Instructions for use AMIZONUM
Amizon® is taken orally after meals without chewing. The maximum single dose is 1 g, daily dose is 2 g. The recommended course of treatment, depending on the severity and etiology of the disease, is from 5 to 30 days.
Influenza and other respiratory viral infections:
for therapeutic purposes,
adults
are prescribed 0.25-0.5 g 2-4 times a day for 5-7 days;
- children aged 6 to 12 years
are prescribed 0.125 g 2-3 times a day for 5-7 days. - 0.5 g 3-4 times/day for 7 days for severe disease.
For meningoencephalitis
Amizon® is taken 0.25 g three times a day for 10 days.
For the treatment of measles, rubella, chickenpox -
children aged 6-7 years
- 0.125 g 3 times a day;
children aged 8-12 years
- 0.125 g 4 times a day;
children aged 13-14 years
- 0.25 g 3 times a day;
adolescents from 14 to 16 years old
- 0.25 g 4 times a day; adults - 0.5 g 3 times a day.
For
the treatment of mumps infection, adults
are prescribed 0.25 g 4 times a day for moderate severity of the disease and 0.5 g 3 times a day for severe disease for 6-7 days;
adolescents aged 12-14 years
are prescribed 0.25 g 3-4 times a day for 6-7 days.
For nonspecific chemoprophylaxis of mumps infection
adults are prescribed 0.25 g 2 times a day for 10-14 days.
For infectious mononucleosis
moderate severity - 0.25 g Amizon® 3-4 times a day
for adults
and 0.125 g 3 times a day
for children.
In severe cases - the first 2-3 days, 1.5-2 g per day
for adults
, up to 1 g per day
for children
.
After achieving a clinical effect, the dose can be halved. For the treatment of fellinosis, adults
are prescribed 0.25 g 3-4 times a day for moderate severity and 0.5 g 3 times a day for severe disease.
Children aged 6-9 years
- 0.125 g 3 times a day; 10-14 years - 0.125 g 4 times a day.
For the cutaneous-articular form of erysipeloid
in adults
- 0.5 g 3 times a day for 7-14 days.
For nonspecific chemoprophylaxis of viral hepatitis A, E
- 0.25 g 3 times/day, in complex therapy - 0.25 g 3 times/day during the first 5 days of illness.
In complex therapy of pneumonia
- 0.25 g 3 times a day for 10-15 days.
In complex therapy of angina
- 0.25 g 3-4 times/day for 5 days with moderate severity of the disease:
For pain syndromes
apply 0.25-0.5 g 3-4 times/day.
For the prevention of influenza and ARVI
Amizon® is recommended
for adults to take -
0.25 g per day for 3-5 days, then - 0.25 g once every 2-3 days for 2-3 weeks;
children 6-12 years old
- 0.125 g every other day for 2-3 weeks;
adolescents from 12 to 16 years old
- 0.25 g every other day for 2-3 weeks.
Amizon® 250 mg
Directions for use and doses
Amizon should be taken orally after meals without chewing.
The maximum single dose is 1000 mg, daily dose is 2000 mg. The recommended course of treatment, depending on the severity and etiology of the disease, is from 5 to 30 days. Influenza and other respiratory viral infections
Treatment.
Adults and children over 12 years of age are prescribed 250-500 mg 2-4 times a day for 5-7 days;
for children from 6 to 12 years old, prescribe 125 mg 2-3 times a day for 5-7 days.
Prevention.
Adults and children over 16 years of age - 250 mg per day for 3-5 days, then - 250 mg once every 2-3 days for 2-3 weeks;
children 6-12 years old - 125 mg every other day for 2-3 weeks;
children from 12 to 16 years old - 250 mg every other day for 2-3 weeks.
For the treatment of measles, rubella, chickenpox for adults and children over 16 years of age - 500 mg 3 times a day; children 6-7 years old - 125 mg 3 times a day; children 8-12 years old - 125 mg 4 times a day; children 13-14 years old - 250 mg 3 times a day; children 14-16 years old - 250 mg 4 times a day.
For the treatment of mumps infection, adults and children over 14 years of age are prescribed 250 mg 4 times a day for moderate severity of the disease and 500 mg 3 times a day for severe disease for 6-7 days; For children 12-14 years old, prescribe 250 mg 3-4 times a day for 6-7 days.
In the complex treatment of pneumonia in adults - 250 mg 3 times a day for 10-15 days.
