Theoretical and practical aspects of the use of sulfur preparations in dermatology

Release form

The product is available in tablet form, as well as in the form of loose, easily crumbling granules with a diameter of 3 to 5 mm, powder or flat flakes of a yellowish (possibly with a grayish tint) color.

The product has a bitter taste and a characteristic odor. It goes on sale packaged in 25, 50 or 100 grams in jars or bags.

The tablets are biconvex, brownish in color, without a shell, with a characteristic yeasty odor. Packaged in 60 or 100 pieces in bottles made of polymer materials.

Drinking yeast tablets instructions. Composition and structure of brewer's yeast

In terms of their structure, brewer's yeast is a unicellular microorganism related to fungi, which is obtained from beer wort during the fermentation of hops and malt. During fermentation, a colony of yeast grows, which in its composition is similar to a “vitamin bomb”.

The beneficial properties of brewer's yeast have been known for a long time. For ailments, doctors recommended drinking beer and other yeast drinks in small quantities. Today everyone has the opportunity to purchase this supplement in different versions:

1. In the form of round, brown tablets with a sour taste and characteristic odor. The types of yeast in tablets may differ in one of the components, which enhances the effect of the product. Pelleted yeast is sold only in dry form. In liquid form, yeast is sold at breweries and has a more pronounced effect.
2. Dry yeast is also available in powder form.
3. Another option is dried yeast granules.

Each tablet contains 500 mg of beneficial fungi. They are produced in plastic jars, which contain, based on packaging, from 50 to 100 tablets with a unique composition:

• a set of mineral compounds;
• a number of essential amino acids;
• vitamins PP, C, E, H, F;
• B vitamins in full;
• some enzymes.

Proteins and amino acids account for up to 40% of the product volume. And proteins are the main component of our diet. Brewer's yeast is important to include in the diet of vegetarians to compensate for the lack of protein foods. The unique composition helps maintain the body’s functioning in case of a variety of problems, allowing you to maintain youth and health for a long time. Therefore, you should not avoid taking them if the yeast dietary supplement is recommended by a certified specialist.

Important! When purchasing yeast tablets, pay attention to the label. If the composition additionally contains iron, zinc, magnesium, then this is an advertising ploy, since these components are initially contained in the dietary supplement, only their amount of the element prescribed on the jar has been increased.

Pharmacodynamics and pharmacokinetics

the B-group vitamins , amino acids and minerals it contains Takes part in the activation of enzymes that regulate oxidation-reduction processes and affects metabolism.

Helps restore and strengthen the immune system , stimulates the secretion of pancreatic fluid, improves the absorption capacity of the intestine and its motility. Accelerates tissue regeneration, increases appetite, helps strengthen hair and intensify its growth. Necessary for the normal functioning of the heart, endocrine, vascular and nervous systems.

The B vitamins contained in brewer's yeast are components of enzyme complexes that are responsible for regulating metabolism, but each of them plays a specific biological role. Their presence in balanced quantities is necessary for continuous metabolism .

The components of the drug belong to the group of water-soluble vitamins , which eliminates the possibility of their accumulation in the body.

Vitamins B1 are absorbed in the small intestine. The absorption of vitamin B12 is determined by the presence of an external factor in the stomach and upper intestines. Subsequently, the substance is transported into tissues using the transcobalamin II transporter protein.

Vitamins B1, B6 and B12 are biotransformed in the liver, vitamin B2 in the body is converted into the coenzyme flavin mononucleotide, and subsequently into the coenzyme FAD (flavin adenine dinucleotide). About 60% of metabolites are bound to blood plasma proteins .

Excretion of vitamins B1 and B6 is carried out by the kidneys (from 8 to 10% of the substance is excreted in pure form). In case of overdose, their excretion with intestinal contents increases significantly.

Vitamin B12 is released into bile and reabsorbed in the intestines. The dose taken is partially (6-30%) excreted by the kidneys within 8 hours. The substance passes through the BBB and enters the milk.

Vitamin B2 is eliminated in the urine, partly in the form of metabolic .

Beneficial properties of brewer's yeast

Brewer's yeast is one of the most effective dietary supplements, containing:

• 14 vitamins: group B (ensure the normal functioning of the central and peripheral nervous system, prevent the occurrence of Parkinson’s disease, accelerate cell regeneration, improve vision, slow down the aging process), as well as C, D, E, F, PP;
• 17 amino acids, most of which are essential;
• unsaturated fatty acids (arachidonic, oleic and linoleic);
• potassium, chromium, calcium, selenium, phosphorus, zinc, iron, sodium, sulfur, copper and other trace elements.
• All vitamins contained in brewer's yeast are water-soluble and therefore do not accumulate in the body. This supplement significantly improves well-being in case of vitamin deficiency and hypovitaminosis. Dietary supplements based on brewer's yeast are useful for vegetarians to take periodically: such preparations contain folic acid, the source of which for the body is mainly meat food. Folic acid is involved in the process of DNA synthesis during cell division and has a beneficial effect on reproductive function.

The benefits of brewer's yeast are as follows:

• improve appetite, normalize digestion and metabolism;
• help achieve optimal weight. If you are overweight, you can lose a few extra pounds by accelerating metabolic processes. People who are underweight take yeast, on the contrary, they gain weight. This effect is often used by athletes who want to build muscle mass;
• due to the high chromium content, they alleviate the condition of patients with type II diabetes;
• The antioxidants contained in yeast slow down the aging process;
• prevent the occurrence and development of liver cancer;
• calms down during stress, emotional exhaustion, sudden mood swings;
• restore strength in case of physical exhaustion, anemia, strengthen the immune system;
• help withstand significant physical and mental stress;
• normalize the functioning of the cardiovascular system;
• maintain an optimal level of acid-base balance in the body;
• help get rid of acne, rashes, improve skin condition with furunculosis, dermatosis, eczema, psoriasis;
• strengthen hair and stop hair loss;
• strengthen nails and make them less brittle.

