Solcoseryl solution for intravenous and intramuscular administration. 42.5 mg/ml in amp 2 ml in pack No. 5x5

Compound

The solution for injection contains 42.5 mg/ml hemoderivate (extract) from calf blood as an active substance and water for injection (Aqua pro injectionibus) as an auxiliary component.
One gram of eye gel contains 8.3 g of active substance and auxiliary ingredients: sodium carboxymethyl cellulose (Sodium carboxymethyl cellulose), sorbitol (Sorbitol), water for injection (Aqua pro injectionibus), benzalkonium chloride (Benzalkonii chloridum).

One gram ointment contains 2.07 mg of active substance and a number of auxiliary components: methyl parahydroxybenzoate (E 218; Methyl parahydroxybenzoate), propyl parahydroxybenzoate (E 216; Propyl parahydroxybenzoate), cetyl alcohol (Cetyl spiritus), cholesterol (Cholesterol), white petroleum jelly ( Vaselinum album), water for injection (Aqua pro injectionibus).

One gram of jelly contains 4.15 mg of active substance and a number of auxiliary components: methyl parahydroxybenzoate (E 218; Methyl parahydroxybenzoate), propyl parahydroxybenzoate (E 216; Propyl parahydroxybenzoate), propylene glycol (Propylene glycol), carboxymethyl cellulose sodium salt (Sodium carboxymethyl cellulose), water for injection (Aqua pro injectionibus), calcium lactate pentahydrate (Calcii lactas pentahydrate).

Composition and release form

in ampoules of 2 ml; there are 25 ampoules in a box; or in ampoules of 5 and 10 ml; There are 5 ampoules in a box.

in tubes of 20 g; 1 tube in a box.

in tubes of 20 g; 1 tube in a box.

pharmachologic effect

Solcoseryl is a medicine that affects mainly metabolic processes in tissues. They activate tissue metabolic processes , improve trophism and stimulate tissue repair and when exposed to damaging factors.

Solcoseryl in injection form belongs to the pharmacotherapeutic group “ Hemodialysates and hemofiltrates ”, ointment and jelly - to the category of drugs used to treat wounds and ulcers (including poorly healing ones), gel - to the category of drugs used to treat ophthalmological diseases .

Pharmacodynamics and pharmacokinetics

The main component of Solcoseryl preparations are fractions of the blood of calves with natural low-molecular substances included in their composition, the molecular weight of which does not exceed 5 thousand daltons.

To date, its properties have only been partially studied. In vitro tests, as well as preclinical and clinical studies, have shown that calf blood extract:

• promotes the restoration and/or maintenance of aerobic metabolism and oxidative phosphorylation processes, and also ensures the replenishment of cells that do not receive sufficient nutrition with high-energy phosphates;
• in vitro enhances the utilization of oxygen and activates the transport of glucose into tissues and cells hypoxia and ;
• helps improve repair and regeneration processes in damaged tissues that do not receive sufficient nutrition;
• prevents the development or reduces the severity of secondary degradation and pathological changes in reversibly damaged cells and cellular systems ;
• in in vitro models activates collagen synthesis ;
• has a stimulating effect on the proliferation (reproduction) of cells and their migration (in in vitro models).

Thus, Solcoseryl protects tissues that are in a state of oxygen starvation and nutritional deficiency, and accelerates the processes of their restoration and healing.

Solcoseryl eye gel is a dosage form that was developed specifically for the treatment of lesions with troma of the cornea .

The gel-like consistency of the product ensures its uniform distribution on the cornea , and good adhesive properties allow it to remain on it for a long period of time. The use of eye gel accelerates the restoration of damaged tissues and prevents scarring.

The rate and extent of absorption, distribution, as well as the rate and route of elimination of the active substance from the patient’s body cannot be determined using conventional pharmacokinetic methods, since protein-free calf blood extract has pharmacodynamic effects that are characteristic of molecules with different chemical and physical properties.

In the process of studying the pharmacokinetic characteristics of Solcoseryl solution in animals, it was found that after a bolus injection, the effect of the drug develops within half an hour. The effect lasts for three hours after administration of the solution.

Solcoseryl solution for intravenous and intramuscular administration. 42.5 mg/ml in amp 2 ml in pack No. 5x5

Name

Solcoseryl.

Release forms

Solution.