In complex therapy for sore throats in adults - 250 mg 3-4 times a day for 5 days with moderate severity of the disease; 500 mg 3-4 times a day for 7 days for severe disease.
Children.
The drug in this dosage form should not be used in children under 6 years of age.
Side effects
Manifestations of adverse reactions are classified according to MedDRA terminology.
From the immune system: hypersensitivity reactions.
From the skin and subcutaneous tissue: rash, itching, urticaria, erythema, angioedema.
From the gastrointestinal tract: dry mouth, dysgeusia (bitter taste in the mouth), swelling of the oral mucosa, hypersalivation, discoloration of the tongue (yellow coloring), nausea, vomiting, diarrhea, dyspepsia, abdominal pain, pain in the upper abdomen, bloating.
From the respiratory system, chest and mediastinum: dyspnea, throat irritation.
General disorders and disorders at the injection site: asthenia, peripheral edema.
From the nervous system: headache, dizziness.
Laboratory and instrumental data: increased blood pressure, decreased blood pressure.
Amizon Kids syrup 10 mg/ml bottle 100 ml No. 1
Name
Amizon Kids syrup 10 mg/ml in bottle. 100ml per pack. No. 1
Description
Transparent, slightly yellowish-greenish liquid with a specific odor.
Main active ingredient
amizon
Release form
syrup
Dosage
1 ml of syrup contains amizon® (enisamium iodide) 10 mg
Pharmacodynamics
Enisamium iodide is a derivative of isonicotinic acid. It has an inhibitory effect on influenza viruses, exhibits interferonogenic properties, increases the body's resistance to viral infections, and has anti-inflammatory, antipyretic and analgesic effects. The antiviral effect of Amizon® Kids is associated with its direct effect on the hemagglutinins of the influenza virus, as a result of which the virion loses the ability to attach to target cells for further replication. The anti-inflammatory effect is the result of stabilizing cellular and lysosomal membranes, slowing down basophil degranulation, antioxidant action, normalizing the level of prostaglandins, cyclic nucleotides and energy metabolism at the site of inflammation. The antipyretic properties of this remedy are due to its effect on the thermoregulatory centers of the brain. Enisamium iodide enhances persistent immunity by increasing the level of endogenous interferon in the blood plasma by 3-4 times, lysozyme and increasing the titer of antibodies to infectious agents, as well as cellular immunity by stimulating the functional activity of T-lymphocytes and macrophages. This drug is a powerful inducer of endogenous interferon.
Pharmacokinetics
After oral administration, enisamium iodide quickly enters the blood; its maximum concentration in the blood is observed 2-2.5 hours after administration. The half-life is 13.5-14 hours. The drug is metabolized in the liver, but is quickly eliminated from tissues (half-life is 2-3 hours). 90-95% is excreted from the body in the form of metabolites.
Indications for use
Treatment of influenza and ARVI.
Directions for use and doses
The drug is recommended for the treatment of children over 3 years of age. The syrup is taken orally, preferably after meals, with a small amount of water. Children from 3 to 4 years old - 5 ml (50 mg) 3 times a day. Children from 4 to 5 years old - 6 ml (60 mg) 3 times a day. Children from 5 to 6 years old - 7 ml (70 mg) 3 times a day. For children aged 6 to 12 years, the drug is prescribed in tablet form. If the child cannot swallow tablets, the drug is taken 12 ml (120 mg) 2-3 times a day. Do not exceed recommended doses. To dispense the syrup, a syringe dispenser with a volume of 5 ml with a division value of 1 ml is included. If you need to measure a dose of more than 5 ml, measure out the first 5 ml of syrup first, and then the rest of the dose. The course of treatment is 5-7 days, depending on the severity of the disease and the therapeutic effect.
Use during pregnancy and lactation
The drug is not intended for use in these categories of patients. Children. The drug is used to treat children over 3 years of age. The ability to influence reaction speed when driving a vehicle or operating other mechanisms. The drug is not intended for use in this category of patients.
Precautionary measures
The drug should be prescribed with caution to patients with thyroid diseases, especially with hyperthyroidism. The syrup contains sorbitol, so patients with rare hereditary fructose intolerance should not take this drug. Sorbitol may also have a slight laxative effect.
