Advil (Advil) American tablets. Instructions for use, price, reviews

Release forms and composition of the drug

The medicine is produced in the form of effervescent soluble tablets. Their main active ingredient is ibuprofen.

Additional components:

• 0.3 g potassium carbonate;
• 0.01 g anhydrous sodium carbonate;
• 0.33 g citric acid;
• 0.29 g monosodium citrate;
• 1.34 g sodium bicarbonate;
• 0.04 g sodium saccharinate;
• 0.01 g sucrose palminate;
• 0.01 g menthol flavoring;
• 0.04 g flavoring (grapefruit flavor);
• magnesium stearate – until the capsule weight is 2.8 g.

The product is packaged in aluminum strips and packaged in cardboard boxes.

Pharmacological properties

The medicine is a derivative of phenypropionic acid. It belongs to the class of non-steroidal anti-inflammatory drugs (NSAIDs). The action of the components of the drug is aimed at suppressing and inhibiting the production of cyclooxygenase. The enzyme is a precursor of prostaglandins and is involved in the development of inflammatory reactions, pain and fever.

The analgesic effect is achieved by inhibiting the synthesis of prostaglandins in the central nervous system. In this case, a decrease in platelet aggregation is observed. The main components eliminate signs of joint stiffness and increase motor function in the joints.

Patient reviews

Of course, it is important to find out not only how the drug Advil is positioned in the instructions for use. Reviews from people who have tested the product themselves are also of great interest.

Patients' opinions were divided. Some argue that the medicine is ineffective. Others, on the contrary, indicate the high ability of the drug to quickly relieve unpleasant pain. Parents of children confirm the excellent antipyretic properties of the drug.

But, unfortunately, a certain category of people also notes the occurrence of side effects. Most often, unpleasant symptoms affect the gastrointestinal tract. However, patients notice that, compared to other NSAIDs, adverse reactions are much less common.

Pharmacodynamics and pharmacokinetics

When administered orally, the active component of the drug is almost completely absorbed from the gastrointestinal tract. In this case, there is a decrease in absorption capacity while eating food.

The main substance is metabolized mainly in the liver - about 90%. The half-life of metabolites is 2-3 hours. Approximately, about 80% of the dosage of the drug is excreted in the urine in the form of metabolites. About 10% of the components are excreted from the body unchanged. 20% of the drug dosage is excreted through the intestines in the form of metabolites.

Interaction

Cholestyramine causes a moderate decrease in the absorption of ibuprofen. Acetylsalicylic acid reduces the concentration of ibuprofen in the blood.

When used with GCS, the risk of adverse reactions from the gastrointestinal tract increases.

Advil tablets, when used together with Warfarin, cause an increase in bleeding time, microhematuria, and the appearance of hematomas; with Baclofen - an increase in its toxic effect.

When used simultaneously with Captopril, Amlodipine and diuretics, their hypotensive effect is slightly reduced.

When used simultaneously with Methotrexate, its toxicity also increases.

When used with lithium, its concentration in the blood increases.

Ibuprofen displaces oral hypoglycemic drugs, indirect anticoagulants, and phenytoin from compounds with proteins.

Indications for use

Advil is an American tablet that is often prescribed as part of a complex treatment of degenerative and inflammatory processes in the joints.

Indications:

• rheumatoid arthritis;
• rheumatoid arthritis;
• presence of osteoarthritis;
• relapses of gout accompanied by joint disorders;
• bursitis;
• radiculitis;
• ankylosing type of spondylitis;
• development of tendinitis;

• inflammatory processes in the area of ​​soft tissues and the musculoskeletal system caused by various injuries.

The medication is also used in the treatment of infectious and inflammatory processes in the ENT organs: adnexitis, algodismenorrhea, pain syndrome. The drug exhibits a therapeutic effect against headaches, toothaches, and feverish conditions caused by infectious and inflammatory processes.

Artelar forte, 90 pcs., film-coated tablets

"Artelar Forte" is a dietary supplement that includes a number of components of natural origin that help support joints and cartilage tissue.

COMPONENTS OF THE COMPLEX:

Glucosamine (an organic compound found in cartilage): promotes the formation of the cartilage matrix; helps maintain joint fluid volumes; has a positive effect on calcium deposition in bones; favors metabolic processes in cartilage cells; is included in the structure of glycosaminoglycans of the intercellular substance of connective tissue and hyaluron; serves for the formation of chondroitin.

Chondroitin sulfate (the main substance of cartilage proteins): participates in the construction of cartilage tissue; stimulates the production of joint fluid; helps increase collagen production; suppresses the activity of enzymes that negatively affect the connective matrix; affects phosphorus-calcium metabolism in joints.

