Veins are blood vessels that carry blood to the heart. In turn, blood is collected in the veins from capillaries. With healthy arteries, the circulatory system works stably. But what happens if problems arise with the veins? Swelling, pain in the legs, slight numbness, goosebumps, heaviness, impaired sensitivity in the form of paresthesia, convulsions, trophic disorders. These signs, repeated day after day, are most likely recognized by the doctor as venous insufficiency.
Excess body weight can lead to varicose veins
Compound
Detralex contains 500 mg of micronized flavonoid fraction (Purified micronized flavonoid fraction), in which diosmin is 90% (450 mg), hesperidin is 10% (50 mg).
Auxiliary components: gelatin, magnesium stearate, MCC, sodium carboxymethyl starch, talc, purified water.
Film shell composition: macrogol 6000, sodium lauryl sulfate, orange-pink premix for p/o (magnesium stearate, glycerol, hypromellose, iron dyes - yellow and red oxides, titanium dioxide).
Pharmacodynamics and pharmacokinetics
It has an angioprotective and venotonic effect, reduces venostasis , venous distensibility and capillary permeability, increases the tone of the venous walls, improves microcirculation and lymphatic drainage. Increases the ability of capillaries to maintain the integrity of the walls under mechanical stress.
The use of the drug Detralex helps to reduce the interaction of leukocytes and endothelium , as well as the adhesion of leukocytes in post-capillary venules, which reduces the severity of the damaging effect of inflammatory mediators on the venous valve leaflets and venous walls.
T½ - 11 o'clock. Excretion of active components is carried out mainly through the intestines. About 14% of the dose taken is excreted by the kidneys.
Composition and therapeutic effect of the drug Detralex
A therapeutic course of venotonic drugs is also prescribed. Detralex is used most often.
It is based on flavonoids - substances of plant origin. The active ingredients are hesperidin and diosmin, which eliminate venostasis (blood stagnation).
Detralex restores and increases the tone of venous walls and blood microcirculation in small vessels. Capillaries become elastic and plastic, their permeability decreases. The medicine reduces the distensibility of the veins, which reduces the release of plasma and proteins from the bloodstream into the surrounding tissues.
Detralex has an angioprotective and venotonic effect.
In addition, the drug Detralex increases the outflow of lymph, thereby providing lymphatic drainage.
Indications for use of Detralex
When are vein pills prescribed?
Indications for the use of Detralex are organic and functional venolymphatic insufficiency of the lower extremities , which is manifested by swelling and pain, a feeling of heaviness in the legs, trophic disorders, and convulsions.
When is the drug used as a pill for hemorrhoids?
The use of the drug Detralex is indicated for the symptomatic treatment of acute hemorrhoidal attack .
Additionally
For both varicose veins and hemorrhoids the drug is used as a symptomatic remedy and often as part of complex therapy.
To reduce the severity of symptoms of venous insufficiency, a venotonic ointment or gel can be prescribed along with tablets.
In the treatment of hemorrhoids Relief , Proctosan , Nigepan , etc.) and ointments ( Ichthyol , Hepatrombin , Bezornil , etc.) can be used to relieve pain and inflammation, improve vascular tone, reduce thrombosis and stop bleeding
Indications
Indications for the use of the drug Detralex are organic and functional venous-lymphatic insufficiency of the lower extremities. Detralex is also used for the symptomatic treatment of acute hemorrhoidal attacks.
The medicine Detralex can be used for tired legs
Detralex is indicated for:
- pain;
- cramps of the lower extremities;
- feeling of heaviness and fullness in the legs;
- "fatigue" in the legs.
- swelling of the lower extremities;
- trophic changes in the skin and subcutaneous tissue;
- venous trophic ulcers.
Side effects
Side effects of Detralex are extremely rare. Most often the body reacts to treatment with dyspeptic disorders ( nausea , diarrhea , etc.), sometimes neurovegetative disorders (malaise, headache , dizziness , etc.) and disorders of the subcutaneous tissue and skin ( urticaria , skin rashes) , itching).
