Pharmacological properties
Pharmacological.
Decasan has an antimicrobial antifungal effect, concentrates on the cytoplasmic membrane (CPM) of the microbial cell and connects with phosphatidic groups of membrane lipids, disrupting the permeability of the CMP of microorganisms. Decamethoxin has a pronounced bactericidal effect on staphylococci, streptococci, diphtheria and Pseudomonas aeruginosa, capsular bacteria and a fungicidal effect on yeast, yeast-like fungi, pathogens of epidermophytosis, trichophytosis, microsporia, erythrasma, some types of mold fungi (Aspergillus, Penici), protistocidal effect on Trichomonas, Giardia, viruscidal effect on viruses. Highly active against microorganisms resistant to antibiotics. Forms resistant to decamethoxin with long-term use are formed slowly and in small quantities. Bacteriostatic (fungistatic) concentrations are similar to its bactericidal (fungicidal), virusicidal, protistocidal concentrations. During treatment, the sensitivity of antibiotic-resistant microorganisms to antibiotics increases.
Pharmacokinetics.
The drug is practically not absorbed by mucous membranes, intact skin and wound surfaces.
Contraindications
Individual hypersensitivity to the components of the drug.
Decasan is an antiseptic drug, which is a 0.02% solution of decamethoxin in a 0.9% sodium chloride solution in bottles.
The Yuria-Pharm company produces the drug in vials for external and intracavitary use, and for the treatment of respiratory infections there is a form of release in nebulas (sterile single-dose containers).
Antiseptics are drugs that are used to disinfect surfaces, equipment, wounds, skin and mucous membranes. Some of them have the effect of inhibiting the reproduction and growth of bacteria, others directly destroy microbes.
Decamethoxin is a surfactant. The mechanism of the antimicrobial action of decamethoxin is based on disruption of the permeability of the cell membrane, inactivation of the exotoxin and inhibition of protein synthesis of microorganisms.
- Bactericidal effect - against staphylococci, streptococci, diphtheria and Pseudomonas aeruginosa;
- fungicidal effect - against many types of fungi (aspergillus, yeast);
- highly active against microorganisms resistant to antibiotics - penicillin, chloramphenicol, tetracyclines, streptomycin, etc.
- anticystoid (Trichomonas, Giardia) and viruscidal effects.
Decamethoxin is able to reduce exudation by inhibiting the production of serotonin by cells.
A unique property of Decasan is the lack of interaction with human cells, due to which it is not absorbed from the surface of the mucous membranes, so there is no risk of systemic side effects. Does not cause irritation of mucous membranes, and consequently, local undesirable manifestations.
It should be noted that Decasan can increase the sensitivity of microorganisms to antibiotic therapy.
The drug is widely used in outpatient and clinical practice; it is effective for abscesses, carbuncles, purulent-inflammatory processes of soft tissues, bacterial and fungal skin diseases.
In addition to external use, it has been shown to be effective as an inhaled drug for pneumonia and diseases of the upper and lower respiratory tract.
The drug has a large evidence base of effectiveness and safety of use. A wide range of antimicrobial, antifungal and antiviral effects with an almost complete absence of side effects allows Decasan to be used as an antiseptic for various therapeutic and prophylactic purposes.
Indications for use
Treatment of pustular bacterial and fungal skin diseases, microbial eczema, purulent-inflammatory lesions of soft tissues (abscesses, carbuncles, phlegmons, boils, purulent wounds, panaritiums) dental diseases (stomatitis, ulcerative-necrotic gingivitis, dystrophic-inflammatory form of periodontal disease I-II degrees in the acute stage).
Also indicated for lung abscess, bronchiectasis, cystic hypoplasia of the lungs, complicated by suppuration, chronic bronchitis in the acute phase, chronic tonsillitis, tonsillitis, carriage of staphylococci and diphtheria bacilli, ulcerative colitis, paraproctitis.
In gynecological practice - for the treatment of candidiasis of the vaginal mucosa, inflammatory diseases of the genitals of microbial origin, prenatal sanitation of the birth canal, treatment of postpartum endometritis.
Purulent-inflammatory diseases of the abdominal and pleural cavities.
For hygienic disinfection of the skin of medical staff's hands and rubber gloves when examining patients and performing medical procedures and minor surgical interventions, pre-sterilization disinfection of medical instruments and diagnostic equipment made of metals, rubber, polymeric materials and glass.
Features of application
Decamethoxin in the concentration used in Decasan ® has no toxic effect. Long-term use of Decasan does not cause any toxic reactions. Warming the drug to 38 ° C before use increases the effectiveness of the action. For inflammatory phenomena and skin irritations, dilute the drug with distilled water in a ratio of 1: 1 or 1: 2.
Use during pregnancy or breastfeeding.
There are no warnings regarding use during pregnancy or breastfeeding.
The ability to influence the reaction rate when driving vehicles or other mechanisms.
There are no warnings regarding the effect on reaction speed when driving or operating other machinery.
Note!
