Pharmacodynamics and pharmacokinetics
The mechanism of action is based on the stabilization of mast cell . The main active ingredient is cromoglycic acid . Intal prevents the process of degranulation of mast cells, blocks the flow of calcium into them, inhibits the release of leukotrienes, bradykinin, histamine and other bioactive components from mast cells.
The drug prevents the formation of bronchospasm. Most often used to prevent an allergic response.
With long-term use, there is a decrease in the frequency of asthma in bronchial asthma, the course of the disease is alleviated, and the need for the use of glucocorticosteroids and bronchodilators is reduced.
A stable effect is registered after ½-1 month of use. With a single use, the effect lasts up to five hours.
Release form and composition
Intal is available in the form of capsules with powder for inhalation and a metered aerosol for inhalation.
The capsules are transparent, hard, gelatinous, consisting of a yellow cap and a colorless body. The contents of the capsules are a homogeneous, almost white powder. Available in blister packs of 10 pieces. 1 sachet contains 1 blister. A cardboard pack contains 3 sachets.
The aerosol after spraying and evaporation is a white powder. Available in 112 doses in aluminum aerosol cans. A cardboard box contains 1 cylinder.
The active ingredient of Intal is sodium cromoglycate.
The auxiliary components in the aerosol are the following substances:
- Hydrofluoroalkane;
- Povidone K30;
- Macrogol 600.
Side effects
Digestive system: dry mouth, use of the aerosol causes an unpleasant taste in the mouth.
Respiratory system: cough, hoarseness, irritation of the respiratory tract.
Nervous system: periodic headaches, dizziness, weakness.
Urinary system: disruption of the renal system, urinary retention.
Allergic reactions may develop in the form of swelling of the eyelids, face, lips, lacrimation, anaphylaxis , and skin rash.
The use of the drug Intal may be accompanied by difficulty, stridor breathing, and instability of blood pressure.
pharmachologic effect
Intal has a strong anti-edematous and anti-inflammatory effect . The active substance, acting on the mucous surface of the respiratory tract, effectively reduces the manifestation of an allergic reaction and reduces swelling.
Thanks to the action of sodium cromoglycate, there is a reduction in the formation of histamines, bradycardin, prostaglandin, which are activated when exposed to allergens: cold air, dust, pollen, and physical or nervous stress.
Very often, Intal is used to relieve acute attacks of bronchial asthma.
Instructions for use of Intal (Method and dosage)
Capsules with Intal powder for inhalation
To prevent attacks of bronchial asthma, swallowing capsules is ineffective. Using a spinhaler, the powder is inhaled. 20 mg of the drug (1 capsule) is used 4 times a day: during the day at intervals of 3-6 hours, in the morning and in the evening. If necessary, the dosage can be increased to 160 mg per day.
Metered aerosol Intal for inhalation
1 dose contains 1 mg of active substance, apply 4 times a day, 2-10 mg. The dosage may be increased to 2 mg, administered up to 8 times daily. After achieving the required therapeutic effect, they switch to a maintenance dosage, which allows optimal control of the course of the disease. In case of severe pathology, the amount of the drug is increased to 20 mg, 4 times a day. The drug is withdrawn gradually over the course of a week.
Solution for inhalation Intal, instructions for use
Using an inhaler, apply 20 mg 4 times a day. Before use, the contents of the container must be shaken thoroughly. During inhalation, the metering valve should be located at the bottom, and the container itself should be in a vertical position.
Intal 5 mg/dose 112 doses aerosol for inhalation dosed
Latin name
Intal
Release form
Aerosol dosed for inhalation.
Package
The cans contain 112 doses. There is 1 cylinder in a cardboard box.
112 doses
pharmachologic effect
Mast cell membrane stabilizer. Intal prevents bronchospasm by preventing the degranulation of mast cells and the release of histamine and other biologically active substances (leukotrienes, the slow-reacting substance of anaphylaxis) from them.
In the lungs, inhibition of the mediator response prevents the development of both the early and late stages of the asthmatic reaction in response to immunological and other stimuli.
Indications
Prevention and treatment of bronchial asthma (including exercise-induced asthma) in children and adults.
Contraindications
- Hypersensitivity to any components of the drug.
- Children under 5 years of age.
Carefully:
- When treating patients with impaired renal and liver function.
Use during pregnancy and breastfeeding
The drug should not be prescribed to women in the first 3 months of pregnancy.
Sodium cromoglicate can be prescribed by a doctor only when the expected benefit to a pregnant or lactating woman outweighs the possible risk to the fetus or infant.
special instructions
Intal is not a drug for relieving attacks of bronchial asthma. The patient should be instructed regarding the need for regular use of Intal, as opposed to taking medications used occasionally to reduce bronchospasm. Bromhexine and ambroxol should not be used simultaneously in the inhalation solution of cromoglycic acid. The contents of the canister are under pressure and should not be punctured or exposed to fire, even if empty.