Indications for use

Indications for use:

• hypovitaminosis group B;
• skin diseases (including dermatoses of neurogenic origin , angular stomatitis , furunculosis , skin abscess , carbuncles , eczema , juvenile acne, psoriasis , acne );
• dysbacteriosis;
• neuralgia;
• polyneuritis;
• anemia;
• diabetes;
• long-term exposure to radiation and toxic chemicals;
• alcoholism;
• the presence of risk factors for the development of heart and vascular diseases;
• unbalanced diet;
• metabolic disorders;
• recovery after illness.

Instructions for brewer's yeast

Instructions for Brewer's yeast tablets

The tablets are taken orally after meals. The recommended dose for a patient over 12 years of age is 2-3 grams per day (4-6 tablets), divided into 2-3 doses. A child 3-7 years old is prescribed to take 0.5 g/day. (1 tablet), child 7-12 years old - 1 g/day. (2 tabs).

The duration of use depends on the severity of the symptoms of vitamin deficiency, the nature of complex therapy and the body’s response to the prescribed treatment. Usually the course lasts 30 days. It can be repeated no earlier than after 1 month (consult a doctor before resuming taking the drug).

Please note that instructions from different manufacturers may vary. For example, the instructions for Brewer's yeast Nagipol-1 indicate that the tablets should be taken with meals, three times a day, 3-5 pieces per dose. Reception is continued for a month, if necessary, the course is repeated after a two-month break.

• Ecco Plus brewer's yeast with zinc and Evisent are taken three times a day, 3 pieces each.
• Brewer's yeast with iodine Ecco Plus should be taken three times a day, 2 tablets.
• Yeast with selenium ECO-MON - twice a day, 2 tablets.
• Drink Ecco Plus yeast with iron once a day, 1 tablet.

How to take the powder?

The powder is taken orally or used externally as part of nourishing masks.

Before taking per os, the product is dissolved in 100 ml of drinking water. For preventive purposes, two two-month courses are prescribed with a two-week break between them. The daily dose for an adult varies from 7 to 10 g/day, for children it ranges from 3 to 5 g/day. Divide it into 2-3 doses.

For an adult, the course dose should not exceed 1800 grams, for a child - 600 g.

People who live in an unfavorable climate should take 3 courses.

The therapeutic dose is 1.5-2 times higher than the prophylactic dose.

People who, due to their occupation, are subject to increased neuropsychic and physical stress, should dose the drug in such a way that for every kilogram of body weight there is 0.3-0.5 g of yeast per day.

Brewer's yeast for hair

To prepare a hair mask, yeast is diluted to the appropriate consistency with vegetable or fruit juice, fermented baked milk, milk, honey or water, and then the resulting mixture is applied to the scalp.

To saturate your strands with vitamins and prevent hair loss, you can mix slightly warmed flower honey and the pulp of 3 aloe vera leaves with yeast. The mass is applied to the scalp for about 25 minutes and then washed off.

Using yeast (1 tbsp) in combination with soy lecithin, honey (1 tbsp), wheat germ (1 tbsp) and yogurt for hair can speed up hair growth and make hair thicker and shinier.

It is also very good to use a hair rinse based on a decoction of rosemary and natural brewer's yeast. To prepare it, pour 3 tablespoons of dried rosemary leaves into a liter of boiling water, and then, after the liquid has infused for 2-3 hours, add yeast.

It is recommended to rinse your hair with this solution every time after washing your hair. It is better to dry your hair without using a hair dryer.

Application for face

When preparing face masks, take into account your skin type: for dry skin, the powder is mixed with vegetable oils (any, at the rate of 1 tablespoon of yeast per 3 tablespoons of oil), for oily skin, with heated kefir and low-fat sour cream or lemon juice and egg white.

To rejuvenate the skin, yeast is used in a mixture with carrot puree (1:2 ratio), honey and egg yolk; For whitening, lemon juice is added to the powder.

Brewer's yeast for acne

Using the product on problem skin helps normalize the functioning of the sebaceous glands and restore the skin's oil balance, helps get rid of acne , cleanse pores and remove fine wrinkles.

-acne mask at home , you can pour 10 grams of powdered mass with a 5% alum solution. The resulting paste is applied to the skin and left until completely dry. Wash off the crust with warm (preferably filtered) water.

For acne, cosmetologists also recommend yeast-based masks and:

• sauerkraut juice;
• raw mashed potatoes and curdled milk;
• streptocide (effectively eliminates inflamed comedones);
• honey and calcium gluconate ;
• blue clay and mineral water.

Brewer's yeast is especially effective against acne in combination with professional and self-care for the skin, physiotherapy and, if necessary, the use of antibiotics (topically or orally).

Brewer's yeast for boils

For boils , liquid brewer's yeast is most often prescribed. The product is diluted in milk at the rate of 1 tablespoon (for adults) or 1 teaspoon (for children) per half glass. Drink the medicine 1-3 times a day about half an hour before meals.

Why are pills taken in bodybuilding?

