Compound
benzydamine hydrochloride as an active substance , as well as the following additional components: sodium chloride, trimethylacetylammonium-p-toluenesulfonate, povidone.
The vaginal solution contains benzydamine hydrochloride , as well as the following additional components: ethyl alcohol 96, purified water, trimethylacetylammonium para-toluene sulfonate, polysorbate 20, rose oil.
Side effects
Cases of adverse reactions during treatment or prevention are quite rare. They manifest themselves mainly as local allergic symptoms: rashes, redness of the mucous membranes, their swelling, itching.
Using the solution for too long can cause a feeling of dry mouth, as the active substance penetrates into the bloodstream. You should stop treatment and consult your supervising physician. He will replace Tantum Rosa with its current analogue and prescribe medications to eliminate all signs of an allergic reaction. Some side effects are reversible and disappear after reducing dosages.
Pharmacodynamics and pharmacokinetics
The medicine belongs to the group of indazoles . This is a remedy that has anti-inflammatory, decongestant, antibacterial, antiseptic, antifungal and analgesic effects.
The active substance of the drug stabilizes cell membranes and inhibits the synthesis of prostaglandins . It also helps restore the integrity of the vaginal epithelium and contributes to its resistance to pathogenic effects .
The antibacterial effect is due to the rapid penetration of microorganisms through the outer membranes, destruction of their cellular structures and disruption of metabolic processes .
When used topically, it is well absorbed through the mucous membranes and penetrates into inflamed tissues. It is excreted primarily through the kidneys and intestines in the form of conjugation products or metabolites .
Operating principle
The therapeutic effect of the drug is based on the pharmacological effects of benzydamine. It inhibits enzymes that trigger the production of pro-inflammatory mediators from arachidonic acids. Reducing the production of prostaglandins and leukotrienes leads to relief of inflammatory processes and prevents their spread to healthy tissue. At the same time, the severity of pain and local temperature decrease, and swelling of the mucous membranes begins to resolve.
The active substance is characterized by antibacterial, antimicrobial, antifungal and antiseptic properties. After its penetration into the cells of pathogenic microorganisms, their structures are damaged and metabolic processes are disrupted. Bacteria are no longer able to reproduce, so the population quickly decreases, and the size of infectious and inflammatory foci decreases.
Opportunistic Candida fungi, which become more active when immunity decreases, have not lost sensitivity to the antifungal effect of benzydamine. It not only disrupts the construction of their cell membranes, making them easily permeable to intercellular fluid. The active substance of the drug directly blocks the reproduction of fungi, which explains its high demand in the treatment of infectious and inflammatory pathologies.
Indications for use
The medicine is used for:
- inflammatory diseases of the cervix, vulva and vagina;
- after radiotherapy ;
- fungal and trichomonas infections ;
- the need to prevent infectious complications in postpartum women;
- the need to accelerate reparative processes after childbirth;
- postpartum infections ( vulvitis , vaginitis and vulvovaginitis , etc.);
- the need to prevent post- and preoperative complications in surgical gynecology;
- inflammatory processes in the area of the uterine pharynx.
In addition, Tantum Rose is used after chemotherapy for tumors.
Indications for treatment
The drug is used after delivery for the timely relief of infectious and inflammatory processes that have developed as a result of trauma to the birth canal. And also to prevent potential complications during this period. The drug is prescribed by doctors to women with the following pathological conditions of the urogenital tract:
- specific vulvovaginitis (in combination with other drugs);
- nonspecific vulvovaginitis and cervicovaginitis of any origin, including those provoked by chemotherapy and radiotherapy;
- bacterial vaginosis.
The drug is used during recovery after gynecological surgery. It is included in therapeutic regimens both to eliminate painful sensations and to prevent the development of infectious complications.
Instructions for use Tantum Roses (Method and dosage)
The instructions for Tantum Rose indicate that douching takes place in a lying position. For a single procedure, use 140 ml. The liquid should remain in the vagina for several minutes.
For those who purchased Tantum Rose powder, the instructions for use indicate that the contents of the sachet should be dissolved in 500 ml of water. How to use the solution depends on the nature of the disease:
- for bacterial vaginosis, you need to use the medicine 1-2 times a day. The course is designed for 7-10 days;
- for the purpose of preventing post- and preoperative complications in surgical gynecology, as well as as a hygienic means after childbirth, douching is performed once a day. The course lasts 3-5 days;
- for vulvovaginitis and cervicovaginitis, the medicine is used 2 times a day. The course lasts 10 days.
The instructions do not indicate how to open the bottle. However, this point is difficult for many. Those who have already tried this product advise, first of all, to open the pink lid upwards, then pull the white pin all the way.
Release forms and composition
The drug is produced by the Italian pharmaceutical company Angelini Francesco.
