The drug Teraligen belongs to the group of antipsychotics or neuroleptics. Sometimes its other name is teraligen valence. The most common form of the drug is tablets. They are recognizable by their dark pink film shell. The active substance in the medicine is alimemazine tartrate in an amount of 5 mg. Auxiliary ingredients used in production are listed in the instructions for use. You should familiarize yourself with the composition of the drug to exclude the occurrence of allergic reactions during treatment.
Pharmacodynamics and pharmacokinetics
Teraligen is an antipsychotic (antipsychotic) that has serotonin-blocking , antispasmodic and antihistamine effects, as well as hypnotic , antiemetic , antitussive and sedative effects.
You can observe the effect after taking it within 10-15 minutes, its duration of action is from 6 to 8 hours.
The drug has low antipsychotic activity , so it is ineffective in the acute stage of psychotic conditions .
It is also used for the treatment of elderly people, as well as children and adolescents, as the drug is well tolerated.
Absorbed completely, quickly, the maximum concentration in plasma can be observed after administration after 1-2 hours. Within 2 days it is excreted as a metabolite by the kidneys (70-80%).
Results and discussion
The most common complaints among patients were general anxiety, tearfulness, fear for their health, sleep disturbances, frequent headaches, increased fatigue, decreased performance, pain and discomfort in the heart, digestive disorders (unstable stool, pain and discomfort in the abdomen). Also, when filling out a questionnaire to identify vegetative changes, most patients noted a tendency to redness (less often, paleness) of the face when excited, difficulty breathing, poor tolerance of stuffy rooms, and episodes of fainting.
When studying cognitive functions according to the MMSE, the most characteristic disorders were errors associated with increased impulsivity or, conversely, decreased initiative, lack of attention, and difficulty following a given program. When assessing the results of learning 10 words (according to A.R. Luria), all patients had a normal indicator of delayed reproduction of memorized words (at least 5). However, during the learning process, approximately 1/3 of the subjects showed increased exhaustion, when, with repeated presentations, the number of words reproduced began to decrease.
Treatment was generally well tolerated. The most common problem was drowsiness during the first days of taking the drug.
When assessing the condition of patients on the 30th day from the start of treatment, most of them noted positive dynamics. First of all, this concerned improving the quality of sleep: easier falling asleep and deeper sleep during the night. Patients with cephalgic syndrome paid attention to a decrease in the frequency and intensity of headaches. Also, many patients noted that they began to react more calmly in the event of stressful situations.
On the 60th day, almost all patients noted a significant improvement in sleep quality, a decrease in anxiety, pain syndromes, as well as an improvement in general well-being and increased activity.
Analysis of the dynamics of autonomic disorders using a questionnaire to identify autonomic changes showed a significant decrease in their severity during treatment. At the same time, in the control group there were no pronounced dynamics of vegetative symptoms, but there was a slight tendency towards their increase (Fig. 1).
Rice. 1. Dynamics of autonomic symptoms during Teraligen therapy according to the autonomic changes questionnaire (scores). p<0.001 for the main group, p=0.518 for the control group.
In the group receiving treatment with teraligen, the rates of ST and LT decreased significantly both on the 30th and 60th days of treatment.
In the control group, contradictory dynamics were noted: on the one hand, CT tended to decrease, but at the same time, a significant increase in the RT indicator was noted (Fig. 2).
Rice. 2. Dynamics of RT and ST indicators according to the Spielberger-Hanin scale in patients during Teraligen therapy. Main group: RT and ST p<0.001, control group: ST p=0.2, RT p<0.05.
Also, a significant decrease in anxiety and depression scores during treatment with Teraligen was noted according to HADS. In the control group there were no significant changes, but, on the contrary, there was a tendency towards a gradual increase in indicators (Fig. 3).
Rice. 3. Dynamics of anxiety (T) and depression (D) indicators according to HADS in patients during Teraligen therapy. Main group: anxiety and depression - p<0.001, control group: anxiety - p=0.42, depression - p=0.17.
Regarding cognitive functions, most patients noted an improvement in the ability to concentrate and, as a result, an improvement in memory and performance.
A neuropsychological examination revealed a significant increase in MMSE scores (from 27.8 to 28.2 by day 30 and 28.6 by day 60, p
<0.001), mainly due to a decrease in the number of errors in serial counting and the execution of a 3-step command, in the control group the dynamics of improvement were unreliable (from 27.6 to 28.0 points by the 30th day and 28.2 points by the 60th day) day,
p
=0.111) (Fig. 4). In the 10-word learning test, there was a decrease in exhaustion during learning and a tendency toward an increase in the number of words during delayed recall. No significant changes were observed in the control group.
