When dealing with colds and coughs, many people try to buy medicine as quickly as possible. A popular remedy for coughs and runny noses are Ambrobene tablets. Before taking this medicine, you should carefully read the instructions and strictly follow the recommendations. Overdose and abuse of the drug can seriously harm your health.
What does the medicine consist of?
The active ingredient is abroxol hydrochloride. One tablet contains 30 mg of this substance. In addition, the tablets contain additional microelements:
- colloidal anhydrous silicon dioxide - 1.8 mg;
- magnesium stearate - 2.41 mg;
- lactose monohydrate - 169.46 mg;
- corn starch - 36.33 mg.
The round white tablets have a slightly convex surface on both sides. There is a score line on one side of each tablet. The package contains 2 or 5 blisters, each containing 10 tablets.
In what forms is it available?
The doctor can prescribe the medicine to the patient in the most suitable form of release. "Ambrobene" is available in 5 different forms:
- pills;
- solution for inhalation and oral administration;
- syrup;
- capsules;
- solution for intravenous injection.
These release forms differ from each other in the dosage of the active substance, as well as additional substances.
How it affects the body
This medicine thins mucus in the bronchi and lungs and stimulates its rapid elimination from the body. Under the influence of the drug, sputum does not increase in volume, but loses its viscosity. The bonds between molecules are broken, and sputum is easily coughed up. "Ambrobene" refers to expectorant and mucolytic drugs.
The tablets begin to act half an hour after taking them. Depending on their quantity, the effect lasts 6–12 hours. The antioxidant properties of Ambrobene have been proven.
The active substance is excreted by the kidneys. Ambroxol easily enters the spinal fluid. It is able to penetrate into the fetus through the placenta, as well as into breast milk. It is completely eliminated from the body within 22 hours.
Ambrobene, 7.5 mg/ml, solution for oral administration and inhalation, 40 ml, 1 pc.
Inside, inhalation, i.v.
The duration of treatment is selected individually depending on the course of the disease. It is not recommended to take Ambrobene for more than 4-5 days without a doctor's prescription.
The mucolytic effect of the drug occurs when taking large amounts of liquid. Therefore, drinking plenty of fluids is recommended during treatment.
Pills
Inside
, after eating, swallow whole, without chewing, with plenty of liquid.
Children from 6 to 12 years old:
1/2 table 2–3 times a day (15 mg ambroxol 2–3 times a day).
Adults and children over 12 years old:
in the first 2–3 days of treatment - 1 tablet. 3 times a day (30 mg ambroxol 3 times a day). If therapy is ineffective, adults can increase the dose to 2 tablets. 2 times a day (120 mg ambroxol per day). In the following days you should take 1 tablet. 2 times a day (30 mg ambroxol 2 times a day).
Extended release capsules
Inside
, after eating, swallow whole, without chewing, with plenty of liquid.
Adults and children over 12 years old:
1 caps. per day (75 mg ambroxol per day).
Syrup
Inside
, after eating, using the included measuring cup.
For children:
up to 2 years - 1/2 measuring cup (2.5 ml syrup) 2 times a day (15 mg ambroxol per day); from 2 to 6 years - 1/2 measuring cup (2.5 ml syrup) 3 times a day (22.5 mg ambroxol per day); from 6 to 12 years - 1 measuring cup (5 ml of syrup) 2-3 times a day (30-45 mg of ambroxol per day).
Adults and children over 12 years old:
in the first 2-3 days of treatment - 2 measuring cups (10 ml of syrup) 3 times a day (90 mg of ambroxol per day). If therapy is ineffective, adults can increase the dose to 4 measuring cups (20 ml of syrup) 2 times a day (120 mg of ambroxol per day). In the following days, you should take 2 measuring cups (10 ml of syrup) 2 times a day (60 mg of ambroxol per day).
Solution for oral administration and inhalation
Inside
, after meals, add to water, juice or tea using the included measuring cup.
For children:
up to 2 years - 1 ml of the drug 2 times a day (15 mg ambroxol per day); from 2 to 6 years - 1 ml of the drug 3 times a day (22.5 mg ambroxol per day); from 6 to 12 years - 2 ml of the drug 2-3 times a day (30-45 mg ambroxol per day).
