Akriderm GK is a combination product used in the treatment of dermatological diseases. The effectiveness of the medicine is ensured by its multicomponent composition and its effect on one of the causes of skin problems - bacteria or fungi.
The use has contraindications and limitations, so it is important to study the instructions before starting use.
Pharmacodynamics and pharmacokinetics
The effect of this combination drug is due to its components, which are a glucocorticosteroid, an aminoglycoside antibiotic and an antifungal agent.
The use of betamethasone dipropionate helps to inhibit the concentration of leukocytes , the formation of lysosomal enzymes and a number of anti-inflammatory mediators in the area of inflammation. In this case, phagocytosis is inhibited, vascular-tissue permeability is reduced and the occurrence of inflammatory swelling is prevented.
Gentamicin, which is a broad-spectrum antibiotic Its action is directed against the causative agents of many primary and secondary bacterial infections of the skin, namely: gram-negative and gram-positive bacteria. However, anaerobes, fungi and viruses are not sensitive to this substance.
The antifungal effect of the drug is provided by clotrimazole. In this case, the synthesis of ergosterol, which makes up the cell membrane of fungi, is disrupted.
Activity is manifested against the most common fungi: Trichophyton rubrum, Epidermophyton floccosum, Candida albicans and so on.
How the drug works
The pharmacological effect of the drug is complex and is determined by the properties of its constituent substances:
- gentamicin has an antibacterial effect, is active against gram-negative bacteria - Proteus, Klebsiella, Enterococcus, Salmonella, Shigella, Staphylococcus;
- clotrimazole has an antifungal effect, destroys the cell membrane of fungi and causes their death. Effective against dermatophytes, mold and yeast-like fungi;
- betamethasone is a hormonal component that fights inflammation, swelling, and has an antiallergic effect.
Contraindications
It is not recommended to use Akriderm GK cream or ointment if:
- hypersensitivity to it;
- skin tuberculosis;
- cutaneous syphilis;
- skin post-vaccination reactions;
- chicken pox;
- herpes simplex;
- lactation;
- children under one year of age;
- otitis externa.
pharmachologic effect
The drug "Akriderm GK" has a versatile effect:
- anti-inflammatory;
- antiallergic;
- antibacterial;
- antifungal (fungicidal).
This effect was achieved largely thanks to betamethasone. This component is a glucocorticosteroid and has a local anti-inflammatory, anti-edematous, anti-allergic effect.
In turn, gentamicin has a bactericidal effect. It even suppresses microorganisms that are resistant to other antibiotics.
The main function of clotrimazole is to prevent the activation of fungal flora against the background of the action of gentamicin. This component is an antifungal agent from the group of imidazole derivatives for topical use. It has an effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Clotrimazole is also active against pathogenic dermatophytes, yeast and mold fungi.
Side effects
The use of GCS often causes side effects such as burning, irritation, excessive dry skin, hypertrichosis, folliculitis, acne , hypopigmentation, dermatitis , and so on.
Long-term use, especially under occlusive dressings, can cause prickly heat, maceration or atrophy of the skin, secondary infection, and purpura.
Children should be treated with extreme caution to avoid the occurrence of systemic undesirable effects such as hyperglycemia, glucosuria , suppression of the adrenal cortex, Cushing's syndrome , etc.
Instructions for use Akriderm GK (Method and dosage)
Akriderm GK ointment instructions for use recommend applying it externally only. In this case, the product is applied in a fairly thin layer to the affected areas of the skin. This needs to be done 2 times every day.
It should be noted that the instructions for use for Akriderm GK cream contain the same therapeutic regimen. But it is also possible for a doctor to prescribe individual treatment, depending on the severity of the disease. Mild cases allow the use of the cream only once a day, and more severe cases, on the contrary, increase the frequency of use.
The duration of therapy usually depends on how effective this remedy was in a particular case, and can be 2-4 weeks.
In the absence of a positive result for a long time, it is necessary to clarify the diagnosis.
Composition and release forms
Akriderm GK is produced in two dosage forms:
- ointment;
- cream.
The main active ingredients in the ointment and cream are identical: antibiotic gentamicin 0.1 g, antifungal component clotrimozole 1 g and glucocorticosteroid betamethasone dipropionate 0.05 g.
Additional components in the ointment include liquid paraffin, petroleum jelly, napazole, and isopropyl myristate. In the cream: water, petroleum jelly, sodium dihydrogen phosphate dihydrate, liquid paraffin, propylene glycol, disodium edetate, macrogol and cetostearic alcohol.
The differences between Akriderm cream and ointment are in the amount of water and petroleum jelly. The cream contains more water and less Vaseline. It absorbs and dries faster. Indicated for weeping skin lesions.
The ointment has a thicker texture due to the larger amount of petroleum jelly, is absorbed longer and has a healing effect on the surface of the skin for a long time. Prescribed for scratching, peeling, thickening of the affected skin.
