Experience with the use of the drug "Estrovel" in the treatment of menopausal syndrome and concomitant estrogen-dependent diseases

Composition and release form

10 pcs in blister; There are 3 blisters in a cardboard pack.

Estrovel capsules No. 30

Name

Estrovel caps. 520 mg No. 30

Description

Hard gelatin capsules, yellow-beige color; average weight 520 mg; odor of capsule contents: weak, specific.

Release form

Capsules.

pharmachologic effect

"ESTROVEL" is a biologically active food supplement for women, which contains standardized plant extracts of chaste vitex fruits, rhizomes with dioscorea roots, soybean seed extract, which is a source of vitamins (B6, E, K1, folic acid), boron, isoflavones, hydroxytryptophan, indole-3-carbinol, diosgenin and aucubin for women. The updated formula of dietary supplement “ESTROVEL” helps reduce the symptoms of premenstrual and menopausal syndrome, normalizes the level of sex hormones, has a mild laxative effect, and helps correct the functional state of the autonomic nervous system. The plant extracts included in the composition exhibit effects similar to the action of the female body’s own estrogens, i.e. devoid of the side effects that synthetic estrogens have. Properties of dietary supplement components for food "ESTROVEL" Soy isoflavones Soy isoflavones are called phytoestrogens. These are substances of plant origin, biologically similar to estrogen, having an estrogen-like effect when there is a lack of own hormones and compensating for the negative effects of estrogen when there is an excess. The use of isoflavones helps reduce the frequency of hot flashes, sweating, headaches and other symptoms observed during menopause. Isoflavones also help regulate hormonal imbalances during premenstrual syndrome (PMS), stimulate bone tissue renewal processes, and contribute to its strengthening and restoration. Isoflavones have antioxidant, anti-inflammatory, antipyretic properties, and also suppress thrombin formation and platelet aggregation, thereby helping to prevent cardiovascular diseases. Dioscorea extract (Chinese yam, Dioscorea opposita) Extract of rhizomes with roots of Dioscorea opposita (another name is Chinese yam) contains substances that are precursors of progesterone and some other hormones. Dioscorea normalizes the condition caused by hormone imbalance during PMS and menopause. Yam prevents the development of atherosclerosis, has an antispasmodic effect and has a vasodilating effect. Chasteberry fruit extract (Vitex Agnus-castus) Chasteberry fruits have a stabilizing effect on the concentration of sex hormones, normalize progesterone levels, and are used to reduce PMS symptoms. The key property of Vitex is to reduce the level of irritability, nervousness, breast tenderness, bloating, and headaches. Vitex fruit extract has an analgesic effect, reducing premenstrual and premenopausal mastalgia, inhibits cholesterol acyltransferases, thus reducing the level of hypercholesterol, which can be used in the complex treatment of cardiovascular diseases. Vitex fruit extract causes an antitumor effect by stimulating the death and mitotic arrest of cancer cells. Indole-3-carbinol is found in high concentrations in cruciferous vegetables (broccoli, cauliflower, Brussels sprouts and cabbage). Indole-3-carbinol helps normalize estrogen metabolism, blocks pathways for stimulating pathological proliferation (hyperplastic processes in the endometrium, uterine fibroids, endometriosis). The use of indole-3-carbinol helps normalize hormonal balance and reduce the risk of tumors, suppress the Herpes simplex virus and human papillomavirus. It has the ability to cause selective death of altered cells with abnormally high proliferative activity. Vitamin K1 Vitamin K1 is involved in the processes of hematopoiesis, has a hemostatic effect, which has a preventive effect for menstrual disorders. Vitamin K1 plays an important role in the formation and restoration of bones, ensuring the synthesis of osteocalcin, a bone tissue protein, thereby helping to prevent osteoporosis in menopausal women. Boron Boron helps enhance the action of phytoestrogens. It increases the effectiveness of treatment, eliminating hot flashes, vaginal dryness and other menopausal symptoms. Boron is essential for maintaining healthy bones and improves calcium absorption. Also, boron in sodium tetraborate has antifungal properties. Vitamin E Vitamin E is the standard of antioxidants; it helps restore reproductive function and normalizes the menstrual cycle. The use of vitamin E helps eliminate the symptoms of vaginal dryness, improves the condition of the skin, nails, and hair. Vitamin B6 Vitamin B6 accelerates the metabolism of proteins, carbohydrates, fats, increases resistance to stress, helps prevent cardiovascular diseases and osteoporosis. It also relieves premenstrual symptoms by reducing swelling caused by water retention in the body. Improves the synthesis of endorphins - natural stimulants of mood and emotions, thereby having a beneficial effect on the symptoms of menopause and PMS. Folic acid (vitamin B9) This vital vitamin is necessary for the development of the hematopoietic and immune systems. Folic acid has an estrogen-like effect, slowing down the onset of menopause and weakening its symptoms. L-5-hydroxytryptophan It is an intermediate product in the synthesis of serotonin by the human body. Together with vitamin B6, it increases the synthesis of endorphins, which are responsible for reducing the perception of pain, and has a positive effect on body functions. Estrovel has a positive effect on various manifestations of menopause and improves conditions after gynecological operations for a number of symptoms:

