Pharmacodynamics and pharmacokinetics
ATP-Long is a drug in a new category of substances that has a molecule containing ATP , and magnesium salts , as well as histidine amino acids . The drug exhibits a specific, unique pharmacological effect that is not typical for its other chemical ingredients.
It has a stimulating effect on energy metabolism , helps normalize the level of saturation with magnesium and potassium , activates ion transport systems of cell membranes, reduces uric acid , and develops the protective antioxidant function of the myocardium.
In patients with paroxysmal supraventricular and supraventricular tachycardia , flutter and atrial fibrillation, the use of the drug helps restore natural sinus rhythm , as well as reduce the intensity of ectopic foci (ventricular and atrial extrasystoles ).
During hypoxia and ischemia, ATP-Long has antiarrhythmic, membrane-stabilizing and anti-ischemic activity, due to its ability to establish metabolic processes in the myocardium . It has a beneficial effect on coronary circulation , peripheral and central hemodynamics , increases the contractility of the heart muscle, improves cardiac output and left ventricular functionality.
This range of effects has a positive effect on physical performance, and also leads to a decrease in the number of attacks of shortness of breath and angina pectoris during physical work, which is what ATP-Long is used for.
Pharmacological properties of the drug Atf-long
The cardiological drug ATP-Long is an original drug of a new class of substances - multi-ligand coordination compounds with high-energy phosphates, the molecule of which consists of adenosine-5'-triphosphate (ATP), the amino acid histidine and magnesium and potassium salts. Due to the original structure of the molecule, the drug has a characteristic pharmacological effect that is absent in any of its other chemical components (ATP, histidine, K+, Mg++). ATP-Long stimulates energy metabolism, the activity of ion transport systems of cell membranes, normalizes the concentration of potassium and magnesium ions, indicators of the lipid composition of membranes, the activity of membrane-dependent enzymes, improves the antioxidant system of myocardial protection, and reduces the concentration of uric acid. ATP-Long has anti-ischemic, membrane-stabilizing, anti-arrhythmic effects due to the normalization of metabolic processes in the myocardium during ischemia and hypoxia. ATP-Long improves central and peripheral hemodynamics, coronary circulation, increases myocardial contractility, functional state of the left ventricle and cardiac output, which leads to improved physical performance. Under conditions of ischemia, the drug reduces myocardial oxygen consumption, improves coronary circulation, and activates the functional state of the heart, which leads to a reduction in the frequency of angina attacks and shortness of breath during exercise. The drug restores normal sinus rhythm in patients with paroxysmal supraventricular and supraventricular tachycardia with atrial fibrillation and flutter, and also reduces the activity of ectopic foci (atrial and ventricular extrasystoles). ATP-Long normalizes the concentration of potassium and magnesium in tissues.
Indications for use
The drug ATP-Long is indicated for use in complex treatment for:
- unstable angina;
- coronary heart disease;
- angina pectoris of exertion and rest;
- heart failure;
- myocardial and post-infarction cardiosclerosis ;
- supraventricular tachycardia ;
- heart rhythm disturbances;
- supraventricular paroxysmal tachycardia;
- vegetative-vascular dystonia;
- myocarditis of infectious-allergic nature;
- myocardial dystrophy;
- hyperuricemia of various origins;
- chronic fatigue syndrome ;
- surgical interventions in the pre- and postoperative periods;
- coronary syndromes , especially with nitrate intolerance, in order to enhance antiarrhythmic effectiveness and reduce the side effects of antiarrhythmic drugs.
