Buy Ampicillin Hemofarm granules for suspension 250mg/5ml 100ml in pharmacies

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Semi-synthetic antibiotic of the penicillin series , has a bactericidal . The mechanism of action is associated with inhibition of the synthesis of the cell membrane of dividing microorganisms: it disrupts the peptide bonds in it, which leads to a decrease in the resistance of the bacterial cell and to lysis. Acid resistant. Shows activity against gram-positive ( staphylococcus , streptococcus ) and gram-negative microorganisms ( Klebsiella pneumoniae , Protea , Salmonella , Shigella , Escherichia coli , influenza bacteria).

It is of interest as a drug for the treatment of purulent surgical infections , urinary tract infections , cholangitis and cholecystitis . Effective for the treatment of bacterial respiratory tract infections (community-acquired pneumonia , bronchitis , otitis media , sinusitis ), meningitis , endocarditis (in combination with Gentamicin ), intestinal infections ( shigellosis )

It is destroyed by penicillinase and is therefore ineffective against penicillinase-forming staphylococci . Attempts have been made to “protect” the antibiotic from destruction by bacterial enzymes. “Protected” penicillins are combinations with enzyme inhibitors: Ampicillin + Sulbactam (drug Unazin , Sultasin and others). Sulbactam does not have an antibacterial effect, but inhibits beta-lactamases, so in this combination the antibiotic also acts on resistant strains of microorganisms.

Pharmacokinetics

Absorption is rapid, bioavailability is 40%. The maximum concentration in the blood is determined after 2 hours. It is 20% bound to proteins. In therapeutic concentrations it is found in pleural and synovial fluids, the contents of blisters, high concentrations in urine, gall bladder, lungs, genitals, bile, bronchial secretions, bones, paranasal sinuses, middle ear, saliva.

Excreted by the kidneys (70-80%), partly with bile, and with breast milk. High concentrations of the antibiotic are found in the urine. Does not accumulate with repeated use.

Ampicillin 250 mg No. 10 tab.