Adults and children over 12 years old:
in the first 2-3 days of treatment - 4 ml of the drug 3 times a day (90 mg ambroxol per day). If therapy is ineffective, adults can increase the dose to 8 ml of the drug 2 times a day (120 mg ambroxol per day). In the following days, you should take 4 ml of the drug 2 times a day (60 mg ambroxol per day).
Inhalation.
When using the drug Ambrobene in the form of inhalations, you can use any modern equipment (except for steam inhalers). Before inhalation, the drug is mixed with a 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a 1:1 ratio) and heated to body temperature. Since during inhalation therapy, a deep breath can provoke coughing impulses, inhalations should be carried out in normal breathing mode. Patients with bronchial asthma can be recommended to carry out inhalation after taking bronchodilator drugs.
1 ml of solution contains 7.5 mg of ambroxol.
For children:
up to 2 years - 1 ml of solution 1-2 times a day (7.5-15 mg ambroxol per day); from 2 to 6 years - 2 ml of solution 1-2 times a day (15-30 mg ambroxol per day).
Adults and children over 6 years old:
2–3 ml of solution 1–2 times a day (15–45 mg ambroxol per day).
Solution for intravenous administration
IV
, slowly, stream or drip. The solvent used is 0.9% sodium chloride solution, 5% glucose solution, Ringer-Locke solution or another basic solution with a pH not higher than 6.3.
The daily dose is 30 mg/kg, evenly distributed over 4 administrations per day.
The solution should be administered intravenously, slowly, over at least 5 minutes.
Injections are stopped after the acute manifestations of the disease disappear and the patient switches to oral administration of other dosage forms of the drug.
In what cases is it recommended to take
There are a number of diseases and conditions for which the doctor prescribes Ambrobene:
- bronchitis;
- cystic fibrosis;
- pneumonia;
- bronchial asthma;
- inflammatory processes in the respiratory tract;
- acute respiratory infections and acute respiratory viral infections.
Chronic and acute diseases of the respiratory tract, in which the mechanism of clearing the lungs of phlegm is disrupted, are successfully treated with the drug "Ambrobene".
Ambrobene, solution for oral administration and inhalation 7.5 mg/ml, 40 ml
The solution for oral administration and inhalation is taken orally after meals with a sufficient amount of liquid (water, juice, tea) using a measuring cup.
1 ml of solution contains 7.5 mg of ambroxol.
Children under 2 years of age are prescribed the drug 1 ml of solution 2 times a day (15 mg/day).
Children aged 2 to 6 years are prescribed the drug 1 ml of solution 3 times a day (22.5 mg/day).
Children aged 6 to 12 years are prescribed the drug 2 ml of solution 2-3 times a day (30-45 mg/day).
, adults and adolescents are prescribed 4 ml of solution 3 times a day (90 mg/day). In the following days - 4 ml 2 times / day (60 mg / day).
When using Ambrobene in the form of inhalations, any modern equipment is used (except for steam inhalations). Before inhalation, the drug should be mixed with a 0.9% sodium chloride solution (for optimal air humidification it can be diluted in a ratio of 1:1) and heated to body temperature. Inhalations should be carried out in normal breathing mode so as not to provoke coughing shocks.
Patients with bronchial asthma should use bronchodilators before inhaling ambroxol to avoid nonspecific irritation of the respiratory tract and their spasm.
Children under 2 years of age are inhaled 1 ml of solution 1-2 times a day (7.5-15 mg/day).
Children aged 2 to 6 years are inhaled 2 ml of solution 1-2 times a day (15-30 mg/day).
Adults and children over 6 years of age inhale 2-3 ml of solution 1-2 times a day (15-45 mg/day).
The injection solution should be administered intravenously (slow stream or drip). The solvent used is 0.9% sodium chloride solution, 5% dextrose solution, Ringer-Locke solution or other basic solution with a pH not higher than 6.3.
