The drug Fenkarol 50 mg is used to treat allergic reactions in adults. It successfully fights any type of allergy:
- food,
- medicinal,
- hay fever,
- urticaria (chronic and acute)
- atopic dermatitis,
- eczema, etc.
It is also prescribed to relieve symptoms of allergic rhinitis or conjunctivitis. The maximum dosage of Fenkarol tablets is 50 mg. The standard prescription of Fenkarol for adults: 50 mg tablet 2 times a day or 25 mg tablet 2-4 times a day.
Pharmacodynamics and pharmacokinetics
The active component of the drug, a derivative of quinuclidyl carbinol , reduces the effect of histamine (which is produced as an immune response to an allergen ) on the body. Its structure contains a cyclic quinuclidine nucleus , the substance has a significant distance between the nitrogen and the diphenylcarbinol .
Hifenadine blocks H1 receptors competitively, while activating the enzyme diamine oxidase . This enzyme is capable of breaking down about 30% of histamine . Thus, the drug is more effective compared to other allergy .
through the blood-brain barrier and has virtually no effect on the deamination of serotonin in the brain or monoamine oxidase .
The product relieves spasm of smooth muscles in the intestines , itching and discomfort due to allergies. The drug reduces hypotensive activity , maintains normal capillary , without clearly affecting blood pressure and the heart muscle. Unlike the well-known and widespread diphenhydramine and pipolfen , the drug does not depress the central nervous system and is present in brain tissue in small quantities. However, if the patient has a specific reaction to the component, mild sedation .
When administered intramuscularly, the maximum concentration of the active substance is achieved after half an hour. When taking the tablet form – after an hour. Accumulates mainly in the liver, kidneys and lungs. Then it undergoes metabolic , their products are excreted in the urine.
What therapeutic effect does
According to the instructions, Fenkarol tablets have a therapeutic effect in four areas:
- relieve swelling;
- relieve itching;
- fight other manifestations of allergies - runny nose, lacrimation;
- eliminate increased vascular permeability.
The main purpose of Fenkarol is to reduce the effect of histamine, which is responsible for the development of an allergic reaction. It selectively blocks receptors and activates the production of the enzyme diamine oxidase, which can break down and remove histamine.
After taking the tablets, spasms in the intestines are relieved, itching sensations and skin rashes characteristic of allergies disappear.
At the same time, the medication does not inhibit the functioning of the central nervous system.
The effect of intramuscular administration is achieved after 30 minutes, taking tablets - after 60 minutes.
Indications for use of Fenkarol
To treat allergies, tablets or an injection solution are used (severe course, urgent need).
What are Fenkarol tablets for?
From hay fever , urticaria , food or medication , hay fever , and other allergic diseases.
Also indications for the use of Fenkarol are:
- dermatosis ( skin itch , eczema , neurodermatitis );
- rhinopathy , which is allergic in nature;
- angioedema;
- reactions to an allergen accompanied by bronchospasm.
Indications for use
The instructions for Fenkarol contain a list of conditions for which the drug can help. Tablets and injections are prescribed by allergists and dermatologists for:
- manifestations of hay fever;
- runny nose of allergic origin;
- urticaria in acute and chronic form;
- angioedema;
- dermatoses (eczema, psoriasis, atopic dermatitis);
- skin itching;
- drug or food allergies.
Side effects
Side effects are very rare.
If the patient is particularly sensitive to the effects of quifenadine, the following may occur:
- dry mouth and mucous membranes;
- indigestion and bitter taste in the mouth;
- nausea and vomiting;
- mild sedative effect ( drowsiness , lethargy );
- headache and loss of consciousness .
If you have gastrointestinal diseases, the likelihood of side effects increases.
If you have any of the above reactions or if new ones occur, you should consult your doctor.
How does Fenkarol for children (10 mg) work?
An allergic reaction and all its manifestations (runny nose, itching, etc.) appear as a result of the formation of a substance such as histamine in the body.