In extremely rare cases, angioedema .
Contraindications and adverse reactions
The medicine has practically no contraindications. You should avoid taking it if you are allergic to any of the ingredients.
Negative effects from taking appear in extremely rare cases. They usually present with nausea and stomach upset. Sometimes dizziness, headache, and deterioration in general health may occur. An allergy may appear in the form of a skin rash.
To date, there have been no cases of drug overdose. In the chronic stage of the disease, experts usually advise taking the medicine in courses of 2-3 months. In case of acute form, take in weekly courses.
If after this time the symptoms have not disappeared, the patient should schedule an examination with a specialist.
Detralex tablets, instructions for use
Instructions for use of Detralex for varicose veins
For venolymphatic insufficiency, the recommended dose is 2 tablets. 500 g per day. The tablets are taken with meals, one in the daytime, the second in the evening.
The medicine is prescribed only to adult patients. To enhance the effect, the doctor may also recommend using external therapy - ointment or gel.
The duration of treatment with Detralex for varicose veins , as well as the need for repeated courses, is determined by the doctor.
Detralex for hemorrhoids. How long to take pills for hemorrhoids?
The description attached to the drug on how to take Detralex for hemorrhoids states that in the acute stage of the disease (during an acute hemorrhoidal attack ) it is necessary to take 6 tablets per day. during the first 4 days of treatment and 4 tablets/day. in the next 3 days. Take the medicine with meals, dividing the daily dose into 2-3 doses.
Treatment of chronic hemorrhoids involves taking 4 tablets daily. They are taken with meals, 2 at each dose. After 7 days, you can reduce the dose by half and reduce the frequency of applications to 1 r./day.
How long to take the medicine depends on the degree of advanced disease and the effectiveness of therapy. On average, doctors for chronic hemorrhoids recommend taking pills in courses lasting 2-3 months. In case of an acute attack, treatment is carried out in short courses lasting 7 days.
If symptoms persist longer than this time, the patient should be examined by a proctologist.
Reviews of Detralex for hemorrhoids are mostly good. The main disadvantage of the drug, according to consumers, is its high price. However, given that Detralex is a drug with proven effectiveness (patients often notice an improvement in the situation after 2-3 days of taking the tablets), many people still prefer it over cheaper analogues.
How long to take Detralex for hemorrhoids
The instructions for the medication say that for acute hemorrhoids, you can take 6 tablets per day during the first 4 days, and in the next 3 days, take 4 tablets per day. The drug should be taken with food. It is better to divide the daily dose into several doses.
For chronic disease, you need to take 4 tablets every day with meals (2 tablets at lunch, 2 tablets in the evening). After a week of taking the dosage can be reduced by 2 times.
The duration of treatment depends on the patient’s condition and the effectiveness of treatment.
special instructions
The use of tablets during an acute hemorrhoidal attack cannot replace specific therapy and creates obstacles to the treatment of other proctological diseases.
If after a short time there is no rapid decrease in the severity of symptoms, the patient should be examined by a proctologist, and the doctor should reconsider the therapy.
For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:
- avoid standing for long periods of time and prolonged exposure to the sun;
- adjust body weight and diet;
- wear compression stockings to improve blood circulation;
- hike.
How to take Detralex?
Detralex is used as a symptomatic remedy for varicose veins and hemorrhoids. Often, the attending physician prescribes therapy that includes venotonic ointments or gels. When treating hemorrhoids, rectal suppositories and ointments can be used to relieve pain and inflammation, improve vascular tone, reduce blood clots and stop bleeding.
Before taking the medicine, you must carefully read the instructions
Detralex tablets are intended for oral use. Depending on the indications and general condition of the patient, the daily dose of the drug and the duration of the course of therapy are determined by the doctor.