Compound
Active ingredient: Sodium cromoglycate 5 mg.
Excipients: Povidone KZO, macrogol (polyethylene glycol) 600, hydrofluoroalkane (HFA-227).
Directions for use and doses
Treatment and prevention of bronchial asthma
2 inhalations 4 times a day. Once the optimal therapeutic effect is achieved, you can switch to a maintenance dose (1 inhalation 4 times a day), which ensures optimal control of the disease.
In severe cases, as well as with a high concentration of allergens, the dose of the drug can be increased to two inhalations 6-8 times a day. After achieving a therapeutic effect, you should not suddenly stop using Intal. If necessary, the drug is discontinued gradually over a week. During dose reduction, symptoms of the disease may recur.
Exercise asthma
An additional dose of the drug can be taken immediately before physical activity to prevent exercise-induced asthma or before contact with suspected allergens.
When concomitant therapy with bronchodilators is used, they must be taken before inhalation of Intal.
In patients receiving corticosteroids, the addition of Intal may allow the dose to be significantly reduced or eliminated entirely.
The basis of effective treatment is the correct use of the inhaler. The use of the inhaler by children is recommended only under adult supervision.
Side effects
- Upper respiratory tract irritation.
- Dry mouth.
- Unpleasant taste sensations.
- Hoarseness.
- Cough.
- Short-term bronchospasm.
- Anaphylaxis:
- Difficulty swallowing.
- Hives.
- Itchy skin.
- Swelling of the face, lips and eyelids.
- Severe wheezing or difficulty breathing.
- Reduced blood pressure.
- Headache.
- Dizziness.
- Painful or difficult urination.
- Frequent urination.
- Nausea.
- Rash.
- Eosinophilic infiltrate of the lung.
- Eosinophilic pneumonia.
Drug interactions
When cromoglycic acid is used with oral and inhaled forms of beta-agonists, oral and inhaled forms of glucocorticoids, theophylline and other methylxanthine derivatives, and antihistamines, a potentiation effect is possible.
Overdose
Symptoms: increased side effects.
Treatment: symptomatic.
Storage conditions
Store at a temperature not exceeding 30°C, but not in the refrigerator; Avoid exposure to direct sunlight.
Best before date
4 years.
Conditions for dispensing from pharmacies
Dispensed with a doctor's prescription.
special instructions
Cromoglicic acid can provoke an attack of bronchospasm, dysuria , cough, swelling of the parotid glands.
During the period of reducing the dosage of the drug, the patient should be under the supervision of the attending physician; the rate of reduction is calculated using the formula: 10% per 1 week.
A gradual reduction in the dosage of the drug helps prevent exacerbation of the disease.
In a long-term study on animals, no teratogenic or carcinogenic effects of the drug were observed.
Contraindications
The use of Intal is contraindicated in cases of hypersensitivity to the active component or to other substances included in the composition.
Capsules should not be taken by children under 2 years of age or in the first trimester of pregnancy. The aerosol is contraindicated in children under 5 years of age.
Capsules should be used with caution during pregnancy in the second and third trimesters, as well as during breastfeeding.
Intal should be used in the treatment of patients with impaired liver and kidney function only under the supervision of a physician.
Analogs
If necessary, doctors replace Intal with the following analogues: Cromoglin , Lecrolin , Ifiral , Nalkrom , Cromogen , Stadaglycin , Thaleum .
Intal price
Intal is sold in pharmacies with a doctor's prescription. The average price for a drug is from 650 rubles per package.
Reviews
I use this medicine constantly. It especially helps during seasonal allergies to poplar fluff. You need to be careful with the dosage and not violate the doctor's instructions. Reviews about the drug are only good. This is my salvation. Victor
Intal always helps out. I use it as prescribed by the attending physician, since Intal has contraindications and is not suitable for all patients. Galina
I have been suffering from bronchial asthma for a long time. Recently I found an effective remedy that became a salvation - Intal capsules. I do inhalations in courses, strictly as prescribed by the doctor. No side effects are observed. This tool allows you to live a full life. Anastasia
Use of the drug during pregnancy
Intal is not used to treat women in the first three months of pregnancy, since there is no clinical data on the effect of the drug on the fetus. Intal, the dosage of the drug is carried out only by the attending physician. Self-medication during pregnancy is unacceptable.
At later stages, the use of the drug is possible only after consultation with a specialist and in cases where it is really necessary for the health of the mother.
Use of the product during lactation is possible under the supervision of a physician. If a child exhibits an adverse reaction, use of the drug should be stopped immediately.
Indications for use
The use of the drug is recommended for the prevention and treatment of bronchial asthma in adults and children.
special instructions
When using the drug, a number of recommendations should be followed. The use of Intal is possible as part of complex therapy together with bronchodilators and glucocorticosteroid drugs, which are used immediately before using the aerosol. On the recommendation of the attending physician, their use can be gradually reduced and, over time, their use can be completely abandoned.