The medicine blocks the receptors with which histamine tries to interact and stops the development of allergies at the very beginning. The drug begins to act within half an hour after administration. What is it used for?
For the treatment of any type of allergy. From insect bites to dermatitis and hay fever. It is not addictive and can be taken for 3 weeks without interruption.
What is treated with Fenkarol?
- Hay fever (hay fever)
- Acute and chronic urticaria
- Food allergies
- Rhinoconjunctivitis
- Skin itching, dermatitis, eczema, neurodermatitis
- Drug-induced allergies
- Allergic rhinitis
- Insect bites
- Allergic conjunctivitis
Instructions for use of Fenkarol (Method and dosage)
If necessary, the appropriate dosage form (tablets or injection solution) and dosage should be used, depending on age, symptoms and adverse reactions.
The tablets are taken after meals with water or other liquid.
Instructions for Fenkarol, 25 mg
Prescribed, as a rule, to adults. 1-2 tablets, 3 or 4 times a day. You can take no more than 200 mg of the drug per day.
For children over 12 years of age, the daily dosage is 50-75 mg, respectively, 1 tablet, in 2-3 doses.
The duration of treatment is from 10 to 20 days.
Instructions for children's Fenkarol (dosage 10 mg)
Inside, orally.
- Children aged 3 to 7 years are prescribed one tablet 2 times a day;
- Ages 7 to 12 – 1 tablet, 2 or 3 times a day;
- For children over 12 years old – 2 tablets 2-3 times a day.
The course of treatment must be agreed with your doctor. Ranges from 10 days to half a month.
Instructions for solution for intramuscular administration
For hay fever , intramuscular injections of 2 ml are prescribed, 2 times a day, for 3 days. Then the dosage is reduced to 2 ml per day for 2 days.
For Quincke's edema or urticaria, for the first 5 days, injections of 2 ml are given, 2 times a day. Then another 3 days, 2 ml per day.
A maximum of 20 mg (2 ml) of the drug can be administered per injection, and a maximum of 40 mg per day.
If the acute allergic reaction has been stopped, then switching to the tablet form is recommended.
In what forms is it produced, composition
Fenkarol has two dosage forms:
- white tablets in the shape of a flat cylinder with dosages of 10, 25 and 50 mg of the active ingredient;
- a transparent solution without a specific odor for injections into the muscle, 1 ml contains 10 mg of the main substance.
All varieties of the drug contain quifenadine as the main substance.
The solution additionally contains glutamic acid and water for injection. The tablets contain sucrose, modified potato and corn starches, and calcium stearate.
The tablets are packaged in contour packages with cells of 10 or 15 pieces, one box contains 20 or 30 tablets and instructions.
The solution is packaged in glass ampoules of 1 or 2 ml. One package contains 10 ampoules in a cell plate and instructions.
Analogs
Level 4 ATX code matches:
Dezal
Histaphene
Clarisens
Telfast
Erius
Claridol
Claritin
Loratadine
Fexofast
Peritol
Desloratadine
LauraHEXAL
Clarotadine
Rupafin
Ciel
Dramamine
Lordestin
Lomilan
Kestin
Loratek
Analogues of Fenkarol: Alerik , Alersis , Alergomax , Alernova , Alergostop Gistafen , , Kestin , Ketotifen , Laurent , Loratadine , Lordes , Lorizan , Semprex , Tigofast , Fexomax , Fexofen - Sanovel , Edem , Erius , Erolin , Eridez , Fribris , Fexofast , Trexil Neo , Telfast , Peritol , Lorano ODT , Claritin , Altiva .
How to give Fenkarol to children?
Any antihistamines for children should be given with extreme caution:
- strictly follow the dosage;
- do not violate the regimen;
- make sure the tablets are not expired.
Find Fenkarol 10 mg in your city's pharmacy
Important! Before giving allergy medicine to a baby, you need to crush it into powder and dilute it in a small amount of water at room temperature.