Rice.
4. Dynamics of cognitive functions according to MMSE data (scores) in patients receiving Teraligen therapy. Main group: p<0.001, control: p=0.111. According to frequency analysis of the EEG, no significant dynamics were observed; a small increase in the amplitude of the α-rhythm was detected, which, in combination with improved EEG synchronization in the control group, can be considered as positive dynamics.
When comparing data from a study of cognitive evoked potentials at the first and final visits, a statistically significant decrease in the P300 latent time was noted in the group receiving treatment with teraligen ( p
<0.05), which indicates positive dynamics.
On the contrary, in the control group a statistically significant decrease in P300 amplitude was detected ( p
<0.05), which may indicate a deterioration in cognitive functions.
Despite the fact that the data from the P300 study, in general, confirm the results of neuropsychological testing, it should be noted that the results of the P300 study should not be taken as absolutes, since a feature of cognitive evoked potentials is high variability depending on age, and in our study there was a fairly significant scatter on this basis.
Indications for use
This medicine is used to treat the following diseases:
- sleep disorders;
- senestopathic depression;
- in case of somatic diseases, a state of anxiety and excitement;
- psychopathy with psychoasthenic and asthenic disorders;
- somatized mental disorders;
- neuroses and neurosis-like conditions of organic or endogenous origin with hypochondriacal , psychovegetative , senestopathic and phobic disorders ;
- allergic reactions;
- anxiety-depressive diseases (with vascular and borderline diseases).
Teraligen® Valenta
In adults and children from 7 years of age
:
As a sedative (calming), anxiolytic (anti-anxiety) and sleep aid
:
— dementia
(including dementia due to epilepsy), occurring with manifestations of psychomotor agitation, anxiety affect (as part of combination therapy);
— organic anxiety disorder
(as monotherapy or as part of combination therapy);
— schizophrenia
(with a predominance of neurosis-like disorders, as part of combination therapy);
— mood disorders
(affective disorders) - as part of combination therapy;
— generalized anxiety disorder
(as part of combination therapy);
— obsessive-compulsive disorder
(as part of combination therapy);
— reaction to severe stress and adaptation disorders
(acute stress reaction, post-traumatic stress disorder, unspecified reaction to severe stress, other reactions to severe stress) - as part of combination therapy;
— dissociative (conversion) disorders
(as part of combination therapy
);
- somatoform disorders
(somatization disorder, undifferentiated somatoform disorder, hypochondriacal disorder, somatoform dysfunction of the autonomic nervous system, persistent somatoform pain disorder, unspecified somatoform disorder, other somatoform disorders) - as part of combination therapy for severe anxiety or when standard therapy is ineffective;
— unspecified autonomic nervous system disorder, other autonomic nervous system disorders
(as part of combination therapy);
— anorexia nervosa
(as part of combination therapy);
— emotionally unstable personality disorder (impulsive and borderline types)
- as part of combination therapy;
— histrionic personality disorder, anxious (avoidant) personality disorder
(as part of combination therapy);
— persistent personality changes after experiencing a disaster
(as part of combination therapy);
— hyperkinetic behavior disorder
(as part of combination therapy);
— family-confined conduct disorder
(as part of combination therapy when standard therapy is ineffective);
— unsocialized behavior disorder
(as monotherapy or as part of combination therapy);
— restlessness, agitation and other symptoms and signs related to emotional state
(as part of combination therapy);
- other neurotic disorders
(neurasthenia, unspecified neurotic disorder)
- as part of combination therapy;
— insomnia of non-organic etiology
(as part of combination therapy when standard therapy is ineffective);
— emotional disorders whose onset is specific to childhood
(phobic anxiety disorder in childhood, social anxiety disorder in childhood, sibling rivalry disorder, unspecified emotional disorder in childhood, other emotional disorders in childhood) - as part of combination therapy.
As an antiallergic agent
:
— itching regardless of location and etiology
(pruritus of the anus, pruritus of the vulva, unspecified anogenital pruritus, pruritus due to photocontact dermatitis and solar urticaria, dermatitis, eczema, urticaria, bites or stings from non-venomous insects or other non-venomous arthropods, chickenpox, measles, Hodgkin's disease, diabetes mellitus, shingles lichen) in the form of monotherapy or as part of combination therapy;
— asthma, hay fever, whooping cough
(as part of complex therapy as an antiallergic agent to relieve cough, shortness of breath and asthma attacks);
— unspecified allergy
(as monotherapy or as part of combination therapy).
