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Hilak forte

Hilak ® forte

(lat.
Hylak® forte
) is an antidiarrheal drug. Available in the form of drops for oral administration in dropper bottles of 30 or 100 ml.

Composition of the drug Hilak forte

The active substance of
Hilaka forte is an embryoless aqueous substrate of metabolic products of the following bacteria, containing, in terms of 100 ml:

Escherichia coli ( Escherichia coli
) DSM 4087 - 24.9481 g
Enterococcus faecium
DSM 4086 - 12.4741 g
lactobacilli acidophilus ( Lactobacillus acidophilus
) DSM 4149 - 12.4741 g
Lactobacillus helveticus ( Lactobacillus helveticus
) DSM 4183 - 49.8960 g

Excipients
: lactic acid 90%, sodium phosphate, potassium phosphate, phosphoric acid 85%, citric acid monohydrate, potassium sorbate.

Pharmacological action of the drug Hilak forte

Hilak forte helps to establish stomach acidity within the physiological norm.
Using biosynthetic lactic acid in an enriched buffer system, a shift in acidity to physiological values for a given section of the intestine is achieved, which creates unfavorable conditions for pathogenic and opportunistic bacteria. The products of bacterial biosynthesis contained in Hilak Fort help maintain the physiological function of the intestinal mucosa. Due to the antagonistic effect against pathogenic and accelerated growth of normal intestinal microflora, the composition of the intestinal microflora is normalized, which is achieved due to the metabolic products of gram-positive and gram-negative obligate intestinal microorganisms contained. Lactic acid and metabolic products of antagonist microorganisms help maintain the sterility of the stomach and upper parts of the small intestine. Hilak Forte promotes the rapid restoration of optimal intestinal flora, disturbed during the use of sulfonamides, antibiotics and other antimicrobial drugs. Hilak forte, due to the growth of acidophilic anaerobic intestinal flora, reduces the period of elimination of Salmonella after Salmonella enteritis. The metabolic products of natural intestinal bacteria contained in Hilak Forte regulate the balance of the intestinal microbiota, normalizes its composition, contributes to the restoration of normal intestinal microflora and allows maintaining the physiological and biological functions of the intestinal mucosa. The acids and their salts included in Hilak Forte restore normal acidity in the intestines, regardless of the patient’s acidity level, thereby helping to destroy harmful microorganisms.

Against the background of accelerating the development of friendly intestinal microflora under the influence of Hilak forte, the natural synthesis of vitamins B and K is normalized. The short-chain volatile fatty acids contained in the preparation ensure the restoration of damaged intestinal microflora in infectious diseases of the gastrointestinal tract, stimulate the regeneration of epithelial cells of the intestinal wall, and restore disturbed water-electrolyte balance in the intestinal lumen.

When using Hilak forte, there is an acceleration of the elimination of Salmonella in infants after Salmonella enteritis, which is due to stimulation of the growth of acidophilic anaerobic flora and its subsequent antagonistic effect on Salmonella.

Professional medical publications addressing the use of the drug Hilak Forte in the treatment of the gastrointestinal tract

Shcherbakov P.L. Issues in pediatric gastroenterology.
Kulikova L.E., Pogorelsky I.P., Mokretsova I.M., Chicherin I.Yu. Characteristics of the antibacterial activity of the biocomplexes “Normoflorins” and the probiotic of the metabolite type Hilak forte against microorganisms isolated from the oral cavity // Eurasian Union of Scientists. 2014. VIII. pp. 126–129.

On the website in the literature catalog there is a section “Probiotics, prebiotics, synbiotics, symbiotics”, containing articles on the treatment of diseases of the gastrointestinal tract with probiotics, prebiotics and synbiotics.

Indications for use of the drug Hilak forte

disturbances of the physiological intestinal microflora (during and after treatment with antibiotics, sulfonamides, radiation therapy);
digestive insufficiency syndrome, dyspepsia;
diarrhea, flatulence, constipation;
gastroenteritis, colitis;
senile intestinal syndrome (chronic, atrophic gastroenteritis);
gastrointestinal disorders caused by climate change;
hypo- and anacid states;
enterogenous diseases of the gallbladder and liver;
allergic skin diseases (urticaria, endogenously caused chronic eczema);
salmonellosis in the convalescent stage (including in infants).

Dosage regimen Hilak forte:

For adults, the drug is prescribed 40-60 drops 3 times a day;
children - 20-40 drops 3 times a day;
infants - 15-30 drops 3 times a day.

After the condition improves, the initial daily dose of Hilak Forte can be reduced by half. The drug is taken orally before or during meals, diluted in a small amount of liquid, excluding milk.

Side effects of Hilak forte:

From the digestive system: constipation, diarrhea are possible.
Allergic reactions: possible skin rash, itching, urticaria.

Contraindications to the use of the drug Hilak forte

Hypersensitivity to the components of the drug.
Use of the drug Hilak forte during pregnancy and breastfeeding.

The use of Hilak Forte during pregnancy and lactation (breastfeeding) is considered safe.
The decision to prescribe the drug is made by the doctor. Special instructions.
It is not recommended to take the drug simultaneously with milk and dairy products.