Compound

per 1 ml: Active ingredient: Solcoseryl (deproteinized dialysate from the blood of dairy calves), in terms of dry matter 42.5 mg Excipients: Hydrochloric acid 25%, sodium hydroxide 27%, water for injection.

Description

Transparent solution, yellowish to yellow. The characteristic light smell of Solcoseryl (the smell of meat broth).

Pharmacotherapeutic group

Other medications. ATX code: V03AX.

Pharmacological properties

Solcoseryl is a deproteinized hemodialysate that contains a significant amount of low-molecular components of cells and blood serum of calves (dialysis/ultrafiltration, maximum molecular weight 5000 Da), the chemical and pharmacological properties of which are only partially described to date. A study of the drug on various cell and tissue cultures, organs, as well as animals showed that Solcoseryl: maintains and/or restores aerobic energy metabolism, as well as oxidative phosphorylation processes in cells deprived of sufficient nutrients, thereby maintaining and/or restoring supply of high-energy phosphates, increases oxygen uptake (in-vitro), as well as glucose transport in hypoxic and metabolically depleted tissues and cells, improves repair and regeneration processes in damaged tissues and/or tissues deprived of sufficient nutrients, prevents and/or reduces secondary degeneration and pathological changes in reversibly damaged cellular systems, enhances collagen synthesis in in-vitro models, and also stimulates cell proliferation and migration in-vitro. Thus, Solcoseryl protects tissues prone to hypoxia and/or substrate depletion. This stimulates the restoration of functions in reversibly damaged tissue, and also accelerates the healing of lesions and improves the quality of this process.

Indications for use

peripheral arterial occlusive disease (PAVK) stage III-IV in patients with contraindications or intolerance to other vasoactive drugs; chronic venous insufficiency, accompanied by trophic disorders.

Contraindications

Known hypersensitivity to the active substance or to one of the excipients according to the composition. Due to possible allergic reactions, treatment with the drug should not be prescribed to patients with known allergies (patients with atopy or allergy to milk). Solcoseryl solution for intravenous and intramuscular administration contains trace amounts of methyl, ethyl and propyl parahydroxybenzoates (E218, E214 and E216) and free p-hydroxybenzoic acid (E 210) due to the manufacturing process, and is therefore contraindicated in patients with a known allergy to these compounds.

Directions for use and doses

If the patient's clinical condition allows, Solcoseryl is recommended, if possible, to be used as an intravenous infusion rather than as an intravenous injection. Solcoseryl solution for intravenous and intramuscular administration should not be used as a bolus injection. When used as an infusion or injection, Solcoseryl should be diluted in a ratio of at least 1:1 with sodium chloride solution or glucose solution, or a mixed glucose/sodium chloride solution and administered slowly. The drug Solcoseryl should not be diluted with infusion solutions containing potassium. Infusion: Solcoseryl should, if possible, be used as an intravenous infusion, primarily if the total volume of the diluted solution is more than 40 ml. The rate of infusion depends on the hemodynamic status of the patient. Injection: If the use of Solcoseryl by injection is unavoidable, the solution should be administered slowly over at least 2 minutes to prevent a rapid increase in potassium levels in the blood. The volume of the diluted injection solution should not exceed 40 ml. The use and safety of Solcoseryl has not been tested in children and adolescents under 18 years of age to date. Recommended dosage: peripheral arterial occlusive disease (stages III-IV according to Fontaine): 850 mg Solcoseryl (corresponding to 20 ml of undiluted solution for injection) daily intravenously. The duration of use is usually up to 4 weeks and depends on the clinical picture. chronic venous insufficiency accompanied by trophic disorders'. 425 mg Solcoseryl (corresponding to 10 ml of undiluted solution) intravenously 3 times a week. The duration of use is usually 4 weeks and depends on the clinical picture. As an existing supportive measure for edema, compression therapy is prescribed: a compression bandage or underwear. Side effects In rare (less than 0.1%) cases, allergic or anaphylactic reactions, probably caused by immunoglobulin E (IgE), may occur. In such cases, you should immediately stop taking the drug and, if necessary, take appropriate measures. Due to the potassium content, administration of Solcoseryl may cause pain at the injection site.

Overdose

There is no information about overdose symptoms.