For children, the drug is usually prescribed in a daily dose of 1.2-1.6 mg/kg body weight.
Children under 2 years of age are prescribed 1 ml (1/2 amp.) 2 times a day (15 mg/day).
Children aged 2 to 6 years are prescribed 1 ml (1/2 amp.) 3 times a day (22.5 mg/day).
Children over 6 years of age are prescribed 2 ml (1 amp.) 2-3 times/day (30-45 mg/day).
Adults are prescribed 1 amp. 2-3 times/day (30-45 mg/day). In severe cases, the dose can be increased to 2 amp. 2-3 times/day (60-90 mg/day).
For respiratory distress syndrome in newborns and premature infants, the daily dose of the drug is 30 mg and, as a rule, is divided into 4 separate administrations.
Injections are stopped after the disappearance of acute manifestations of the disease and switched to oral administration of other dosage forms of Ambrobene.
Treatment of children under 2 years of age should be carried out only under the supervision of a physician.
Drinking plenty of fluids is recommended while using the drug.
The duration of treatment depends on the characteristics of the disease. It is not recommended to use the drug without medical prescription for more than 4-5 days.
Side effects
Tablets, syrup and capsules may cause unwanted side effects:
- itching and rash on the skin;
- swelling on the face;
- hives;
- dry mouth and mucous membranes;
- anaphylactic shock (extremely rare);
- weakness;
- profuse runny nose;
- headache;
- nausea, vomiting;
- diarrhea or constipation;
- abdominal pain;
- fever;
- urination disorder.
Solutions for inhalation and injection sometimes provoke other side effects:
- anaphylactic reactions, up to shock;
- impaired taste sensations;
- pain and discomfort in the abdomen;
- vomiting and diarrhea;
- swelling of the veins.
The patient must take care of his health, strictly adhere to the dosage and follow the instructions for use.
Ambrobene solution for oral administration and inhalation 7.5 mg/ml, 100 ml
Registration Certificate Holder
Teva Pharmaceutical Industries (Israel)
Dosage form
Medicine - Ambrobene
Description
Solution for oral administration and inhalation
transparent, colorless to light yellow with a brown tint, odorless.
1 ml
ambroxol hydrochloride 7.5 mg
Excipients
: potassium sorbate - 1 mg, hydrochloric acid - 0.6 mg, purified water - 991.9 mg.
40 ml - dark glass bottles with a dropper stopper (1) complete with a measuring cup - cardboard boxes. 100 ml - dark glass bottles with a dropper stopper (1) complete with a measuring cup - cardboard boxes.
Indications
Injection
used for diseases of the respiratory tract with the release of viscous sputum and with difficulty in sputum discharge in cases where it is necessary to obtain a quick therapeutic effect or it is impossible to take the drug orally:
- acute and chronic bronchitis;
- pneumonia;
- bronchial asthma;
- bronchiectasis;
- stimulation of surfactant synthesis during respiratory distress syndrome in premature infants and newborns (as part of complex therapy).
The solution for oral administration and inhalation
is used for diseases of the respiratory tract with the production of viscous sputum and difficulty in sputum discharge:
- acute and chronic bronchitis;
- pneumonia;
- bronchial asthma;
- bronchiectasis.
Contraindications for use
- peptic ulcer of the stomach and duodenum;
- epileptic syndrome;
- hypersensitivity to ambroxol and/or other components of the drug.
with caution
in case of impaired renal function and/or severe liver disease, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under the supervision of a physician).
With extreme caution
and only under the supervision of a physician should Ambrobene be used in cases of impaired bronchial motility and large volumes of secreted secretions in order to avoid the danger of stagnation of secretions in the bronchi.
pharmachologic effect
Mucolytic and expectorant drug.
Ambroxol, an active metabolite of bromhexine, improves the rheological properties of sputum, reduces its viscosity and adhesive properties, facilitating its removal from the respiratory tract.
Ambroxol stimulates the activity of the serous cells of the bronchial lining glands, the production of enzymes that break down the bonds between sputum polysaccharides, the formation of surfactant and the direct activity of the bronchial cilia, preventing their adhesion.