- Venous-lymphatic insufficiency: 2 tablets/day (1 tablet in the middle of the day and 1 tablet in the evening with meals).
- Chronic hemorrhoids: 2 tablets/day (1 tablet in the middle of the day and 1 tablet in the evening with meals). After 7 days, you can change the dosage regimen of Detralex and use the drug 2 tablets once, with meals.
- Acute hemorrhoids: 6 tablets/day (2-3 tablets at equal intervals) for 4 days, then 4 tablets/day (2 tablets in the morning and 2 tablets in the evening) for the next 3 days.
The duration of treatment with Detralex depends on the severity of the disease, the patient’s medical history and, on average, is about 2-3 months. As prescribed by a doctor, the therapeutic course can be repeated.
Please note that taking Detralex for acute hemorrhoids does not replace specific therapy. That is why it is necessary to contact a specialist who will prescribe a therapeutic course, including drug treatment.
Tips for taking the drug
For people with impaired venous circulation, to increase the effectiveness of the drug, it is recommended:
- avoid standing for long periods of time and prolonged exposure to the sun;
- adjust body weight and diet;
- wear compression stockings to improve blood circulation;
- hike.
As for drinking alcohol during treatment with Detralex, there is no direct prohibition. You just need to consider the effects of alcoholic beverages on the cardiovascular system. Thus, alcohol increases blood pressure and dilates blood vessels, in turn, a sharp blood flow provokes stagnation. That is, alcohol reduces the effectiveness of treatment.
Detralex's analogs
Level 4 ATX code matches:
Rutin
Venosmin
Indovazin
Venoruton
Troxevasin Neo
Troxevasin
Ginkor Gel
Ginkor fort
Vasocket
Anavenol
Troxerutin
Askorutin
Antistax
Venarus
What can replace the drug?
Drugs similar to Detralex with a similar mechanism of action, but a different composition:
- Antistax
- Askorutin
- Vasocket
- Venolek
- Venoruton
- Rutin
- Troxevasin
- Troxerutin
- Phlebodia 600
- Yuglanex
- Phlebofa
Substitutes based on Hesperidine + Diosmin:
- Venozol
- Venarus
The medicine and its analogues are used to treat functional and organic venous insufficiency , as well as hemorrhoids (both acute and chronic).
The price of Detralex analogues is from 60 rubles. The cheapest analogues of Detralex are the drugs Rutin and Ascorutin .
In Ukraine, if Detralex is not available in the pharmacy, they may offer to replace it with the following drugs:
- Venorin
- Venosmin
- Juantal
- Dioflan
- Normoven
- Nostalex
Which is better: Detralex or Phlebodia 600?
On forums, the drug is often compared with its analogues. And most often with the drug Phlebodia 600 . The basis of both products is diosmin. Its concentration in Phlebodia is 600 - 600 mg/tab., in Detralex - 450 mg/tab., however, in the latter its effect is enhanced by the presence of hesperidin (50 mg/tab.).
For varicose veins , take Phlebodia 600 1 tablet per day, Detralex - 2 tablets per day, that is, the daily dose of diosmin in the first case is 600 mg, in the second - 900 mg.
If we compare the pharmaceutical effect of the drugs and the specifics of their use, there are practically no differences.
However, thanks to the use of a unique technology for processing the active substance in its production, Detralex is absorbed into the body faster and more completely than its analogue, while its concentration in the blood plasma reaches a maximum after three to four hours.
Which is better: Detralex or Antistax?
Antistax is a herbal medicine that is used for venous circulation disorders. The capsules are based on a dried extract of red grape leaves with a high content of isoquercetin and quercetin glucuronide - flavonoids that help stabilize cell membranes, normalize vascular permeability, and reduce swelling.
However, if the effectiveness of Detralex was confirmed during clinical experiments, there is currently no scientific confirmation of the effectiveness of Antistax.