Description of the drug Decasan solution 0.2 mg/ml cont. 2ml No. 12 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Directions for use and doses
For purulent and fungal skin lesions, purulent wounds, use the solution in the form of rinses and lotions. For the treatment of proctitis and ulcerative colitis, administer a warm solution in the form of enemas of 50-100 ml 2 times a day until the signs of acute inflammation completely disappear. Fistulas with chronic paraproctitis should be washed with Decasan ® daily for 3-4 days. To wash the bladder in adult patients, use decamethoxin solution after preliminary dilution 1:7 with purified water in a dose of 500-600 ml (7-20 washes per course of treatment).
Damage to the oral mucosa is treated by applying 25-50 ml for 10-15 minutes or rinsing (100-150 ml). The dystrophic-inflammatory form of periodontal disease I-II in the acute stage is treated by irrigating pathological gum pockets with a warm solution (50-70 ml) or applying applications to the gums to attenuate inflammatory phenomena. Patients with candidiasis of the oral mucosa and ulcerative-necrotizing gingivitis should be prescribed mouth rinses (100-150 ml) 4 times a day for 5-10 days.
Treatment of candidiasis of the tonsils and chronic tonsillitis is carried out by washing the lacunae of the palatine tonsils (50-75 ml per wash).
Sanitation of carriers of staphylococcus and diphtheria bacillus is carried out by rinsing the pharynx with a solution, washing the lacunae, irrigating the nasopharynx and tonsils. Wash the lacunae 3-5 times every other day.
In adults with lung abscess, bronchiectasis, cystic hypoplasia of the lungs complicated by suppuration, chronic bronchitis in the acute phase, administer Decasan ® endobronchially:
- through a microtracheostomy 25-50 ml 1-2 times a day; through a transnasal catheter 5-10 ml 1 time per day
- by ultrasonic inhalation method, 5-10 ml 1-2 times a day;
- using lavage of the tracheobronchial tree in a volume of 100 ml.
Duration of treatment is 2-4 weeks.
When treating purulent-inflammatory diseases of the abdominal and pleural cavities, fill the affected area to the brim with Decasan ® with an exposure of at least 10 minutes. If necessary, including when suturing “tightly” (without drainage), carry out repeated filling of the operating cavity with subsequent removal of the solution to clean rinsing water. Flow-flushing drainage of the cavity is performed using drains or the puncture method.
For the treatment of microbial and fungal trichomonas lesions of the vaginal mucosa, use Decasan ® in the form of douching (50-100 ml of the drug heated to 38 ° C 3 times a day). In the same way, carry out prenatal sanitation of the birth canal once. Treatment of postpartum endometritis is carried out by washing the uterine cavity with a warm preparation (150-200 ml) 2 times a day.
Disinfection of the skin of hands and rubber gloves is carried out by applying 5-10 ml of the drug to a previously washed surface to be disinfected for 5 minutes.
Cleaned medical instruments, mouthpieces, tubes and equipment are disinfected by immersing in the solution for 30 minutes.
Children.
Use for the treatment of children over 12 years of age with chronic bronchitis in the acute phase, using ultrasonic inhalation, 5-10 ml 1-2 times a day. For other indications, there is no experience of use in children under 18 years of age.
DEKASAN RR 0.02% 200ML
Instructions
Trade name of the drug: Decasan® (Decasanum)
Active ingredients: Decamethoxin*
Pharmacotherapeutic group: Antiseptic and disinfectants., Antiseptic and disinfectants.
Release form:
200 ml, 400 ml in glass bottles. 1000 ml in polymer containers. 2 ml in single-dose containers; 10 containers per pack.
Dosage form:
Solution 0.2 mg/ml 200 ml, 400 ml (glass bottles), 1000 ml (polymer bags), 2 ml (in a single-dose polymer container)
Compound:
1 ml of solution contains: Active substance: 0.2 mg decamethoxin; Excipients: sodium chloride, water for injection.
Pharmacological properties:
Decasan® exhibits an antimicrobial, antifungal effect and is concentrated on the cytoplasmic membrane (CPM) of the microbial cell and combines with the phosphatidic groups of membrane lipids, disrupting the permeability of the CMP of microorganisms. Decamethoxin has a pronounced bactericidal effect against staphylococci, streptococci, diphtheria and Pseudomonas aeruginosa, capsular bacteria and a fungicidal effect against yeast, yeast-like fungi, pathogens of epidermophytosis, trichophytosis, microsporia, erythrasma, some types of mold fungi (aspergillus, penicillin), protistocidal effect in against Trichomonas, Giardia, viruscidal effect against viruses. Highly active against microorganisms resistant to antibiotics. The formation of forms resistant to decamethoxin during long-term use occurs slowly and does not exceed the effective concentrations of the drug. Bacteriostatic (fungistatic) concentrations are similar to its bactericidal (fungicidal), virusicidal, protistocidal concentrations. During treatment with the drug, the sensitivity of antibiotic-resistant microorganisms to antibiotics increases. The drug is practically not absorbed by mucous membranes, intact skin and wound surfaces.
