Pirantel tablets and suspension: instructions for use, price, reviews from parasitologists for children

Compound

The drug tablets contain the active component pyrantel , as well as additional components: methyl parahydroxybenzoate, gelatin, acacia gum, starch, sodium carboxymethyl starch, talc, magnesium stearate, propyl parahydroxybenzoate, colloidal silicon dioxide.
Pyrantel suspension contains the active component pyrantel , as well as additional components: sucrose, xanthan gum, sorbic acid, polysorbate 80, methyl parahydroxybenzoate, sorbitol solution 70%, propyl parahydroxybenzoate, flavorings, purified water.

Pyrantel suspension orally 250mg/5ml 15ml

Latin name Pyrantel

Release form Suspension

Pharmacological action of Pirantel is anthelmintic. Blocks neuromuscular transmission in sensitive helminths.

Pharmacodynamics Acts on helminths in the early phase of development and on mature forms, does not affect larvae in the migration stage. Active against Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.

Pharmacokinetics: Practically not absorbed from the gastrointestinal tract. After oral administration in a single dose of 10 mg/kg body weight, Cmax is 0.005–0.13 μg/ml and is achieved within 1–3 hours. Partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted in feces (50% of the dose taken unchanged) and in urine (about 7% unchanged and in the form of a metabolite).

Indications Enterobiasis, ascariasis, hookworm disease, necatoriasis.

Contraindications Hypersensitivity.

Use during pregnancy and breastfeeding Use during pregnancy and breastfeeding is possible only under the strict supervision of a physician.

Special instructions In case of enterobiasis, simultaneous treatment of persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool test for worm eggs.

Composition 5 ml of suspension contain: Active substance: pyrantel 250 mg; Excipients: sorbic acid, sucrose, xanthan gum, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sorbitol 70% solution, polysorbate 80, chocolate flavor S 2761 (composition: propylene glycol, water, caramel coloring, natural, identical to natural and artificial flavoring substances), ice cream flavor "(composition: propylene glycol, water, caramel coloring, natural, identical to natural and artificial aromatic substances), purified water.

Method of administration and dosage For ascariasis and enterobiasis, for mixed infestations by these helminths - orally, once, after breakfast at the rate of 10 mg/kg. Adults and children over 12 years old - 750 mg, with body weight over 75 kg - 1 g. Children from 6 months to 2 years - 125 mg, 2 - 6 years - 250 mg, 6 - 12 years - 500 mg. To avoid self-infection, the course may be repeated 3 weeks after the first dose. For hookworm, a combination of necatoriasis with ascariasis, or for other combined helminthic lesions, 10 mg/kg/day is prescribed for 3 days or 20 mg/kg/day for 2 days. For isolated ascariasis – 5 mg/kg once.

Side effects From the nervous system and sensory organs: rarely - headache, dizziness, drowsiness, insomnia, weakness; in some cases - hearing loss, hallucinations, confusion, paresthesia. From the gastrointestinal tract: nausea, vomiting, diarrhea, stomach pain; rarely - increased activity of liver transaminases. Other: skin rash, fever.

Storage conditions The drug should be stored in a dry place, protected from light, at a temperature not exceeding 25°C.

Shelf life 3 years

Conditions for dispensing from pharmacies Dispensed with a doctor's prescription

The appearance of the product may differ from the product shown in the photo.

Side effects

During treatment, the following side effects may occur:

nervous system: drowsiness , headache , dizziness , insomnia ;
digestive system: vomiting, diarrhea , periodic abdominal cramps , anorexia , tenesmus ;
skin and subcutaneous tissue: urticaria , rash ;
hepatobiliary system: increased levels of liver enzymes;
other manifestations: feeling of weakness, increased fatigue.

Instructions for use of Pirantel (Method and dosage)

The product is used according to doctor's indications.

Pyrantel suspension, instructions for use

The suspension for children is used according to indications; it must be shaken before taking. Patients with ascariasis and enterobiasis are prescribed an average dose of 10–12 mg per 1 kg of weight in one dose. Children after 6 months should receive syrup at a dose of 2.5 ml per 10 kg of weight in one dose. Adult patients (up to 75 kg) receive 15 ml per dose. If a person’s weight exceeds 75 kg, you need to drink 20 ml of the product at one time.