For athletes who engage in strength sports, the supplement is a valuable source of B vitamins , protein , amino acids , nucleic acids and enzymes .

the BCAA amino acid complex in the product , of which approximately 35% human muscle tissue consists. BCAA reduces the loss of other amino acids, increases muscle endurance, promotes better and faster protein absorption; stimulates synthesis and also prevents protein breakdown and prevents the loss of muscle fibers; has a positive effect on insulin , maintains optimal levels of testosterone and cortisol , and stimulates growth hormones.

Protein makes up more than half the weight of yeast, making the supplement an excellent source of additional protein . For athletes, it can be added to gainers, protein shakes, regular food, or consumed separately as a food supplement.

Application in veterinary medicine

Animals that live in large cities are exposed to a large number of unfavorable factors: an environment contaminated with organic and chemical waste, increased electromagnetic background, poor-quality tap water, etc.

The use of dietary supplements for dogs and cats allows you to compensate for the lack of nutrients in food, strengthen immunity , reduce hair loss and strengthen the hair structure, remove excess cholesterol body, improve the condition of the central nervous system, reduce itching, dryness and irritation of the skin, and contain the appearance of blood-sucking parasites.

Normalizing the balance of B vitamins helps reduce the secretion of the hormone adrenaline , which in turn leads to a decrease in the animal’s anxiety and allows it to cope with stress more easily.

Theoretical and practical aspects of the use of sulfur preparations in dermatology

Basic sciences (pharmacology, biochemistry, physiology) include in their fundamentals the correction of vitamin and metal ligand homeostasis as a necessary background for conducting pharmacotherapy in a patient. Maintaining the balance of micro- and macroelements is, first of all, preserving the regenerative and reparative abilities of the body. Micro- and macroelements are contained in the human body in very small quantities, but the element can be part of an enzyme or coenzyme molecule, can simply activate a biological reaction, also form weak and super-weak biocoordination bonds or create an ionic environment. Of the 92 naturally occurring elements, 81 are found in the human body, among which sulfur is one of the important elements [1].

Research on sulfur content in the body and its metabolism continues, opening up new possibilities for its use in pharmacology. Currently, products containing sulfur have appeared on the Russian market, presented in the form of tablets for oral administration: dry purified yeast Evisent (dietary supplement) and specialized cosmetics for the care of problematic facial skin and scalp - Evisent based on brewer's yeast and sulfur. The Evisent drug complex is recommended for use in the treatment of onychodystrophies, trichodystrophies, acne, seborrheic dermatitis, rosacea and oral dermatitis. However, not only reliable information about drugs, but also its competent interpretation for subsequent justification of prescriptions is of particular importance. The success of therapy depends, among other things, on fundamental knowledge of the role of elements in the human body, which allows us to evaluate and rationally use drugs.

The macroelement sulfur is necessary for many vital functions in the human body and is an integral part of any living matter. The biological significance of sulfur is determined primarily by the fact that it is part of the amino acids methionine, glutathione and cysteine ​​and, consequently, in the composition of proteins and peptides [1]. This macroelement plays its role through the formation of disulfide bonds and sulfhydryl groups.

Disulfide bonds or cysteine ​​bridges (–S–S–) in polypeptide chains are involved in the formation of the spatial structure of proteins. Cysteine ​​bridges link amino acids together to form a peptide, providing its unique structure, thus determining its basic physicochemical properties [2]. The cleavage of disulfide bonds leads to disruption of the native structure of proteins and their loss of biological activity [3]. It is thanks to disulfide compounds that the strength and elasticity of hair and tendons is maintained; without disulfide bridges, collagen formation is impossible.

Sulfhydryl groups or thiol compounds (–SH) play an important role in the active sites of enzymes. Possessing unique physicochemical properties and the highest reactivity, sulfhydryl groups easily enter into a reversible redox reaction under normal physiological conditions. Sulfur, as part of sulfhydryl groups, entering into alkylation, acylation, thiol-disulfide exchange reactions, forms mercaptides (when reacting with heavy metal ions), mercaptals, mercaptols (when reacting with aldehydes and ketones), thereby helping to neutralize toxic substances in the body. Sulfhydryl groups, being an integral part of coenzyme A and lipoic acid, are involved in enzymatic reactions of the formation and transfer of acyl residues associated with the metabolism of lipids and carbohydrates. It has been proven that blocking sulfhydryl groups using specific reagents causes partial or complete inhibition of the activity of many enzymes [3].

The scientific literature discusses the antioxidant properties of sulfur, which are manifested in the ability to attach an oxygen atom, thus, the oxidation of sulfur in the body reduces the free production of excess oxygen radicals. According to the authors, it is thanks to its antioxidant properties that sulfur slows down the aging process and increases life expectancy [4, 5]. Similarly, sulfur interacts with free radicals, neutralizing their damaging effects under conditions of oxidative stress [4–6].

According to the results of a scientific study conducted by V. A. Malozemova (2010), it was found that, with increasing age of the subjects, there is a tendency to increase the level of oxidized sulfur and to decrease the level of reduced sulfur, a decrease in its total amount and thiol-disulfide ratio with a significant change in indicators with every decade of life. This indicates the accumulation of oxidized products in the human body over the years of life and the intensification of free radical oxidation processes, which is confirmed by a significant decrease in the level of thiol-disulfide ratio and a decrease in SH groups with increasing age. In elderly patients, the greatest activity of sulfur oxidation and a decrease in its total amount were noted. These changes are associated with a decrease in the buffer capacity of the antioxidant system and can lead to pathological modification of the protein substrate, and also increase the risk of developing oxidative stress and associated morbidity [7].

