Pharmacodynamics and pharmacokinetics
Distreptase suppositories contain 2 active components:
- Streptokinase is a fibrinolytic enzyme that promotes the transfer from the inactive form of the proenzyme plasminogen to its active form - plasmin , aimed at dissolving fibrin fibers of blood clots.
- Streptodornase is a biocatalyst for the dissolution of pus and other dead cells without negatively affecting the integrity and functioning of healthy cells.
Thus, the drug provides access to antibacterial agents directly at the site of inflammation.
Pharmacokinetics have not been studied.
Pharmacological properties of the drug Distreptase
The drug contains two active substances: streptokinase and streptodornase. Streptokinase is an activator of the proenzyme plasminogen contained in human blood, and under the influence of streptokinase it is converted into plasmin, which has the property of dissolving human blood clots. Streptodornase is an enzyme that has the ability to dissolve sticky masses of nucleoproteins, dead cells or pus without affecting living cells and their physiological functions. The drug facilitates the access of antibiotics or chemotherapeutic agents to the site of inflammation.
Distreptase suppositories, instructions for use (Method and dosage)
The instructions for Distreptaza involve the rectal use of Distreptaza suppositories with the deepest possible administration.
The dose is calculated depending on the severity of inflammation. Highlight:
- Severe degree with the prescription of 1 suppository three times a day for 3 days, then 1 suppository twice a day for 3 days, and then 1 suppository once a day for 3 days.
- Moderate and mild severity , in which the following regimens are followed: 1 suppository twice a day for 3 days, then 1 suppository once a day for 4 days or twice a day for 2 days.
Indications
Based on the research results, it was concluded that Distreptase is a safe and effective medicine. It is used to treat the following diseases:
- chronic salpingitis;
- chronic adnexitis;
- chronic salpingoophoritis;
- postoperative infiltrative processes in the pelvis;
- adhesions in the abdominal cavity after surgery or inflammatory diseases;
- follicular ovarian cysts;
- swelling in diseases of the pelvic organs;
- endometritis;
- acute and chronic hemorrhoids;
- abscesses and fistulas in the anus and rectum with extensive inflammation;
- inflammation of the tissue surrounding the rectum;
- purulent caudal (lower spine) cysts.
Analogs
Level 4 ATC code matches: Biostrepta
Actilyse
Gemaza
Fibrinolysin
Thrombovazim
Streptokinase
- Aktilise
- Biostrepta
- Metalize
Contraindications
Increased sensitivity to the composition of the drug.
The medication should not come into contact with a wound covered with fresh scab or with a fresh suture, as this may cause relaxation of the sutures and, as a result, bleeding.
Not used to treat people with bleeding disorders.
Not prescribed for children.
Not used during pregnancy and lactation.
Anticoagulants and calcium supplements can be combined with Distreptase strictly under the supervision of a specialist.
Distreptase price, where to buy
The price ranges from 1400 to 1600 rubles for 6 suppositories in a blister. The price of Distreptase suppositories is indicated taking into account the dosage of 15,000 IU + 1,250 IU; one course of treatment usually lasts on average 7 to 10 days and requires from 8 to 18 suppositories.
You can buy candles in Moscow at almost any pharmacy; use search engines to find out availability and prices.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
LuxPharma* special offer
- Dystreptase suppositories rect.
2g N6 3100 rub. order
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Pharmacy24
- Dystreptase 2 g N6 suppositories Biomed-Lublin Witturnia Surowiec i Szczepionek Spulka Akcijna, Poland
374 UAH.order
PaniPharmacy
- Dystreptase suppository Supp.dystreptase rect. 2g No. 6 Poland, Biomed-Lublin
406 UAH order
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Dystreptase rectal suppositories 15000IU+1250IU No. 6x1
Name
Dystreptase supp. rect. 15000IU+1250IU per bl. in pack №6x1
Description
Physico-chemical properties Suppositories in the form of cones or “torpedoes” with a pointed end, without mechanical damage; color from white to cream*; It is allowed to have inclusions of a darker color distributed throughout the mass of the suppository, as well as unevenness and depressions at the base of the suppository.
