Genferon Light suppositories 125000IU+5mg No. 10

Features of the composition of Genferon

The instructions indicate that the medicine is prepared in suppositories; the main active ingredients are presented:

human recombinant interferon alpha-2b;
taurine;
benzocaine.

The role of additional components is given to macrogol 1500, citric acid, dextran 60000, solid fat, sodium hydrogen citate, purified water, polysorbate 80, emulsifier T2.

Genferon is available in whitish or yellowish suppositories, packaged in cardboard packs of 5 or 10 pieces.

Composition and release form

Suppositories for vaginal or rectal use 1 sup.
- active substances: -
human recombinant interferon alpha-2 250000 IU
- taurine 0.01 g - anesthesin 0.055 g - excipients: solid fat; dextran 60000; polyethylene oxide 1500; twin 80; emulsifier T 2; sodium citrate; citric acid; purified water - sufficient quantity to obtain a suppository weighing 1.65 g in a blister pack of 5 pcs.; in a cardboard pack 1 or 2 packages.

active substances: - human recombinant interferon alpha-2 500000 IU

- taurine 0.01 g - anesthesin 0.055 g - excipients: solid fat; dextran 60000; polyethylene oxide 1500; twin 80; emulsifier T 2; sodium citrate; citric acid; purified water - sufficient quantity to obtain a suppository weighing 1.65 g in a blister pack of 5 pcs.; in a cardboard pack 1 or 2 packages.

active substances: - human recombinant interferon alpha-2 1 million IU

Contraindications and indications from the instructions for Genferon

Rectal or vaginal suppositories are prescribed for adults and children. In the latter case, the drug Genferon Light is used. The medication is suitable for the complex treatment of individual pathologies that provoke inflammation of the genitourinary

department:

for chlamydia, genital herpes;
mycoplasmosis, ureaplasmosis;
gardnerellosis, HPV;
trichomoniasis, bacterial vaginosis;
cervical erosion, vulvovaginitis;
cervicitis, adnexitis;
urethritis, balanitis, bartholinitis;
prostatitis, balanoposthitis;
thrush.

Genferon is contraindicated in patients with individual intolerance to the component composition in the first 4 months of pregnancy. Caution during therapeutic procedures is necessary for patients with acute diseases affecting the immune system.

Nosological classification (ICD-10)

— A49.3 Mycoplasma infection, unspecified — A56 Other sexually transmitted chlamydial diseases — A59 Trichomoniasis — A60 Anogenital herpetic viral infection [herpes simplex] — A63.8 Other specified sexually transmitted diseases — B37.3 Vulvar candidiasis and vagina (N77.1) - B97.7 Papillomaviruses - N34 Urethritis and urethral syndrome - N41 Inflammatory diseases of the prostate gland - N48.1 Balanoposthitis - N48.6 Balanitis - N70 Salpingitis and oophoritis - N72 Inflammatory diseases of the cervix - N74.4 Inflammatory diseases of the female pelvic organs caused by chlamydia (A56.1+) - N75.9 Bartholin's gland disease, unspecified - N76 Other inflammatory diseases of the vagina and vulva - N86 Erosion and ectropion of the cervix

Adverse reactions

Treatment with Genferon 10,000,000 IU can lead to non-standard responses of the body:

headache attacks, decreased levels of leukocytes and platelets in the blood;
painful sensations in joints and bones;
active work of sweat glands, increased temperature;
loss of appetite, rapid fatigue;
skin itching, rashes, and the appearance of red spots.

These symptoms are reversible and spontaneously disappear three days after stopping the suppositories.

Features of therapy

The instructions recommend the following procedures with Genferon:

Infectious and inflammatory pathologies of the genitourinary tract in women - depending on the disease, a suppository twice a day, for 10 days. Chronic and long-term forms of diseases - 1 suppository every 24 hours, for 1-3 months.
Lesions of the urogenital tract in men of an infectious-inflammatory nature - 1 suppository in the morning and evening, for 10 days.

The abstract does not indicate any reported cases of overdose. If a large amount of medication is accidentally used, therapy is stopped for 24 hours, then the patient should return to the previously prescribed regimen. If the treatment has caused non-standard symptoms, the patient should attend a consultation with a doctor and describe in detail the changes that have occurred. In some cases, it is necessary to replace the drug with an analogue.

