Osteoarthritis is the leader in prevalence among other joint diseases. In world rankings for the incidence of osteoarthritis, Russia, like other post-Soviet countries, is in the top positions: up to 48% of the population suffer from one form or another of the disease. In advanced cases, osteoarthritis leads to disability, disability, and worsens the quality of life. And treating this disease is a costly undertaking. Especially if the disease has progressed to late stages and has significantly affected the cartilage tissue.
Articular cartilage and intervertebral discs regenerate even in adults. This process is ensured by the activity of chondrocytes and chondroblasts. When there are enough of these cells in the joint, and they receive enough nutrition with micro- and macroelements, then the cartilage is able to regenerate from the inside. But if (due to illness or age) cell metabolism is disrupted, and synovial fluid, the main source of nutrients, is not produced in the required quantities, then cartilage needs outside help. For these purposes, pharmacology identifies a group of drugs - stimulants and correctors of metabolism in cartilage and bone tissues. Piaskledin also belongs to these drugs.
Data on the production of the drug
- The manufacturer is the French company Expansiance.
- Supplied in capsules with 300 mg of substance.
- 1 blister contains 15 capsules.
- A pack made of cardboard contains 1-2 blisters and instructions.
- 1 capsule contains the following components: 200 mg of the unsaponifiable fraction of soybean oil, 100 mg of the unsaponifiable fraction of avocado oil.
In oils, in their saponified part, the constituent elements are glycerin and fatty acids; they determine how the oil looks externally and its consistency. This fraction has a peculiarity: when alkali is introduced into their composition, soap is formed. If you mix the unsaponifiable fraction of oils with alkali, no soap is formed; they have a different composition and properties.
It is the unsaponifiable fraction of oils that contains such useful substances as:
- phytosterols;
- enzymes;
- acids;
- minerals;
- vitamins;
- carotenoids.
It also contains many other useful elements. For the treatment of joints, as well as for cosmetic procedures, the unsaponifiable fraction of oils is extracted and used. It is the unsaponifiable fraction of the oil that has beneficial pharmacological properties.
Piascledine 300
Capsules contain such auxiliary compounds as:
- colloidal silicon dioxide;
- butylated hydroxytoluene.
Piaskledin 300, patient reviews of which describe it as an effective drug, is sold at different prices in different pharmacies, its cost is approximately 1200-1300 rubles.
Reviews
In addition to doctors, whose job is to know everything about the latest products on the pharmaceutical market in order to select the optimal drug therapy for their patients, Piaskledin is also appreciated by ordinary people. Here's what patients say about the drug:
Alevtina Pavlovna, 63 years old, Moscow “Pain in the knees does not give life, but I don’t want to poison myself with chemicals. But here the composition is natural, and the result was promised to be good. Only very expensive! But thanks to the children for buying Piaskledin. I was skeptical at first, but after a week my knees hurt less. At least I can sleep normally at night. No additional painkillers were needed. I finished one pack and asked my daughter to buy more. It’s easier to move, my knees started to bend, which hasn’t happened to me for a long time.”
Mikhail, 48 years old, Krasnoyarsk “I have been suffering from rheumatoid arthritis for several years now. Nothing helped. I bought expensive medicines, and cheap ones, and homeopathy. I picked up Piaskledin from the pharmacy, not really expecting it. Recommended by a friend. After all, if it helped him, where is the guarantee that I will feel better too? But the effect came immediately. It feels like the pain has become twice as weak after just a week of taking it. I’ve been taking it for three months now, and the effect is still there and very significant. A good natural remedy. My salvation."
Valentina, 37 years old, Omsk “My case is not quite typical. It was not my joints that were damaged, but my fifteen-year-old son’s. You need to take chondroprotectors, but they are all contraindicated for teenagers. Discuss the issue with an orthopedist at your own risk. He recommended Piaskledin. Prescribed to take it for 3 months. Although the price, of course, is rather high. We have now completed the course. A month later, repeat. X-ray shows positive changes. I hope it will help my son.”