Interaction with other drugs

Solcoseryl should not be prescribed together with other drugs (especially herbal extracts such as ginkgo biloba extract) other than saline solution of sodium chloride or glucose. You should be especially careful when using Solcoseryl together with drugs that increase serum potassium levels, such as potassium supplements, ACE inhibitors, potassium-sparing diuretics (see section "Precautions").

Precautionary measures

The mixture of active ingredients contained in Solcoseryl is of animal origin. Therefore, if there is an unknown history of allergic reactions, it is recommended that before starting treatment with the drug, a test subcutaneous injection with 0.5 ml of Solcoseryl injection solution is administered. Due to possible allergic reactions, mixed infusions and combination treatments should not be used, especially with herbal extracts such as ginkgo biloba extract. The drug Solcoseryl is produced from the blood of dairy calves. Therefore, it contains potassium and is subject to precautions similar to those applied to other potassium-containing drugs. Particular caution should be exercised in patients with diseases for which elevated serum potassium levels pose a particular risk (eg, hyperkalemia, renal failure, cardiac arrhythmias, acute myocardial infarction), as well as in all diseases for which medications that increase serum potassium levels are prescribed. serum potassium content (see “Interaction with other drugs”). The use and safety of the drug Solcoseryl has not been tested in children and adolescents under 18 years of age to date.

Pregnancy, breastfeeding period

Animal reproductive studies have not shown a risk to fetal development, but no controlled studies have been conducted in pregnant women. Therefore, unless absolutely necessary, Solcoseryl should not be used during pregnancy. There are no data on the use of Solcoseryl during breastfeeding. If treatment during lactation is necessary, breastfeeding should be discontinued as a precaution. Effect on the ability to drive vehicles and operate machinery No relevant studies have been conducted.

Release form

Solution for intravenous and intramuscular administration 42.5 mg/ml. 2 or 5 ml in ampoules made of neutral hydrolytically stable dark glass (class I according to Evr.F.) with a white dot above the break point. 5 ampoules per blister polymer packaging. 1 contour package with the drug in 5 ml ampoules or 5 contour packages with the drug in 2 ml ampoules along with instructions for use in a cardboard box.

Storage conditions

In a place protected from light at a temperature not exceeding 25°C. Keep out of the reach of children!

Best before date

5 years from the date of production. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

On prescription.

Buy Solcoseryl solution for IV and IM administration. 42.5 mg/ml in amp 2 ml in pack No. 5x5 in the pharmacy

Price for Solcoseryl solution for IV and IM administration. 42.5 mg/ml in amp 2 ml in pack No. 5x5

Instructions for use for Solcoseryl solution for intravenous and intramuscular administration. 42.5 mg/ml in amp 2 ml in pack No. 5x5

Indications for use

Solcoseryl injections: what are they for and what groups of patients are they prescribed for?

Solcoseryl in ampoules is indicated for patients who have been diagnosed with occlusive peripheral artery disease of the third or fourth degree according to the Fontaine classification and who have contraindications or intolerance to other vasoactive drugs .

It is also prescribed to patients with chronic venous insufficiency , which is accompanied by the formation of treatment-resistant trophic ulcers , as well as to patients with disorders of cerebral metabolism .

What is Solcoseryl ointment and jelly for?

The use of ointment and jelly is advisable for the treatment of minor injuries (for example, abrasions or cuts), frostbite, first and second degree burns (thermal or solar), difficult-to-heal wounds (for example, trophic skin disorders of venous etiology or bedsores ).

Indications for use of eye gel

Solcoseryl eye gel is recommended:

• for the treatment of mechanical injuries and erosive damage to the cornea and conjunctiva ;
• to accelerate the healing processes of postoperative scars in the postoperative period (for example, after a cornea transplant , surgery to remove a cloudy lens , surgical treatment of glaucoma , etc.);
• for the treatment of burns of the cornea of ​​various origins (thermal, chemical or radiation);
• for the treatment of ulcerative lesions of the cornea and keratitis of various etiologies ;
• for dystrophic lesions of the cornea of ​​various etiologies, including neuroparalytic keratitis , endothelial-epithelial dystrophy ( bullous keratopathy ), etc.;
• for the treatment of corneal xerophthalmia with lagofatalmos (non-closure of the palpebral fissure);
• to improve the tolerability of contact lenses and reduce the time of adaptation to them.