Summarizing the above, we can say that sulfur ensures the stability of the structure of proteins, is part of the essential amino acids - methionine, cysteine, cystine and taurine, which are involved in the synthesis of proteins and enzymes, is an important catalyst for many biological processes and has antioxidant properties. It should be noted that the macroelement sulfur restores and maintains the elasticity and firmness of the skin, due to its participation in the synthesis of collagen, is part of the structure of hair and nails, normalizes the functioning of the sebaceous glands, and when applied topically has antiseptic, fungicidal and antiparasitic effects.

As is known, two groups of proteins are present in hair keratin: with a high sulfur content (16–24% cysteine) and ultra-high sulfur content (> 30% cysteine) [8]. According to numerous studies, trichodystrophy is based on defective synthesis of proteins with a high sulfur content. As a result, the macroelement is distributed unevenly along the entire length of the hair shaft, causing hair fragility [9–12]. When examined under a polarizing microscope, alternating dark and light zones are found in the hair [13], caused by defective synthesis of proteins with a high sulfur content.

However, according to observations conducted by British scientists, clinical signs of brittle hair in childhood are more common in sulfur deficiency conditions than in genetically determined trichodystrophies [14]. Taking all these observations into account, we can once again emphasize the important role of the macronutrient sulfur in the formation of a strong hair shaft structure.

Speaking about the therapeutic potential of sulfur preparations in the treatment of skin diseases, it is enough to recall the widespread use of precipitated sulfur (sulfur praecipitatum) in the treatment of seborrheic dermatitis, eczema and allergic processes. However, when precipitated sulfur enters the body's intestines, sulfates are immediately formed. Sulfates are poorly absorbed from the intestines and are quickly excreted through the kidneys. It is well known that a dose of sulfates of 1.0–2.0, when taken orally, has a laxative effect on a person, leading to cleansing of the digestive canal. For example, magnesium sulfate, widely used in medicine, in concentrations above 100 mg/l acts on people as a laxative. Thus, the bioavailability of sulfur salts is very low. It follows from this that it is difficult to correct sulfur deficiency in a patient by consuming precipitated sulfur, since when it is taken orally, there is low absorption and assimilation, weak inclusion in metabolism and side effects, mainly from the gastrointestinal tract [15].

Currently, there is a modern solution to the problem using the second generation of organoelement preparations, in which macro- and microelements are contained in the form of organic salts or complexes with amino acids. Evisent dietary supplement - dry purified brewer's yeast contains a wide range of macro- and microelements: calcium, purified sulfur, vitamins (B1 (thiamine), B6 ​​(pyridoxine), B2 (riboflavin) and other B vitamins). Brewer's yeast, which is part of the drug, contains vitamin PP (niacin), vitamin D (in the past, before obtaining a synthetic analogue, brewer's yeast was used as a raw material for the production of vitamin D); amino acids and orotic acid, which stimulates metabolic processes in the body.

However, the main advantage of Evisent is that vitamins and elements, including sulfur, are found in protein complexes, which determines the gradual nature of their entry into the human body and ensures easy digestibility of active substances. This property is achieved through a special technology for preparing the drug; incubation (growing) of yeast cultures occurs in special sulfur-enriched media. The technology ensures the absorption and preservation of micronutrients by the yeast cell. The unique low-temperature drying technology at the final stage of production guarantees an increased content of B vitamins in Evisent yeast.

It is important that in the production of the product an important point was taken into account - the synergism of vitamins, micro- and macroelements and amino acids. For example, vitamin B6, folic acid and magnesium, acting in synergy, suppress the active functioning of the sebaceous glands.

Brewer's yeast is also a source of other microelements - selenium and zinc. Selenium protects cells from ultraviolet damage, inhibits skin photoaging, and is also involved in the production of the sulfur-containing cellular antioxidant glutathione. Zinc has anti-inflammatory and sebum-regulating effects, is involved in the proliferation of skin cells, stabilizes cell membranes and regulates cellular immunity.

Don’t forget about the effectiveness of sulfur when applied topically to the skin. The keratolytic and antiseptic properties of sulfur are due to the reaction that occurs during direct interaction between sulfur and keratinocytes. Under the influence of sulfur, the cysteine ​​present in the stratum corneum is converted into cystine, and hydrogen sulfide (H2S) is released. As a result of this reaction, an antiseptic effect is achieved due to hydrogen sulfide and lysis of keratinocytes. In addition, the finer the sulfur when applied externally, the greater the degree of such interaction and, consequently, the therapeutic effect increases [16].

The effectiveness of external use of sulfur has been studied by many authors. A number of advantages in the use of sulfur preparations in anti-acne creams with simple manufacture, high stability and low cost have been demonstrated by JQ del Rosso (2009) and PY Chen et al. (2011). According to the authors, external therapy products containing 5% sulfur and widely used in the treatment of acne, rosacea, and seborrheic dermatitis from 1962 to the present are effective and non-addictive [17–20]. The continued relevance of using sulfur in external products is explained by its main advantage - the absence of the development of microflora resistance. Thus, the complex use of external cosmetics for problem skin “Evisent Yeast with Sulfur” (foam wash, lotion and spot cream) makes it possible to widely use the properties of sulfur in the treatment of seborrheic dermatitis, oral dermatitis, rosacea, grade 1–2 acne and, as cosmetic care products for severe acne.

Evisent cleansing foam is created on the basis of a bioactive yeast complex, sulfur, which normalizes the drainage of sebum, zinc, which relieves inflammation and regulates the level of skin oiliness, and natural anti-inflammatory extracts - string and birch, allantoin with antioxidant and regenerating effects and inulin to increase local skin immunity. Thanks to its natural composition, Evisent cleansing foam thoroughly cleanses the skin, removes makeup residues, prevents the formation of comedones, narrows enlarged pores, regulates the functioning of the sebaceous glands, mattifies, eliminating oily skin, does not dry out, does not cause a feeling of tightness of the skin after use and is therefore ideal for deep cleansing of problem skin prone to acne.