Active ingredients
Active ingredients of the medicinal product:
- unsaponifiable fraction of avocado oil, in an amount of 100 mg;
- unsaponifiable fraction of soybean oil, in an amount of 200 mg.
The unsaponifiable component of soybean and avocado oils has demonstrated high effectiveness in reducing inflammatory substances involved in the decomposition of cartilage in pathologies such as arthritis and arthrosis.
This combination of unsaponifiable oils was first invented and produced in France in the first half of the 1990s. for the treatment of a widespread disease - osteoarthritis.
Avocado and soybean oils contain small amounts of unsaponifiable fractions. To achieve therapeutic concentrations of nutrients, it is impossible to eat such volumes of soy and avocado. In this regard, taking these elements exclusively in the form of a supplement can have a therapeutic effect on the joints.
As a result of studies of avocado and soybean unsaponifiable oils, it was found that the most effective ratio is 1:2. If you use other ratios of these oils, or oils separately, for treatment, then their effect is much lower.
At the same time, the unsaponifiable fraction of oils is a combination of a large number of other natural active elements, and now no one has been able to accurately determine which substances from it have a therapeutic effect.
Most studies suggest that the therapeutic effect is exerted by a group of tocopherols (various natural modifications of vitamin E) and natural phytosterols.
Piascledine 300, which has only positive reviews from patients, effectively eliminates the symptoms of osteoarthritis. However, unsaponifiable fractions from oils do not lead to a cure for arthrosis. Their main effect is to slow down the progression of the disease, reduce pain, inflammation and the degree of decomposition of cartilage tissue.
Additionally, Piaskledin 300 stimulates the synthesis of proteoglycans and collagen, which decrease in patients with joint pathologies and the presence of an inflammatory reaction in them. Researchers believe that this effect is due to increased synthesis and release of growth factors. The unsaponifiable fraction from oils reduces the level of inflammatory cytokines.
Proteoglycans are protein substances that regulate metabolic processes inside cells. Proteoglycans surround connective tissue and thereby provide its strength. Various manufacturers from Japan are now increasingly listing proteoglycans as one of the main components of their joint supplements.
Benefits of Piascledine for athletes
The joints of athletes and people whose work involves heavy physical labor experience increased stress. In addition, playing sports is often accompanied by injuries, inflammation and pain.
You can take Piaskledin 300 to prevent sports injuries to joints and cartilage, to quickly relieve the inflammatory process to prevent it from becoming chronic. For sprains and injuries to the knee and hip joints, the capsules will help you recover faster.
To reduce the severity of inflammation, as well as the natural restoration of the joint and cartilage tissue, Piascledine should be taken in the postoperative period.
pharmachologic effect
A product made from natural components in cartilage tissue corrects metabolism. It has a symptomatic effect on joints, including analgesic and anti-inflammatory. With long-term use of the drug, the degree of cartilage degradation decreases, joint mobility is restored, and pain associated with joint diseases is reduced.
Among the main mechanisms of action of the drug is the presence of an effect on the production of cytokines. Piascledine 300 inhibits IL-1 and prevents it from damaging synoviocytes and chondrocytes, and enhances the production of collagen and proteoglycans in the joints.
The drug blocks the IL-1-stimulated production of MP (stromelysin and collagenase) by cartilage cells, the synthesis and release of prostaglandin E2, IL-6 and IL-8. This is the basis for the anti-catabolic effect on cartilage tissue.
The drug inhibits the “secondary” inflammatory reaction in the joints: in hyaline cartilage, subchondral bone, entheses and synovial membrane. In clinical experiments, it was found that the constituent substances of Piascledine prevent the occurrence of post-traumatic osteoarthritis and are able to enhance the restoration of cartilage tissue.
Piaskledin 300 reviews from patients are described as a powerful therapeutic agent. Studies have found that this remedy repairs cartilage tissue, enhancing the creation of collagen in it, by inhibiting the enhancing effect of interleukin-1 on the production of collagenase.