Oral tablets ATP-LONG (ATP-LONG)
Instructions for medical use of the drug
Description of pharmacological action
ATP-LONG® is an original drug of a new class of substances - multi-ligand coordination compounds with high-energy phosphates, the molecule of which consists of adenosine-5'-triphosphate (ATP), the amino acid histidine and magnesium and potassium salts. Thanks to its original structure, the molecule has a pharmacological effect unique to it, which is not inherent in any of its chemical components (ATP, histidine, K+, Mg++). ATP-LONG® stimulates energy metabolism, the activity of ion transport systems of cell membranes, normalizes the concentration of potassium and magnesium ions, indicators of the lipid composition of membranes, the activity of membrane-dependent enzymes, improves the antioxidant system of myocardial protection, and reduces the concentration of uric acid. ATP-LONG® has anti-ischemic, membrane-stabilizing, antiarrhythmic effects due to the normalization of metabolic processes in the myocardium during ischemia and hypoxia. ATP-LONG® improves central and peripheral hemodynamics, coronary circulation, increases myocardial contractility, functional state of the left ventricle and cardiac output, which leads to increased physical performance. Under conditions of ischemia, the drug reduces myocardial oxygen consumption, improves coronary circulation, and activates the functional state of the heart, which leads to a reduction in the frequency of angina attacks and shortness of breath during exercise. The drug restores normal sinus rhythm in patients with paroxysmal supraventricular and supraventricular tachycardia, with atrial fibrillation and flutter, and also reduces the activity of ectopic foci (atrial and ventricular extrasystoles). ATP-LONG® normalizes the concentration of potassium and magnesium ions in tissues.
Indications for use
The drug is prescribed in the complex treatment of coronary heart disease, unstable angina, post-infarction and myocardial cardiosclerosis, paroxysmal supraventricular and supraventricular tachycardia and in the complex treatment of other rhythm disturbances; for autonomic disorders, microcardiac dystrophy, chronic fatigue syndrome, hyperuricemia of various origins.
Release form
10 tablets in a blister pack; 4 contour packs per pack. 20 tablets in a blister pack; 2 contour packs per pack.
Pharmacodynamics
ATP-LONG® is an original drug of a new class of substances - multi-ligand coordination compounds with high-energy phosphates, the molecule of which consists of adenosine-5'-triphosphate (ATP), the amino acid histidine and magnesium and potassium salts. Thanks to its original structure, the molecule has a pharmacological effect unique to it, which is not inherent in any of its chemical components (ATP, histidine, K+, Mg++). ATP-LONG® stimulates energy metabolism, the activity of ion transport systems of cell membranes, normalizes the concentration of potassium and magnesium ions, indicators of the lipid composition of membranes, the activity of membrane-dependent enzymes, improves the antioxidant system of myocardial protection, and reduces the concentration of uric acid. ATP-LONG® has anti-ischemic, membrane-stabilizing, antiarrhythmic effects due to the normalization of metabolic processes in the myocardium during ischemia and hypoxia. ATP-LONG® improves central and peripheral hemodynamics, coronary circulation, increases myocardial contractility, functional state of the left ventricle and cardiac output, which leads to increased physical performance. Under conditions of ischemia, the drug reduces myocardial oxygen consumption, improves coronary circulation, and activates the functional state of the heart, which leads to a reduction in the frequency of angina attacks and shortness of breath during exercise. The drug restores normal sinus rhythm in patients with paroxysmal supraventricular and supraventricular tachycardia, with atrial fibrillation and flutter, and also reduces the activity of ectopic foci (atrial and ventricular extrasystoles). ATP-LONG® normalizes the concentration of potassium and magnesium ions in tissues.
Pharmacokinetics
Pharmacokinetics have not been studied.
Contraindications for use
Acute myocardial infarction, severe forms of bronchial asthma, hyperkalemia, hypermagnesemia, hypersensitivity to the components of the drug. AV block II-III degree, hemorrhagic stroke, pregnancy, breastfeeding.
Side effects
Not installed. Nausea, discomfort in the epigastrium may occur, and with prolonged and uncontrolled use - hyperkalemia or hypermagnesemia. Allergic reactions.