Indications for use of Solcoseryl dragees

The drug in the form of pills is taken to treat trophic and radiation ulcers , bedsores , gangrene , and chronic venous insufficiency . They are also prescribed to patients with gastric and duodenal ulcers and patients who require skin and/or corneal transplantation .

Indications for the drug Solcoseryl

Solcoseryl solution for injection.

Occlusive diseases of peripheral arteries in stages III–IV according to Fontaine in patients with contraindications/intolerance to other medications;

chronic venous insufficiency, accompanied by trophic disorders (Ulcera cruris), in cases of their persistent course;

disorders of cerebral metabolism and blood circulation (ischemic and hemorrhagic stroke, traumatic brain injury).

Solcoseryl gel, ointment.

Minor damage (abrasions, scratches, cuts).

1st and 2nd degree burns (sunburn, thermal burns).

Frostbite.

Difficult-to-heal wounds (including trophic ulcers and bedsores).

Contraindications

Administration of the solution is contraindicated in patients with known hypersensitivity to calf blood dialysates. The solution is also contraindicated for atopy and for persons allergic to milk .

Since the ointment, jelly and solution contain derivatives of parahydroxybenzoic acid , which are used as preservatives, as well as trace concentrations of benzoic acid in free form, it is not used in the presence of allergic reactions to the above substances.

With caution, ointment and jelly are prescribed to persons with a predisposition to allergic reactions .

A contraindication to the use of eye gel is hypersensitivity to its components. Since the eye gel can cause temporary visual impairment, you should not drive a car or operate potentially dangerous machinery for half an hour after its use.

Interaction

Solcoseryl injections should not be mixed when administered with other medications, especially with phytoextracts.

The pharmaceutical incompatibility of Solcoseryl in the form of an injection solution with parenteral forms has been established:

Ginkgo biloba extract,

naftidrofuryl,

bencyclane fumarate.

As solutions for diluting Solcoseryl injection, only isotonic sodium chloride solution and 5% glucose solution should be used.

The interaction of Solcoseryl with other topical medications has not been established.

Side effects

Administration of Solcoseryl IV or IM in very rare cases (their frequency does not exceed 0.1%) provokes the development of allergic or anaphylactic reactions , which are most likely caused by class E immunoglobulins .

If body temperature rises, urticaria , swelling and hyperemia at the site of drug administration, the use of Solcoseryl is stopped, and symptomatic treatment will be prescribed to eliminate the symptoms that appear.

Since the solution contains potassium, its administration may cause pain at the injection site.

When using Solcoseryl cream, a short-term burning sensation may be felt at the site of application. Discontinuation of the drug is required only in cases where the unpleasant sensation does not disappear for a long period of time.

In isolated cases, the use of jelly and ointment can cause the development of allergic reactions . If allergy symptoms , the use of these products should be discontinued.

Toxicological studies of Solcoseryl eye gel have shown the high safety of this drug when used for its intended purpose in accordance with the instructions.

After instillation of the product, a short-term burning sensation and mild irritation may be observed, which are not reasons for stopping treatment. Repeated instillation in rare cases provokes the development of allergic reactions (a similar effect is also observed during treatment with other ophthalmic drugs for topical use).

Instructions for use of Solcoseryl (Method and dosage)

Solution for injection: instructions for use

In cases where the patient's condition allows, the drug is recommended to be used in the form of an injection solution diluted at least 50:50 with saline or glucose solution .

Solcoseryl in ampoules is intended for slow administration in the form of intravenous injections or infusions. If intravenous administration is not possible, the drug can be injected into the muscle.

Since the drug in its pure form is a hypertonic solution, it should be administered slowly.

For intravenous infusion, the drug should be pre-diluted with 0.25 l of 0.9% NaCl solution or 5% glucose solution . Solcoseryl solution is administered intravenously by drip. The rate of administration depends on the hemodynamic status of the patient.

Patients with occlusive disease of peripheral arteries of the third or fourth degree according to the Fontaine classification are shown daily injection into a vein of 0.85 g (or 20 ml of undiluted solution) Solcoseryl.

The duration of use is usually up to four weeks and depends on the clinical situation.

Patients with chronic venous insufficiency , which is accompanied by the formation of treatment-resistant trophic ulcers , are indicated for intravenous administration of 0.425 g (or 10 ml of undiluted solution) Solcoseryl three times a week.

The duration of the course of treatment should not exceed four weeks (it is determined depending on the nature of the disease).