In children from 3 years old
:
As an antiallergic agent
:
— itching regardless of location and etiology
(itching from photocontact dermatitis and solar urticaria, dermatitis, eczema, urticaria, bites or stings from non-venomous insects or other non-venomous arthropods, chickenpox, measles, Hodgkin's disease, diabetes mellitus, herpes zoster, anal itching, vulvar itching, unspecified anogenital itching) as monotherapy or as part of combination therapy.
As a sedative (calming) agent
:
— during medicinal preparation for surgery
(for the purpose of sedation before surgery).
Contraindications
Teraligen has a number of contraindications:
- children under 7 years old;
- hypersensitivity to any ingredient of the drug;
- myasthenia gravis;
- pregnancy;
- prostatic hyperplasia;
- taking MAO inhibitors ;
- lactation;
- parkinsonism;
- angle-closure glaucoma;
- Reye's syndrome;
- kidney and liver diseases (severe stage).
The drug is prescribed with caution in the following cases: bone marrow suppression , epilepsy , arterial hypotension , chronic alcoholism, jaundice , predisposition to urinary retention, open-angle glaucoma , bladder neck obstruction .
Side effects
Teraligen tablets are well tolerated and rarely cause side effects.
The following side effects are possible:
- tachycardia , decreased blood pressure , dizziness ;
- accommodation paresis , ringing, tinnitus;
- increased viscosity of bronchial secretions, dry throat and nose;
- lethargy, drowsiness, fatigue (these symptoms usually occur in the first days and do not require discontinuation of the drug), nightmares, anxiety, irritability, agitation; in rare cases, hypokinesia , confusion, tremor , akathisia , and in children - increased convulsive activity;
- urinary retention, bladder atony ;
- loss of appetite, constipation , gastrointestinal atony, dry mouth;
- muscle relaxation , inhibition of hematopoiesis in the bone marrow, photosensitivity , allergic reactions, increased sweating.
Teraligen and alcohol
The combination of drugs and alcohol does not go away without leaving a trace; it can often lead to very serious consequences. You should be especially careful when taking psychotropic medications like Teraligen.
Teraligen should not be taken with alcohol!
The instructions attached to the medication clearly indicate that it is strictly forbidden to take it with alcohol, since it can only increase the severity and intensity of the underlying pathology.
The annotation for the drug indicates the side effects that occur when combining Teraligen + Alcohol:
- irritability and anxiety, nightmares and emotional overexcitement;
- drowsiness and excessive fatigue, lethargy;
- confusion;
- visual impairment, manifested by blurred perceived image;
- disorders such as tremor, an internal need to constantly move, or, conversely, a condition associated with insufficient movement activity;
- frequent cases of respiratory arrest during night sleep;
- extraneous sounds in the ears, frequent dizziness and fainting, decreased blood pressure;
- dryness of the mucous membranes in the mouth, nasal cavity, pharynx, lack of appetite, various allergic manifestations;
- tachycardia disorders, hyperhidrosis, disorders in bone marrow hematopoiesis;
- urinary retention;
- lack of normal tone in the muscular system of the gastrointestinal tract, bladder, as well as muscle relaxation, etc.
Remember that antipsychotic drugs have a strong effect on the central nervous system. Only a doctor can prescribe antipsychotics. In addition, a prescription is required to purchase such medications.
Instructions for use of Teraligen (Method and dosage)
The tablets are intended for oral administration.
To obtain a hypnotic effect, adults need to take 5-10 mg per day, an anxiolytic effect - 60-80 mg, and in a psychotic state - 0.2-0.4 g.
Instructions for Tiralijen for children (over 7 years old): to achieve a hypnotic effect - 2.5-5 mg, anxiolytic effect - 20-40 mg, for the treatment of allergic reactions - 5-20 mg. The daily dose for a psychotic state can be increased to 60 mg.
The daily dose should be divided into 3-4 doses.
Interaction
The drug can enhance the effect of anxiolytics , hypnotics , antipsychotics , narcotic analgesics , general anesthesia , antihypertensive drugs and m-anticholinergic drugs . In such cases, it is necessary to adjust the dose.
Teraligen reduces the effectiveness of m-cholinergic stimulants , dopamine , ephedrine , amphetamine , levodopa , guanethidine . Significant depression of the central nervous system is observed when taken simultaneously with drugs that suppress central nervous system functions and ethanol . Combination with barbiturates and antiepileptic drugs leads to a decrease in the threshold of convulsive readiness.