To improve the effectiveness of the treatment of enterobiasis, you should very carefully adhere to all the rules of personal hygiene. It is recommended to conduct another course of therapy after three weeks.

For patients with hookworm in endemic areas or with severe infestation, the drug is prescribed based on a dosage of 20 mg per 1 kg of weight for 2 or 3 doses, treatment lasts 2-3 days.

The dosage per day is calculated as follows:

children after 6 months receive 5 ml of syrup per 10 kg of weight;
with a weight of up to 75 kg - 30 ml of syrup per day;
with a weight of 75 kg - 40 ml of syrup per day.

Under conditions of mild infestation of Ankylostoma duodenale, sometimes it is enough to take a single dose of 10 mg per 1 kg.

Pirantel tablets, instructions for use

Adults are usually prescribed Pirantel in tablets. It should be taken before or during the use of food. The tablet is chewed and washed down with plenty of liquid.

How to take Pirantel for children depends on their body weight and age:

at the age of 2-6 years, 250 mg of the drug is indicated;
at the age of 6-12 years - 500 mg;
children over 12 years of age and adult patients weighing up to 75 kg - 750 mg;
adults whose weight exceeds 75 kg - 1000 mg.

If only infection with a human nematode is noted, you should take Pyrantel 5 mg per 1 kg of weight in one tablet.

For patients with enterobiasis and ascariasis, as well as with mixed infestations, the dose intended for the entire course is administered once (10 mg per 1 kg).

Patients with hookworm disease are advised to take the same dose for three days.

In case of massive infestations of Necator americanus, a dose of 20 mg/kg is indicated for two days.

You should ask your doctor for more information about how many days to take the drug, how to take tablets and suspension for adults and children for treatment, as well as for prevention for adults and children.

Pyrantel 250mg/5ml 15ml oral suspension Poland

pharmachologic effect

Anthelmintic. Causes neuromuscular blockade of sensitive helminths. Active against Enterobius vermicularis, Ancylostoma duodenale, Necator americanus and, to a lesser extent, Trichocephalus trichiurus. It affects both sexually mature and immature individuals of both sexes.

Composition and release form Pirantel 250mg/5ml 15ml suspension for oral administration Poland

Suspension - 5 ml: pyrantel (in the form of embonate) 250 mg.

15 ml - dark glass bottles (1) complete with measuring cap - cardboard packs.

Directions for use and doses

For ascariasis and enterobiasis, use a single dose of 10 mg/kg. When necatoriasis is combined with ascariasis or other combined helminthic lesions, use for 3 consecutive days at a dose of 10 mg/kg/day or for 2 days at a dose of 20 mg/kg/day.

Pharmacokinetics

Practically not absorbed from the gastrointestinal tract. After taking a single dose of 10 mg/kg, the plasma concentration is 0.005-0.13 mcg/ml and is achieved within 1-3 hours. It is partially metabolized in the liver to N-methyl-1,3-propanediamine. It is excreted unchanged through the intestines (about 93%), 7% is excreted by the kidneys unchanged or as a metabolite.

Indications for use Pirantel 250mg/5ml 15ml oral suspension Poland

Ascariasis, hookworm disease, necatoriasis, trichocephalosis.

Contraindications

Pregnancy, hypersensitivity to pyrantel, myasthenia gravis (treatment period).

Use of Pyrantel 250 mg/5 ml 15 ml oral suspension Poland during pregnancy and lactation

Pyrantel is contraindicated for use during pregnancy.

If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.

Use in children

Prescribe with caution to children under 6 months of age.

special instructions

Use with caution in case of liver failure.

After taking pyrantel, laxatives are not prescribed.

In case of enterobiasis, simultaneous treatment of all persons living together should be carried out. After completion of treatment, it is necessary to conduct a control stool examination for the presence of parasite eggs.

Prescribe with caution to children under 6 months of age.

Side effects Pirantel 250mg/5ml 15ml oral suspension Poland

From the digestive system: nausea, vomiting, diarrhea, anorexia, increased activity of liver transaminases.

