Klion-D 100: instructions for use. Price and reviews of the drug

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Manufacturers: Gedeon Richter (Hungary)

Active ingredients

Miconazole
Metronidazole

Disease class

Trichomoniasis
Candidiasis
Other inflammatory diseases of the vagina and vulva

Clinical and pharmacological group

Not indicated. See instructions

Pharmacological action

Antifungal
Antiprotozoal
Antibacterial

Pharmacological group

Antifungal agents in combinations
Other synthetic antibacterial agents in combinations

Pharmacodynamics and pharmacokinetics

The effect of the drug is due to the complex effect on the vaginal microflora of its constituent components.

Miconazole is an antifungal agent that destroys dermatophytes and yeasts , but does not disturb the pH or destroy healthy microflora in the vagina. The substance directly affects the synthesis of lipid components in the fungal membrane, thereby destroying it. It does not penetrate into the blood and is not found in the kidneys and products of the excretory organs; 90% remains in the vagina. The maximum concentration is after 8 hours.

Metronidazole is an antibiotic . It inhibits the process of RNA and DNA of destructive bacteria by restoring the 5-nitro group by transport proteins inside the cell. After entering the vagina, it penetrates into the blood. Its maximum concentration in the blood (half of the administered dose) can be detected after 9 hours.

Pharmacological properties of the drug Klion-d 100

Combined drug for intravaginal use for infections caused by Trichomonas vaginalis and/or pathogenic fungi. The active ingredients of the drug are metronidazole (1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole) and miconazole (1-[2,4-dichloro-β-((2,4-dichlorobenzyl)oxy)-phenethyl]- imidazole). Metronidazole has antiprotozoal and antibacterial effects. Active against Trichomonas vaginalis , Entamoeba histolytica , obligate anaerobes, including anaerobic gram-negative bacilli ( Bacteroides spp. Bacteroides fragilis group , Fusobacterium spp. ), anaerobic gram-positive bacilli ( Clostridium spp. and sensitive strains of Eubacterium ), anaerobic gram-positive cocci cove ( including Peptococcus spp. and Peptostreptococcus spp. ). Metronidazole penetrates into microorganisms, where its nitro group is converted into hydroxylamine, which enhances the effect of the drug on the DNA of microorganisms, leading to their death. Miconazole nitrate has an antifungal (fungicidal) effect. Active (when used intravaginally) mainly against Candida albicans . When administered intravaginally, metronidazole is absorbed and enters the systemic circulation, the maximum concentration in the blood plasma is observed after 6-8 hours. It is about 50% of the maximum concentration achieved 1-3 hours after a single oral dose of the same dose. When administered intravaginally, miconazole is absorbed and enters the systemic circulation in small quantities.

Interaction

The medicine is not combined with ethanol, disulfiram , non-depolarizing muscle relaxants, cimetidine, and lithium preparations .

When taking indirect anticoagulants , it is worth additionally monitoring the prothrombin index .

The effectiveness of metronidazole is reduced when combined with phenobarbital and phenytoin .

Use of the drug Klion-d 100

Locally, for vaginitis caused by Trichomonas vaginalis , 1 tablet of the drug, moistened with water, is injected deep into the vagina once a day, in the evening before bed. The course of treatment is 10 days. At the same time, metronidazole is prescribed for oral administration (1 tablet during or immediately after meals, 2 times a day in the morning and evening). It is advisable to simultaneously treat the sexual partner with metronidazole (orally). If the effectiveness is insufficient, local treatment is continued for another 10 days. For candidal vaginitis, 1 tablet of the drug, moistened with water, is injected deep into the vagina once a day, in the evening before bed. The course of treatment is 10 days.

Analogs

Level 4 ATX code matches:
Gainomax

Sertaconazole

Ornisis

Metrogil Plus

Livarol

Flagyl

Ginofort

Zalain

Ketoconazole

Candide B6

Candide

Gyno-Travogen Ovulum

Kanizon

Metromicon-Neo

Lomexin

Neo-Penotran

Gyno-Pevaril

Ginesol

Antifungol

Analogs of suppositories are: Metromicon-Neo, Ginalgin, Clomezol, Neo-Penotran Forte, Clevazol, Pulsitex, Candibene, Ketodin, Candide, Ketonazole, Livarol, Metronidazole, Clotrimazole, Trichopolum, Econazole.