Also an indispensable condition for proper daily care of problem skin is the use of a specialized lotion after washing Evisent. Evisent lotion, in addition to the bioactive yeast complex and sulfur, contains white willow bark extract, which is a natural source of salicylic acid with a pronounced antiseptic and anti-inflammatory effect, and D-panthenol, which has a moisturizing and regenerating effect. Evisent lotion does not contain alcohol and has a neutral pH, so it is suitable for caring for any skin type.

Evisent spot-action cream based on yeast, sulfur and salicylic acid (source: white willow bark extract) is applied directly to the area of ​​inflammation and the problem area, eliminates inflammation, has a keratolytic effect, and prevents the formation of “post-acne” type rashes. The patented component Sepitonic® M3 (zinc, copper, magnesium) normalizes the functioning of the sebaceous glands, stimulates cellular renewal, accelerates collagen production, stimulates skin regeneration and increases the energy potential of cells. Natural components - clover extract and rosewood oil - restore the skin, stimulate the synthesis of collagen and hyaluronic acid, have an antioxidant and soothing effect and eliminate swelling with a slight drainage effect.

The Evisent cosmetic line includes specialized cosmetics for problematic and thinning hair for basic care in the form of a soft shampoo without sulfates and Evisent balm based on a bioactive yeast complex, sulfur and garlic extract to improve microcirculation of the scalp and enhanced nutrition of the hair follicle. Evisent conditioner also contains dexpanthenol, which moisturizes and restores damaged hair structure.

Specialized cosmetics Evisent for problem skin and weakened, thinning hair and Evisent yeast, when used in combination, have a synergistic effect, potentiating each other’s action.

Thus, specialized cosmetics Evisent and Evisent yeast, containing the macroelement sulfur, vitamins, amino acids, can be considered as promising products in dermatology, the complex use of which can improve the treatment of acne, rosacea, seborrheic dermatitis, onychodystrophies, trichodystrophies, maintain the beauty and health of skin and hair and nails.

Literature

1. Rebrov V. G., Gromova O. A. Vitamins, macro- and microelements. M.: GEOTAR-Media, 2008. 960 p.
2. Byshevsky A. Sh., Odysseus A. T. Biochemistry for the doctor. Ekaterinburg, 1994. 384 p.
3. Torchinsky Yu. M. Sulfhydryl and disulfide groups of proteins, M., 1971. 43 p.
4. Nishida M., Kumagai Y., Ihara H., Fujii S., Motohashi H., Akaike T. Redox signaling is regulated by electrophiles and reactive sulfur species // J Clin Biochem Nutr. Mar 2021; 58 (2): 91–98.
5. Spolitak T., Hollenberg PF, Ballou DP Oxidative hemoglobin reactions: Applications to drug metabolism // Arch Biochem Biophys. 2021 Jun 15; 600: 33–46.
6. Wang MJ, Cai WJ, Zhu YC Hydrogen sulphide in the cardiovascular system: A cascade from interaction between sulfur atoms and signaling molecules // Life Sci. 2021, May 15; 153:188–197.
7. Malozemova V. A. The role of sulfur in the pathogenesis of acute inflammatory diseases of the respiratory system and correction of its content in blood plasma. Author's abstract. diss. Ph.D. St. Petersburg, 2010. 30 p.
8. Emonet N., Michaille JJ, Dhouailly D. Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins // J Dermatol Sci. Jan 1997; 14 (1): 1–11.
9. Itin PH, Sarasin A., Pittelkow MR Trichothiodystrophy: update on the sulfur-deficient brittle hair syndromes // J Am Acad Dermatol. 2001 Jun; 44 (6): 891–920; quiz 921–924.
10. Price VH, Odom RB, Ward WH, Jones FT Trichothiodystrophy: sulfur-deficient brittle hair as a marker for a neuroectodermal symptom complex // Arch Dermatol. 1980 Dec; 116(12):1375–1384.
11. Khumalo NP, Dawber RP, Ferguson DJ Apparent fragility of African hair is unrelated to the cystine-rich protein distribution: a cytochemical electron microscopic study // Exp Dermatol. 2005 Apr; 14 (4): 311–314.
12. Sass JO, Skladal D., Zelger B., Romani N., Utermann B. Trichothiodystrophy: quantification of cysteine ​​in human hair and nails by application of sodium azide-dependent oxidation to cysteic acid // Arch Dermatol Res. 2004 Sep; 296(4):188–191.
13. Elkin V.D., Mitryukovsky L.S. Selected dermatology. Rare dermatoses and dermatological syndromes. Handbook of diagnosis and treatment of dermatoses. Perm, 2000. 699 p.
14. Cheng S., Stone J., de Berker D. Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease // Br J Dermatol. 2009 Dec; 161(6):1379–1383.
15. Zupanets I. A., Naletov S. V., Viktorov A. P. Clinical pharmacology. In 2 volumes. Kharkov, 2005. 448 p.
16. Fridman R. A. Cosmetics technology. 2nd ed., revised. and additional M.: Publishing house of food. prom-sti, 1984. 488 p.
17. Del Rosso JQ The use of sodium sulfacetamide 10%-sulfur 5% emollient foam in the treatment of acne vulgaris // J Clin Aesthet Dermatol. 2009 Aug; 2 (8): 26–29.
18. Draelos ZD The multifunctionality of 10% sodium sulfacetamide, 5% sulfur emollient foam in the treatment of inflammatory facial dermatoses // J Drugs Dermatol. Mar 2010; 9 (3): 234–236.
19. Lin AN, Reimer RJ, Carter DM Sulfur revisited // J Am Acad Dermatol. Mar 1988; 18(3):553–558.
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Yu. A. Gallyamova, Doctor of Medical Sciences, Professor

FGOU DPO RMANPO Ministry of Health of the Russian Federation, Moscow

Contact Information

Interaction

Brewer's yeast is a multicomponent product. When used simultaneously with other drugs, on the one hand, the activity of each of its constituent substances and the activity of the drug as a whole may change, on the other hand, the pharmacological profile of drugs that are used in combination with Brewer's yeast may change.