Action

- reduction in the frequency of hot flashes; - helps normalize unstable blood pressure; - reducing the intensity of headaches and dizziness; - reduction in feelings of weakness, fatigue and nervousness; - improved mood, increased sexual activity. All this creates conditions for increasing performance and improving vitality in women with neurovegetative and psycho-emotional disorders during menopause, conditions after gynecological operations and PMS. The use of Estrovel in complex therapy of chronic cystitis reduces the frequency of relapses.

Directions for use and doses

Adults: 1-2 capsules per day with meals. Duration of treatment – ​​2 months.

Compound

dextrose; gelatin capsule (gelatin; food dyes E171, E104, E122); soybean seed extract (soy isoflavones); griffonia seed extract (L-5-hydroxytryptophan); rhizome extract with dioscorea roots; chasteberry fruit extract; tocopherol acetate (fillers: maltodextrin, modified starch, DL-alpha tocopherol acetate, silicon dioxide); indole-3-carbinol; sodium tetraborate; anti-caking agents: amorphous silicon dioxide (E551), magnesium stearate (E470); pyridoxine hydrochloride; phytomenadione (fillers: guar gum (E414), sucrose); folic acid. 1 capsule: vitamin B6 (pyridoxine hydrochloride) 2 mg vitamin E (tocopherol acetate) 15 mg vitamin K1 (phytomenadione) 60 mcg folic acid 200 mcg L-5-hydroxytryptophan 60 mg indole-3-carbinol 25 mg boron 1 mg isoflavones ≥25 mg diosgenin ≥8 mg aucubin ≥240 mg

Buy Estrovel caps. 520 mg No. 30 in the pharmacy

Price for Estrovel caps. 520 mg No. 30

Instructions for use for Estrovel caps. 520 mg No. 30

Component Properties

Cimicifuga racemosa has a positive effect on the autonomic nervous system, relieving and eliminating hot flashes, sweating, palpitations and dizziness. Cohosh alleviates symptoms associated with hormonal imbalance during menopause, helps reduce muscle, joint and headaches, improves bone metabolism and leads to a reduction in calcium loss.

Soy isoflavones are substances of plant origin, similar in structure to estrogen, one of the main female sex hormones. They have an estrogen-like effect on the body when there is a lack of its own hormones, and also compensate for the negative effects of estrogen when it is in excess.

The use of isoflavones helps regulate hormonal imbalances during premenstrual syndrome (PMS), helps reduce the main symptoms of menopause, such as hot flashes, sweating, and headaches. They also stimulate the processes of renewal and strengthening of bone tissue.

Wild yam (Dioscorea) contains substances that are precursors to progesterone and other female hormones. Dioscorea helps normalize hormone levels during PMS and menopause. Wild yam prevents the development of atherosclerosis, has an antispasmodic effect and has a vasodilating effect.

Indole-3-carbinol is found in high concentrations in vegetables such as broccoli, cauliflower, Brussels sprouts and cabbage.

Indole-3-carbinol has the ability to neutralize the negative effects of estrogens during hormonal imbalance during PMS and menopause. An important property of indole-3-carbinol is its ability to reduce the risk of developing cancer.

Stinging nettle extract contains, in addition to vitamins C, B and K, carotenoids, flavonoids, and chlorophyll. Vitamin K is involved in hematopoiesis and has a hemostatic effect, which has a preventive effect in cases of menstrual irregularities. Vitamin K plays an important role in the formation and restoration of bones, ensuring the synthesis of osteocalcin, a bone tissue protein, thereby helping to prevent osteoporosis in menopausal women. Stinging nettle extract has a restorative and antioxidant effect due to its high content of vitamin C and carotenoids. It has a diuretic effect and reduces the symptoms of PMS associated with fluid retention in the body.

Boron (as part of calcium fructoborate, an organic form of boron) enhances the effect of phytoestrogens and helps increase the level of own estrogens in postmenopausal women. Boron significantly reduces the intensity of the development of osteoporosis, which is one of the most dangerous manifestations of menopause.

Vitamin E (natural origin) - softens hot flashes and mood swings, reduces fatigue, dizziness, palpitations and nervousness. Vitamin E helps restore reproductive function, eliminates menstrual irregularities, helps eliminate symptoms of vaginal dryness, and improves the condition of skin, nails, and hair.