To prevent the appearance of peripheral “venous” edema , therapy is supplemented by applying a pressure bandage using an elastic bandage. If the patient has skin trophic disorders, treatment is carried out by combining injections or infusions of Solcoseryl solution with the use of jelly, and then ointment.

Patients who have suffered ischemic or hemorrhagic stroke are prescribed daily intravenous administration of 0.425 or 0.85 g of Solcoseryl (10 or 20 ml of undiluted solution) as the main course. The duration of the main course is 10 days.

Further treatment involves daily administration of 85 mg (or 2 ml of undiluted solution) Solcoseryl for one month.

In severe forms of brain contusions, daily injection of 1000 mg of Solcoseryl into a vein (corresponding to 23-24 ml of undiluted solution) is prescribed for 5 days.

The drug is administered intramuscularly undiluted at a dose of 2 ml/day.

Solcoseryl jelly and ointment: instructions for use

Cream and ointment are intended for application directly to the wound surface. Before using these dosage forms, the wound is first cleaned using a disinfectant solution.

Patients with trophic ulcers , as well as in cases of purulent infection of wounds , require preliminary surgical treatment before starting treatment.

When using jelly and ointment for frostbite , as well as for the treatment of ulcers and skin injuries , it is important to remember that only sterile dressings should be used to treat damaged areas.

The gel is intended for application to fresh (including wet) wounds and weeping ulcers . The product is applied in a thin layer to a previously cleaned wound surface two or three times a day.

To treat areas where epithelization has begun, the use of ointment is indicated. The use of jelly is advisable until pronounced granulation tissue begins to form on the damaged surface of the skin and the wound begins to dry out.

The ointment is used primarily for the treatment of dry (without weeping) wounds . The product is applied in a thin layer to a previously cleaned wound surface once or twice a day. If necessary, cover the treated surface with a bandage.

The course of treatment with the drug in this dosage form continues until the wound heals and is completely healed with elastic tissue.

For patients with severe trophic damage to the skin and soft tissues, it is recommended to combine jelly and ointment with the injection form of Solcoseryl.

Experience with the use of jelly and ointment for children is limited.

The drug does not have such release forms as suppositories. However, in the complex therapy of chronic colitis (inflammation of the colon), microenemas with Solcoseryl jelly are often prescribed.

Before use, the jelly contained in the tube (all 20 g) is added to 30 ml of warm water and after the enema procedure, which is carried out to cleanse the intestines , it is administered daily for 10 days.

Solcoseryl eye gel: instructions for use

Unless otherwise instructed by the attending physician, the eye gel is instilled into the conjunctival cavity , one drop three or four times a day. It is recommended to use the product daily until complete recovery.

In particularly difficult cases, eye ointment can be used one drop per hour. If the patient is simultaneously prescribed eye drops and Solcoseryl eye gel, the gel should be applied approximately half an hour after the drops.

During the period of adaptation to contact lenses, the drug is instilled into the conjunctival cavity immediately before installing the lenses and immediately after removing them.

Dragee Solcoseryl: instructions for use

The instructions recommend taking 100 mg tablets three times a day.

Solcoseryl injections: what for

Any surgical intervention is accompanied by a violation of the integrity of the skin and tissues. If the operation involves the removal of some fragment of an internal organ, the body will require a long rehabilitation period, during which the body will be fully or partially restored. Solcoseryl in ampoules can be instantly delivered to tissues, shortening the recovery period. Injections allow you to mobilize all the internal forces of the body to heal wounds, cuts and sutures not only on the outside, but on the internal organs that remain after operations.

Special cases include the prescription of intravenous or intramuscular administration to patients after ophthalmological operations. Solcoseryl ensures active blood circulation, which accelerates the process of adaptation of the organ of vision in the postoperative period, and also reduces the risk of complications.

special instructions

Studies regarding the safety of using Solcoseryl solution for the treatment of children have not been conducted, therefore the drug is not recommended for the treatment of children under the age of 18 years.

Experience in treating children with the use of eye gel and topical dosage forms of the drug is also limited.

Solcoseryl in ampoules should be administered separately from other drugs (it is especially incompatible with phytoextracts). The exceptions are isotonic 0.9% NaCl solution and 5% glucose solution . It is also not recommended to dilute the product in potassium-containing solutions for infusion.