Another difference between the drugs is that Detralex can be used during pregnancy, but there is no information regarding the safety and effectiveness of Antistax for pregnant women.
According to experts, Antistax for vascular diseases can be recommended more as a prophylactic agent and as an addition to the main treatment.
Thrombovazim or Detralex - which is better?
Thrombovazim is an enzyme preparation with thrombolytic, cardioprotective and anti-inflammatory activity. Its active ingredient is a complex of proteinases produced by Bacillus subtilis.
The medicine is prescribed as part of complex therapy for chronic venous insufficiency . It is strictly contraindicated for peptic ulcers , pregnancy and breastfeeding.
Considering that the drugs Detralex and Trombovazim have different pharmacological effects, it is not correct to compare them. Especially if you take into account that doctors often recommend taking them in combination.
Which is better: Detralex or Venarus?
Venarus is a Russian analogue of the drug. If you compare which is better - Detralex or Venarus, then you can come to the conclusion that there is no fundamental difference between them.
The basis of both drugs are the substances diosmin and hesperidin; the products differ only slightly in the composition of the auxiliary components. The principle of action of Venarus is the same as that of its analogue, and the drug is prescribed for the same thing as Detralex tablets.
Recommendations on how to take both remedies for varicose veins and hemorrhoids are also identical.
The annotations for the drugs are distinguished by the fact that an additional contraindication to the use of Venarus is the lactation period. In addition, the cheaper analogue of Detralex is characterized by lower bioavailability and is somewhat more likely to cause side effects than the drug produced by Les Laboratoires Servier.
Detralex during pregnancy and lactation
Detralex is not recommended for pregnant women
The use of Detralex by pregnant women and children during breastfeeding is not recommended due to insufficient research and clinical data. There is no information on the occurrence of side effects in pregnant women, nor has there been any information recorded on the ability of the active ingredients - diosmin and hesperidin - to pass into breast milk during breastfeeding, as well as in children during breastfeeding.
Alcohol compatibility
There is no categorical ban on drinking alcohol during treatment with Detralex. The active ingredients of the drug are flavonoids hesperidin and diosmin, which, according to Wikipedia, are plant pigments and powerful natural antioxidants, do not interact with other substances and have no significant side effects.
However, it should be taken into account that, by affecting the cardiovascular system, alcoholic drinks provoke an increase in blood pressure and dilation of blood vessels, and a sharp influx of blood causes an increase in its stagnation in places of accumulation.
Thus, alcohol reduces the effectiveness of therapy and contributes to the progression of the disease.
Side effects
When taking the drug Detralex, in rare cases, the following adverse reactions may develop:
- from the gastrointestinal tract: dyspepsia, diarrhea, nausea, vomiting, colitis;
- from the central nervous system: headache, dizziness, general malaise;
- from the skin: urticaria, itching, rash, isolated swelling of the face, eyelids, lips, angioedema.
If any side effects occur, you should consult your doctor and adjust your treatment.
Detralex during pregnancy
Despite the fact that studies have not revealed the teratogenic properties of Detralex, it is used with caution during pregnancy.
Due to the lack of information on the ability of diosmin and hesperidin to pass into breast milk during breastfeeding, the use of the drug should be avoided.
The category of effect on the fetus according to the FDA classification has not been determined.
Studies on rats have shown that the drug does not have reproductive toxicity.
Reviews of Detralex during pregnancy allow us to conclude that the drug really helps with problems with veins and hemorrhoids . With the use of tablets, pain in the legs disappears, the legs become less tired and do not swell (and if they swell, then not so much), the development of varicose veins hemorrhoids disappear (or are significantly reduced) .