Vitamin C (ascorbic acid): takes part in collagen synthesis; is an antioxidant - plays an important role in the regulation of redox reactions; involved in processes associated with tissue regeneration; enhances calcium absorption; maintains capillary permeability.

Methylsulfonylmethane (organosulfur compound): contains sulfur in a bioavailable form, which is part of proteins, promotes the formation of bones, ligaments, muscles; helps reduce discomfort in the joints; influences the strength and elasticity of ligaments; activates the formation of immunoglobulins; promotes cell renewal, the membranes of which begin to transmit nutrients more intensively.

With age, the level of methylsulfonylmethane in the body decreases.

Sodium hyaluronate (hyaluronic acid): the main component of the synovial fluid of cartilage, responsible for its viscosity; helps reduce the excitability of nerve endings inside the joint; activates the production of chondroitin sulfate, prevents its loss by the intercellular substance in the joint; supports nutrition of cartilage tissue; has a beneficial effect on the functional state of cartilage cells - chondrocytes.

Boswellia extract (a plant that produces a special type of resin) Boswellic acid prevents the penetration of leukocytes and macrophages into cartilage and joint fluid, blocks the formation of leukotrienes, which can exhibit spasmogenic activity.

Boswellia resin helps relieve joint discomfort.

Promotes increased blood microcirculation.

Manganese (manganese sulfate): takes part in the formation of connective and bone tissue; necessary for the functioning of enzymes involved in the biosynthesis of chondroitin, acts as an “activator” in the process of formation of glycosaminoglycans.

These two properties of manganese are unique: they are not shared by other micro- and macroelements.

Selenium (sodium selenite): is involved in tissue respiration processes; as an antioxidant it is able to reduce damage to cell membranes and reduce lipid peroxidation; supports the functions of selenium-containing enzymes; exhibits anticoagulant activity; Selenium deficiency may be one of the reasons for the development of joint deformities.

Contraindications

The medicine is contraindicated in the presence of hypersensitivity to the main component, as well as during pregnancy (3rd trimester).

Additional contraindications:

• kidney and liver dysfunction;
• disorders in the hematopoietic system;
• lesions in the area of ​​the optic nerve;
• the presence of erosions and ulcers in the gastrointestinal tract during an exacerbation;
• asthmatic triad.

The drug can be prescribed during breastfeeding only with the permission of the treating specialist.

Contraindications of the drug

Advil should not be used if:

• erosive and ulcerative diseases of the gastrointestinal tract;
• hypersensitivity;
• impaired blood clotting (hemophilia, hemorrhagic diathesis);
• bleeding tendency;
• recurrent nasal polyposis, bronchial asthma;
• renal failure in a severe stage;
• liver diseases;
• pregnancy (3rd trimester);
• inflammatory bowel diseases;
• coronary artery bypass grafting.

Instructions for use, dosage of the drug

Advil - American tablets that must be used according to the instructions of a specialist or the recommendations noted in the instructions. The dosage is selected individually according to the established form of the disease and clinical manifestations.

American Advil tablets are very expensive compared to domestic ibuprofen

• When taking capsules orally, a single dosage should not exceed 0.2-0.8 g. Take 3-4 times a day.
• In childhood, the dosage is calculated according to the child’s weight - 20 mg/kg/day several times a day.
• When used externally, the duration of therapy varies between 2-3 weeks.

The maximum permissible dose per day is no more than 2.4 g.

Advil

Dosage form:

dragees, oral drops, capsules, extended-release capsules, syrup, oral suspension, oral suspension [for children], tablets, lozenges, lozenges [lemon], lozenges

Pharmachologic effect:

NSAIDs; has an analgesic, antipyretic and anti-inflammatory effect due to the non-selective blockade of COX1 and COX2 and has an inhibitory effect on the synthesis of Pg. The analgesic effect is most pronounced for inflammatory pain. Like all NSAIDs, ibuprofen exhibits antiplatelet activity.

Indications:

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, juvenile chronic, psoriatic arthritis, osteochondrosis, neuralgic amyotrophy (Personage-Turner disease), arthritis in SLE (as part of complex therapy), gouty arthritis (in case of an acute attack of gout, fast-acting dosage forms are preferred) , ankylosing spondylitis (ankylosing spondylosis). Pain syndrome: myalgia, arthralgia, ossalgia, arthritis, sciatica, migraine, headache (including menstrual syndrome) and toothache, cancer, neuralgia, tendinitis, tendovaginitis, bursitis, neuralgic amyotrophy (Personage-Turner disease) , post-traumatic and postoperative pain syndrome, accompanied by inflammation. Algodismenorrhea, inflammatory process in the pelvis, incl. adnexitis, childbirth (as an analgesic and tocolytic agent). Feverish syndrome with “colds” and infectious diseases.