Interaction with other drugs
Amizon® Kids enhances the effect of antibacterial and immunomodulatory agents. It is advisable to combine this drug with ascorbic acid and other vitamins. Amizon® Kids can also be prescribed simultaneously with recombinant interferon preparations.
Contraindications
– Hypersensitivity to the components of the drug and iodine preparations. – The presence of allergic reactions, regardless of the nature of the allergen in the anamnesis. – Severe organic damage to the liver and kidneys.
Compound
active ingredient: amizon® (enisamium iodide); 1 ml of syrup contains amizon® (enisamium iodide) 10 mg; excipients: sodium hydrogen phosphate, dodecahydrate; citric acid, monohydrate; flavoring "Tutti-Frutti"; “Peach” flavor; purified water; sorbitol solution, non-crystallizing (E 420).
Overdose
In case of overdose, it is possible to increase the manifestations of adverse reactions: brown staining of the mucous membranes, vomiting, abdominal pain and diarrhea. The development of edema, erythema, acne-like and bullous rashes, and fever is possible. Treatment: gastric lavage, symptomatic treatment.
Side effect
Allergic reactions: hypersensitivity reactions, including skin rashes, urticaria, angioedema, itching. From the digestive system: dryness and bitterness in the mouth, swelling of the oral mucosa, hypersalivation, yellow tongue, nausea, vomiting, heartburn, abdominal pain, heaviness in the right hypochondrium, diarrhea, bloating. From the respiratory system: shortness of breath, burning sensation in the throat. Others: headache, dizziness, weakness, fluctuations in blood pressure.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °. Keep out of the reach of children.
Amizon® for children
Recommendations for use
Dosage regimen
For adults, the maximum single dose is 1 g and the maximum daily dose is 2 g. The recommended course of treatment, depending on the severity and etiology of the disease, is from 5 to 7 days. If the condition worsens or does not improve within 3 days, you should consult a doctor.
Children from 6 to 12 years of age are prescribed Amizon® tablets 0.125 g.
Adults and children over 12 years of age are prescribed Amizon® tablets 0.25 g.
Flu and other respiratory viral infections.
Treatment.
Adults and children over 12 years of age are prescribed 1 tablet (0.25 g) 3 times a day for 7 days.
Children from 6 to 12 years old are prescribed 1 tablet (0.125 g) 3 times a day for 7 days.
Prevention.
Children 6-12 years old are prescribed 1 tablet (0.125 g) every other day for 3 weeks.
Children from 12 to 16 years old are prescribed 1 tablet (0.25 g) every other day for 3 weeks.
Adults and children over 16 years of age are prescribed 1 tablet (0.25 g) per day for 3 days, then 1 tablet (0.25 g) per day every other day for 2 weeks.
Treatment of measles, rubella, chickenpox.
Children 6-7 years old – 1 tablet (0.125 g) 3 times a day.
Children 8-12 years old – 1 tablet (0.125 g) 4 times a day.
Children 13-14 years old – 1 tablet (0.25 g) 3 times a day.
Children 14-16 years old – 1 tablet (0.25 g) 4 times a day.
Adults and children over 16 years of age – 2 tablets (0.25 g) 3 times a day.
Treatment of mumps infection.
Adults and children over 14 years old: 1 tablet (0.25 g) 4 times a day for moderate severity of the disease and 2 tablets (0.25 g) 3 times a day for severe disease for 7 days.
Children 12-14 years old: 1 tablet (0.25 g) 3 times a day for 7 days.
In the complex therapy of pneumonia.
Adults – 1 tablet (0.25 g) 3 times a day for 10-15 days.
In complex therapy of angina.
Adults – 1 tablet (0.25 g) 3 times a day for 5 days with moderate severity of the disease; 2 tablets (0.25 g) 3 times a day for 7 days for severe disease.
Method and route of administration
Take orally after meals, without chewing.
Frequency of use with indication of time of administration
The frequency of use depends on the severity and etiology of the disease.
Duration of treatment
The recommended course of treatment, depending on the severity and etiology of the disease, is from 5 to 7 days.
Measures to be taken in case of overdose
No cases of overdose with Amizon® have been reported.
Symptoms: brown discoloration of mucous membranes, vomiting, abdominal pain and diarrhea. The development of edema, erythema, acne-like and bullous rashes, and fever may occur.
Emergency procedures: gastric lavage, symptomatic treatment.
Recommendations for seeking advice from a healthcare professional to explain how to use the drug