What is the difference between Klion and Klion-D 100?

Klion tablets contain metronidazole and have a wider range of applications. Usually, to combat trichomoniasis, oral intake of tablets alone is not enough, for which Klion-D 100 suppositories are prescribed.

Vaginal tablets Klion-D 100 (Klion-D 100)

Instructions for medical use of the drug

Description of pharmacological action

The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms. Metronidazole is a broad-spectrum antimicrobial and antiprotozoal agent. Active against Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis as well as against obligate anaerobes (spore-forming and non-spore-forming) - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Clostridium spp., Peptostreptococcus spp., sensitive strains of Eubacterium. Aerobic microorganisms and facultative anaerobes are not sensitive to metronidazole. Miconazole has antifungal activity against common dermatophytes, yeasts and various other fungi and antibacterial activity against certain gram-positive bacteria. Miconazole inhibits the biosynthesis of ergosterol in fungi and changes the composition of other lipid components in the membrane, which leads to the death of fungal cells. Quickly relieves itching that often accompanies infections caused by yeast and dermatophytes. Does not change the composition of the microflora and pH of the vagina.

Indications for use

Trichomonas, candidal and nonspecific vaginitis (local treatment).

Release form

vaginal tablets; contour packaging without cells 10, cardboard pack 1; vaginal tablets 100 mg + 100 mg; strip 10, cardboard pack 1; vaginal tablets 100 mg + 100 mg; strip 10, box 100; Composition Vaginal tablets 1 table. metronidazole 100 mg miconazole nitrate 100 mg excipients: sodium lauryl sulfate; colloidal silicon dioxide; magnesium stearate; povidone; sodium bicarbonate; tartaric acid; sodium carboxymethyl starch (type A); crospovidone; hypromelose; lactose monohydrate in contour-free packaging 10 pcs.; in a cardboard pack 1 package.

Pharmacodynamics

Pharmacokinetics

Metronidazole. When administered intravaginally, it is absorbed into the systemic circulation. Cmax in the blood is determined after 6–12 hours and is approximately 50% of the Cmax that is achieved (after 1–3 hours) after a single dose of metronidazole orally. Miconazole. Systemic absorption of miconazole nitrate after intravaginal use is limited. 8 hours after application of the drug, 90% of miconazole is still present in the vagina. Unchanged miconazole is not detectable in either plasma or urine.

Use during pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications for use

- hypersensitivity to the components of the drug (including other nitroimidazole derivatives); - blood diseases, leukopenia (including history); — impaired coordination of movements, organic lesions of the central nervous system (including epilepsy); - liver failure (in case of prescribing large doses); - pregnancy; - period of breastfeeding. With caution: - diabetes mellitus; - microcirculation disturbance.

Side effects

Local: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge without odor or with a faint odor, frequent urination; a burning sensation or irritation of the penis in a sexual partner. From the gastrointestinal tract: nausea, changes in taste, “metallic” taste and dry mouth, loss of appetite, cramping pain in the abdominal cavity; vomiting, constipation or diarrhea. Allergic reactions: urticaria, itching of the skin, rash. From the nervous system: headache, dizziness. Other: leukopenia or leukocytosis. In rare cases, urine is colored red-brown (due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole).

Directions for use and doses

Intravaginally (deeply), after moistening the tablet with water. Trichomonas vaginitis - 1 table. per day for 10 days in combination with oral metronidazole. Nonspecific vaginitis or candidal vaginitis - 1 table. 2 times a day for 10 days, if necessary in combination with oral metronidazole. Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

Interactions with other drugs

Like disulfiram, it causes ethanol intolerance. Concomitant use with disulfiram can lead to the development of various mental disorders and depression of consciousness. Strengthens the effect of indirect anticoagulants (warfarin, etc.), which leads to an increase in the time of prothrombin formation. It is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide). Co-administration with barbiturates may accelerate the elimination of metronidazole, resulting in a decrease in its effect. Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects. When taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase.

