Nazivin: instructions for use, price, reviews during pregnancy, analogues

Compound

In 1 ml drops of oxymetazoline hydrochloride 500 µg, 250 µg or 100 µg. A solution of benzalkonium chloride , sodium dihydrogen phosphate dihydrate, EDTA, sodium hydroxide, water, sodium hydrogen phosphate dihydrate - as excipients.
Spray composition: of oxymetazoline hydrochloride . A solution of benzalkonium chloride, sodium dihydrogen phosphate dihydrate, EDTA, sodium hydroxide, water, sodium hydrogen phosphate dihydrate - as excipients.

Composition and release form

Drops - 1 ml:

Active ingredient: Oxymetazoline hydrochloride - 0.1/0.25/0.5 mg;
Excipients: Citric acid monohydrate - 0.6093 mg; Sodium citrate dihydrate - 3.823 mg; Glycerol (85%) - 24.348 mg; Benzalkonium chloride (50% solution) - 0.100 mg; Purified water - 979.020/978.870/978.600 mg.

Nasal drops 0.01%; 0.025% and 0.05%.

For Nazivin® 0.01%: 5 ml in a dark glass bottle with a pipette cap.

1 bottle with instructions for use is placed in a cardboard box.

For Nazivin® 0.025% and 0.05%: 10 ml in a dark glass bottle with a pipette cap.

1 bottle with instructions for use is placed in a cardboard box.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Vasoconstrictor, alpha2-adrenergic agonist . Reduces swelling of the mucous membrane when applied topically and the amount of discharge. By eliminating swelling of the mucous membranes, it restores breathing and aeration of the paranasal sinuses and middle ear. The use of the drug prevents the development of sinusitis , sinusitis , and otitis media .

In therapeutic concentrations it does not cause hyperemia and does not irritate the mucous membranes. It begins to act in 10 minutes and the effect lasts 12 hours.

Pharmacokinetics

When applied topically, it has no systemic effect. The half-life is about 35 hours. 2.1% is excreted in urine and 1.1% in feces.

pharmachologic effect

Alpha 2 is an adrenergic agonist.

Pharmacokinetics

When administered locally intranasally, oxymetazoline does not have a systemic effect. The half-life of oxymetazoline when administered intranasally is 35 hours. 2.1% of oxymetazoline is excreted in the urine and about 1.1% in the feces.

Pharmacodynamics

The drug Nazivin® (oxymetazoline) has a vasoconstrictor effect. When applied topically to the inflamed mucous membrane of the nasal cavity, it reduces swelling and nasal discharge.

Restores nasal breathing.

Elimination of swelling of the nasal mucosa helps restore aeration of the paranasal sinuses and middle ear cavity, which prevents the development of bacterial complications (sinusitis, sinusitis, otitis media).

When used locally intranasally in therapeutic concentrations, it does not irritate or cause hyperemia of the nasal mucosa.

The drug begins to act quickly (within a few minutes).

The duration of action of the drug is up to 12 hours.

The results of a double-blind, placebo-controlled study in patients with acute viral rhinitis aged 12-70 years showed that the use of Nazivin® nasal drops 0.05% reduced the median duration of a runny nose from 6 to 4 days.

Side effects

All side effects are rare:

sneeze;
dryness and burning of the nasal mucosa;
reactive hyperemia after completion of treatment, manifested by nasal congestion (in case of overdose);
insomnia;
anxiety;
headache;
nausea;
tachycardia and arterial hypertension (in case of overdose);
atrophy of the mucous membranes (in case of overdose).

Instructions for use of Nazivin (Method and dosage)

Spray Nazivin, instructions for use

Spray 0.05% is prescribed for adults and children over 6 years of age. It is recommended to spray 1 spray into the nasal passages 2-3 times a day. The recommended dose can be used for up to 7 days. If symptoms worsen within 3 days, you should consult a doctor.

