- Ponomarev L. E. et al. The influence of chronic tonsillitis on the formation of a group of frequently ill children from preschool institutions // News of otorhinolaryngology and logopathology. 1995. No. 3 (4).
- Palchun V. T., Kryukov A. I. Otorhinolaryngology. M.: Litera, 1997.
- Polyakova T. S., Polyakova E. P. Chronic tonsillitis: diagnosis, treatment, prevention // Breast cancer. 2004. T. 12. No. 2.
- Lopatin A.S. //RMJ. 2000. T. 2. No. 2.
N. V. Ziborova , Candidate of Medical Sciences S. A. Loseva Research Institute of Pediatric and Agricultural Chemistry, Moscow
Indications for use
The medicine is used for:
- the need to eliminate unpleasant odor in the oral cavity ;
- infectious and inflammatory diseases, fungal diseases and injuries occurring in the larynx and oral cavity;
- prevention of infection of the alveoli after tooth extraction ;
- prevention of superinfection in destructive tumors of the larynx and oral cavity.
Instructions for Stopangin (Method and dosage)
For those who decide to use Stopangin spray, the instructions for use recommend using it 2 times a day. It is advisable to do this after meals or between meals.
Before using the product, you need to remove the cap and then attach the applicator. At the beginning, you should make 2-3 clicks so that the solution ends up in the sprayer. Before use, it is better to hold your breath and then spray on the affected area. After the procedures, the applicator must be rinsed in warm water.
The instructions for Stopangin provide for a maximum duration of use of the drug of 5-7 days.
The solution is used undiluted and serves as a mouth rinse. Apply 10-15 ml (1 tablespoon) for at least half a minute 2 times a day. In addition, children and adults can lubricate the oral mucosa using a cotton swab on a stick.
The solution is used after meals or in between. The duration of treatment is maximum 5-7 days.
Stopangin 0.2% spray for local use 30ml
Stopangin spray - instructions for use
Trade name: STOPANGIN Dosage form:
spray for topical use
Composition:
Active substances: hexetidine 57.7 mg;
essential oil blend (anise essential oil 14 mg, eucalyptus essential oil 0.4 mg, orange blossom essential oil 3.3 mg, sassafras essential oil 3.3 mg, peppermint essential oil 23.1 mg); menthol 6.7 mg; methyl salicylate 6.7 mg. Excipients: sodium saccharinate monohydrate, glycerin 85%; ethanol 96%. Description: transparent, colorless or almost colorless liquid with a specific odor.
After spraying, a finely atomized aerosol is formed.
Pharmacotherapeutic group:
antiseptic
ATX code: R02AA20
PHARMACOLOGICAL ACTION Antiseptic for topical use.
It also has antifungal activity and analgesic properties when applied to the mucous membrane.
Stopangin has an enveloping effect. The effect lasts 10 - 12 hours. INDICATIONS
?
inflammatory diseases of the oral cavity and larynx (tonsillitis, tonsillitis, pharyngitis, stomatitis, aphthae, glossitis, periodontal disease and periodontopathies, infection of the alveoli); ? fungal diseases of the oral cavity and larynx (thrush); ? before and after surgical interventions, as well as injuries to the oral cavity and larynx; ? as an adjuvant in the complex treatment of sore throats. CONTRAINDICATIONS The drug should not be used in cases of hypersensitivity to the components of the drug, in case of dry atrophic pharyngitis, in children under 8 years of age, or during pregnancy (1st trimester).
SIDE EFFECTS There may be a temporary burning sensation in the oral mucosa after using the drug, which spontaneously quickly disappears.
In exceptional cases, people with hypersensitivity may experience an allergic reaction.
If unusual reactions occur, you should consult your doctor about the advisability of further use of the drug. INTERACTIONS WITH OTHER MEDICINES Not known.
Directions for use and doses
Locally.
Remove the protective cap and attach the applicator. Press 2-3 times so that the solution enters the sprayer. Then hold your breath and spray on each of the tonsils. Carry out the procedure 2-3 times a day. The drug should be used after meals or between meals. After use, the applicator should be rinsed with warm water. SPECIAL INSTRUCTIONS The drug should not be inhaled!
In this regard, it can be prescribed only to children over 8 years of age and only in cases where they do not resist a foreign object (applicator) in the mouth, and if they are able to hold their breath when injecting the drug.
In case of overdose or if the drug is taken orally by a child, you should consult a doctor. The drug should not come into contact with the eyes. The advisability of simultaneous use of the drug "Stopangin" with other medications is determined by the doctor. If your doctor prescribes other medications, inform him about the use of Stopangin. If, within 3 days after starting to use the drug, the manifestations of the disease do not change, or, on the contrary, worsen, you should consult your doctor about the possibility of further use of the drug. Without consulting a doctor, the drug can be used for no longer than 5-7 days. The drug can be used by pregnant and breastfeeding women. The drug contains 64% alcohol (ethanol). Attention drivers: The drug should be taken no later than 30 minutes before driving a vehicle. RELEASE FORM Plastic bottle of 30 ml, equipped with a mechanical sprayer and a cap to protect the sprayer.
Each bottle complete with applicator is placed in a cardboard box along with instructions for medical use.
STORAGE CONDITIONS List B.
At a temperature of 10C to 25C in a place protected from light and out of reach of children.
Shelf life: 2 years.
Should not be used after the expiration date stated on the packaging.
CONDITIONS OF DISCHARGE FROM PHARMACIES Without a doctor's prescription
MANUFACTURER IVEX - CR a.s., Czech Republic Part of IVAX Corporation, USA Moscow representative office of IVEVEKS A.S. (formerly GALENA A.S.) Czech Republic Moscow, Dmitrovsky per.,
building 9, Medical Director of the Moscow representative office of IVEX A.S., Czech Republic February 10, 2014
The appearance of the product may differ from the photographs on the website.
Information about medications posted on the site is intended for specialists and includes materials from publications from different years. The information provided on the site is general and is presented for informational purposes only, does not replace consultation with a doctor and cannot serve as a guarantee of the positive effect of the drug. Tvoyaapteka.rf warns you about possible negative consequences that may arise as a result of incorrect use of the information presented on the site and strongly recommends that you consult with a specialist before choosing a drug.
You can find detailed and up-to-date instructions for the drug on the website of the State Register of Medicines www.grls.rosminzdrav.ru.
Stopangin price, where to buy
The price of Stopangin spray is, on average, about 200 rubles. In some pharmacies the cost may be lower.
The price of Stopangin in the form of a solution is slightly less. In Russian pharmacies the cost is, on average, about 120 rubles. However, the price of Stopangin in the form of a solution can be 140 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Stopangin spray for local use.
approx. 30mlTeva Pharm. enterprises s.r.o. 200 rub. order
Pharmacy Dialogue
- Stopangin spray 30mlTeva
RUB 231 order
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