APPROVED by the Order of the Chairman of the Pharmaceutical Control Committee of the Ministry of Health of the Republic of Kazakhstan dated "____" __________ 200__ No. ____________________ Instructions for the medical use of the drug AMPICILLIN Trade name Ampicillin International nonproprietary name Ampicillin Dosage form Tablets 250 mg Composition One tablet contains the active substance - ampicillin trihydrate (in terms of for ampicillin) 250 mg, excipients: potato starch, magnesium stearate, povidone, polysorbate, talc. Description White, flat-cylindrical tablets with an imprint of the company's trademark on one side, a score and a chamfer on the other side. Pharmacotherapeutic group Broad-spectrum penicillins. ATC code J01CA01 Pharmacological properties Pharmacokinetics After oral administration, ampicillin is rapidly absorbed, bioavailability is 40%; time to reach maximum concentration after oral administration of 500 mg is 2 hours, maximum concentration in blood plasma is 3-4 ng/ml. Connection with blood plasma proteins – 20%. Evenly distributed in organs and tissues of the body, found in therapeutic concentrations in pleural, peritoneal, amniotic and synovial fluids, cerebrospinal fluid, the contents of blisters, urine (high concentrations), intestinal mucosa, bones, gall bladder, lungs, tissues of the female genital organs, bile , in bronchial secretions (in purulent bronchial secretions the accumulation is weak), paranasal sinuses, saliva, fetal tissues. It penetrates the blood-brain barrier poorly (permeability increases with inflammation). It is excreted primarily by the kidneys (70-80%), and very high concentrations of unchanged antibiotic are created in the urine; partly with bile, in nursing mothers - with milk. Does not accumulate. Removed by hemodialysis. Pharmacodynamics Ampicillin is a broad-spectrum antibacterial bactericidal agent from the group of semisynthetic penicillins, obtained by acytylation of 6-aminopenicillanic acid with an aminophenylacetic acid residue, acid-stable. Inhibits peptidoglycan polymerase and transpeptidase, prevents the formation of peptide bonds and disrupts the late stages of cell wall synthesis of a dividing microorganism, which leads to a decrease in the osmotic stability of the bacterial cell and causes its lysis. Shows the greatest activity against gram-positive aerobic bacteria: Staphylococcus spp. (except beta-lactamase-producing strains), Staphylococcus aureus (except beta-lactamase-producing strains), Streptococcus pyogenes, Streptococcus viridans, Streptococcus agalactiae, Streptococcus pneumoniae, Listeria monocytogenes, Corynebacterium diphtheriae, Corynebacterium xerose, Bacillus anthracis, Enterococcus spp .; gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitides, Haemophilus influenzae, moderately active against gram-negative Escherichia coli, Proteus mirabilis, Shigella spp., Salmonella spp., Leptospira spp., Borrelia spp., Treponema pallidum, Vibrio cholerae; gram-negative anaerobic cocci: Peptostreptococcus spp., Clostridium spp., Propionibacterium acnes, Fusobacterium spp. Beta-lactamase-producing strains of Staphylococcus spp. are resistant to ampicillin. and other gram-negative bacteria, Pseudomonas aeruginosa, indole-positive strains of Proteus spp., Bacteroides spp., Enterobacter aerogenes, Klebsiella pneumoniae, Rickettsia spp., Mycoplasma spp., Chlamydia spp., H. pylori, Mycobacterium tuberculosis. Currently, most hospital strains of Escherichia coli and Proteus mirabilis are resistant to the drug (resistance level 20-30%). Indications for use - bronchitis, pneumonia, lung abscess - sinusitis, tonsillitis, pharyngitis, otitis media - pyelonephritis, pyelitis, cystitis, urethritis - cholangitis, cholecystitis - gonorrhea - cervicitis - erysipelas, impetigo, secondarily infected dermatoses - infections of the musculoskeletal system - pasteurellosis - listeriosis - typhoid and paratyphoid fever, dysentery, salmonellosis, salmonella carriage, peritonitis. Method of administration and dosage: Orally, adults – 0.25 g 4 times a day 0.5-1 hour before meals with a small amount of water; if necessary, the dose is increased to 3 g/day. Infections of the gastrointestinal tract and genitourinary system: 0.5 g 4 times a day. For gonococcal urethritis - 3.5 g orally once. Children over 6 years old are prescribed 1-2 g per day. The daily dose is divided into 4-6 doses. The duration of treatment depends on the severity of the disease (5-10 days). Side effects Allergic reactions: Sometimes: - skin peeling, itching, urticaria, rhinitis, conjunctivitis, Quincke's edema - dysbacteriosis, abdominal pain, nausea, vomiting Rarely: - fever, arthralgia, eosinophilia, erythematous and maculopapular rash, exfoliative dermatitis, exudative multiforme erythema, incl. Stevens-Johnson, reactions similar to serum sickness - stomatitis, gastritis, dry mouth, change in taste, diarrhea, stomatitis, glossitis, impaired liver function, moderate increase in the level of "liver" transaminases, pseudomembranous enterocolitis - agitation or aggressiveness, anxiety, confusion consciousness, changes in behavior - leukopenia, neutropenia, thrombocytopenia Very rare: - anaphylactic shock. - depression, convulsions (with high-dose therapy) - agranulocytosis, anemia Other adverse reactions: Sometimes: - vaginal candidiasis Rarely: - interstitial nephritis, nephropathy, superinfection (especially in patients with chronic diseases or reduced body resistance) Contraindications - hypersensitivity to the drug - infectious mononucleosis - lymphocytic leukemia - liver failure - history of gastrointestinal tract diseases (especially colitis associated with the use of antibiotics) - lactation period - children's age (up to 6 years) Drug interactions Antacids, glucosamine, laxatives, food slow down and reduce absorption, ascorbic acid increases the absorption of Ampicillin. Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) – synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) – antagonistic. Ampicillin increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives (it is necessary to use additional methods of contraception), drugs during the metabolism of which para-amino-benzoic acid, ethinyl estradiol are formed (in the latter case, the risk of “breakthrough” bleeding increases). Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs; drugs that block tubular secretion increase the concentration (by reducing tubular secretion) of Ampicillin. When used together with Allopurinol, the risk of developing a skin rash increases. Ampicillin reduces the clearance and increases the toxicity of methotrexate and enhances the absorption of digoxin. Special instructions Use with caution: bronchial asthma, hay fever and other allergic diseases, renal failure, history of bleeding. During a course of treatment, it is necessary to monitor the function of the hematopoietic organs, liver and kidneys. It is possible that superinfection may develop due to the growth of microflora that is insensitive to it, which requires a corresponding change in antibacterial therapy. When treating patients with bacteremia (sepsis), the development of a bacteriolysis reaction (Jarisch-Herxheimer reaction) is possible. In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible. When treating mild diarrhea during a course of treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; You can use kaolin- or attapulgite-containing antidiarrheal agents. Treatment must be continued for another 48-72 hours after the disappearance of clinical signs of the disease. When using estrogen-containing oral contraceptives and ampicillin simultaneously, other or additional methods of contraception should be used if possible. Effect on laboratory parameters When treated with ampicillin, false-positive results may occur when determining glucose in urine using Benedict's solution, Fechtling. With the enzymatic method of determining glucose levels, the introduction of ampicillin does not affect the result of the analysis. Pregnancy Use during pregnancy is possible only for health reasons in cases where the expected benefit to the mother outweighs the potential risk to the fetus. When taking ampicillin, it is possible to develop decreased tone and weakness of uterine contractions during childbirth. Influence on the ability to drive vehicles and operate machinery. During the treatment period, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Overdose Symptoms: manifestations of toxic effects on the central nervous system (especially in patients with renal failure); nausea, vomiting, diarrhea, water and electrolyte imbalance (as a result of vomiting and diarrhea). Treatment: gastric lavage, activated carbon, saline laxatives, drugs to maintain water-electrolyte balance and symptomatic. Eliminated by hemodialysis. Release form and packaging 250 mg tablets. 10 tablets in blister packs. 1 blister pack together with instructions for medical use in the state and Russian languages ​​are placed in a cardboard pack. Storage conditions Store in a dry place, at a temperature of + 15 to + 25 ° C. Keep out of the reach of children! Shelf life: 2 years Do not use after expiration date. Conditions for dispensing from pharmacies By prescription. Russian Federation, 640008, Kurgan, Constitution Avenue, 7. tel./fax