Chronic venous insufficiency
Chronic venous insufficiency is a common peripheral vascular disease that occurs as a result of impaired blood flow through the veins of the lower extremities and changes in the permeability of the vascular wall. Most often, venous insufficiency develops in women. The disease occurs when the valves that close the veins are unable to prevent blood from flowing back due to increased pressure on them. As a result, this leads to stretching of the walls of the venous vessels. The permeability of the vascular wall for blood and plasma proteins increases, swelling and compaction of adjacent tissues appear. Where small vessels are compressed, areas of ischemia (insufficient blood supply with oxygen) occur, which contributes to the formation of trophic ulcers.
The main risk factors for the development of chronic venous insufficiency include:
- weakness of the muscular wall of the veins (hereditary);
- overweight and obesity;
- pregnancy and childbirth;
- long-term constant work in a standing or sitting position, with limited movement (cooks, office workers, surgeons, etc.);
- chronic constipation;
- fluctuations in hormonal levels in women (contraception with hormonal drugs, hormonal treatment during menopause, etc.);
- wearing tight underwear and clothing, corsets.
The following stages of development of varicose veins are distinguished:
- Stage 0 – no major symptoms upon examination.
- Stage I - “morning fatigue” of the legs, complaints of intermittent swelling in the evenings (disappears in the morning).
- Stage II – persistent swelling, skin pigmentation disorders; some areas of the skin become thicker, the skin above them cannot be folded (lipodermatosclerosis), redness appears on the skin, accompanied by itching and weeping (eczema).
- Stage III – the formation of trophic ulcers (active or healed), difficult to treat with medication.
The disease is accompanied by pain of varying intensity and the presence of evening cramps. In the treatment of varicose veins in the early stages, compression with elastic bandages and compression hosiery, physiotherapy and therapy in a sanatorium are used.
Reviews of Detralex
On the forums you can find a variety of (and often completely opposite) reviews about Detralex tablets on the forums you can find different ones. But still, most patients respond well to the drug.
If you take pills for hemorrhoids , the result becomes noticeable already on the 2-3rd day of treatment. Moreover, the medicine “works” even in advanced cases (including during pregnancy, when almost all drugs are contraindicated, and surgical intervention is simply unacceptable).
If you take pills for varicose veins , the effect develops somewhat more slowly, but the achieved result can significantly improve the quality of life. Analyzing doctors' reviews about Detralex, we can come to the conclusion that the drug is effective, but:
- the result is more noticeable the earlier treatment is started (reviews of Detralex for varicose veins indicate that if you start taking pills when the first signs of the disease appear, you can forget about it (the disease) for many years);
- the effect develops gradually, that is, if the doctor said that the medicine should be taken for 2 months, then it really needs to be taken for the specified amount of time, and to maintain the achieved results, repeat the course 1-2 times a year;
- the approach to treatment must be comprehensive - in order to achieve the desired effect, do not forget about the regimen, diet, adequate physical activity, and the use of other medications.
Side effects from the use of tablets develop extremely rarely, and they do not require special treatment or discontinuation of Detralex. This effect is due to the unique medicinal formula of the drug and a special production technology: the particles of the active components of Detralex are so small that they are very easily absorbed by the body (due to its high bioavailability, the drug is considered more effective than its more inexpensive analogues).
Detralex price, how much it costs
Detralex 500 mg tablets in Russia sell for an average of 800 rubles. for package No. 30 and 1500 rubles. per package No. 60.
The average price of Detralex tablets for hemorrhoids and varicose veins in Ukraine (for 60 tablets 500 mg) is about 300 UAH.
The drug is available exclusively in the form of tablets and suspension. You won’t be able to find Detralex ointment or lyophilisate.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Detralex tablets p.p.o.