From the central nervous system and peripheral nervous system: headache, hallucinations, confusion, paresthesia, dizziness, drowsiness or insomnia.

Dermatological reactions: skin rash, urticaria.

Other: hearing impairment, hyperthermia.

Drug interactions

Should not be administered concomitantly with piperazine (decreased effect).

With simultaneous use, pyrantel increases the concentration of theophylline in plasma.

Overdose

In case of an overdose of the drug, the patient may experience the following negative manifestations: nausea, vomiting , diarrhea , anorexia . But it should be borne in mind that pyrantel is poorly absorbed in the body, which is why signs of intoxication appear very rarely even with a significant overdose. If there is such a need, gastric lavage is prescribed; there is no specific antidote. It is important to monitor the functions of blood vessels, heart, and respiratory system.

special instructions

The drug is prescribed with caution to people who have impaired liver function. During therapy, you should not abstain from eating or take laxative medications. This does not determine how quickly the drug works.

The drug is prescribed for simultaneous administration to all members of the family who live together. You should consider how to give the suspension or tablets to your child and follow the instructions. After completion of the study, the patient's stool is examined.

To prevent re-infection, it is important to carefully adhere to hygiene rules.

Sometimes during treatment, weakness, drowsiness , and dizziness . This should be taken into account when driving or when working with precision mechanisms.

The drug is not prescribed to people undergoing treatment for myasthenia gravis .

How long the drug takes to work depends on the diagnosis and the individual characteristics of the course of the disease.

How worms after using the drug depends on the disease.

Pyrantel is also used to treat animals. The dosage for cats and the dosage for dogs should only be determined individually by a veterinarian.

Pyrantel suspension for oral use 250mg/5ml 15ml No.1

Name

Pirantel.

Release form

Suspension for oral administration.

Dosage

250 mg / 5 ml 15 ml. Packing quantity: 1 pc.

Manufacturer

Medana Pharma S.A.

INN

Pirantel.

FTG

Anthelmintic.

Compound

active substance: pyrantel 0.750 g/15 ml (in the form of pyrantel embonate 2.1625 g/15 ml). excipients: sodium benzoate, sodium salt of carboxymethylcellulose, sorbitol 70% (E420), glycerol, magnesium aluminum silicate, polysorbate 80, povidone, apricot flavor, antifoam, citric acid, sodium hydroxide, purified water up to 15 ml.

Description

The suspension is light yellow in color with a characteristic odor.

Pharmacotherapeutic group

Anthelmintic drugs, tetrahydropyrimidine derivative. ATX code: Р02СС01

Pharmacological properties

Pyrantel is an anthelmintic agent that acts on nematodes. It acts on the muscles of intestinal nematodes by depolarizing their neuromuscular junction and blocking the action of cholinesterase. Non-moving parasites are removed from the intestines due to peristaltic movements. Does not irritate or cause worm migration. It acts on mature forms and parasites at an early stage of development, but does not affect larvae during their migration in tissues. The drug is used primarily for infections with pinworms (Enterobius vermicularis) and roundworms (Ascaris lumbricoides). Can be used for hookworm infection; more effective in treating duodenal hookworm (Ancylostoma duodenale) infection than American hookworm (Necator americanus). After oral administration, the drug is poorly absorbed from the digestive tract. After oral administration of the drug, it reaches very low concentrations in plasma, at the limit of detection. After taking a single dose of the drug 11 mg/kg body weight, the maximum plasma concentration achieved after 1-5 hours (Tmax) ranged from 0 μg/ml to 0.1 μg/ml. There is no data regarding the penetration of the drug through the placenta and into the milk of a nursing woman. The minimal amount of the drug resorbed from the digestive tract is partially metabolized in the liver to N-methyl-1,3-propanediamine. About 93% of an oral dose of the drug is excreted unchanged in the feces and no more than 7% is excreted in the urine either unchanged or in the form of metabolites.