Indications for use

• sinusitis , tonsillitis , otitis , pharyngitis , bronchitis , abscess , pneumonia ;
• urinary tract infection;
• pyelonephritis;
• cholangitis;
• gonorrhea , cervicitis ;
• chlamydia in pregnant women;
• erysipelas , impetigo , infected dermatoses ;
• scarlet fever;
• pasteurellosis , listeriosis ;
• salmonellosis and its carriage, typhoid fever , dysentery ;
• peritonitis;
• endocarditis;
• meningitis;
• septicemia.

Side effects

• itching, peeling of the skin;
• rhinitis , urticaria , Quincke's edema ;
• rarely - maculopapular rash, fever, dermatitis , erythema and anaphylactic shock ;
• dysbiosis , gastritis , change in taste, dry mouth, abdominal pain, nausea, diarrhea, vomiting;
• stomatitis , glossitis , pseudomembranous enterocolitis ;
• agitation, aggressiveness, anxiety, depression, convulsions;
• leukopenia , thrombocytopenia , agranulocytosis ;
• nephritis , nephropathy ;
• vaginal candidiasis.

Side effects of Ampicillin for injection

Allergic reactions are possible in the form of skin rash, urticaria, Quincke's edema, rhinitis, conjunctivitis, fever, joint pain, eosinophilia; rarely - anaphylactic shock. Possible toxic effects on the central nervous system (when using the drug in high doses in patients with renal failure); as well as dyspeptic symptoms, candidiasis, intestinal dysbiosis, colitis caused by C. difficale ; at the injection site - swelling, itching, hyperemia; increase in body temperature. If allergic reactions occur, administration of the drug must be stopped and desensitizing therapy performed. If signs of anaphylactic shock appear, urgent measures are taken to remove the patient from this condition. With prolonged treatment with the drug in weakened patients, superinfection caused by microorganisms resistant to the drug may develop.

Instructions for use of Ampicillin (Method and dosage)

Ampicillin tablets, instructions for use

The drug in tablets or capsules is taken orally. Dosage for adults: 250-500 mg (depending on the severity of the disease) 1 hour before meals 4 times a day.

For urinary tract infections, 500 mg 4 times a day. For gonococcal urethritis, a single dose of 3.5 g is prescribed. Adults can take ampicillin tablets in a maximum daily dose of 4 g. For children, it is preferable to prescribe it in the form of a suspension, as will be discussed below.

Ampicillin/sulbactam tablets contain two parts standard dosage ampicillin and one part sulbactam. The method of their use and dosage is the same.

Ampicillin injections, instructions for use

After preparing the solution, it is administered intramuscularly or intravenously. When performing intramuscular injections, add 2 ml of Novocaine , water for injection or Lidocaine . For intravenous administration, a single dose is dissolved in 10 ml of isotonic solution or glucose solution. For a single dose of more than 2 g, it is administered dropwise; for this, 250 ml of an isotonic solution is added to the resulting antibiotic solution and 60 drops per minute are administered.