Contraindications:

Hypersensitivity, erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum in the acute stage, ulcerative colitis, peptic ulcer, Crohn's disease - nonspecific ulcerative colitis), "aspirin" asthma, blood clotting disorders (in including hemophilia, prolongation of bleeding time, bleeding tendency, hemorrhagic diathesis), pregnancy, lactation period. With caution. Cirrhosis of the liver with portal hypertension, hyperbilirubinemia, peptic ulcer of the stomach and duodenum (history), gastritis, enteritis, colitis; liver and/or kidney failure, nephrotic syndrome; CHF, arterial hypertension; blood diseases of unknown etiology (leukopenia and anemia), childhood (for tablet forms - up to 12 years, 6 months - for oral suspension). Children 6-12 months are prescribed only on the recommendation of a doctor.

Side effects:

From the digestive system: NSAID gastropathy (nausea, vomiting, abdominal pain, heartburn, loss of appetite, diarrhea, flatulence, pain and discomfort in the epigastric region), ulceration of the gastrointestinal mucosa (in some cases complicated by perforation and bleeding); irritation, dryness of the oral mucosa or pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis. From the respiratory system: shortness of breath, bronchospasm. From the senses: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma. From the nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases). From the cardiovascular system: development or worsening of heart failure, tachycardia, increased blood pressure. From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis. Allergic reactions: skin rash (usually erythematous, urticaria), skin itching, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome) , eosinophilia, allergic rhinitis. From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia. Other: increased sweating. The risk of developing ulcerations of the gastrointestinal mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia) increases with long-term use in large doses. Overdose. Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, decreased blood pressure, bradycardia, tachycardia, atrial fibrillation, respiratory arrest. Treatment: gastric lavage (only within an hour after administration), activated charcoal, alkaline drinking, forced diuresis, symptomatic therapy (correction of CBS, blood pressure).

Directions for use and dosage:

Inside, after eating. Adults: for osteoarthritis, psoriatic arthritis and ankylosing spondylitis - 400-600 mg 3-4 times a day. For rheumatoid arthritis - 800 mg 3 times a day; for soft tissue injuries, sprains - 1.6-2.4 g/day in several doses. For algodismenorrhea - 400 mg 3-4 times a day; for moderate pain syndrome - 1.2 g/day. For children over 12 years of age, the initial dose is 150-300 mg 3 times a day, the maximum dose is 1 g, then 100 mg 3 times a day; for juvenile rheumatoid arthritis - 30-40 mg/kg/day in several doses. To reduce body temperature 39.2 degrees C and above - 10 mg/kg/day, below 39.2 degrees C - 5 mg/kg/day. Oral suspension - 5-10 mg/kg 3 times a day: children aged 6-12 months (only as prescribed by a doctor) - an average of 50 mg 3-4 times a day, 1-3 years - 100 mg 3 times per day, 4-6 years - 150 mg 3 times a day, 7-9 years - 200 mg 3 times a day, 10-12 years - 300 mg 3 times a day. For febrile syndrome after immunization - 50 mg, if necessary, after 6 hours, repeat administration at the same dose, maximum daily dose - 100 mg.

Special instructions:

During treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine Hb, hematocrit, and a stool test for occult blood. To prevent the development of NSAID gastropathy, it is recommended to combine it with PgE drugs (misoprostol). If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. Patients should refrain from all activities that require increased attention, rapid mental and motor reactions. During the treatment period, ethanol intake is not recommended.

Interaction:

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators (including BMCC and ACE inhibitors), natriuretic and diuretic activity - furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increasing the risk of hemorrhagic complications), ulcerogenic effect with bleeding of MCS and GCS, colchicine, estrogens, ethanol; enhances the effect of oral hypoglycemic drugs and insulin. Antacids and cholestyramine reduce the absorption of ibuprofen. Increases the blood concentration of digoxin, Li+ drugs and methotrexate. Caffeine enhances the analgesic effect. When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effects of ASA (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of ASA as an antiplatelet agent is possible after starting ibuprofen). When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases. Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprothrombinemia. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug. Cyclosporine and Au preparations enhance the effect of ibuprofen on Pg synthesis in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

Side effects

The drug can cause various side effects related to the physiological characteristics of the patient.

Side effects:

• From the digestive system: discomfort in the abdomen, nausea and vomiting, diarrhea, formation of erosions and ulcers in the gastrointestinal tract, bleeding; in rare cases, functional liver disorders may develop.
• From the nervous system: dizziness and headaches, increased excitability, sleep disorders, decreased visual ability.
• From the hematopoietic system: development of anemic syndrome; agranulocytosis, thrombocytopenia.
• From the urogenital tract: functional disorders of the kidneys.
• Allergic signs: rashes, Quincke's edema, spasms in the bronchi, aseptic form of meningitis.
• Local manifestations: possible development of hyperemia, burning sensation and unpleasant tingling.