A country

Russia
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Interferon alpha-2b + Taurine

Compound

Interferon alpha-2b, taurine.

pharmachologic effect

Has local and systemic effects. The drug contains recombinant human interferon alpha-2b. Interferon alpha-2b has antiviral, immunomodulatory, antiproliferative and antibacterial effects. The immunomodulatory effect is manifested, first of all, by enhancing cell-mediated reactions of the immune system, which increases the effectiveness of the immune response against viruses, intracellular parasites and cells that have undergone tumor transformation. Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, restoration of the production of secretory immunoglobulin A is achieved. The antibacterial effect is mediated by reactions of the immune system, enhanced under the influence of interferon. Taurine helps to normalize metabolic processes and tissue regeneration, has a membrane-stabilizing and immunomodulatory effect. Taurine helps maintain the biological activity of interferon, enhancing the therapeutic effect of the drug. With rectal administration of the drug, high bioavailability of interferon is observed, and therefore both local and pronounced systemic immunomodulatory effects are achieved; when used intravaginally, due to the high concentration at the site of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect is insignificant due to the low absorption capacity of the vaginal mucosa. The maximum concentration of interferon in the blood serum is achieved 5 hours after administration of the drug. The main route of elimination of α-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.

Indications for use

For the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women. As a component of complex therapy - for the treatment of other infectious diseases of viral etiology.

Mode of application

The drug can be used both vaginally and rectally. The method of administration, dosage and course duration depend on age, the specific clinical situation and are determined by the attending physician.

Interaction

The drug is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs, mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect

Side effect

Local allergic reactions (itching and burning sensation in the vagina). These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor. Phenomena that occur when using all types of interferon alfa-2b may be observed, such as chills, fever, fatigue, loss of appetite, muscle and headaches, joint pain, sweating, as well as leukemia and thrombocytopenia. In these cases, it is recommended to consult your doctor to decide whether to discontinue the drug or reduce the dose.

Contraindications

Individual intolerance to interferon and other substances included in the drug. With caution: Exacerbation of allergic and autoimmune diseases. Use during pregnancy and lactation: Clinical studies have proven the effectiveness and safety of the drug in the second and third trimesters of pregnancy. The safety of using the drug in the first trimester of pregnancy has not been studied.

Overdose

If you accidentally administer more suppositories at a time than were prescribed by your doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed regimen.

special instructions

The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving vehicles, machinery, etc.).

Nuances of interaction and manufacturer's instructions

The instructions indicate the following features:

taking vitamins C and B enhances the activity of Genferon;
the bactericidal and bacteriostatic activity of sulfonamides decreases when combined with benzocaine;
Non-narcotic analgesics improve the effectiveness of benzocaine.

The greatest results with therapy with Genferon are recorded when combined with antimicrobial medications. The drug must be used with caution during menstruation due to the lack of sufficient clinical trials.

The drug is incompatible with alcohol; you should avoid drinking alcohol during therapeutic procedures. In the 2-3 trimester of pregnancy, the medication is used when obsessive itching, discomfort and other symptoms occur caused by an infectious-inflammatory lesion of the genitourinary tract.

Analogs

If unusual reactions of the body or signs of intolerance to the component composition occur, the drug requires replacement. The list of analogues is presented:

Vitaferon, Viferon, Viferon-Feron;
Laferobion, Laferon Farmbiotek, Kipferon;
Alfarekin, Alfarona, Bioferon;
Virogel, Gerpferon, Grippferon;
Introbion interferon alpha-2b, Intron A;
Lipoferon, Okoferon, Realdiron, etc.

The selection of a suitable remedy is carried out by the attending physician.

Pharmacodynamics

Genferon® is a combination drug, the effect of which is determined by the components included in its composition.
Has local and systemic effects. Interferon alpha-2 has antiviral, antimicrobial and immunomodulatory effects. Under the influence of interferon alpha-2, the activity of natural killer cells, T-helper cells, phagocytes, as well as the intensity of differentiation of B-lymphocytes in the body increases. Activation of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of primary pathological foci and restoration of the production of secretory immunoglobulin A. Interferon alpha-2 also directly inhibits the replication and transcription of viruses and acts on chlamydia. Taurine has regenerating, reparative, membrane- and hepatoprotective, antioxidant, anti-inflammatory properties. Anestezin is a local anesthetic. Reduces the permeability of the cell membrane to sodium ions, displaces calcium ions from receptors located on the inner surface of the membrane. Prevents the occurrence of pain impulses at the endings of sensory nerves and their conduction along nerve fibers.

Reviews

On the forums there are both neutral and positive responses about Genferon. Most reviews are related to treatment procedures in women during therapy for HPV, herpetic and cytomegalovirus infections. Good clinical results occur when treated with suppositories of 1 million IU.

Deterioration in well-being and an increase in temperature are associated with large dosages, especially when using suppositories for minors. To avoid the development of adverse reactions, the patient must strictly follow the doctor’s instructions, without deviations from the original regimen.