Taking alcohol, diuretics , and oral contraceptives can reduce vitamin B1 .

Since the transformation of vitamin B1 into its active form occurs with the participation of magnesium, it is advisable to take dietary supplements with magnesium-containing preparations.

The drug is contraindicated for people taking Levodopa , since vitamin B6 reduces the effectiveness of this drug. In addition, vitamin B6 is capable of:

• interfere with the absorption and reduce the plasma concentration of anticonvulsants such as phenobarbital and phenytoin ;
• increase intracellular levels of zinc and magnesium.

When used simultaneously with Theophylline , Penicillin , Isoniazid , Cycloserine and oral contraceptives, the dose of Brewer's yeast must be increased.

Antifungal drugs reduce the effectiveness of brewer's yeast.

special instructions

What is brewing yeast?

According to Wikipedia, brewer's (or brewer's) yeast are single-celled fungi from the class Saccharomyces , which are used in brewing to ferment wort enzymes.

Brewer's yeast: benefits and harms

In terms of quantity and balance of components, brewing yeast protein is similar to animal proteins: it contains about 12.7 g of high-value protein, 2.7 g of fat and 18 amino acids (including essential ones). Yeast is easily absorbed and digested well. Nutritional value of 100 g of product is 75 kcal.

Yeast also contains plant enzymes (proteinase, glucosidase, β-fructofuranosidase), which help digestive juices break down complex nutrients into more easily digestible ones.

The product is rightfully considered a natural mineral-multivitamin complex . Its chemical composition contains a complex of vitamins B1-B7 , B13 , B10 , K , E , provitamin D , folic acid , potassium , manganese , magnesium , selenium , zinc , calcium , iron .

Daily use of this supplement allows you to give a healthy look to your hair and nails, helps regulate all metabolic processes and cleanse the skin of acne and boils , provides effective prevention of malignant liver diseases , allows you to stabilize the function of the central nervous system (stimulating mental activity, increasing stress resistance, improving sleep and helping to fight depression ) and increase the saturation of tissues and organs with oxygen.

More than 70 years ago, brewer's yeast was first used to treat diabetes . During the experiment, it was found that just 10-15 g of yeast can replace 7 to 10 units of insulin . This property of the product is due to the presence of chromium in its composition.

Chromium increases tissue sensitivity to insulin and enhances the effect of the latter. By interacting with insulin , it improves the absorption of glucose in the blood and its penetration into cells, thereby reducing the need for insulin in diabetic and helping to prevent the development of diabetes .

Taking brewer's yeast allows the body to more easily cope with physical and emotional stress, helps maintain the body's natural acid-base balance of biological fluids, normalizes muscle contractility, pancreatic and the cardiovascular system .

Brewer's yeast has no less beneficial effects on the structure and function of the mucous membranes, as well as on the functional activity of the digestive tract. The use of the supplement helps prevent constipation, stimulates digestive processes, and accelerates the elimination of all kinds of waste from the body.

Another useful property of yeast is its ability to increase the level of HDL-cholesterol (or, in other words, “good” cholesterol ), while reducing its overall level in the body: regularly taking two tablespoons of the product once a day for 2 months, of total cholesterol by about 10% .

However, like any other useful supplement, yeast in large quantities can cause harm to the body. In some people, some components of the product can cause allergic reactions , which are manifested by itching, skin rashes, and difficulty breathing.

Yeast can worsen the course of acid-related diseases ( pancreatitis , gastritis , peptic ulcer ), chronic renal failure and gout . You should also not take them if have celiac enteropathy (intolerance to wheat and a number of other grains) and during treatment with Levodopa .

Brewer's yeast - which is better? What are the benefits of yeast with various additives?

You can find two types of brewer's yeast on sale: autolyzed and raw.

Raw yeast mushrooms are a fairly difficult product to digest. This, in turn, complicates the extraction of vitamins , amino acids and minerals , and also provokes quite strong reactions in people who are prone to allergies , suffer from fungal dysbiosis or have a “weak” stomach.

Most food additives are not live yeast, but dry autolysate. The benefit of brewer's yeast in tablets is that they are characterized by much higher digestibility and digestibility.

At the same time, despite the fact that the structure of the mushrooms is almost completely destroyed during autolysis, the composition of the final product remains unchanged - the autolysate contains the same set of amino acids , minerals and vitamins as in the living culture, however, they are found in it in free, easily digestible form. form.

Due to this, the percentage of absorption of autolyzed yeast is higher than that of raw yeast. Another advantage of this product is that it does not provoke fermentation in the intestines and does not cause bloating.

Many pharmaceutical preparations sold under the name “Brewer's Yeast” contain additional vitamin or mineral supplements . Theoretically, such funds have increased value. However, it should be borne in mind that yeast is a completely natural product; the additive is often synthesized in the laboratory.