An increase in the plasma concentration of alimemazine is caused by beta-blockers , which can lead to the development of arrhythmia and a decrease in blood pressure.
Teraligen increases the level of prolactin in the blood and reduces the effectiveness of bromocriptine .
The M-anticholinergic activity of alimemazine increases while taking anticholinergics and tricyclic antidepressants .
The risk of extrapyramidal disorders and arterial hypotension increases when taking MAO inhibitors and phenothiazine derivatives .
Reviews of Teraligen
The overall rating given by buyers on the forums is 3.8 out of 5 points. Many patients write about the effectiveness of the drug, its rapid action and the absence of side effects. In addition, there are reviews from customers for whom the drug did not help, and many also write about severe side effects, in particular weakness, drowsiness, and dizziness. Regarding its use for children, reviews are positive. This drug is safe for children as it is very well tolerated.
Doctors' reviews of Teraligen are positive, however, they note that the drug should not be taken without a prescription, as this can only worsen the patient's condition.
There is no data on this drug in the Wikipedia encyclopedia.
Analogs of the drug Teraligen
Teraligen has no analogues for the active substance - alimemazine tartrate. Substitutes that have a similar pharmacological effect belong to the group of neuroleptics.
Remember that the attending physician must prescribe medications, as well as substitutes!
Remember that the attending physician prescribes medications or their analogues
Klopiksol
Clopixol tablets contain zuclopenthixol hydrochloride. Although this is in some sense a substitute for Teraligen, and they are similar in pharmacological action, Klopixol has a stronger antipsychotic effect. Thanks to this, Clopixol is more often used to treat serious mental health disorders: schizophrenia, hallucinations, paranoia, manic states, dementia.
Clopixol is contraindicated in comatose states, acute poisoning by barbiturates, alcohol, opiates, pregnancy and breastfeeding. Clopixol, unlike Teraligen, is better tolerated by patients. Side effects are similar to Teraligen, but occur even less frequently and are not as pronounced.
Conapax
It is also an antipsychotic drug based on thioridazine hydrochloride. Sonapax has a more pronounced antihistamine and anticholinergic effect compared to other neuroleptics. Indicated for use in those cases described in the instructions for Teraligen. But it can be used to treat children from 4 years of age. Conapax is contraindicated in comatose states, acute depression, porphyria, pheoxomocytoma, hematopoietic disorders, in the first trimester and in the last week of pregnancy, during lactation tions. Sonapax is well tolerated, it can be taken by children, and its price is lower than Teraligen.
Chloprothixene Zentiva
The main active ingredient of Sanofi Chloprothixene tablets is chlorprothixene. Medicines are indicated for the treatment of: psychoses, schizophrenia, depressive states, mental disorders during menopause and for diseases of the brain (traumatic brain injuries, enc ephalopathy), alcoholic delirium, sleep disorders caused by psychosomatic and neurotic disorders, insomnia due to burns, skin diseases, accompanied by itching. Contraindications for use: hypersensitivity, coma, poisoning with drugs that depress nervous activity. When taking tablets, in addition to the side effects characteristic of Teraligen, disorders of the mammary glands and reproductive organs are possible: galactorrhea, amenorrhea, gynecomastia, c decreased libido.
Pipolfen
This is a Hungarian analogue of Teraligen based on promethazine hydrochloride. It is often used as a sedative for postoperative pain (in combination with analgesics), allergic diseases and other cases. Pipolfen has a fairly large list of contraindications and age restrictions, so before treatment, be sure to consult a specialist and read the instructions.
Teraligen price, where to buy
In Russia, the average price for a package of 25 tablets is 282 rubles, for 50 tablets - 465 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Teraligen Valenta tablets p.p.o.
5 mg 50 pcs. JSC Valenta Pharmaceuticals 831 rub. order - Teraligen tab. p/o captivity. 25pcs JSC Valenta Pharmaceuticals
RUR 711 order
- Teraligen retard tab. with prolong. release p/o captivity 20mg 30pcs JSC Valenta Pharmaceuticals
RUB 1,430 order
- Teraligen tab. p/o captivity. 100pcs JSC Valenta Pharmaceuticals
RUB 1,434 order
- Teraligen solution for intramuscular injection. input 5mg/ml amp. 5 ml 10 pcs. Federal State Budgetary Institution "RKNPK" of the Ministry of Health of Russia - EPMBP
1126 rub. order