After oral administration, the therapeutic effect occurs within 30 minutes and lasts for 6-12 hours (depending on the dose taken).
When administered parenterally, the effect of the drug occurs quickly and lasts for 6-10 hours.
Drug interactions
The simultaneous use of Ambrobene with drugs that have antitussive activity (for example, containing codeine) is not recommended due to the difficulty of removing sputum from the bronchi while reducing cough.
The simultaneous use of Ambrobene with antibiotics (including amoxicillin, cefuroxime, erythromycin, doxycycline) improves the flow of antibiotics into the pulmonary tract. This interaction with doxycycline is widely used for therapeutic purposes.
Ambrobene mixture cannot be used for injection with solutions having a pH higher than 6.3.
Dosage regimen
Solution for oral administration and inhalation
taken orally after meals with a sufficient amount of liquid (water, juice, tea) using a measuring cup.
1 ml of solution contains 7.5 mg of ambroxol.
Children under 2 years of age
prescribe the drug 1 ml of solution 2 times a day (15 mg/day).
Children aged 2 to 6 years
the drug is prescribed 1 ml of solution 3 times/day (22.5 mg/day).
Children aged 6 to 12 years
prescribe the drug 2 ml of solution 2-3 times/day (30-45 mg/day).
Adults and teenagers
in the first 2-3 days, 4 ml of solution is prescribed 3 times a day (90 mg/day). In the following days - 4 ml 2 times / day (60 mg / day).
When using Ambrobene in the form of inhalations
use any modern equipment (except steam inhalation). Before inhalation, the drug should be mixed with a 0.9% sodium chloride solution (for optimal air humidification it can be diluted in a ratio of 1:1) and heated to body temperature. Inhalations should be carried out in normal breathing mode so as not to provoke coughing shocks.
Patients with bronchial asthma should use bronchodilators before inhaling ambroxol to avoid nonspecific irritation of the respiratory tract and their spasm.
Children under 2 years of age
inhale 1 ml of solution 1-2 times/day (7.5-15 mg/day).
Children aged 2 to 6 years
inhale 2 ml of solution 1-2 times/day (15-30 mg/day).
Adults and children over 6 years of age
inhale 2-3 ml of solution 1-2 times/day (15-45 mg/day).
Injection
should be administered intravenously (slow stream or drip). The solvent used is 0.9% sodium chloride solution, 5% dextrose solution, Ringer-Locke solution or other basic solution with a pH not higher than 6.3.
For children
The drug is usually prescribed in a daily dose of 1.2-1.6 mg/kg body weight.
Children under 2 years of age
prescribed 1 ml (1/2 amp.) 2 times/day (15 mg/day).
Children aged 2 to 6 years
prescribed 1 ml (1/2 amp.) 3 times/day (22.5 mg/day).
Children over 6 years of age
Prescribe 2 ml (1 amp.) 2-3 times/day (30-45 mg/day).
For adults
prescribed 1 amp. 2-3 times/day (30-45 mg/day). In severe cases, the dose can be increased to 2 amp. 2-3 times/day (60-90 mg/day).
For respiratory distress syndrome in newborns and premature infants
The daily dose of the drug is 30 mg and, as a rule, is divided into 4 separate injections.
Injections are stopped after the disappearance of acute manifestations of the disease and switched to oral administration of other dosage forms of Ambrobene.
Treatment of children under 2 years of age
should only be carried out under the supervision of a physician.
Drinking plenty of fluids is recommended while using the drug.
The duration of treatment depends on the characteristics of the disease. It is not recommended to use the drug without medical prescription for more than 4-5 days.
Overdose
Ambroxol is well tolerated when taken orally at a dose of up to 25 mg/kg/day.
Symptoms:
increased salivation, nausea, vomiting, decreased blood pressure.
Treatment:
gastric lavage in the first 1-2 hours after taking the drug, taking fat-containing foods. Hemodynamic parameters should be monitored. If necessary, symptomatic therapy should be carried out.
Side effect
From the digestive system:
rarely - salivation, gastralgia, nausea, vomiting, diarrhea, constipation.