Special instructions for use

Simultaneous treatment of the sexual partner is recommended, regardless of whether he has manifestations of the disease. During the treatment period you should abstain from sexual intercourse. If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or with its long-term use, monitoring of a general blood test is necessary. Metronidazole can immobilize treponemes, leading to a false-positive Nelson test. Use with caution while working for drivers of vehicles and people whose profession is associated with increased concentration of attention (dizziness associated with taking the drug may occur).

Storage conditions

List B.: In a dry place, protected from light, at a temperature of 15–30 °C.

Best before date

60 months

ATX classification:

G Genitourinary system and sex hormones

G01 Antiseptics and antimicrobials for the treatment of gynecological diseases

G01A Antiseptics and antimicrobials for the treatment of gynecological diseases (excluding combinations with corticosteroids)

G01AF Imidazole derivatives

G01AF20 Combinations of imidazole derivatives

Reviews about Klion-D 100

Reviews on forums: Overall good. Many people used Klion-D 100 for thrush and were satisfied with the result. Some women complain of severe side effects. The drug is quite effective not only against thrush, but also against other types of vaginitis .

Reviews during pregnancy: Despite the fact that the use of the product during pregnancy is not recommended, women are often prescribed suppositories. Reviews of Klion-D 100 suppositories were divided; some women tolerated the medication well and it did not affect their children in any way. Many experienced severe burning, itching, abdominal pain and voluntarily stopped taking the drug.

Klion-D 100

Klion-D 100 (metronidazole + miconazole) is a combined two-component drug for use in gynecological practice. Indicated for combined inflammation of the vagina caused by Trichomonas and Candida. Itching and hyperemia in the genital area, pain during urination, vaginal discharge and an unpleasant odor are constant companions to inflammation of the vagina (vaginitis), which most often develops as a result of trichomoniasis and candidiasis. The causative agent of candidiasis is the microscopic fungus candida. The balance between saprophytic and potentially pathogenic vaginal microflora is maintained by lactic acid bacteria (lactobacteria). They inhibit the growth and reproduction of candida by releasing lactic acid and hydrogen peroxide. However, under the influence of a number of factors (weakened immunity, hormonal imbalance, pregnancy, increased psycho-emotional stress), this balance can be disrupted, resulting in the development of candidiasis. Subsequently, other infections may join it, which greatly complicates treatment. In this regard, gynecologists currently prefer combination drugs for the treatment of vaginal infections, the components of which are active against both fungi (candida) and bacteria. A striking example of such a drug is Klion-D 100 from the Hungarian pharmaceutical company, the effect of which is determined by the components included in its composition.

Metronidazole is active against protozoa and bacteria, because is able to penetrate the cell wall of the pathogen, causing its death. Miconazole is effective for fungal infections of the vagina, incl. candidiasis Klion-D 100 ensures balance in the qualitative and quantitative composition of the vaginal microflora and brings the acid-base balance to the physiological norm. The drug reduces the risk of complications after abortion and implantation of an intrauterine device by 4.83 times. The use of Klion-D 100 before gynecological surgical interventions shortens recovery time and reduces the risk of developing postoperative complications. The high effectiveness of the drug makes it possible to exclude the use of systemic anti-inflammatory drugs, which have a large number of unwanted side effects. Kliona-D 100 is well tolerated and has a favorable safety profile. The drug is active against Trichomonas, Garnerella, Bacteroides, Fusobacteria, Velionella, Prevotella, Clostridia, Peptococcus and a number of other bacteria. In pediatric practice, the drug can be used starting from the age of 12. Single dose – 1 vaginal tablet. The duration of the drug course is 10 days in combination with additional oral administration of metronidazole drugs. Klion-D 100 is not compatible with alcohol. During treatment it is necessary to abstain from sexual activity.

Price Klion-D 100 (where to buy)

On average, the price of Klion-D 100 suppositories in Ukraine is 100 UAH for 10 vaginal tablets.

How much does it cost to buy medicine in Kyiv? About 120 UAH for 10 pieces.

Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

Pharmacy24

Klion-D 100 N10 tablets VAT "Gedeon Richter", Ugorshchina
201 UAH. order

PaniPharmacy

Klion-D 100 tablets Klion D tab. vag. No. 10 Hungary, Gedeon Richter
212 UAH order

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Klion-D 100, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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