Vitamin B6 (pyridoxine) relieves PMS symptoms by reducing swelling caused by water retention in the body. Promotes the synthesis of endogenous endorphins, reducing the symptoms of PMS and menopause. Vitamin B6 increases resistance to stress, helps prevent cardiovascular diseases and osteoporosis, and supports the immune system.

Folic acid helps strengthen the immune system and increases the ability to withstand stress and depression. Folic acid has an estrogen-like effect, slowing down the onset of menopause and weakening its symptoms, and also takes an active part in the processes of regulating the functions of the hematopoietic organs and has an antianemic effect.

5-Hydroxytryptophan, an amino acid found in the seeds of the Griffonia plant, is a natural precursor to serotonin. Together with vitamin B6, it increases the synthesis of endorphins, which are responsible for reducing the perception of pain and positive emotions, allowing to alleviate the symptoms of menopausal syndrome, especially hot flashes. 5-hydroxytryptophan is an antidepressant that is effective in treating PMS. It has a beneficial effect on symptoms such as despondency, depression, tension, anxiety, emotional instability, tearfulness, irritability that occur in the last week of the cycle.

D,L-phenylalanine is an amino acid with analgesic properties. This ability of phenylalanine is due to its ability to block enzymes that break down neuropeptides that reduce the sensation of pain. Due to its ability to influence the synthesis of mediators involved in the transmission of nerve impulses, phenylalanine and its derivatives are used as antidepressants.

Estrovel has a positive effect on various manifestations of menopause for a number of symptoms:

helps normalize unstable blood pressure;

reduces the intensity of headaches and dizziness;

reduces the frequency of hot flashes;

reduces feelings of weakness, fatigue and nervousness;

improves mood, increases sexual activity.

Instructions

Drug name:

ESTROVEL®

Release form:

30 capsules weighing 520 mg, in a blister and a cardboard pack

Description:

Food supplement "ESTROVEL®" is a complex for women, which contains standardized plant extracts of the fruits of Vitex sacred, rhizomes with roots of Dioscorea, soybean seed extract, which is a source of vitamins (B6, E, K1, folic acid), boron, isoflavones, hydroxytryptophan, indole-3-carbinol, diosgenin and aucubin for women. The updated formula of dietary supplement "ESTROVEL®" helps reduce the symptoms of premenstrual and menopausal syndromes, normalizes the level of sex hormones, has a mild laxative effect, and helps correct the functional state of the autonomic nervous system. The plant extracts included in the composition exhibit effects similar to the action of the female body’s own estrogens, i.e. devoid of the side effects that synthetic estrogens have.

Compound:

dextrose; gelatin capsule (gelatin; food dyes E171; E104; E122); soybean seed extract (soy isoflavones); griffonia seed extract (L-5-hydroxytryptophan); rhizome extract with dioscorea roots; chasteberry fruit extract; tocopherol acetate (fillers: maltodextrin, modified starch, DL-alpha tocopherol acetate, silicon dioxide); indole-3-carbinol; sodium tetraborate; anti-caking agents: amorphous silicon dioxide (E551); magnesium stearate (E470); pyridoxine hydrochloride; phytomenadione (fillers: guar gum (E 414), sucrose), folic acid.

Properties of the components of the dietary supplement "ESTROVEL®":

Soy isoflavones

Soy isoflavones are called phytoestrogens. These are substances of plant origin, biologically similar to estrogen, having an estrogen-like effect when there is a lack of own hormones and compensating for the negative effects of estrogen when there is an excess. The use of isoflavones helps reduce the frequency of hot flashes, sweating, headaches and other symptoms observed during menopause. Isoflavones also help regulate hormonal imbalances during premenstrual syndrome (PMS), stimulate bone tissue renewal processes, and contribute to its strengthening and restoration. Isoflavones have antioxidant, anti-inflammatory, antipyretic properties, and also suppress thrombin formation and platelet aggregation, thereby helping to prevent cardiovascular diseases.

Dioscorea extract (Chinese yam, Dioscorea opposita)

The rhizome extract with the roots of Dioscorea contrafolia (another name is Chinese yam) contains precursors of progesterone and some other hormones. Dioscorea normalizes the condition caused by hormonal imbalance during PMS and menopause. Yam prevents the development of atherosclerosis, has an antispasmodic effect and has a vasodilating effect.

Chasteberry fruit extract (Vitex Agnus-castus)

Vitex fruits have a stabilizing effect on the concentration of sex hormones, normalize progesterone levels, and are used to reduce PMS symptoms. The key property of Vitex is to reduce the level of irritability, nervousness, breast tenderness, bloating, and headaches. Vitex fruit extract has an analgesic effect, reducing premenstrual and premenopausal mastalgia, inhibits cholesterol acyltransferases, thus reducing the level of hypercholesterol, which can be used in the complex treatment of cardiovascular diseases. Vitex fruit extract causes an antitumor effect by stimulating the death and mitotic arrest of cancer cells.