Main active ingredient
Streptokinase+streptodornase
Release form
rectal suppositories
Dosage
15000 iu+1250 iu 2 g
Indications for use
DYSTREPTASE® in the form of suppositories is used in adults as part of complex therapy in the following cases: 1. Chronic salpingoophoritis. 2. Postoperative infiltrative changes. 3. Endometritis. 4. Hemorrhoids with acute and chronic course. 5. Perirectal abscesses and fistulas with extensive inflammatory infiltrate. 6. Purulent caudal cysts. The effectiveness of DYSTREPTASE® in inflammatory diseases of the pelvic organs in women has not been demonstrated in placebo-controlled randomized trials. The use of the drug is based on experience in clinical use.
Directions for use and doses
After removing the suppository from the blister cell, it must be inserted deep into the rectum. The dosage depends on the type and intensity of the inflammatory process. Use as directed by your doctor. In case of severe disease in adults: 1 suppository 3 times a day for the first 3 days; 1 suppository 2 times a day for the next 3 days; 1 suppository 1 time per day for the next 3 days. For mild to moderate severity of the disease in adults: 1 suppository 2 times a day for 3 days; 1 suppository 1 time a day for the next 4 days, or 1 suppository 2 times a day for 2 days. On average, 8–18 suppositories are used per course of treatment. The average duration of treatment is 7 - 10 days. All unused remains of the medicinal product, as well as its waste, should not be disposed of in the sewer or with household waste. These measures will help protect the environment. Instructions for disposing of unused medicine can be obtained from your pharmacist.
Precautionary measures
Features of the use of the drug by certain categories of patients (children, pregnant or breastfeeding women, elderly people, patients with certain types of pathologies) The drug DISTREPTAZA® should not be used by pregnant women, or during breastfeeding. There are no data regarding the specifics of use in persons with impaired liver and kidney function, as well as in elderly patients. Data on the safety and effectiveness of the drug in pediatric practice are limited, therefore its use in children under 18 years of age is not recommended.
Interaction with other drugs
DYSTREPTASE® should not be used concomitantly with anticoagulants because local bleeding may occur. If you are taking other medications, be sure to tell your doctor!
Contraindications
Hypersensitivity to any component of the drug, hemorrhagic diathesis, early period after surgery on the pelvic and rectal organs. The drug should not come into contact with a fresh wound covered with scab, as well as with a freshly applied suture, as this can cause relaxation of the sutures and, as a result, hemorrhage from the wound.
Compound
Streptokinase Streptodornase 15000 IU ± 10% 1250 IU – 20000 IU Active substances Liquid paraffin (Paraffin oil) 0.16 g Excipient Neutral fat Witepsol H15 1.84 g Excipient
Overdose
There are no known symptoms of overdose.
Side effect
Sometimes allergic reactions, increased body temperature and a tendency to bleed may occur. If any atypical reactions occur, stop using the drug and be sure to consult your doctor about the possibility of continuing to use the drug!
Storage conditions
The place for storing the medicine should be inaccessible and invisible to children. Store at a temperature of 2oC - 8oC (in the refrigerator). Do not freeze. Shelf life: 3 years.
Composition and pharmacological properties
“Distreptaza” suppositories are a combination drug. The main active ingredients of this product are streptodornase and streptokinase, which have special enzymatic characteristics. The combination of these ingredients provides the drug with many specific pharmacological capabilities:
- dissolving blood clots, preventing the occurrence of blood clots;
- splitting proteins contained in plasma and accelerating the process of dissolving clots;
- dissolution of accumulations of keratinized cells and resorption of purulent contents.
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In combination, the active components of the drug have antithrombotic, absorbable and anti-inflammatory effects.
Each suppository contains 15,000 IU of streptokinase and 1,250 IU of streptodornase. In addition to these ingredients, Distreptaza suppositories include solid fat and mineral oil.
Side effects
Negative reactions from using the medication can manifest themselves as:
- allergies;
- increased body temperature;
- intensification of existing bleeding or its development.
If such symptoms occur, you should immediately stop using the drug and consult a specialist.
Candles should be stored in the refrigerator until use. The drug does not reduce concentration and does not affect the patient’s performance and control of vehicles and complex mechanisms.
If there are any contraindications to the use of the product, you should definitely consult a specialist.
Note!
The description of the drug Distreptase on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