Unsaponifiable fraction from avocado and soybean oil:
- accelerates the synthesis and release of TGF 1 in cartilage cells, which has a strong anabolic effect;
- ensures a balanced expression of the components of the intercellular substance in the cartilage tissue, enhances the production of the components of hyaline cartilage and periodontal tissue, thereby preventing tooth loss;
- accelerates the synthesis and release of plasminogen activator inhibitor, thanks to this effect, it reduces the degree of decomposition of cartilage tissue, both indirectly, by enhancing the expression of metalloproteinases, and by directly affecting cartilage tissue, stopping the degradation of proteoglycans, which prevents the destruction of cartilage tissue.
Instructions
The medicine is taken orally, 1 capsule per day, it is better to take it during meals, in the morning. Take with 1 glass of water. Therapy lasts six months (6 months). Only a medical specialist can increase the duration of the course of therapy and prescribe additional ones.
Piaskledin 300 has active ingredients with a pharmacological effect, which makes it possible to reduce the dosage of NSAIDs, which are now the main medications in medical practice for the treatment of pain, but, according to doctors, at the same time, have some harmful effects on the patient’s body.
A similar effect of Piascledine in reducing dependence or quitting NSAIDs is a big advantage of this drug.
Artra
Manufacturer: Ameripharma Labs, USA
Release form: film-coated tablets
Active ingredient: Glucosamine + Chondroitin sulfate
Synonyms: Teraflex, Condronova, Artrafik Pro
Artra is a regenerator of cartilage tissue, promotes the restoration of cartilage, and prevents its destruction.
This American analogue of Piascledine is used for various diseases of the musculoskeletal system, accompanied by pain and decreased joint mobility.
In the first 20 days, Arthra is taken one tablet twice a day, then switched to a single dose. The most lasting effect is observed after a six-month course of treatment.
Side effects
Allergies sometimes occur during drug therapy. Even more rarely, laboratory parameters may increase, including: gamma-glutamyl transpeptidase, bilirubin, alkaline phosphatase and transaminases.
The medicine can be used in work that requires high concentration and high speed of psychomotor reactions.
Piaskledin 300 reviews from patients are described mostly positively. In clinical studies, according to their assessment, the drug was excellently tolerated - in 84.7%, well - in 8.7% and satisfactory - in 6.6%.
In this regard, the researchers concluded that Piaskledin 300 is an effective therapeutic agent with a slow but powerful development of pharmacological effect in the treatment of osteoarthritis. This drug is considered a biological response modifier with a specific mode of action on body tissue.
Piascledine significantly reduces pain in diseased joints, both during the patient’s physical activity and at rest, reduces synovitis, helps reduce the severity of coxarthrosis and gonarthrosis, reduces the need to use NSAIDs, and helps maintain the functionality of diseased joints.
Piascledine also has a significant modifying effect on the structure of joint tissues; this was established during continuous treatment of coxarthrosis for 2 years.
This medication has high safety and good tolerability. Those few side effects that may appear at the beginning of therapy completely disappear with continued treatment, without requiring a change in the treatment regimen.
The data presented have been proven in a large number of controlled studies that fully meet the requirements for modern medications used to treat osteoarthritis.
Indications
Indications for taking Piascledine - complex therapy for degenerative joint diseases:
- Osteoarthritis of the hip joints stages 1-3;
- Osteoarthritis of the knee joints stages 1-3;
- Spondyloarthrosis;
- Rheumatoid arthritis;
- Osteoarthritis of the joints of the hands;
- Traumatic joint injuries.
In addition, clinical studies conducted from 1995 to 2013 showed that taking Piascledine has a positive effect on the health of damaged joints of any location. In people suffering from these ailments, a significant reduction in regular pain syndrome is observed after two months of taking the drug.
Another purpose of “Piascledin” is the auxiliary therapy of periodontitis (inflammation of the soft tissues surrounding the roots of the tooth).
