Amoxicillin
Antacids, glucose, laxatives, food, aminoglycosides
slow down and reduce absorption,
ascorbic acid
increases absorption.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomytium, rifampicin, quinolones)
have a synergistic effect,
bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) are
antagonistic (the effectiveness of amoxicillin is reduced).
Increases the effectiveness of indirect anticoagulants
(by suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index), reduces the effectiveness
of drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol
- the risk of developing “breakthrough” bleeding.
However, the literature describes cases of increased international normalized ratio (INR) in patients receiving maintenance therapy with acenocoumarol
or
warfarin
who are prescribed a course of treatment with amoxicillin. If concomitant use of drugs is necessary, the INR should be carefully monitored when amoxicillin is added or removed. In addition, it may be necessary to adjust the dose of oral anticoagulants.
Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs and drugs that block tubular secretion by reducing tubular secretion
, increase the concentration of amoxicillin in the blood plasma.
When used simultaneously with allopurinol
the risk of developing a skin rash increases.
Reduces clearance and increases toxicity of methotrexate
.
Enhances the absorption of digoxin
.
Use of amoxicillin and probenecid
not recommended, because probenecid reduces the renal tubular secretion of amoxicillin, thereby increasing its plasma concentration and lengthening the time it remains in the blood serum.