If reactions develop that are not noted in the instructions, you should consult a specialist.

Side effects

In some cases, Advil may cause completely undesirable symptoms.

Instructions for use warn of side effects:

1. Gastrointestinal tract. Abdominal pain, flatulence, heartburn, diarrhea, and discomfort in the epigastric region may occur. Sometimes ulcerations of the mucous membrane appear. Even bleeding is possible. Patients may experience irritation, dry mouth, ulceration of the gingival mucosa, pancreatitis, and aphthous stomatitis. Some complain of constipation, nausea, indigestion, loss of appetite, and vomiting.
2. Hepato-biliary system. Hepatitis may occur.
3. Respiratory system. Patients sometimes feel short of breath.
4. Hearing impairment. There is ringing and noise in the ears. Sometimes hearing decreases.
5. Nervous system. Insomnia, nervousness, irritability, and anxiety may appear. Sometimes depression, hallucinations, and confusion occur. Sweating increases, headaches, drowsiness, dizziness appear, and mood changes sharply.
6. Cardiac system. Tachycardia may occur and blood pressure may increase. Sometimes heart failure occurs.
7. Urinary system. The development of such unpleasant pathologies as renal failure in the acute stage, allergic nephritis, polyuria, cystitis, nephrotic syndrome is possible.
8. Hematopoiesis. Sometimes patients develop hemolytic anemia, thrombocytopenic purpura, aplastic anemia, agranulocytosis, leukopenia.
9. Allergic reaction. The most common skin rash and itching. Angioedema, anaphylactoid reaction, bronchospasm, fever, anaphylactic shock, and allergic rhinitis may occur.

Overdose

Tablets that exceed the specified dose can cause various negative manifestations. In this regard, it is recommended to strictly adhere to the dosage prescribed by the American manufacturer, specified in the official instructions for Advil.

Symptoms of drug overdose are associated with signs of ibuprofen overdose: nausea and vomiting, drowsiness, dizziness, abdominal pain, low blood pressure, renal and hepatic disorders, acidosis.

In rare cases, a decrease in pressure, confusion or loss of consciousness is observed, respiratory depression is noted, convulsions and hyperkalemia develop.

Drug interactions

The drug reduces the therapeutic effect of diuretics, as well as drugs aimed at treating hypertension. There is an increase in the effect of anticoagulants with simultaneous use of capsules.

The combined use of tablets and glucocorticosteroids leads to the risk of side effects from the gastrointestinal tract. The medication prevents the processes of binding the active substances of drugs belonging to the group of anticoagulants, hypoglycemic agents, and hydantoin derivatives.

Concomitant use with amlodipine leads to a decrease in the therapeutic effectiveness of the antihypertensive drug.

Other interactions:

• Aspirin - decreases the concentration of the active component of Advil.

• Baclofen – toxic effects.
• Warfarin – increased bleeding time, hematoma formation, microhematuria.
• Captopril – decreased antihypertensive activity.
• Metatrexate – increased toxicity.
• Colesteramine – reduces the absorption time of the active component.

Lithium preparations temporarily increase the concentration of the substance in the blood. The level of absorption of ibuprofen increases with simultaneous use of the drug with magnesium hydroxide.

Analogues of the drug

Drugs that share the same active ingredient as Advil:

• "Deblok."
• "Ibuprofen."
• "ArthroCam".
• "Burana".
• "Nurofen".
• "Bonifen."
• "Ibuprom".
• "Faspic".
• "Solpaflex".

If the drug is not suitable for the patient due to sensitivity to the main component, then the doctor can select a replacement from medications that have similar pharmacological effects:

• "Flexen".
• "Artrosilene".
• "Artrum".
• "Bystrumkaps".
• "Khairumat."
• "Ketoprofen".
• "Vimovo".
• "Dexalgin".
• "Naproxen."
• "OKI".
• "Ketonal".
• "Next".
• "Nalgesin".
• "Brustan".

Analogs

Advil are American tablets that have several structural analogues and are often replaced by other drugs that have a similar therapeutic effect.

Before changing the drug, you should consult a specialist.

Advil's analogs

Based on their belonging to the same pharmacological group and similar mechanism of action, the following drugs are analogues of Advil:

• Apo-Ibuprofen;
• No pain;
• Burana;
• Bonifen;
• Ibalgin;
• Brufen and Brufen Retard;
• Bren;
• Dolgit;
• Ibupron;
• Ibuprof;
• Ibusan;
• Ibuprofen;
• Ibutad;
• Ibufen;
• Ibutop;
• Markofen;
• Yprene;
• MIG 200;
• Nurofen;
• Motrin;
• Solpaflex;
• Pro-Final;
• Profen;
• Perofen 200;
• Reumafen.