In pharmacies Akriderm GK is sold in tubes of 15 and 30 g, packaged in a box along with instructions.
special instructions
The appearance of symptoms of sensitivity, skin irritation and other undesirable symptoms caused by the use of the drug requires abandoning this therapy and choosing another suitable remedy.
Long-term treatment, application of cream or ointment to large skin surfaces, use of occlusive dressings and therapy in children can cause systemic absorption of GCS.
This external remedy can be used in the treatment of children over one year of age, but only on the recommendation and under the close supervision of a specialist, which will avoid systemic side effects. It has been established that applying Akriderm GK cream or ointment over large areas for a long time leads to inhibition of the hypothalamic-pituitary-adrenal system, hypercortisolism, decreased excretion of hormone and increased intracranial pressure.
In addition, with prolonged application to the face, atrophic changes often occur, compared to other areas of the skin. For this reason, you should adhere to the standard therapeutic course, which is 5 days.
It is contraindicated to use any form of the drug in ophthalmology, avoiding accidental contact not only with the eyes, but also with mucous membranes.
Analogues of Akriderm GK
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Triderm
Kanizon Plus
Betasalik
Triacutan
Momat-S
The main analogues are represented by the following drugs: Triderm and Kanison.
At the same time, the price of analogues varies between 470-720 rubles.
Reviews about Akriderm GK
According to many users, this external remedy is one of the most effective. Although reviews of Akriderm GK cream are more common than ointment reviews. In any case, each form of this drug is prescribed to treat a variety of skin diseases and usually patients notice improvement within a couple of days.
It should be noted that in addition to positive reviews, you can also find reports of side effects. Symptoms that indicate intolerance or sensitivity to this drug are usually described: increased redness, peeling, development of inflammation, and so on.
In addition, patients often report that the drug helps only while you use it, and soon after discontinuation, the symptoms of the disease return again.
The reason for this is, most likely, that Akriderm GK helps suppress the manifestations of the disease, but still does not affect the disease itself. Therefore, in addition to the drug that alleviates the patient’s condition, the main treatment of the source of the health disorder must also be carried out.
In any case, it is not recommended to use this remedy without the prescription of a specialist. In addition to the fact that therapy may simply be useless, it is possible that severe complications may arise, which usually require long-term treatment.
Composition of the drug
The uniqueness of the drug lies in three active substances:
- Betamethasone dipropionate. It penetrates deeply into the site of inflammation, has high hydrophobicity, provides a rapid therapeutic effect and long-lasting action. One tube of cream contains 0.064 g of betamethasone dipropionate.
- Gentamicine. This substance is a broad-spectrum antibiotic from the aminoglycoside group. Provides a bactericidal effect against many gram-positive and gram-negative microorganisms. Akriderm GK cream contains 0.1 g of gentamicin sulfate.
- Clotrimazole. It has a pronounced antifungal effect. The drug contains 1 g of clotrimazole.
Thanks to the combined composition, the drug not only relieves itching, redness and inflammation, but also helps eliminate pathogenic microorganisms. The active substances present in the cream complement and enhance each other’s actions, which will allow for more successful treatment of both subjective and objective symptoms of the disease.
Due to the higher concentration of water, the product is absorbed faster and is suitable for wet and thin areas of the skin. Also suitable for use on lesions localized in large folds of the skin.
In addition to purified water, the auxiliary components of the Akriderm GK preparation are:
- petrolatum;
- propylene glycol;
- liquid paraffin;
- cetostearyl alcohol;
- macrogol cetostearate;
- disodium edetate;
- sodium dihydrogen phosphate dihydrate.
Akriderm GK price, where to buy
The price of Akriderm GK cream is 130-400 rubles.
The price of Akriderm GK ointment is 350-650 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Akriderm GK cream 30g JSC Akrikhin
RUB 681 order - Akriderm GK cream 15gAO Akrikhin
RUB 482 order
Pharmacy Dialogue
- Akriderm GK cream (tube 15g) Akrikhin OJSC
RUR 521 order
- Akriderm GK ointment (tube 30g) Akrikhin OJSC
RUB 802 order
- Akriderm GK cream 30g Akrikhin OJSC
RUR 787 order
- Akriderm GK ointment (tube 15g) Akrikhin OJSC
480 rub. order
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Indications for use
During the use of Akriderm GK cream, a positive therapeutic effect is observed in relation to acute and subacute conditions. The drug has average penetrating ability and has a softening and cooling effect on the source of inflammation. Also used to combat diseases such as:
- simple and allergic dermatitis, especially complicated by secondary infection;
- diffuse neurodermatitis, including atopic dermatitis;
- limited neurodermatitis, including simple chronic lichen;
- eczema;
- dermatomycosis (dermatophytosis, candidiasis, lichen versicolor), especially when localized in the groin area.
The unique composition places the drug "Akriderm GK" in the most popular group of products that provide significant improvement after use.