Indications for use:
Treatment of pustular bacterial and fungal skin diseases, microbial eczema, purulent-inflammatory lesions of soft tissues (abscesses, carbuncles, phlegmons, boils, purulent wounds, felons); dental diseases (stomatitis, ulcerative-necrotic gingivitis, dystrophic-inflammatory form of periodontal disease I - II degrees in the acute stage). Also indicated for lung abscess, bronchiectasis, cystic hypoplasia of the lungs, complicated suppuration, chronic bronchitis in the acute phase, chronic tonsillitis, tonsillitis, carriage of staphylococci and diphtheria bacilli, ulcerative colitis, paraproctitis. In gynecological practice - for the treatment of candidiasis of the vaginal mucosa, inflammatory diseases of the genitals of microbial origin, prenatal sanitation of the birth canal, treatment of postpartum endometritis. Hygienic disinfection of the skin of medical staff’s hands and rubber gloves during examination of patients and carrying out medical procedures and minor surgical interventions, pre-sterilization disinfection of medical instruments and diagnostic equipment made of metals, rubber, polymeric materials and glass.
Mode of application:
For purulent and fungal skin lesions, purulent wounds, the solution is used in the form of rinses and lotions. For the treatment of proctitis and ulcerative colitis, a warm solution is administered in the form of enemas of 50-100 ml 2 times a day until the signs of acute inflammation completely disappear. Fistulas with chronic paraproctitis are washed with Decasan® daily for 3-4 days. To wash the bladder in adults, a decamethoxin solution is used after preliminary dilution 1:7 with purified water in a dose of 500-600 ml (7-20 washes per course of treatment). Lesions of the oral mucosa are treated by applying 25-50 ml for 10-15 minutes, or rinsing (100-150 ml). The dystrophic-inflammatory form of periodontal disease of the I-II degree in the acute stage is treated by irrigating pathological gum pockets with a warm solution (50-70 ml) or applying applications to the gums until the inflammatory phenomena subside. Patients with candidiasis of the oral mucosa and ulcerative-necrotizing gingivitis are prescribed mouth rinses (100-150 ml) 4 times a day for 5-10 days. Treatment of candidiasis of the tonsils and chronic tonsillitis is carried out by washing the lacunae of the palatine tonsils (50-75 ml per wash). Sanitation of carriers of staphylococcus and diphtheria bacillus is carried out by rinsing the throat with a solution, washing the lacunae, irrigating the nasopharynx and tonsils. Lacunae are washed 3-5 times every other day. For lung abscess, bronchiectasis, cystic hypoplasia of the lungs, complicated by suppuration, chronic bronchitis in the acute phase, Decasan® is administered endobronchially: - through a microtracheostomy, 25-50 ml 1-2 times a day; through a transnasal catheter 5-10 ml 1 time per day; - ultrasonic inhalation method, 5-10 ml 1-2 times a day; - by washing the tracheobronchial tree in a volume of 100 ml. Duration of treatment is 2-4 weeks. For the treatment of microbial and fungal Trichomonas lesions of the vaginal mucosa, Decasan® is used in the form of douching (50-100 ml of the drug heated to 38 0C 3 times a day). In the same way, prenatal sanitation of the birth canal is carried out once. Treatment of postpartum endometritis is carried out by washing the uterine cavity with a warm preparation (150-200 ml) 2 times a day. Disinfection of the skin of hands and rubber gloves is carried out by applying 5-10 ml of the drug to a previously washed surface, evenly distributing it over the entire surface to be disinfected for 5 minutes. Cleaned medical instruments, mouthpieces, tubes and equipment are disinfected by immersing in the solution for 30 minutes.
Side effects:
In isolated cases, individual hypersensitivity is possible. Such persons may develop a skin rash, burning, dryness, itching after using the drug and other local allergic reactions; with endobronchial administration, a feeling of heat behind the sternum, which goes away on its own 20-30 minutes after the end of the procedure.
Contraindications:
Individual hypersensitivity to the components of the drug.
Drug interactions:
Pharmaceutical: Decamethoxin is a cationic surfactant and is therefore incompatible with soap and other anionic compounds. Pharmacodynamic: decamethoxin increases the sensitivity of antibiotic-resistant microorganisms to antibiotics.
Special instructions:
Decamethoxin in the concentration used in Decasan® has no toxic effect. Long-term use of Decasan® does not cause any toxic reactions. Warming the drug to 38°C before use increases its effectiveness. For inflammatory phenomena and skin irritations, the drug is diluted with distilled water in a ratio of 1:1 or 1:2. Use during pregnancy or breastfeeding. There are no warnings regarding use during pregnancy or breastfeeding. Children. There is no experience of use in children. The ability to influence the reaction rate when driving a vehicle or working with other mechanisms. There are no warnings regarding the effect on reaction speed when driving or operating other machinery. The drug should not be used after the expiration date and should be stored out of the reach of children.
Overdose:
Due to the lack of absorption, an overdose is not observed.
Storage conditions: Store in a place protected from light at a temperature not exceeding 25°C. Do not freeze.
Shelf life: 3 years.
Dispensing conditions: Without a prescription.
Manufacturer: Yuria-Pharm, LLC, Ukraine