Finding and buying Fenkarol for children in Minsk and other cities of Belarus is not difficult; you can go to any nearby pharmacy near your home. You can find out the price of Fenkarol in advance at the help desk.
Instructions for use of the drug Fenkarol 10 mg tablets
Reviews about Fenkarol
Mostly people leave good reviews about Fenkarol. The product helps with severe bronchospasms, relieves swelling during bronchitis, acute respiratory infections and runny nose . The drug is inexpensive and effective. However, adverse reactions may occur, most often nausea and bitterness in the mouth.
Reviews of Fenkarol for children on the Internet
On various forums, people write that Fenkarol is a fast-acting and effective medicine that is generally well tolerated; there are reports of adverse reactions.
The medicine is not suitable for children under one year of age; some consider this a disadvantage.
Reviews
Most reviews of Fenkarol are positive. The drug quickly helps with swelling and bronchospasm that occurs due to an allergic reaction, insect bites and hypersensitivity to certain foods. There is good tolerability and no side effects, including in children.
According to experts, the medication does not cause drowsiness or addiction, and is good for treating chickenpox and urticaria. ENT doctors prescribe Fenkarol for swelling of the nasal mucosa after surgery, for adenoiditis and sinusitis.
Price, where to buy
The price of Fenkarol in tablets is 153 rubles, for 20 pieces, 10 mg each.
The cost of the same amount, but with a dosage of 25 mg, is about 220 rubles.
It is currently difficult to find out the price of Fenkarol in ampoules.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Fenkarol tablets 50 mg 15 pcs. Olainfarm JSC
348 rub. order
Pharmacy Dialogue
- Fenkarol tablets 25 mg No. 20Olainfarm OA
RUB 357 order
- Fenkarol tablets 10 mg No. 20Olainfarm OA
RUB 251 order
- Fenkarol tablets 50 mg No. 15Olainfarm OA
RUB 421 order
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Pharmacy24
- Fenkarol 25 mg No. 20 tablets AT "Olainfarm", Latvia
150 UAH. order - Fenkarol 50 mg No. 30 tablets AT "Olainfarm", Latvia
303 UAH. order
- Fenkarol 10 mg No. 20 tablets AT "Olainfarm", Latvia
101 UAH order
PaniPharmacy
- Fenkarol tablets Fenkarol tablets. 0.010g No. 20 Latvia, Olainfarm JSC
90 UAH order
- Fenkarol tablets Fenkarol tablets. 50 mg No. 30 Latvia, Olainfarm JSC
302 UAH. order
- Fenkarol tablets Fenkarol tablets. 25 mg No. 20 Latvia, Olainfarm JSC
162 UAH order
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Instructions for medical use of the drug FENKAROL® 50 mg tablets
Trade name of the drug
FENKAROL® 50 mg tablets International nonproprietary name: quifenadinum (quifenadine).
Composition of the drug
One tablet contains: Active ingredient - hifenadine hydrochloride 10 mg; excipients - sugar, potato starch, calcium stearate.
Release form
Tablets, dosage 50 mg.
general characteristics
Flat-cylindrical tablets with a chamfer, white or almost white.
Pharmacotherapeutic group and ATC code
Other antihistamines for systemic use. ATX code: R06AX31
Pharmacological properties
Fenkarol is an antihistamine that reduces the effect of histamine on organs and their systems. Unlike other classical drugs in this group, Fenkarol has a special mechanism of action: the drug blocks histamine H1 receptors in peripheral tissues, and also activates the enzyme diamine oxidase (histaminase), thus reducing the content of histamine in tissues. This explains the effectiveness of Fenkarol for patients whose treatment with other antihistamines is ineffective.
Fenkarol is quickly absorbed from the gastrointestinal tract and is found in body tissues within 30 minutes. The maximum concentration of the active substance in the blood plasma is reached after an hour. Fenkarol is metabolized in the liver. Metabolites of Fenkarol and the unchanged portion of the drug are excreted mainly in urine and bile within 48 hours.