Overdose.

No special measures are required other than routine medical supervision.

Drug interactions.

When used simultaneously with antacids, it is possible to neutralize lactic acid, which is part of the drug Hilak Forte.

Hilak forte is an over-the-counter product.

According to the pharmacological index, Hilak forte belongs to the group “Medicines that normalize intestinal microflora”. For ATC - to the group “Antidiarrheal microorganisms”, code A07FA.

Manufacturer: Merckle GmbH (Merckle, GmbH), Germany. Back to section

Hilak Forte drops for internal use sachet 1.1ml No. 30

Compound

Active substances:

100 ml
aqueous substrate of metabolic products of Escherichia coli DSM 4087*	24.9481 g
aqueous substrate of metabolic products Enterococcus faecalis DSM 4086*	12.4741 g
aqueous substrate of metabolic products Lactobacillus acidophilus DSM 4149*	12.4741 g
aqueous substrate of metabolic products Lactobacillus helveticus DSM 4183*	49.896 g

*substrates contain lactose.

Excipients: sodium phosphate heptahydrate - 1.159 g, dipotassium phosphate - 1.265 g, lactic acid - 2.5-6.25 g, concentrated phosphoric acid - 0.352 g, potassium sorbate - 0.1114 g, citric acid monohydrate - 0.0322 g, water - up to 100 ml.

Indications for use

Disorders of the physiological flora of the small and large intestines (during and after treatment with antibiotics or sulfonamides, radiation therapy);
digestive insufficiency syndrome, dyspepsia;
diarrhea, flatulence, constipation;
gastroenteritis, colitis;
senile intestinal syndrome (chronic, atrophic gastroenteritis);
gastrointestinal disorders caused by climate change;
hypo- and anacid states;
enterogenous diseases of the gallbladder and liver;
allergic skin diseases (urticaria, endogenously caused chronic eczema);
salmonellosis in the convalescent stage (including in infants).

Contraindications

Hypersensitivity to the components of the drug;
lactase/isomaltase deficiency, lactose intolerance, glucose-galactose malabsorption.

Directions for use and doses

Hilak forte is taken orally before or during meals, diluted in a small amount of liquid, excluding milk.

The drug is prescribed 3 times a day.

For adults, the drug is prescribed 40-60 drops (2.2-3.3 ml) per dose; children - 20-40 drops (1.1-2.2 ml) per dose; infants - 15-30 drops per dose.

In infants, it is recommended to use the drug in vials.

After the condition improves, the daily dose can be reduced by half.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Best before date

4 years. After opening the bottle - 6 weeks. Do not use after the expiration date indicated on the package.

special instructions

It is not recommended to take this drug simultaneously with milk and dairy products.

Description

A drug that regulates the balance of intestinal microflora.

Use in children

For children, the drug is prescribed 20-40 drops 3 times a day; infants - 15-30 drops 3 times a day. After the condition improves, the initial daily dose of Hilak Forte can be reduced by half.

Pharmacodynamics

The natural physiological intestinal microflora can be significantly disrupted by external influences such as antibiotic therapy, radiation, gastric surgery, as well as due to inappropriate or unusual nutrition, changes in water, climate change and other conditions.
Hilak forte regulates the balance of intestinal microflora and normalizes its composition. Due to the content of metabolic products of normal microflora in Hilak Forte, the drug helps restore normal intestinal microflora biologically and allows you to preserve the physiological and biological functions of the intestinal mucosa.

The biosynthetic lactic acid and its buffer salts included in Hilak Forte restore the normal acidity value in the gastrointestinal tract, regardless of whether the patient suffers from high or low acidity.

Against the background of accelerating the development of normal intestinal symbionts, under the influence of Hilak Forte, the natural synthesis of vitamins B and K is normalized. The short-chain volatile fatty acids contained in Hilak Forte ensure the restoration of damaged intestinal microflora in infectious diseases of the gastrointestinal tract, stimulate the regeneration of epithelial cells of the intestinal wall, restore impaired water and electrolyte balance in the intestinal lumen.

There is evidence that Hilak forte enhances the body's protective functions by stimulating the immune response.

When using Hilak forte, there is an acceleration of the elimination of Salmonella in infants after Salmonella enteritis, which is due to stimulation of the growth of acidophilic anaerobic intestinal flora and its subsequent antagonistic effect on Salmonella.

Side effects

No adverse reactions have been observed to date.

From the digestive system: constipation, diarrhea are possible.

Allergic reactions: possible skin rash, itching, urticaria.

Hilak Forte is well tolerated by patients of any age.

Use during pregnancy and breastfeeding

The use of Hilak Forte during pregnancy and lactation is considered safe. However, the decision to prescribe the drug is made by the attending physician.

Interaction

Under the influence of antacids, it is possible to neutralize lactic acid, which is part of the drug Hilak Forte.

Overdose

No special measures are required other than routine medical supervision.

Impact on the ability to drive vehicles and operate machinery

The drug does not affect the ability to drive or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.