What to give preference to - a pure product without additives or a drug with a richer composition - is best decided with your doctor.

Brewer's yeast with calcium is usually recommended to drink as a general tonic that supports the body's defenses, stimulates mental activity and serves as an additional source of Ca. The use of yeast with calcium helps strengthen bone tissue and improve the condition of the central nervous system, and also helps in the treatment of allergic diseases .

Brewer's yeast with selenium is prescribed for alcoholism and liver diseases . Taking a selenium supplement is also advisable for the prevention of infertility , diabetes , anemia , heart attack , cancer , endemic goiter , and hair loss.

Brewer's yeast with zinc should be included in the diet of people who suffer from varicose veins and skin diseases . In combination with zinc, yeast accelerates the regeneration of the skin, normalizes blood sugar levels, metabolism and microcirculation in tissues, and helps reduce swelling of the legs.

Brewer's yeast with sulfur is used as a detoxifier and as an acne . In addition, the use of dietary supplements in combination with sulfur allows you to more effectively protect cells and tissues from oxidative processes.

How to choose the right brewer's yeast enriched with microelements

To make the benefits of brewer's yeast even more significant, various beneficial substances are added to it. Knowing why the body needs a specific microelement, you can easily choose the right dietary supplement for yourself:

• iron prevents a decrease in hemoglobin levels in the blood. It is recommended to drink yeast with iron for anemia;
• zinc lowers cholesterol levels, has antiviral and antibacterial properties, and also has a beneficial effect on reproductive function. Dietary supplements with zinc are primarily advisable for those who are planning to conceive a child;
• magnesium is involved in the process of protein synthesis in the body; this trace element is necessary for the functioning of the heart muscle;
• succinic acid makes muscles more elastic, helping to withstand significant physical activity;
• selenium is an immunomodulator that slows down aging and is necessary for normal liver function;
• sulfur strengthens nails and hair, cleanses the skin;
• calcium prevents the development of osteoporosis and ensures bone strength;
• iodine – supports the immune system, thyroid function, and has a calming effect. First of all, yeast with iodine is needed by those who suffer from constant stress;
• potassium – improves oxygen supply to the brain, lowers blood pressure, and ensures muscle function (including the heart).

Analogs

Level 4 ATX code matches:
Verona

Phibs

Gastrikumel

Fitogastrol

Thyroidea Compositum

Berlition

Thiolepta

Gastric collection

Espa-Lipon

Lipoic acid

Rosehip syrup

Octolipen

Thioctacid

Thiogamma

Figurin

Synonyms: Brewer's yeast Nagipol , Nagipol 2. For acne , Nagipol 1 , Brewer's yeast Evisent , Brewer's yeast ECO-MON , AMT brewer's yeast , Brewer's yeast Ecco Plus .

Analogues: Angiovit , Beviplex , Multi-Tabs-V-complex , Neuromultivit , Medivitan .

Brewer's yeast for weight gain and weight loss

The advisability of using Brewer's yeast for weight loss and weight gain is due to the fact that under the influence of this product the body is cleansed and the functioning of all its organs is improved, the energy supply of cells is replenished, the functioning of the endocrine gland and digestion are improved, the process of absorption of nutrients is accelerated and, in particular, proteins, and the process of burning fats.

The main cause of low or overweight is metabolic disorders. By gently correcting it, Saccharomyces thus allows some people to compensate for their weight deficit, and others to get rid of a certain amount of extra pounds.

There is an opinion that the product can be used for breast growth, but there is no evidence of its effectiveness or, on the contrary, ineffectiveness.

Drinking yeast in tablets. Indications for use

The harm or benefit of brewer's yeast depends on various indicators.
They have a positive effect on the liver and hair condition. Actively used to gain muscle mass. Additionally, they can be prescribed to a child to increase appetite or strengthen the immune system. Pharmacological action and variations of techniques depend on the following indicators:

• dysbacteriosis;
• alcoholism;
• dermatology and cosmetology;
• improve the functioning of the gastrointestinal tract;
• promote high-quality digestion of foods;
• removes toxins;
• produces an immunostimulating effect;
• detoxification effect;
• protective effect;
• eliminates sleep problems.

Yeast is a natural storehouse of vitamins.
Regular intake of dietary supplements helps strengthen the immune system, i.e., the body's resistance to viruses and stress. Increases brain activity and improves mood. It is most often prescribed to children and adolescents, elderly people or professional athletes. Doctors also prescribe the drug for skin diseases. Included in cosmetic masks.

Brewer's yeast is available in tablets, and the price depends on the manufacturer and region. The average cost ranges from 40 rubles to 250 - it is influenced by the policy of the pharmacy kiosk and the manufacturing country.

One capsule of brewer's yeast contains 500 mg of the product. The active excipients are silicon dioxide and magnesium stearate.

For what diseases is it prescribed?

Medical indications for taking the drug:

• if metabolism is disturbed;
• at high loads;
• for nervous disorders;
• alcohol addiction;
• skin diseases;
• mucosal injury;
• stomatitis;
• dysbacteriosis and hypovitaminosis;
• radiation;
• poor climatic conditions;
• exposure to chemical elements;
• poor nutrition;
• overweight or underweight;
• infection;
• somatic diseases.

Many doctors prescribe this drug as a prophylactic substance.

It can be used to prevent the following diseases:

• malfunction of the gastrointestinal tract;
• hypertension;
• dyslipoproteinemia;
• itching and burning of the skin;
• psoriasis and eczema;
• acne;
• weight gain.

Note: before purchasing or using the drug, you should consult a doctor.