For moderate infections, adults and children weighing more than 20 kg - intramuscularly 250 - 500 mg 4 times a day, in more severe cases - 1 - 2 g 4 times a day. For meningitis - 14 g/day, divided into 6 - 8 injections. For children weighing up to 20 kg, the dose is 12.5 - 25 mg/kg per day, over 20 kg - 50-100 mg/kg per day. For meningitis, newborns weighing up to 2 kg are prescribed intravenously 25 mg per kg body weight every 12 hours throughout the first week, then 50 mg per kg body weight every 8 hours.

Pharmacological properties of the drug Ampicillin for injection

Pharmacodynamics . Ampicillin has a wide spectrum of antibacterial (bactericidal) action. Active against gram-positive microorganisms ( Staphylococcus spp. , with the exception of strains producing penicillinase; Streptococcus spp. , including S. pneumoniae; Corynebacterium diphtheriae, Bacillus anthracis, Clostridium spp ., most enterococci) and gram-negative (E scherichia coli, Shigella spp. , Salmonella spp., Neisseria meningitidis, N. gonorrhoeae, Proteus mirabilis , some strains of Klebsiella pneumoniae, Haemophilus influenzae ) microorganisms. The drug is destroyed by penicillinase and therefore has no effect on penicillinase-forming strains of bacteria. The drug inhibits peptidoglycan polymerase and transpeptidase, prevents the formation of peptide bonds and disrupts the late stages of cell wall synthesis of microorganisms that divide. The resulting defects in the membrane reduce the osmotic resistance of the bacterial cell, which leads to its death (lysis). Pharmacokinetics . When administered intramuscularly or intravenously, it circulates in high concentrations in the blood. The maximum concentration in the blood is determined 15 minutes after intravenous administration and 30 minutes to 1 hour after intramuscular administration. With the intramuscular administration of 0.5–1.0 g of ampicillin with an interval between administrations of 4–6 hours, a therapeutic concentration is maintained in the blood. Penetrates well into tissues and body fluids, and is determined in therapeutic concentrations in pleural, peritoneal and synovial fluid. It is determined in bile in concentrations 4–100 times higher than in blood. A relatively small portion (10–30%) binds to plasma proteins. Does not penetrate the BBB. Almost does not undergo biotransformation. Excreted mainly by the kidneys, partially with bile; during breastfeeding - with milk. Over the course of 12 hours, 45–70% of the administered dose is excreted in the urine. If the excretory function of the kidneys is impaired, the level of the drug in the blood plasma increases and its elimination slows down. With creatinine clearance ≤10 ml/min, the level of antibiotic in the blood can be 10 times higher than in patients with normal renal function. The half-life increases from 1–2 hours normally to 10–12 hours. Ampicillin does not accumulate upon repeated administration, which allows it to be used in higher doses and for a long time.

Interaction

Bacteriostatic agents ( macrolides , chloramphenicol , sulfonamides , lincosamides , tetracyclines ) have an antagonistic effect, bactericidal antibiotics ( aminoglycosides , Vancomycin , cephalosporins , Rifampicin ) have a synergistic effect.

Antacids and laxatives , food intake reduce absorption, and ascorbic acid .

Strengthens the effect of anticoagulants , reduces the effectiveness of estrogen- containing contraceptives .

Diuretics , Allopurinol , Phenylbutazone , Oxyphenbutazone , NSAIDs , increase the concentration of the active substance due to a decrease in tubular secretion.

Concomitant use of Allopurinol causes a risk of skin rash.

Enhances the absorption of Digoxin . Increases the toxicity of Methotrexate .

Ampicillin for children

The suspension for children is intended for use from one month of age. To prepare it, add boiled water to the bottle with granules to the mark, shake, and store at room temperature for 2 weeks. Shake thoroughly before use. Pay attention to the dosage - there are suspensions containing 125 mg and 250 mg of active substance. If we take the last option, then in 1 full measuring spoon (5 ml of suspension) there will be 250 mg of the active substance, the bottom mark of the spoon corresponds to 125 mg.

Dosage for children with mild infection: up to 1 year - at the rate of 100 mg/kg body weight per day, from 1 year to 4 years - 100-150 mg/kg body weight per day, over 4 years - 1-2 g per day. The required dose should be given in 4 or 6 doses.