Nazivin drops, instructions for use

Adults and children over 6 years of age are prescribed 0.05% drops, 1-2 drops 2-3 times a day. Children from 1 year to 6 years - 0.025% drops, 1-2 drops 2-3 times. Children under 1 year of age are prescribed 0.01% of the drug: newborns 1 drop 2-3 times. The bottle of 0.01% of the drug has a graduated pipette on which the number of drops is marked (1, 2, etc.).

It is possible to administer the drug into the nose in another way: the required number of drops is applied to a cotton swab and the nasal cavity is wiped with it. The duration of use of the drug is 3-4 days.

Contraindications to the use of Nazivin

Atrophic rhinitis; angle-closure glaucoma; hypersensitivity to the components of the drug.

You should adhere to the recommended concentrations of the drug intended for different age categories.

Carefully

In patients taking monoamine oxidase inhibitors and other drugs that increase blood pressure for up to 10 days after their use; with increased intraocular pressure, during pregnancy and lactation, with severe forms of cardiovascular diseases (hypertension, angina); with thyrotoxicosis and diabetes mellitus.

Analogs

Level 4 ATX code matches:
Xymelin Eco

Xymelin

Galazolin

Lazorin

Nazivin Sensitive for children

Otrivin

Naphthyzin

Sanorin

Knoxprey

For the nose

Lazolvan Rino

Afrin

Rhinorus

Eucazoline Aqua

Rinazolin

Grippostad Reno

Farmazolin

Xylometazoline

Nazol Advance

Nazol Baby

Drugs that have the same active ingredient: Nazol , Nazol Advance , Sanorinchik , Noxprey , Afrin , Nesopin , Fazin . Analogue drugs that have a similar effect: Galazolin , Xylometazoline , ForNos , Xymelin .

How to use Nazivin spray

The Nazivin form is indicated for the treatment of runny nose in children 1–6 years old. The bottle with the drug must first be shaken and a test spray into the air.

Before use, the nasal passages are cleared of mucus clots with a cotton swab, the child is allowed to blow his nose, and if possible, the sinuses are washed with a special saline solution or water.
Throwing your head up, carefully bring the dispenser to your nostrils and inject the drug once.
The procedure is repeated up to three times a day.

The general course of treatment is up to 7 days.

Reviews about Nazivin

Nazivin vasoconstrictor drops, like other drops, should be considered as an “ambulance” and used only for 3-5 days of severe nasal congestion. With long-term use, mucosal atrophy is possible. It should be noted that Nazivin, when used in the recommended dosage regimen, does not cause significant damage to the mucous membrane, is not addictive even with long-term use, and its therapeutic effectiveness, compared to other vasoconstrictor drops, is achieved at low concentrations. Therefore, the 0.01% solution of oxymetazoline of rhinitis even in newborns and infants.

It is a known fact that this drug also has antiviral and anti-inflammatory effects. This explains its high effectiveness in rhinitis of viral etiology. This drug is the only anticongestant that is approved in Russia for use in newborns. Research has shown its high efficiency. This is evidenced by reviews of Nazivin:

“... I use Nazivin 0.01% children's nasal drops for my 2-year-old child. They act for a long time, so I drop them 2 times a day, but not for long”;
“... The child often has a runny nose and we can only save ourselves with these drops - 2 days of treatment are enough and the congestion goes away”;
“...I like these drops most of all. We use it with the whole family, but we give it to children in less concentration”;
“... It is enough to instill the drops for 1-1.5 days, and then we switch to medicinal drops (such as Pinosol), or simply instill herbal decoctions and treat the runny nose completely.”

Nazivin spray is convenient for use in adults and some people find it more effective than drops. This is true: aerosol forms are distributed more evenly throughout the mucous membrane, which creates a pronounced therapeutic effect. In addition, the spray does not roll into the nasopharynx, as happens when using drops.