From the respiratory system:
rarely - dry mouth and respiratory tract, rhinorrhea.
Allergic reactions:
very rarely - skin rash, angioedema of the face, respiratory failure, temperature reaction with chills;
in some cases - contact dermatitis; One case of anaphylactic shock was recorded. Other:
weakness, headache, dysuria, exanthema.
With rapid intravenous administration:
intense headaches, feeling of fatigue and heaviness in the legs, numbness, increased blood pressure, shortness of breath, hyperthermia, chills.
Storage conditions
The solution for oral administration and inhalation should be stored at a temperature not exceeding 25°C.
Best before date
Shelf life: 5 years.
The solution for injection should be stored under normal conditions. Shelf life: 4 years.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - With caution. Restrictions when breastfeeding - With caution. Since to date there is no reliable data on the negative effects of ambroxol on the fetus and newborn, the use of Ambrobene during pregnancy, especially in the first trimester, and during breastfeeding is only possible if there is an expected benefit for the mother outweighs the potential risk to the fetus.
Use for renal impairment
Restrictions for impaired renal function - With caution.
Carefully _
the drug should be used in case of impaired renal function, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under the supervision of a doctor).
Use for liver dysfunction
Restrictions for liver dysfunction - With caution.
Carefully _
The drug should be used for severe liver diseases, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under the supervision of a doctor).
Use in children
Restrictions for children - With caution.
The drug in the form of tablets and injection solution is contraindicated for use in children under 6 years of age. The drug in the form of retard capsules is contraindicated for use in children under 12 years of age.
Treatment
of children under 2 years of age
should be carried out only under the supervision of a physician.
Terms of sale
The drug in the form of a solution for oral administration and inhalation is approved for use as an over-the-counter product.
The drug in the form of an injection solution is available with a prescription.
Contacts for inquiries
TEVA (Israel)
Teva LLC
115054 Moscow Valovaya st. 35 Business Tel.
Contraindications
Despite its harmlessness, Ambrobene has many contraindications. "Ambrobene" in all forms of release is prohibited from taking in the following conditions:
- first trimester of pregnancy;
- hypersensitivity to the active substance and (or) to other components.
Other contraindications depend on the form of release of the medicine. Capsules should not be given to children under 12 years of age. Tablets are prohibited in a number of cases:
- disturbances in the absorption of galactose and glucose - GGM syndrome, malabsorption;
- lactase deficiency;
- lactose intolerance;
- children under 6 years old;
You should not drink syrup if you have the following health problems:
- fructose intolerance;
- GGM syndrome
- malabsorption (intolerance) of sucrose and isomaltose;
Ambrobene should be taken with great caution for many conditions and diseases:
- exacerbation of stomach ulcers and duodenal ulcers;
- serious kidney and liver diseases (it is necessary to reduce the dose of the medicine and increase the time intervals between doses);
- primary ciliary dyskinesia;
- second and third trimester of pregnancy;
- breastfeeding period.
Caution when taking tablets must be strictly observed: do not increase the dose without the doctor's permission and do not take the drug too often.
Buy Ambrobene solution for internal use and for inhalation 7.5 mg/ml 40 ml in pharmacies
Trade name:
Ambrobene
International nonproprietary or chemical name:
ambroxol
Dosage form:
solution for oral administration and inhalation, 7.5 mg/ml
Composition 100 ml of the drug contains:
active ingredient: ambroxol hydrochloride 0.750 g;
excipients: potassium sorbate 0.100 g, hydrochloric acid (25%) 0.060 g, purified water 99.190 g.
Description
A clear, colorless to slightly yellowish-brown solution.
Pharmacotherapeutic group:
mucolytic expectorant.
pharmachologic effect
Pharmacodynamics.
Ambroxol is a benzylamine metabolite of bromhexine. It differs from bromhexine in the absence of a methyl group and the presence of a hydroxyl group in the para-trans position of the cyclohexyl ring. It has secretomotor, secretolytic and expectorant effects.
After oral administration, the effect occurs within 30 minutes and lasts for 6-12 hours (depending on the dose taken).