Eye gels are characterized by the ability to stick to contact lenses, so it is recommended to stop wearing lenses during treatment with the drug.

If allergic reactions associated with the use of the drug, you should immediately report them to your doctor. If the drug is used to treat an infectious disease of the cornea , therapy is supplemented with the prescription of appropriate antimicrobial agents .

Avoid contact of the gel with soft contact lenses as it may discolor them.

If necessary, treatment with Solcoseryl can be supplemented with antibacterial , vasodilating and other drugs.

Solcoseryl in cosmetology: for the face, hands, rough elbows and heels, for the skin around the eyes

In medicine, Solcoseryl preparations are used to accelerate the healing of damaged skin; in home cosmetology, they are used as a remedy for acne, stretch marks, and wrinkles. They are used to soften the skin, increase its turgor, improve complexion and eliminate acne .

In cosmetology, the ointment can be used as a stand-alone product (it is applied pointwise to problem areas, in the form of a mask once a week before bedtime and two to three times a week on the skin around the eyes), or in combination with other products, in particular with the drug Dimexide . Let's look at how to use these medications together.

For the face, Dimexide and Solcoseryl are used as follows: on the face, neck and décolleté, previously cleaned with peeling agents (you can also do alkaline peeling using tar soap, salt and soda), apply a solution of Dimexide with water, prepared in a ratio of 1:10 (enough dilute 5 ml (teaspoon) of Dimexide in 50 ml of water); Before the product has time to be absorbed, Solcoseryl ointment is applied to it in a thick layer.

If the gel is used in cosmetology, then the mask should be periodically sprayed with thermal water (you can also use regular water through a spray bottle). The mask is left on the face for about half an hour to an hour, then washed off and a light hypoallergenic cream is applied to the skin.

According to women who have tried this mask recipe on themselves, Solcoseryl ointment is more comfortable for the face than gel (after application, you don’t have to wash it off, just remove the residue with a napkin). In addition, it is not recommended to use a gel mask more than once a month.

Used as a remedy for wrinkles around the eyes, Solcoseryl ointment has proven itself to be a very effective remedy. Applying it like a regular cream, within a week you can see that the number of wrinkles and wrinkles has decreased, the skin has tightened and smoothed, and its color has become fresher and healthier.

Dimexide and Solcoseryl are no less effective against wrinkles, and perhaps even more effective. This is due to the ability of Dimexide to enhance the penetration of the active substance of drugs deep into the tissue. After using these products in combination, skin irregularities and imperfections disappear, and the effect of the mask is comparable to the effect of Botox .

The gel and ointment can also be used to soften rough skin on the elbows and heels. It is best to apply them to problem areas before bed.

Solcoseryl solution d/in 5ml No. 5

Compound

Active substance: deproteinized dialysate from the blood of healthy dairy calves (in terms of dry matter) - 42.5 mg. Excipients: water for injection.

Pharmacokinetics

Carrying out studies of the pharmacokinetic processes of absorption, distribution and excretion of the drug using standard chemical analytical methods is not possible, because The drug contains blood components and substances that are usually found in the body.

Indications for use

Peripheral arterial or venous circulation disorders:

• occlusive diseases of peripheral arteries in stages III-IV according to Fontaine;
• chronic venous insufficiency, accompanied by trophic disorders.

Disorders of cerebral metabolism and blood circulation:

• ischemic stroke;
• hemorrhagic stroke;
• traumatic brain injuries.

Contraindications

• children and adolescents under 18 years of age (no data on safety of use);
• pregnancy (no safety data available);
• lactation (no data on safety of use);
• established hypersensitivity to calf blood dialysates;
• hypersensitivity to parahydroxybenzoic acid derivatives (E216 and E218) and to free benzoic acid (E210).

Carefully

The drug should be used for hyperkalemia, renal failure, cardiac arrhythmias, with concomitant use of potassium supplements (since Solcoseryl contains potassium), for oliguria, anuria, pulmonary edema, severe heart failure.

Directions for use and doses

Intravenously (drip or stream), intramuscularly.

If the patient’s clinical condition allows, it is recommended to administer Solcoseryl solution intravenously by drip, rather than intravenously by stream or intramuscularly.

Intravenous drip

Solcoseryl solution for intravenous drip administration should be used in a dilution of at least 1:1 with 0.9% sodium chloride solution or 5% dextrose (glucose) solution and administered slowly. Solcoseryl should not be diluted with potassium-containing intravenous solutions.