Indications for use

Enterobiasis Ascariasis Ankylostomiasis Necatoriasis

Contraindications

Hypersensitivity to pyrantel or other components of the drug. Myasthenia gravis (treatment period). Concomitant use of piperazine. Special instructions Special care should be taken: in children under 2 years of age; in patients with impaired liver function (the drug may cause a short-term increase in the activity of aspartate aminotransferase - AST); in malnourished patients and in patients with anemia (anemia). After taking Pyrantel, laxatives are not prescribed. When treating enterobiasis, all persons living together should be treated at the same time. To prevent re-infection, it is necessary to strictly follow the rules of hygiene (wash hands, trim and clean nails, avoid scratching the perineal area, change bedding and underwear daily). 14 days after treatment with Pyrantel, control parasitological studies should be carried out. The suspension contains sorbitol. The drug should not be used in patients with rare hereditary fructose intolerance. Sorbitol may have a mild laxative effect.

Interaction with other drugs

May increase plasma theophylline concentrations. The simultaneous use of piperazine inhibits the effect of pyrantel.

Use during pregnancy and breastfeeding

Adequate and strictly controlled studies of the safety of the use of pyrantel during pregnancy and lactation (breastfeeding) have not been conducted. The use of the drug during these periods is possible only if absolutely necessary, if the expected benefit to the mother outweighs the potential risk to the fetus or child, and only under the strict supervision of a physician. Use of the drug in elderly people There is no information on the effect of age on the effect of Pyrantel in geriatric patients. Effect on the ability to drive vehicles and operate machinery Considering the possible side effects on the nervous system (dizziness, headache, etc.), when using the drug, care must be taken when engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions. .

Directions for use and doses

Directions for use: The drug should be taken orally, during or after meals, with water. Before use, shake until a homogeneous suspension is obtained. There is no need to take laxatives before using Pirantel. The package comes with a graduated measuring cup to make dosing easier. 5 ml of suspension (1 scoop) contains 250 mg of pyrantel. Recommended dose in adults and children weighing more than 10 kg - For ascariasis Adults and children weighing > 10 kg: single dose 11 mg/kg. Usually a single dose is prescribed, but if there is no effectiveness, the dose should be repeated after 2 or 3 weeks. – For enterobiasis Adults and children weighing > 10 kg: single dose 11 mg/kg. This dose of the drug should be repeated after 2 or 3 weeks. – For duodenal hookworm or necator infestation Adults and children weighing > 10 kg: 11 mg/kg once daily for 3 days. Below is the dosage of Pyrantel suspension depending on body weight: Body weight Single dose (ml) Single dose (mg) 11–16 kg 2.5 ml 125 mg 17–28 kg 5.0 ml 250 mg 29–39 kg 7.5 ml 375 mg 40–50 kg 10.0 ml 500 mg 51–62 kg 12.5 ml 625 mg 63–75 kg 15.0 ml 750 mg Adults weighing > 75 kg 20.0 ml 1000 mg Dosing in patients with Impaired liver function If you have existing liver diseases, you should inform your doctor. Dosing in patients with impaired renal function In case of existing kidney disease, the doctor should be informed.

Overdose

After an overdose of the drug, the following symptoms may develop: blurred vision, confusion, dizziness, fainting or a feeling of dizziness when rising from a lying or sitting position, increased sweating, a previously unknown feeling of tiredness or weakness, irregular pulse, convulsions, tremors and muscle weakness, exhaustion , breathing problems, loss of consciousness. In case of intoxication, you should immediately consult a doctor.

Side effects

Side effects of pyrantel are rare and disappear after cessation of treatment. The frequency of adverse reactions is defined as follows: very common (≥ 1/10); frequent (≥ 1/100 and

Storage conditions

Store at a temperature not exceeding 25 °C, in the original packaging. Keep out of the reach of children.

Best before date

3 years. After opening the bottle for the first time, the drug must be used within 21 days. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

Over the counter.

Package

15 ml in dark glass bottles with a polyethylene cap with a guarantee ring. 1 bottle along with an insert and a measuring cup in a cardboard box.

Buy Pyrantel susp.d/peror.prim. 250mg/5ml in bottle 15ml in pack. No. 1 in pharmacy

Price for Pirantel susp.d/peror.prim. 250mg/5ml in bottle 15ml in pack. No. 1

Instructions for use for Pirantel susp.d/or.prim. 250mg/5ml in bottle 15ml in pack. No. 1

Pyrantel's analogs

Level 4 ATC code matches:
Helmintox

Analogues of this remedy are the following drugs: Nemotsid , Helmintox , Pyrantel pamoate , which contain a similar active ingredient.