Preclinical studies have shown that ambroxol stimulates the serous cells of the glands of the bronchial mucosa. By activating ciliated epithelial cells and reducing the viscosity of sputum, ambroxol improves mucociliary transport.
Ambroxol activates the formation of surfactant, having a direct effect on type 2 alveolar pneumocytes and Clara cells of the small airways.
Studies on cell cultures and in vivo studies on animals have shown that ambroxol stimulates the formation and secretion of a substance (surfactant) active on the surface of the alveoli and bronchi of the embryo and adult.
Also, preclinical studies have proven the antioxidant effect of ambroxol. Ambroxol, when used together with antibiotics (amoxicillin, cefuroxime, erythromycin, doxycycline), increases their concentration in sputum and bronchial secretions.
Pharmacokinetics.
When taken orally, ambroxol is almost completely absorbed from the gastrointestinal tract. The maximum concentration is reached 1-3 hours after oral administration. Due to first-pass metabolism, the absolute bioavailability of ambroxol after oral administration is reduced by approximately ⅓. The resulting metabolites (such as dibromanthranilic acid, glucuronides) are eliminated in the kidneys. Plasma protein binding is about 85% (80-90%). The plasma half-life ranges from 7 to 12 hours. The total half-life of ambroxol and its metabolites is approximately 22 hours.
It is excreted mainly by the kidneys in the form of metabolites - 90%, less than 10% is excreted unchanged.
Given the high binding to plasma proteins, large volume of distribution and slow redistribution from tissues to blood, significant elimination of ambroxol does not occur during dialysis or forced diuresis.
In patients with severe liver disease, the clearance of ambroxol is reduced by 20-40%. In patients with severe renal impairment, the half-life of ambroxol metabolites increases.
Ambroxol penetrates into the cerebrospinal fluid and through the placental barrier, and is also excreted into breast milk.
Indications for use
Acute and chronic diseases of the respiratory tract, accompanied by impaired formation and discharge of sputum.
Contraindications
Hypersensitivity to ambroxol or one of the excipients; pregnancy (first trimester).
Carefully
Impaired bronchial motor function and increased sputum production (with fixed cilia syndrome), peptic ulcer of the stomach and duodenum during an exacerbation, pregnancy (II-III trimester), breastfeeding period.
Patients with impaired renal function or severe liver disease should take Ambrobene with extreme caution, observing long intervals between doses or taking the drug in a lower dose.
Use during pregnancy and breastfeeding
Pregnancy. There is insufficient data regarding the use of ambroxol during pregnancy. In particular, this applies to the first 28 weeks of pregnancy. Animal studies have not revealed a teratogenic effect.
The use of Ambrobene during pregnancy (II-III trimester) is possible only as prescribed by a doctor, after a thorough assessment of the risk/benefit ratio.
Breastfeeding period. Animal studies have shown that ambroxol passes into breast milk. Due to insufficient study of the use of the drug in women during breastfeeding, the use of Ambrobene is possible only as prescribed by a doctor, after a thorough assessment of the risk/benefit ratio.
Directions for use and doses
Use of the drug internally
The drug is taken orally after meals, adding to water, juice or tea using the supplied measuring cup.
Children under 2 years of age should take 1 ml of the drug 2 times a day (15 mg ambroxol per day).
Children from 2 to 6 years old should take 1 ml of the drug 3 times a day (22.5 mg ambroxol per day).
Children from 6 to 12 years old should take 2 ml of the drug 2-3 times a day (30 - 45 mg ambroxol per day).
Adults and children over 12 years of age should take 4 ml of the drug 3 times a day (90 mg ambroxol per day) in the first 2-3 days of treatment. If therapy is ineffective, adults can increase the dose to 8 ml of the drug 2 times a day (120 mg ambroxol per day). In the following days, you should take 4 ml of the drug 2 times a day (60 mg ambroxol per day).