500 mg 60 pcs. LLC Servier Rus 1613 rub. order - Detralex tablets p.p.o. 1000 mg 30 pcs. Servier Rus LLC
RUB 1,443 order
- Detralex tablets p.p.o. 1000 mg 60 pcs. Servier Rus LLC
RUB 2,573 order
- Detralex tablets p.p.o. 500 mg 30 pcs. Servier Rus LLC
840 rub. order
- Detralex tablets p.p.o. 1000 mg 18 pcs. Servier Rus LLC
RUR 887 order
Pharmacy Dialogue
- Detralex tablets 1000 mg No. 60Servier
RUB 3,003 order
- Detralex (tab.pl.vol.1000mg No. 60)Servier
RUB 2996 order
- Detralex tablets 1000 mg No. 18 Serdix LLC
RUB 858 order
- Detralex tablets 500 mg No. 60Servier
RUB 1,514 order
- Detralex tablets 500 mg No. 30Servier
RUR 788 order
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Pharmacy24
- Detralex 500 mg N60 tablets Lab.Serv e Industries, France
271 UAH order
PaniPharmacy
- Detralex tablets Detralex tablets. p/o No. 60 France, Servier Industrie
309 UAH. order
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Detralex
Detralex (micronized flavonoid fraction Diosmin + Hesperidin) is an original drug from the group of venoprotectors and venotonics. Manufacturer: Servier Laboratory (France), one of the oldest pharmaceutical companies in the world. Available in tablets. The uniqueness of Detralex lies in the fact that it is the only micronized drug in medical practice today. The diameter of the microparticles forming the tablet is 2 microns or less, which allows diosmin to be absorbed from the digestive tract four times faster and have a pronounced positive effect on venous and lymphatic drainage just 4 hours after taking 2 tablets (1 g). For comparison: the “colleagues” of the drug in the pharmacological group in a non-micronized form have a therapeutic effect only 1-2 days after administration.
Detralex is used as a venotonic and angioprotector. It reduces the distensibility of venous walls, facilitates venous outflow, reduces the permeability of capillary vessels, and increases their ability to maintain integrity under damaging influences. The results of multicenter clinical trials demonstrate the effectiveness of the drug in the treatment of venous hemodynamic disorders. The effect of Detralex in relation to such venous plethysmographic indicators as the capacity of the venous bed, the distensibility of the venous wall, and the time of emptying of the venous system has been statistically confirmed. Clinically, the therapeutically optimal dose/action ratio was determined - 1000 mg (2 tablets). Detralex has proven effectiveness in the treatment of chronic venous insufficiency of the lower extremities and hemorrhoids. The drug also has a fairly strong anti-inflammatory effect. It is based on blocking the production of key inflammatory mediators - prostaglandins and thromboxane. The antioxidant properties of Detralex are determined by its ability to prevent the appearance of aggressive free radicals that damage the walls of blood vessels.
One of the factors contributing to the development of an inflammatory focus is an increase in capillary permeability, mass migration of white blood cells and phagocytosis, due to the activation of complement at the initial stage of inflammation. The drug prevents the adhesion of leukocytes to the internal lining of blood vessels, blocks their migration to the site of inflammation and prevents the release of components that have a damaging effect - free radicals, cytokines, leukotrienes, proteolytic enzymes. According to this mechanism, the direct protective effect of Detralex on the microvasculature of patients suffering from chronic venous insufficiency develops. A number of independent sources call Detralex the only venotropic drug with proven effectiveness, leaving out horse chestnut preparations. It affects all pathogenetic patterns of venous diseases: the tone of the venous walls, lymphatic outflow, microcirculation. The drug is effective at any stage of the development of chronic venous insufficiency, from the incubation stage to the occurrence of severe complications.
The main route of elimination of Detralex is through feces (urine accounts for only about 10% of the dose taken). Its half-life is 11 hours. Subjects to active metabolic transformation in the liver. Available exclusively in tablets with a dosage of 1000 mg, 30, 60, 90 pieces per package. It is administered orally. The optimal time to take it is in the morning, with food. The duration of drug therapy can be up to 1 year. In case of relapse of the disease, with the permission of the doctor, a repeated treatment course is allowed. If there is no improvement in the clinical picture for a long time, you should consult a proctologist. Cases of pharmacological interaction with other drugs have not been recorded.