Medicines have a similar effect on the body: Vermox , Biltricid , Vormin , Dekaris , etc.

Which is better: Decaris or Pirantel?

Decaris is an anthelmintic agent that has a similar effect. The drug Dekaris has more contraindications, side effects are almost the same as when using Pirantel. It is believed that Pirantel is more preferable for treating children.

Which is better: Vermox or Pyrantel?

Vermox is a broad-spectrum drug. It is especially effective against enterobiasis and trichuriasis . Which of the two drugs is preferred should be determined taking into account individual characteristics.

Which is better: Nemozol or Pirantel?

Nemozol is a drug with a wide spectrum of effects; it eliminates most known types of parasites. But only a doctor should select the medicine.

Pyrantel (suspension)

Precautionary measures

Use of the drug in elderly people There is no information on the effect of age on the effect of pyrantel in geriatric patients.

Pregnancy and lactation Data on the use of pyrantel during pregnancy in humans are insufficient to exclude all possible risks. The drug can be used during pregnancy only if absolutely necessary, after a careful assessment by the doctor of the balance of benefit to the mother and risk to the fetus. Breastfeeding should be stopped during treatment.

Effect on the ability to drive vehicles and operate machinery In some cases, dizziness may occur while taking the drug, so care should be taken when performing work that requires rapid psychomotor reactions.

Pirantel price, where to buy

The price of Pirantel suspension 15 ml is, on average, 60 rubles. The cost may be slightly lower or higher. The price of Pyrantel tablets depends on the packaging and manufacturer. On average, buy a pack of 3 tablets. possible at a price of 30 to 40 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Pyrantel Susp.
for internal approx. 250mg/5ml 15mlPharmaceutical plant POLFARMA JSC Medan Department in Sieradz 62 rub.order

Pharmacy Dialogue

Pyrantel (tab. 250 mg No. 3) Ozone LLC
29 RUR order
Pyrantel bottle 250mg/5ml 15mlMedana Pharma
63 RUR order
Pyrantel bottle 250mg/5ml 15mlOxford Pvt.
36 RUR order
Pyrantel tablets 250 mg No. 3Polpharma
43 RUR order
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Pyrantel 250 mg No. 30 tablets Kusum Healthker PVT.LTD, India
101 UAH.order
Pyrantel 15 ml suspension Medana Pharma Aktsionerne Tovaristvo, Poland
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Pyrantel 250 mg/5 ml 15 ml suspension TOV "Kusum Pharm", Ukraine
25 UAH order
Pirantel-Vishfa 250 mg/5 ml 15 ml No. 1 suspension TOV DKP Pharm.Fabrika, Ukraine
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PaniPharmacy

PYRANTEL liquid Pyrantel suspension 0.25g 15ml Poland, Medana Pharma SA
41 UAH order
Pyrantel-Vishfa liquid Pyrantel-Vishfa suspension. oral 250mg/5ml fl 15ml Ukraine, Zhitomir FF LLC
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PYRANTEL liquid Pyrantel suspension 250mg/5ml 15ml Ukraine, Kusum Pharm LLC
29 UAH order
PYRANTEL tablets Pyrantel tablets. 250 mg No. 30 India, Kusum Healthcare
107 UAH order

Directions for use and doses

Inside, during or after meals.

Enterobiasis, ascariasis and mixed invasions: once 10 mg/kg.

Age	Drug dose, mg	Number of measures (1 measure=5 ml)
Children 6 months – 2 years	125	1/2 scoop = 2.5 ml
Children 2 years – 6 years	250	1 measure = 5 ml
Children 6 years – 12 years	500	2 measures = 10 ml
Children over 12 years of age and adults weighing less than 75 kg	750	3 measures = 15 ml
Adults weighing more than 75 kg	1000	4 scoops = 20 ml

Hookworm: 10 mg/kg/day for 3 days.

Necatoriasis: 20 mg/kg for 2 days (for severe forms).