Directions for use and doses
ATP-LONG® tablets are taken sublingually (under the tongue) and kept until completely absorbed. Single dose - 10-40 mg 3-4 times a day, regardless of meals. The duration of treatment is determined by the doctor, on average it is 20-30 days. If necessary, the course is repeated after 10-15 days. For acute cardiac conditions and paroxysmal atrial fibrillation, a single dose of 10-40 mg is taken every 5-10 minutes until the negative symptoms disappear. The maximum daily dose is 400-600 mg. There is no experience using the drug in children.
Overdose
Bradycardia may develop, which requires the administration of atropine sulfate. AV block and arterial hypotension may also occur.
Interactions with other drugs
ATP-LONG® cannot be used simultaneously with cardiac glycosides due to the increased risk of atrioventricular block. When used simultaneously with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases, and with Magnerot - hypermagnesemia. Dipyridamole enhances the therapeutic effect of ATP-LONG®, and xanthinol nicotinate reduces it.
Special instructions for use
When atrioventricular block is combined with other rhythm disturbances, the drug is not prescribed. With prolonged use of ATP-LONG®, it is necessary to monitor the level of potassium and magnesium in the blood.
Storage conditions
Store out of reach of children, in a dry, dark place at a temperature of 3 to 5 °C.
Best before date
12 months
ATX classification:
C Cardiovascular system
C01 Drugs for the treatment of heart diseases
C01E Other drugs for the treatment of heart disease
C01EB Other drugs for the treatment of heart disease
C01EB10 Adenosine phosphate
Contraindications
- cardiogenic , as well as other types of shock ;
- hyperkalemia;
- lactation;
- hypersensitivity to ingredients;
- myocardial infarction in the acute period;
- pregnancy;
- hypermagnesemia;
- childhood;
- obstructive pathologies of the bronchi and lungs;
- AV block and sinoatrial block (2-3 degree);
- severe bronchial asthma
- hemorrhagic stroke.
Side effects
- feeling of discomfort in the chest and epigastric region;
- itchy skin;
- nausea;
- rashes on the skin;
- decreased blood pressure;
- bronchospasm;
- hyperemia ;
- tachycardia;
- headache;
- increased diuresis;
- feeling of heat;
- dizziness;
- increased gastrointestinal motility;
- Quincke's edema;
- hypermagnesemia or hyperkalemia (in case of uncontrolled and prolonged use).
Instructions for use of ATF-Long
ATP-Long tablets, instructions for use
ATP-Long tablets are recommended to be taken sublingually (under the tongue) until completely absorbed. Reception is carried out regardless of food 3-4 times in 24 hours, in a single dose of 10-40 mg. The average period of taking the tablets is 20-30 days (further use is on the recommendation of a doctor). It is possible to repeat the course of treatment after 10-15 days. It is not recommended to exceed the maximum daily dose of 160 mg.
ATP-Long injection solution, instructions for use
ATP-Long injection solution is administered 1-2 times every 24 hours, intramuscularly, 1-2 ml, at a rate of 0.2-0.5 mg/kg.
Intravenous administration is carried out in the form of infusions (slowly) in a dose of 1-5 ml, at a rate of 0.05-0.1 mg/kg/min. Infusions are carried out in a hospital setting and under blood pressure control. The average duration of therapy is 10-14 days.
Mode of application
ATP-long is prescribed 3-4 times a day, 10-40 mg. The average duration of therapy is 20-30 days. The course of treatment can be repeated after 10-15 days. In the treatment of arrhythmias and acute cardiac conditions, ATP-long is prescribed as follows: a single dose of 10 to 40 mg is taken 10 minutes later until acute symptoms are relieved. The maximum daily dosage of the drug is 400-600 mg. ATP-long tablets are taken sublingually and completely dissolve. Taking the drug does not depend on food.
Interaction
Parallel use of cardiac glycosides increases the possibility of AV blockade .
Co-administration of magnesium can lead to hypermagnesemia .
Combination with Dipyridamole enhances the effect of ATP-Long, and with Aminophylline , Caffeine , Xanthinol Nicotinate , Theophylline , on the contrary, reduces its effectiveness.
ACE inhibitors , potassium and potassium-sparing diuretics increase the risk of hyperkalemia .