Ampicillin Sodium Salt 1g For Injection

Release form

Powder for the preparation of solution for injection.

Compound

1 bottle contains ampicillin (in the form of sodium salt) 0.5, 1 or 2 g.

Package

1 bottle in a cardboard box.

pharmachologic effect

Ampicillin is a broad-spectrum semisynthetic penicillin antibiotic. It has a bactericidal effect by inhibiting the synthesis of bacterial cell walls. Active against gram-positive aerobic bacteria: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. (including Enterococcus spp.), Listeria monocytogenes; gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae. Destroyed by penicillinase. Acid resistant.

Ampicillin sodium salt, indications for use

Infectious and inflammatory diseases caused by microorganisms sensitive to ampicillin, including: – respiratory tract infections (including bronchitis, pneumonia, lung abscess); – infections of the ENT organs (including tonsillitis); – biliary tract infections (including cholecystitis, cholangitis); – urinary tract infections (including pyelitis, pyelonephritis, cystitis); – gastrointestinal infections (including salmonella carriage); – gynecological infections; – infections of the skin and soft tissues; – peritonitis; – sepsis, septic endocarditis; – meningitis; – rheumatism; - erysipelas; – scarlet fever; – gonorrhea.

Contraindications

– hypersensitivity to antibiotics from the penicillin group and other betalactam antibiotics; – severe liver dysfunction (for parenteral use).

Directions for use and doses

They are set individually depending on the severity of the disease, the location of the infection and the sensitivity of the pathogen.

For parenteral administration (i.m., intravenous jet or intravenous drip), a single dose for adults is 250-500 mg, a daily dose is 1-3 g; for severe infections, the daily dose can be increased to 10 g or more. For newborn children the drug is prescribed at a daily dose of 100 mg/kg, for children of other age groups - 50 mg/kg. In severe cases of infection, the indicated doses may be doubled. The daily dose is divided into 4-6 injections with an interval of 4-6 hours. The duration of intramuscular administration is 7-14 days. The duration of intravenous administration is 5-7 days, followed by a transition (if necessary) to intramuscular administration. A solution for intramuscular administration is prepared by adding 2 ml of water for injection to the contents of the bottle. For intravenous jet administration, a single dose of the drug (no more than 2 g) is dissolved in 5-10 ml of water for injection or isotonic sodium chloride solution and administered slowly over 3-5 minutes (1-2 g over 10-15 minutes) . For a single dose exceeding 2 g, the drug is administered intravenously. To do this, a single dose of the drug (2-4 g) is dissolved in 7.5-15 ml of water for injection, then the resulting solution is added to 125-250 ml of isotonic sodium chloride solution or 5-10% glucose solution and administered at a rate of 60-80 drops. /min. When administered intravenously to children, a 5-10% glucose solution (30-50 ml depending on age) is used as a solvent. Solutions are used immediately after preparation.

Use during pregnancy and breastfeeding

It is possible to use the drug during pregnancy according to indications in cases where the benefit to the mother outweighs the potential risk to the fetus. Ampicillin is excreted in breast milk in low concentrations. If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Side effects

Allergic reactions: skin rash, urticaria, Quincke's edema, itching, exfoliative dermatitis, erythema multiforme; in rare cases - anaphylactic shock. From the digestive system: nausea, vomiting, diarrhea, glossitis, stomatitis, pseudomembranous colitis, intestinal dysbiosis, increased activity of liver transaminases. From the hematopoietic system: anemia, leukopenia, thrombocytopenia, agranulocytosis. Effects caused by chemotherapy: oral candidiasis, vaginal candidiasis.

special instructions

The drug should be prescribed with caution and against the background of simultaneous use of desensitizing agents for bronchial asthma, hay fever and other allergic diseases. During the use of Ampicillin, systematic monitoring of renal, liver and peripheral blood function is necessary. In case of liver failure, the drug should be used only under monitoring of liver function. Patients with impaired renal function require adjustment of the dosage regimen depending on QC. When using the drug in high doses in patients with renal failure, toxic effects on the central nervous system are possible. When using the drug to treat sepsis, a bacteriolysis reaction (Jarisch-Herxheimer reaction) is possible. If allergic reactions occur during the use of Ampicillin, the drug should be discontinued and desensitizing therapy should be prescribed. In weakened patients, with prolonged use of the drug, superinfection caused by ampicillin-resistant microorganisms may develop. To prevent the development of candidiasis, nystatin or levorin, as well as vitamins B and C, should be prescribed simultaneously with Ampicillin.