Intravenous bolus administration

Solcoseryl solution for intravenous jet administration should be used in a dilution of at least 1:1 with 0.9% sodium chloride solution or 5% dextrose (glucose) solution. Solcoseryl should not be diluted with potassium-containing intravenous solutions. Solcoseryl solution should be administered slowly (at least 2 minutes) to prevent a rapid increase in potassium levels in the blood. If the volume of a diluted solution of Solcoseryl during intravenous administration exceeds 20 ml, then the drug is administered intravenously by drip.

Intramuscular administration

If intravenous administration is not possible, the drug can be administered intramuscularly without dilution, 2 ml per day.

Recommended dosages:

Occlusive diseases of peripheral arteries in stages III-IV according to Fontaine: 850 mg of Solcoseryl (20 ml of undiluted drug) daily intravenously.

The duration of therapy is up to 4 weeks and is determined by the clinical picture of the disease.

Chronic venous insufficiency with trophic disorders: 425 mg of Solcoseryl (10 ml of undiluted drug) intravenously 3 times a week. The duration of therapy is no more than 4 weeks and is determined by the clinical picture of the disease. In the presence of local trophic tissue disorders, simultaneous therapy with Solcoseryl gel and then Solcoseryl ointment is recommended.

Traumatic brain injury, metabolic and vascular diseases of the brain: 425 - 850 mg of Solcoseryl (10 - 20 ml of undiluted drug) intravenously daily for 10 days. Then 85 mg (2 ml of undiluted drug) intramuscularly or intravenously for up to 30 days.

Storage conditions

In a place protected from light at a temperature not exceeding 25°C.

Keep out of the reach of children.

Best before date

5 years from the date of production. Do not use after the expiration date stated on the package.

special instructions

If adverse reactions develop, you should stop using the drug and prescribe symptomatic therapy.

Description

A drug that activates tissue metabolism, improves trophism and stimulates the regeneration process.

Dosage form

The solution for intravenous and intramuscular administration is yellowish to yellow in color, transparent, with a characteristic slight odor of meat broth.

Use in children

Contraindication: children and adolescents under 18 years of age (no data on safety of use).

Pharmacodynamics

Stimulator of tissue regeneration. It is a deproteinized dialysate from the blood of dairy calves, containing a wide range of low-molecular components of cell mass and serum with a molecular weight of 5000 D (including glycoproteins, nucleosides and nucleotides, amino acids, oligopeptides).

Solcoseryl improves the transport of oxygen and glucose to cells under hypoxic conditions, increases the synthesis of intracellular ATP and helps increase the dose of aerobic glycolysis and oxidative phosphorylation, activates repair and regenerative processes in tissues, stimulates the proliferation of fibroblasts and the synthesis of collagen in the vascular wall.

Side effects

Allergic reactions: rarely - urticaria, increased body temperature.

Local reactions: rarely - hyperemia, swelling at the injection site.

Use during pregnancy and breastfeeding

To date, not a single case of the teratogenic effect of Solcoseryl is known, however, during pregnancy, the drug should be used with caution, according to strict indications and under the supervision of a physician.

There are no data on the safety of using the drug Solcoseryl during lactation; if it is necessary to prescribe the drug, breastfeeding should be stopped.

Interaction

Use with caution simultaneously with drugs that increase potassium levels in the blood (potassium supplements, potassium-sparing diuretics, ACE inhibitors).

Pharmaceutical interactions

The drug should not be mixed when administered with other drugs (especially phytoextracts).

The drug is incompatible with parenteral forms of Ginkgo biloba, naftidrofuryl and bencyclane fumarate.

Overdose

To date, no cases of overdose of the drug Solcoseryl have been reported when used according to indications in recommended doses.

Impact on the ability to drive vehicles and operate machinery

The use of the drug does not affect the performance of potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving vehicles, working with moving mechanisms).

Analogues of Solcoseryl

Level 4 ATX code matches:
Badyaga Forte

Badyaga

Rogaine

Capsiol

Vulnuzan

Skin cap

Petrolatum

Generolon

Alerana

Apilak

Tsinocap

Silocast

Analogs of Solcoseryl: Aekol , Acerbin , Bepanten , Shostakovsky balm , Vundehil , Depantol , Contractubex , Pantekrem , Pantexol Yadran , Panthenol , Pantestin , Hepiderm Plus , Echinatsin Madaus .