Forms and composition

Nazivin Sensitive is available in the form of intranasal drops and spray:

transparent light yellow solution, packaged in plastic bottles of 5 and 10 ml with special dispensing nozzles;
concentration of the active substance in the drop preparation: 0.01%, and 1 ml of spray contains 250 mcg of oxymetazoline;
auxiliary components of the medicinal solution: distilled water, glycerin, stabilizers.

Drops are allowed to be used in the treatment of children in the first days of life. The spray is indicated for runny noses in children 1–6 years old. Unlike drugs intended for adolescents and adults, Nazivin Sensitive contains a lower dosage of oxymetazoline, which is safe for infants.

Nazivin price, where to buy

You can buy the drug at any pharmacy. The price of Nazivin spray 0.05% ranges from 221 rubles. up to 248 rubles, the cost of Nazivin Sensitive spray is 231-352 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Nazivin spray nasal.
dosage 22.5 µg/dose vial. 10ml Merck KGaA / Sofarimex Industria Kimika e Pharmasuetica Lda RUB 205 order
Nazivin administered drops. 0.01% 5ml Sofarimex Industria Kimica e Pharmasuetica, S.A.
RUB 169 order
Nazivin Sensitive nasal spray. dosage 22.5mcg/dose 10mlPharmaster/Famar Health Care Services Madrid/Merck KGaA and Co.
RUB 236 order
Nazivin Sensitive nasal spray. dosage 11.25mcg/dose 10mlPharmaster/Famar Health Care Services Madrid/Merck KGaA and Co.
RUB 208 order
Nazivin administered drops. 0.025% 10ml Sofarimex Industria Kimica e Pharmasuetica, S.A.
164 RUR order
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Pharmacy Dialogue

Nazivin (sensitive 22.5 µg/dose 10 ml-220 doses spray dosage) Merck KgaA
RUB 234 order
Nazivin (drops 0.05% 10ml)Merck KgaA
RUB 183 order
Nazivin (drops 0.025% 10ml)Merck KgaA
150 rub. order
Nazivin (spray 22.5 µg/dose 10 ml) Merck KGaA/Sofarimex
RUB 197 order
Nazivin (drops 0.01% 5ml)Merck KgaA
170 rub. order

Pharmacy24

Nazivin Sensitive 0.05% 10 ml spray Merck Selbstmedication GmbH, Nimechchina/Merck KgaA & Co.
Werk Spittal, Austria 65 UAH.order
Nazivin 0.01% 5 ml drops Merck KGaA, Nimechchina
53 UAH order
Nazivin Sensitive 0.025% 10 ml spray
66 UAH order
Nazivin 0.025% 10 ml drops Merck KGaA, Nimechchina
55 UAH order
Nazivin 0.05% 10 ml spray Merck KGaA, Nimechchina
55 UAH order

PaniPharmacy

Nazivin sensitive liquid Nazivin Sensitive nasal spray 0.025% 10ml Germany, Merck Selbstmedikation GmbH
79 UAH order
Nazivin liquid Nazivin nasal drops 0.01% 5ml Germany, Merck KGaA
57 UAH order
Nazivin liquid Nazivin nasal drops 0.025% 10ml Germany, Merck KGaA
58 UAH order
Nazivin sensitive liquid Nazivin Sensitive nasal spray 0.05% 10ml Germany, Merck Selbstmedikation GmbH
87 UAH order
Nazivin liquid Nazivin spray 0.05% 10ml Germany, Merck KGaA
64 UAH order

How to use children's Nazivin drops: instructions

Newborns and infants up to 4 weeks are allowed to instill 1 dose of the drug into each nostril three times a day:

shake the bottle;
Carefully turn the child's head up and insert the dispenser into the nasal sinus, drip the solution.

Starting from the fifth week of life, you can increase the dosage by instilling 2 doses of the drug once. You can repeat the procedure up to 4 times a day. If there is a fear of overdose, it is allowed to use the solution as follows:

moisten a cotton swab with liquid and gently wipe the child’s nasal passages from the inside;
Repeat the application of drops as many times as necessary.

The maximum duration of treatment without pediatrician supervision is no more than 1 week.