Drug interactions

Probenecid, when used simultaneously with Ampicillin, reduces the tubular secretion of ampicillin, resulting in an increase in its concentration in the blood plasma and an increased risk of toxicity. With the simultaneous use of Ampicillin with allopurinol, the likelihood of skin rash increases. When used simultaneously with Ampicillin, the effectiveness of estrogen-containing oral contraceptives is reduced. When used simultaneously with Ampicillin, the effectiveness of anticoagulants and aminoglycoside antibiotics increases.

Overdose

It has a toxic effect on the central nervous system (especially in patients with renal failure). Treatment: symptomatic.

Storage conditions

Store in a dry place, protected from light; at a temperature not exceeding 20°C.

Best before date

2 years. Prepared solutions for intramuscular and intravenous administration cannot be stored.

Ampicillin and alcohol

The instructions do not mention anything about whether alcohol and ampicillin are combined. However, upon reflection, we can conclude that drinking alcohol can cause or intensify adverse reactions, reduce the content of the active substance in tissues and reduce the effectiveness of antibiotic therapy. And this is due to the fact that when drinking alcohol, the cytochrome P450 (it is induced), and the enzymes of other cytochromes necessary for drug metabolism are suppressed. of glucuronic acid , which is necessary for binding toxic substances and drug metabolites, is also reduced

Ampicillin analogues

Level 4 ATC code matches:
Hiconcil

Ampioks

Ampicillin Trihydrate

Ospamox

Amoxicar

Penicillin

Flemoxin Solutab

Amoxicillin

Amosin

Amoxil

Ecoball

Analogs with one active ingredient: Pentrexil , Penodil , Zetsil , Standacillin .

Reviews about Ampicillin

What is Ampicillin tablets for? This is an antibiotic of the penicillin , so it is used for various infections, including, has not lost its relevance in the treatment of shigellosis . Ampicillin is still widely used today, primarily due to the fact that it is available to the vast majority of patients and practically does not cause liver dysfunction (frequency less than 0.1%, compared to Cefotaxime 8% and aminoglycodides - 15%). In medical practice, Ampicillin capsules and tablets are used in the form trihydrate , as well as granules for preparing a suspension. It must be said that oral forms of this drug have low bioavailability - only 40%. As a drug for intramuscular administration, it is effective in the treatment of many infections, but as a drug for oral administration in most cases it is inferior to Amoxicillin , the advantage of which is better and stable absorption, the absence of influence on it by food intake, and also a smaller frequency of use. In addition, oral administration of this drug can cause dysbiosis , while Amoxicillin slightly suppresses the flora. Frequent use of the drug in children (every 4 months) can lead to fluorosis - a defect in tooth enamel.

Reviews of Ampicillin are mostly related to its use for sore and sinusitis , for severe cases of which injections of “pure” ampicillin or its combination with sulbactam - Ampisulbin , Sultasin or Ouanazine .

Indications for use include its use for infections of the ear, throat, paranasal sinuses, cystitis and pyelonephritis . The choice of this drug for pyelonephritis is explained by the lack of nephrotoxicity, the effect on E. coli (the main cause of urinary tract infections) and the ability to be excreted in urine in therapeutic concentrations.

For uncomplicated pyelonephritis, treatment began with ampicillin. fluoroquinolones or cephalosporins were added after 2–3 days . Only some patients experienced nausea, vomiting, stool upset, rash and itching during treatment.

Special instructions for the use of Ampicillin for injection

It is unacceptable to mix Ampicillin with other medications in the same container. During treatment, systematic monitoring of renal, liver and peripheral blood function is necessary. Patients with impaired renal function require adjustment of the dosage regimen in accordance with the creatinine clearance value. Caution should be used when treating during pregnancy, as well as in children whose mother's medical history indicates increased sensitivity to penicillins. For asthma, hay fever and other allergic diseases, the drug is used simultaneously with desensitizing agents. The drug does not affect the ability to drive vehicles.

Ampicillin price, where to buy

You can buy this drug in many pharmacies in Moscow.

The price of Ampicillin tablets 250 mg No. 20 ranges from 16 rubles. up to 21 rub. One bottle of Ampicillin sodium salt powder 500 mg costs 7-9 rubles.

To purchase the drug, you will need a prescription in Latin, issued by a doctor.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

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