Indications for use
Adults: Hay fever, acute and chronic urticaria, allergic rhinitis, allergic conjunctivitis, angioedema, allergic skin diseases (atopic dermatitis, eczema), skin itching (against the background of hyperparathyroidism, in the active phase of hepatitis), allergic reactions associated with taking medications or foods products.
Directions for use and doses
Fenkarol is taken orally immediately after meals. Adults are prescribed 25-50 mg 2-4 times a day. The maximum daily dose is 200 mg.
Fenkarol 50 mg tablets cannot be divided into two equal doses, therefore, in the case of dosing the drug for adult patients at 25 mg, Fenkarol 25 mg tablets should be used.
The duration of treatment is 10-20 days. If necessary, the course is repeated. If you miss a dose, take the medicine as soon as you remember, but skip it if it is already time for your next dose. Never take double dosages.
Side effects
Classification of undesirable side reactions by frequency of development: very often (> 1/10); often (> 1/100 to < 1/10); uncommon (> 1/1000 to < 11/100); rare (> 1/10,000 to < 1/1000); very rare (<1/10,000).
Nervous system disorders: uncommon - headache, drowsiness. Gastrointestinal disorders: often - dry mouth; infrequently - dyspeptic disorders (nausea, vomiting), which usually disappear when the dose is reduced or the drug is discontinued.
If side effects occur, especially those that are not listed in the package insert, you should consult a doctor.
Contraindications
- Hypersensitivity to the active substance and/or any of the auxiliary components of the drug.
- The first three months of pregnancy. In the second and third trimesters of pregnancy - not recommended.
- Breast-feeding.
Overdose
If you suspect an overdose, call a doctor immediately. Symptoms: taking high doses of the drug can cause dry mucous membranes, headache, vomiting, epigastric pain and dyspeptic symptoms. Treatment: it is necessary to provide symptomatic and supportive therapy for the vital functions of the body. There is no specific antidote.
Precautionary measures
Use with caution in severe diseases of the cardiovascular system, gastrointestinal tract, liver and/or kidneys. Fenkarol does not have a depressant effect on the central nervous system, but in some cases a weak sedative effect is observed. The medicinal product contains sugar, so if you are intolerant to any sugars, consult your doctor before using this medicinal product.
Use with caution in severe diseases of the cardiovascular system, gastrointestinal tract, liver and/or kidneys. The tablets are not recommended for use in children under 6 years of age, who may have difficulty swallowing. The medicinal product contains sugar, so if you are intolerant to any sugars, consult your doctor before using this medicinal product.
Use during pregnancy and lactation
In the first three months of pregnancy, the use of the drug is contraindicated. In the second and third trimester - not recommended. It is not known whether the drug is excreted in breast milk, therefore breastfeeding while using the drug is contraindicated.
Impact on the ability to drive vehicles
Persons whose work requires a quick physical or mental reaction (transport drivers, etc.) should first determine (by short-term prescription) whether the drug has a sedative effect. Persons who exhibit sedative effects are not recommended to drive a vehicle or operate dangerous machinery.
Interaction with other drugs
Fenkarol does not enhance the inhibitory effect of alcohol and hypnotics on the central nervous system (CNS). Fenkarol has weak M-cholinergic blocking properties, but with a decrease in gastrointestinal motility, the absorption of slowly absorbed medications may increase (for example, indirect anticoagulants - coumarins).
Best before date
5 years. Do not use the medicine after the expiration date.
Storage conditions
In a place protected from moisture and light at a temperature not exceeding 25 o C. Keep out of the reach of children.
Package
Tablets of 10 pieces are packed in blisters made of polyvinyl chloride film and varnished aluminum foil. 2 blisters (20 tablets) together with instructions (leaflet) for medical use are placed in a cardboard pack.
Conditions for dispensing from pharmacies
Dispensed without a doctor's prescription.
Information about the manufacturer (applicant)
JSC "Olainfarm" Address: st. Rupnicu 5, Olaine, LV-2114, Latvia.