Analogs
https://www.youtube.com/watch?v=nxyUW5v4AMU
Piascledine 300 has the following analogues:
| A drug | Price | Description |
| Alflutop | Produced in Romania by Biotechnos SA, in the form of: ampoules of 2 ml, 10 mg/1ml, 5 pcs., costing from 1978 rubles; ampoules of 1 ml, 10 mg/1ml, 10 pcs., costing from 2008 rub. | It is a Romanian remedy used to treat joint dysfunction. It is produced in the form of a solution for injection. The main active ingredient is a concentrate isolated from small marine fish, which has high biological activity. Alflutop has restrictions on its use. You should carefully study the instructions in advance of using the drug. The medicine is expensive. However, therapy will be more profitable than treatment with Piascledine, because the course of therapy with Alflutop requires less time, and less money is needed, since it is administered intramuscularly and inside the joint. This remedy can be used by elderly patients, but it must be used with caution if there are liver and kidney diseases. |
| Avocado 300 Soy Unsaponifiables | Published by Maximum International. Unsaponifiable fractions of soybean and avocado oil, 60 tablets of 600 mg, price from 2000 rub. | One tablet of the drug contains 300 mg of unsaponifiable oils, as well as the natural mineral complex SierraSil. According to the manufacturer, the combination of substances in the remedy is balanced and created for the most complete therapeutic effect on the joints. |
| Artra | Produced by the American company Unipharm, in the form of: tablets, in the amount of 30 pcs. Price from 695 rub. | It is a medicinal product from the USA used for the treatment of joint diseases. Produced in tablet form. The active ingredients are chondroitin sulfate sodium in an amount of 500 mg and glucosamine hydrochloride in an amount of 500 mg. However, the use of the drug is prohibited for those patients who have impaired renal function. |
| Rumalon | Produced in the Russian Federation by the pharmaceutical company Bryntsalov, in the form of: ampoules of 1 ml, 5 mg/ml, 10 pcs., costing from 1241 rubles; ampoules of 1 ml, 10 mg/ml, 10 pcs., costing from 2008 rub. | The drug is a Russian medicinal product used to treat joint pathologies. It is produced in the form of a solution for injection, administered intramuscularly. Indications are degenerative joint diseases. Contraindications to the use of Rumalon are rheumatoid arthritis and high susceptibility to the constituent components of the drug. |
| Teraflex Advance | Produced by the German company Bayer in the following form: capsules of 30 pieces, costing from 569 rubles; capsules of 60 pcs., costing from 1184 rubles. | It is an antirheumatic and anti-inflammatory drug. Prescribed for osteochondrosis and osteoarthrosis of large joints. |
| Rumalaya | Produced by the Indian company Panacea Biotek in the form of: capsules of 30 pieces, costing from 459 rubles; capsules of 60 pcs., costing from 1184 rubles. The cost of the gel product is approximately 265 rubles. | It is an additive with high biological activity, and includes extracts of various medicinal herbs as components. Due to powders of medicinal plants and extracts from them, used more often by healers in India, the product acts on the same principle as Piascledine: it enhances metabolism in cartilage tissue. Additionally, as indicated by the manufacturer, this remedy eliminates pain and inflammation. Rumalaya is prohibited from use during pregnancy and breastfeeding, as well as by patients who have an increased sensitivity to the active substances of this dietary supplement. Additionally, Rumalaya is available in the form of a gel. Before initiating therapy with this medication, you should consult with a healthcare professional to ensure that this dietary supplement can be used as a substitute for approved medications. |
If you need direct analogues of the drug, then they need to be selected based on the main component. Piascledine's main active component is the unsaponifiable component of soybean and avocado oils.
Taking into account the unique mechanism of action of Piascledine 300, its increased effectiveness, low number of side effects, ease of use, and also focusing on the positive assessments of patients, this remedy can be recommended as effective, eliminating the symptoms of the disease and improving the structure of tissues in the treatment of osteoarthritis.
Article design: Vladimir the Great