It is produced in the form of a clear, colorless liquid with a specific odor. The solution is in plastic bottles with screw caps, equipped with devices for convenient dosing of the product and its intravaginal use. The active composition of the drug is represented by benzydamine from the clinical-pharmacological group of non-steroidal anti-inflammatory drugs. To form the auxiliary, the manufacturer used the following substances:
- benzalkonium chloride;
- disodium edetate;
- ethyl alcohol;
- polysorbate;
- natural oil;
- purified water.
These ingredients contribute to the rapid penetration of the active substance into inflammatory foci and the manifestation of pharmacological effects. Tantum Rose is also available in powder form, consisting of white, homogeneous granules without foreign inclusions in paper bags. In addition to benzydamine, its composition is represented by the following components:
- trimethylcetylammonium paratoluenesulfonate;
- sodium chloride;
- povidone.
Secondary packaging for all dosage forms is a cardboard box with detailed instructions for use inside.
Reviews of Tantum Rose
Reviews about Tantum Rose on the Internet can be found very contradictory. Someone was prescribed this drug by a doctor, and the medicine helped, while others did not even dare to use it because of the inconvenience of use. It is precisely because of the last factor that many women still try to buy analogues. Also, experts do not recommend using this remedy during pregnancy, but there are no direct contraindications to this.
In general, there are practically no categorical negative reviews about Tantum Rose, so this product is popular.
List of restrictions
This is one of the safest drugs used in gynecological practice. He has only one contraindication to therapy. This is an individual intolerance to the active substance or one of the auxiliary components.
The drug is prescribed by doctors to patients with any concomitant pathologies. Liver or kidney diseases, pregnancy and breastfeeding are not contraindications to therapy. But preliminary consultation with a doctor is necessary.
Adolescence and childhood are not included in the list of contraindications to the use of the solution. It does not contain components that are toxic to the child's body. If necessary, the use of the drug in pediatric practice is permitted in doses carefully calculated by the doctor.
Price Tantum Roses, where to buy
The price of Tantum Rose solution is usually about 700 rubles. Although in some places you can find this product at a much lower cost.
The price of Tantum Roses in powder form is also much lower - approximately 330 rubles. However, when using it, you need to spend time preparing the solution. So many women still prefer to buy a ready-made douche, despite the fact that the price of Tantum Rose in this case is noticeably higher.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Tantum Rose powder for vaginal preg solution.
500 mg 10 pcs.Angelini Francesco RUR 427 order
Pharmacy Dialogue
- Tantum Rose 140ml No.5Angelini Francesco SpA
1045 rub. order
- Tantum Rose sachets 0.5g No. 10Angelini Francesco SpA
RUR 442 order
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Overdose
Intravaginal use of the drug, even in high doses or too frequent use, does not cause an overdose. No such cases have been observed in clinical practice. Theoretically, the pathological condition is possible due to accidental ingestion of the solution. It will manifest itself as severe gastrointestinal disorders.
After taking a large amount of solution, after which your health worsens, you need to induce vomiting, take activated charcoal and consult a doctor. It may be necessary to use medications to relieve discomfort.
Interaction
In gynecological practice, there have been no cases of interaction of benzydamine with the ingredients of local products. But doctors recommend maintaining a 20-minute interval between applying it and antiseptic drugs, regeneration stimulants, local antibiotics and antimycotics. If a doctor prescribes douching by other means, then the treatment procedure should be carried out an hour after irrigation with Tantum Rose. You cannot use drugs with it whose active composition is the same active substance.
Pharmacodynamics
It has anti-inflammatory and local analgesic effects, has antibacterial, antifungal and antiseptic effects. The mechanism of action of the drug is associated with the stabilization of cell membranes and inhibition of PG synthesis.
Benzidamine has an antibacterial and specific antimicrobial effect due to rapid penetration through the membranes of microorganisms with subsequent damage to cellular structures, disruption of metabolic processes and cell lysosomes.
Has antifungal effect against Candida albicans. Causes structural modifications of the cell wall of fungi and their metabolic chains, thus preventing their reproduction, which was the basis for the use of benzydamine in inflammatory processes, including infectious etiology.
Recommendations
It is advisable to pre-test the drug. To do this, rub a little solution into the elbow bend. There is no hypersensitivity if the skin does not turn red or swell within 30-40 minutes.
If the solution gets into your eyes, rinse them with plenty of running water. Severe burning and redness of the conjunctiva requires consultation with a doctor.
During treatment you do not need to stop driving vehicles. It is also acceptable to perform work that requires special concentration and increased reaction speed.
It is advisable to avoid drinking alcohol. Ethyl alcohol upsets metabolic processes, which can negatively affect the speed of recovery.