Indole-3-carbinol

It is found in high concentrations in cruciferous vegetables (broccoli, cauliflower, Brussels sprouts and cabbage). Indole-3-carbinol helps normalize estrogen metabolism, blocks pathways for stimulating pathological proliferation (hyperplastic processes in the endometrium, uterine fibroids, endometriosis). The use of indole-3-carbinol helps normalize hormonal balance and reduce the risk of tumors, suppress the Herpes simplex virus and human papillomavirus. It has the ability to cause selective death of altered cells with abnormally high proliferative activity.

Vitamin K1

Vitamin K1 is involved in the processes of hematopoiesis, has a hemostatic property, which has a preventive effect in cases of menstrual irregularities. Vitamin K1 plays an important role in the formation and restoration of bones, ensuring the synthesis of osteocalcin, a bone tissue protein, thereby helping to prevent osteoporosis in menopausal women.

Bor

Boron helps enhance the action of phytoestrogens. It increases the effectiveness of treatment, eliminating hot flashes, vaginal dryness and other menopausal symptoms. Boron is essential for maintaining healthy bones and improves calcium absorption. Also, boron in sodium tetraborate has antifungal properties.

Vitamin E

Vitamin E is the standard of antioxidants; it helps restore reproductive function and normalizes the menstrual cycle. The use of vitamin E helps eliminate the symptoms of vaginal dryness, improves the condition of the skin, nails, and hair.

Vitamin B6

Vitamin B6 accelerates the metabolism of proteins, carbohydrates, fats, increases resistance to stress, and helps prevent cardiovascular diseases and osteoporosis. It also relieves premenstrual symptoms by reducing swelling caused by water retention in the body. Improves the synthesis of endorphins - natural stimulants of mood and emotions, thereby having a beneficial effect on the symptoms of menopause and PMS.

Folic acid (vitamin B9)

This vital vitamin is necessary for the development of the hematopoietic and immune systems. Folic acid has an estrogen-like effect, slowing down the onset of menopause and weakening its symptoms.

L-5-hydroxytryptophan

It is an intermediate product in the synthesis of serotonin by the human body. Together with vitamin B6, it increases the synthesis of endorphins, which are responsible for reducing the perception of pain, and has a positive effect on body functions.

Indications for use:

Menopause (menopause)

Menopause is a natural and natural stage in a woman’s life, usually starting after 45 years, and represents the extinction of the menstrual cycle and reproductive function. Climacteric syndrome is a complex of various disorders and symptoms that complicate the natural course of the menopausal period. It is caused by hormonal changes in the female body due to decreased ovarian activity.

Depending on the severity of symptoms, there are three degrees of severity of menopausal syndrome:

• Mild degree - occurs in only 16% of women. In this case, the woman’s general condition and performance are not affected.
• Medium degree – occurs in 33% of women. Characterized by deterioration of well-being and decreased performance.
• Severe degree is the most common, occurring in 51% of women. The woman’s well-being deteriorates significantly, up to a sharp decrease in performance.

ESTROVEL® dietary supplement has a positive effect on various manifestations of menopause for a number of symptoms:

• Helps normalize unstable blood pressure.
• Reduces the intensity of headaches and dizziness.
• Reduces the frequency of hot flashes.
• Reduces feelings of weakness, fatigue and nervousness.
• Improves mood, increases sexual activity.

All this creates conditions for increasing performance and improving vitality in women with neurovegetative disorders during menopause.

Premenstrual syndrome (PMS)

Premenstrual syndrome is a complex of psycho-emotional and vegetative-vascular disorders that occur before the onset of menstruation and disappear immediately after its onset or in the first days. The frequency of PMS manifestations depends on age. Thus, under the age of 30, PMS occurs in a fifth of women and in more than half of women over 40 years of age. PMS is based on a change in the ratio of female sex hormones. Other reasons for its occurrence may be fluid retention in the body and a lack of B vitamins, in particular B6.

Contraindications:

individual intolerance to components, pregnancy, breastfeeding. It is recommended to consult a doctor before use.

Directions for use and dosage:

adults: 1-2 capsules per day with meals. Duration of treatment – ​​2 months.

Storage conditions:

in a dry place, protected from direct sunlight and out of reach of children at a temperature not exceeding 25°C.

Shelf life: 2 YEARS.

State registration certificate No. RU.77.99.88.003.R.004621.12.19 dated 12/18/2019. Not a medicine. THE PRODUCT HAS PASSED VOLUNTARY CERTIFICATION.