Reviews of Solcoseryl

Almost all reviews left on the forums about injections, eye gel, jelly and Solcoseryl ointment are positive. Rare negative reviews are due largely to the fact that the drug provoked allergic reactions associated with intolerance to its active component.

Reviews of Solcoseryl gel and the drug in the form of an ointment allow us to conclude that these drugs effectively cope not only with minor scratches and minor burns, but also help cure difficult-to-heal wounds and ulcers .

The average rating of a drug on sites where people share their impressions of certain drugs is 4.8 on a 5-point scale.

The effectiveness of the ointment in cosmetology is also highly appreciated. Reviews of Solcoseryl ointment for the face indicate that this is truly an indispensable product for those who want to quickly get rid of wrinkles, acne, and simply improve the color and tone of the skin.

Gel is no less effective against wrinkles, but cosmetologists believe that it should not be used as part of masks too often (optimally - once a month). The ointment can be used as a regular cream.

The effectiveness of Solcoseryl against wrinkles increases when combined with Dimexide, which is due to the latter’s ability to improve the penetration of the active substance deeper into the skin.

Note!

Description of the drug Solcoseryl solution d/in. amp. 5ml No. 5 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Solcoseryl price, where to buy

How much does Solcoseryl cost in Ukraine?

The average price of Solcoseryl in ampoules in Ukrainian pharmacies is from 265 to 515 UAH (depending on the volume of ampoules and their number in the package). The price of Solcoseryl ointment in Ukraine is 57-60 UAH. You can buy jelly for an average of 52 UAH. Eye cream costs on average from 60 to 74 UAH.

Cost of the drug in Russia

The price for Solcoseryl injections in Russian pharmacies varies from 400 to 1300 rubles (depending on the volume of ampoules and their number in the package). The price of Solcoseryl gel (which can be used as an anti-wrinkle gel) is 180-200 rubles. The price of the eye gel is 290-325 rubles. Pharmacies provide information on the price of tablets upon request.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

• Solcoseryl ointment tube 20g
  RUB 2,170 order
• Solcoseryl dental adhesive paste 5g

  RUR 2,480 order

• Solcoseryl injections/solution for injection (Solcoseryl ampoules) 42.5 mg/ml 5 ml No. 5

  RUR 4,780 order

ZdravCity

• Solcoseryl Dent adhesive paste. 5 gLEGASY PHARMACEUTICALS

  RUR 2,480 order

Pharmacy Dialogue

• Solcoseryl paste (dental, tube 5% 5g)Legacy

  RUB 2,470 order

• Solcoseryl gel (tube 20g)Legacy

  RUB 2,633 order

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Pharmacy24

• Solcoseryl 5 ml No. 5 injection solution Legacy Pharmaceuticals, Sweetseland GmbH, Switzerland
  515 UAH. order
• Solcoseryl 4.15 mg/g 20 g gel Legacy Pharmaceuticals, Sweetseland GmbH, Switzerland

  164 UAH order

• Solcoseryl 2.07 mg/g 20 g ointment Legacy Pharmaceuticals, Sweetseland GmbH, Switzerland

  136 UAH order

• Solcoseryl 42.5 mg/ml 2 ml N25 injection solution Legacy Pharmaceuticals, Sweetsland GmbH, Switzerland

  919 UAH. order

• Solcoseryl 5% 5 g paste

  176 UAH order

PaniPharmacy

• Solcoseryl ampoule Solcoseryl injection solution ampoules 2ml No. 25 Switzerland, Legacy Pharmaceuticals Switzerland

  950 UAH order

• Solcoseryl gel Solcoseryl jelly 10% 20g Switzerland, Legacy Pharmaceuticals Switzerland

  161 UAH order

• Solcoseryl injection solution ampoules 5 ml No. 5 Australia, Legacy Pharmaceuticals Sweetsland GmbH

  476 UAH. order

• Solcoseryl ampoule Solcoseryl injection solution ampoules 5ml No. 5 Switzerland, Legacy Pharmaceuticals Switzerland

  545 UAH. order

• Solcoseryl jelly 10% 20g Australia, Valeant Pharmaceuticals Sweetsland

  181 UAH order

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