Look

Medical purpose

From a medical point of view, brewer's yeast has a wide range of uses. The main thing is to take into account the peculiarities of the organism. You must take the drug strictly according to the instructions, and also study the list of contraindications.

Table of effects and list of diseases that can be cured with brewer’s yeast tablets:

Doctors also prescribe the drug in the postoperative period, especially if the treatment was accompanied by radiation therapy. Long-term use replenishes the lack of elements and promotes additional insulin production. Consumer reviews note the effectiveness of the product and indicate that the dietary supplement has a good effect on individual organs.

Note: danger can be caused by incorrect dosage and duration of use of the drug.

Reception scheme

The use of this drug must be justified.

The consumption schedule is given in table form:

To avoid harm to the body, this dietary supplement should be taken with caution. If you have chronic diseases, you should first consult a doctor. For children under 12 years of age, it is better to give a reduced dosage and divide 1 tablet into two parts.

Reviews of Brewer's yeast

Reviews about brewer's yeast (either in tablets or in pure form) are mostly positive. Most of them are reviews of brewer's yeast for hair and nails, acne and weight loss. As a rule, the effectiveness of products from different manufacturers (ECO-MON, Nagipol, Farmakom, Evisent, Ecco-Plus, Osokor) is assessed approximately the same - on average 4-4.8 points on a five-point scale.

According to most consumers, yeast really improves the appearance of facial skin, accelerates hair growth, makes nails smoother and stronger, and allows you to enrich your diet with substances necessary for the body. Another big plus of the supplement is its low price. However, there are also disadvantages.

Thus, among the general mass of positive reviews about ECO-MON Brewer's Yeast with Zinc, there are reviews that note that taking the supplement provoked severe weight gain.

And in one of the reviews about Brewer's yeast with sulfur Evisent it is noted that against the background of the use of this dietary supplement, hair became significantly stronger and nails began to grow more quickly, but the problem of thrush .

The reasons for negative reviews about Brewer's yeast Nagipol 1 were:

• disruption of the menstrual cycle due to the use of the supplement;
• strong increase in appetite;
• increased blood pressure, headaches, nausea;
• no effect.

However, almost everyone who left this kind of feedback, along with the minuses, also noted the advantages of the product, and associated the minuses with the individual reaction of the body to the components of dietary supplements.

Brewer's yeast in cosmetology

In order to strengthen your hair and clear your skin of pimples and blackheads, you should not only take brewer’s yeast, but also make face and hair masks with it.

Facial masks with brewer's yeast

For rashes, acne, peeling skin, age spots, it is recommended to dilute 2 teaspoons of dry brewer's yeast or 2 tablespoons of live yeast with kefir. The mixture should infuse for an hour and a half. The thickened mass is applied to the face and neck, and after 15 minutes, washed off with warm boiled water. The mask is designed to cleanse normal and oily skin, whitens it and smoothes out fine wrinkles.

For mature and dry skin, you should replace kefir with warm milk, leave the mixture for an hour and keep it on your face for 20 minutes. The mask perfectly rejuvenates. It is recommended to apply 5-7 days in a row, then take a break for 2-3 weeks.

How much does Brewer's yeast cost? Where to buy Brewer's yeast?

The price of Brewer's yeast in Ukraine varies from 6 to 200 UAH. You can buy dry brewer's yeast in Russian pharmacies for 20 rubles. Typically, the price depends on the number of tablets in the package, as well as who manufactured the product and what components are used as a supplement.

For example, the average price of Brewer's yeast with Evisent sulfur is 185 UAH/225 rubles, and Brewer's yeast with zinc (for acne) from Farmakom can be purchased for about 16 UAH/45 rubles.

Many people are interested in the question, where can I buy liquid brewing yeast? As a rule, you can find this product either in specialized online stores or directly at the brewery. It should be remembered that its shelf life does not exceed 7-8 days.

• Online pharmacies in RussiaRussia

Features of taking brewer's yeast for various diseases

Brewer's yeast, unlike beer, does not contain alcohol. Therefore, they are allowed to be taken by children starting from the age of three.

Before use, live yeast is diluted with milk, fruit or vegetable juice, and water in the proportion: one tablespoon of the drug per half a glass of liquid.

The medicine is taken 30–40 minutes before meals. For prevention, the following dosage is recommended:

• for children from 3 to 6 years old, the dosage of the drug should be prescribed by a doctor;
• for children from 6 to 12 years old – 3 times a day, a teaspoon;
• for children aged 12–16 years – 3 times a day, a tablespoon;
• for adults (over 16 years old) – 3 times a day, 2-3 tablespoons.
• The duration of the course is 30 days, after which you need to take a break for 1–3 months.

In other cases, the dosage regimen depends on the disease:

• for skin problems (acne, rashes), as well as vitamin deficiency, you should drink a tablespoon of live yeast diluted in milk at least 2 times a day half an hour before meals;
• with low stomach acidity - 3 times a day, half an hour before meals, drink 2 tablespoons of yeast diluted in water;
• for burning and cramping in the intestines - 3 times a day, half an hour before meals, take a tablespoon of yeast (mix with water). Add half a teaspoon of grated ginger to the solution;
• for colitis and enterocolitis - drink a tablespoon of yeast (diluted with a glass of carrot juice) 2-3 times a day between meals.
• for insomnia, drink a tablespoon of live yeast mixed with a glass of warm milk at night for 20 days. A pinch of ground cardamom is added to the medicine.

The easiest way to dose brewer's yeast is in tablets: the dosage regimen is indicated in the instructions. However, it is better to discuss the exact dosage with your doctor.