Use of the drug in the form of inhalations
When using the drug Ambrobene in the form of inhalations, you can use any modern equipment (except for steam inhalers). Before inhalation, the drug is mixed with a 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a 1:1 ratio) and heated to body temperature. Since during inhalation therapy, a deep breath can provoke coughing impulses, inhalations should be carried out in normal breathing mode. Patients with bronchial asthma can be recommended to carry out inhalation after taking bronchodilator drugs.
For inhalation, the following dosages are used (1 ml of solution contains 7.5 mg of ambroxol):
children under 2 years of age: 1 ml of solution 1-2 times a day (7.5-15 mg ambroxol per day);
children from 2 to 6 years: 2 ml of solution 1-2 times a day (15-30 mg ambroxol per day);
children over 6 years of age and adults: 2-3 ml of solution 1-2 times a day (15-45 mg ambroxol per day).
The duration of treatment is selected individually depending on the course of the disease. It is not recommended to take Ambrobene for more than 4-5 days without a doctor's prescription.
The mucolytic effect of the drug occurs when taking large amounts of fluid, so drinking plenty of fluids is recommended during treatment.
Side effect
The incidence of side effects is classified according to the recommendations of the World Health Organization: very often - at least 10%; often – at least 1%, but less than 10%; infrequently - at least 0.1%, but less than 1%; rarely - not less than 0.01%, but less than 0.1%; very rarely - less than 0.01%.
From the immune system: uncommon - hypersensitivity reaction, frequency not established - anaphylactic reactions, including rash, itching, urticaria, angioedema, anaphylactic shock.
From the nervous system: often - impaired taste perception.
From the gastrointestinal tract: often – nausea; uncommon – dryness of the mucous membrane of the mouth and throat, vomiting, dyspepsia, abdominal pain, diarrhea.
Overdose
Symptoms There were no signs of intoxication with an overdose of ambroxol. There are reports of nervous agitation and diarrhea.
Ambroxol is well tolerated when taken orally at doses up to 25 mg/kg/day.
In case of severe overdose, increased salivation, nausea, vomiting, and decreased blood pressure are possible.
Treatment. Intensive therapy methods, such as inducing vomiting and gastric lavage, should be used only in cases of severe overdose, in the first 1-2 hours after taking the drug. Symptomatic treatment is indicated.
Interaction with other drugs
With the simultaneous use of ambroxol and antitussives, stagnation of secretions may occur due to suppression of the cough reflex. Such combinations should be selected with caution.
When ambroxol is taken together with the antibiotics amoxicillin, cefuroxime, erythromycin and doxycycline, the concentration of the latter in sputum and bronchial secretions increases.
special instructions
It should not be combined with antitussive drugs that impede the removal of sputum.
In children under 2 years of age, the drug can only be used as prescribed by a doctor. Severe skin reactions, such as Stevens-Johnson syndrome and Lyell's syndrome, have been observed extremely rarely with the use of ambroxol. If there is a change in the skin or mucous membranes, you must immediately consult a doctor and stop taking the drug.
Impact on the ability to drive vehicles and machinery
There have been no studies on the effect of Ambrobene on the ability to drive vehicles and operate machinery. If side effects develop, caution should be exercised when performing actions that require increased concentration and speed of psychomotor reactions.
Release form
Solution for oral administration and inhalation 7.5 mg/ml.
40 or 100 ml of the drug in a dark glass bottle, sealed with a dropper stopper and a plastic screw cap. One bottle with instructions for use and a measuring cup is placed in a cardboard box, on which protective stickers can additionally be applied.
Storage conditions
Store at a temperature not exceeding 25 ºС.
Keep out of the reach of children!
Best before date
5 years.
After opening the bottle, the drug is suitable for use for 1 year.
Do not use after the expiration date.
Vacation conditions
Available without a prescription.
Overdose symptoms
Cases of Ambrobene poisoning due to overdose have not been recorded. If the dose is sharply exceeded, diarrhea and restlessness may occur. The maximum daily dose should not exceed 25 mg per 1 kg of human weight.
Signs of a severe overdose:
- decrease in pressure;
- vomiting and nausea;
- increased salivation.
If these symptoms appear, then in the first 1–2 hours after taking the medicine, the patient should rinse the stomach.