ATP-Long can enhance the antianginal effectiveness of calcium channel blockers , beta-blockers and nitrates .
pharmachologic effect
Anti-ischemic, membrane stabilizing. ATP-long is a multi-ligand coordination compound with high-energy phosphates, containing in the ATP molecule, magnesium and potassium salts, and the amino acid histidine. The drug has the ability to stimulate energy metabolism, activate ion transport systems of cell membranes, restore the necessary concentrations of magnesium and potassium ions, and improve the antioxidant system that provides myocardial protection. ATP-long activates membrane-dependent enzymes, restores the lipid composition of cell membranes and reduces the content of uric acid. Due to the ability to correct metabolic processes in the myocardium under conditions of hypoxia and ischemia, ATP-long has a membrane-stabilizing, antiarrhythmic and anti-ischemic effect. ATP-long is characterized by the ability to improve hemodynamics of both central and peripheral blood flow, increase cardiac output, contractility of the heart muscle and functional activity of the left ventricle, thereby increasing physical performance. The drug is able to reduce oxygen consumption by the heart muscle under conditions of ischemia, improve blood circulation in the coronary vessels, activate the functional state of the heart muscle, resulting in a reduction in the frequency of angina attacks and shortness of breath during exercise. ATP-long in patients with paroxysmal supraventricular tachycardia or supraventricular tachycardia, as well as atrial flutter and fibrillation, is able to restore sinus rhythm and reduce the activity of ectopic foci (ventricular and atrial extrasystoles).
special instructions
Both tablets and injections of the drug should be used with caution in conjunction with cardiac glycosides and in case of arterial hypotension and, due to the risk of AV blockade , as well as in diabetes mellitus , the patient’s predisposition to bronchospasm , fructose, sucrose-isomaltose, glucose tolerance disorders -galactose (for tablets).
Long-term use should be combined with monitoring plasma levels of magnesium and potassium .
During therapy, the consumption of caffeine-containing products should be limited.
Analogs
Level 4 ATX code matches:
Vazonat
Phosphaden
Hawthorn fruit
Preductal
Meldonium
Angiosil Retard
Ranexa
Lily of the valley tincture
Neocardil
Rimecore
Triductane
Hawthorn tincture
Triductan MV
Trimectal MV
Trimectal
Neoton
Predisin
Trimetazidine
Tivortin Aspartate
Metamax
- Adexor;
- Vasopro;
- Dibikor;
- Vazonat;
- Cardazin;
- Kapikor;
- Coraxan;
- Cardimax;
- Mexicor;
- Metamax;
- Mildronate;
- Methonate;
- Neocardil;
- Preductal;
- Riboxin;
- Thiotriazolin;
- Triductane;
- Trimetazidine;
- Energoton , etc.
Reviews for ATF-Long
As a rule, reviews of ATP-Long are neutral and most likely this is due to the frequent use of this drug in combination with other drugs, the effects of which often overlap to such an extent that it becomes difficult to determine which drug has a positive effect on the body.
The same situation occurs with side effects and undesirable consequences.
If you have been prescribed this medication, you should rely on the doctor’s opinion and strictly follow his recommendations and instructions.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug ATP-LONG, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug ATP-LONG is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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ATF-Long price, where to buy
The average price of ATF-Long is:
- tablets 10 mg No. 40 – 60 hryvnia;
- tablets 20 mg No. 40 – 90 hryvnia;
- ampoules 1 ml No. 10 – 25 hryvnia.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- ATP-long tablets 20 mg 40 pcs.
1850 rub. order
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Pharmacy24
- ATF-Long 0.01g No. 40 tablets PAT NEC "Borshchagivsky chemical and pharmaceutical plant", Kiev, Ukraine
58 UAH. order - ATF-Long 20 mg No. 40 tablets TOV FC Farkos, Ukraine
72 UAH order
- ATF-Long 0.02g No. 40 tablets PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine
85 UAH order
