Vitamins Duovit: instructions for use, price, reviews. How to take the drug

Composition of Duovit

Duovit red vitamins contain (1 tablet):

α-tocopherol acetate (vitamin E) – 10 mg;
retinol palmitate (vitamin A) – 2.94 mg;
cyanocobalamin (vitamin B12) – 3 mcg;
ascorbic acid (vitamin C) – 60 mg;
Thiamine mononitrate (vitamin B1) – 1 mg;
colecalciferol (vitamin D3) – 200 mcg;
calcium pantothenate (vitamin B5) – 5 mg;
folic acid – 400 mcg;
riboflavin (vitamin B2) – 1.2 mg;
pyridoxine hydrochloride (vitamin B6) – 2 mg;
nicotinamide (vitamin PP) – 13 mg.

One blue dragee contains:

calcium hydrogen phosphate dihydrate – 64.5 mg (this corresponds to 15 mg calcium and 12 mg phosphorus );
magnesium lactate dihydrate – 200 mg (this corresponds to 20 mg magnesium );
ferrous fumarate – 30.3 mg (this corresponds to 10 mg of iron );
copper sulfate pentahydrate – 4 mg (this corresponds to 1 mg copper );
zinc sulfate heptahydrate – 13.3 mg (this corresponds to 3 mg zinc );
manganese sulfate monohydrate – 3.1 mg (this corresponds to 1 mg manganese );
sodium molybdate dihydrate – 220 mcg (this corresponds to 100 mcg molybdenum ).

Excipients: lactose monohydrate, polysorbate 80, orange oil, glycerol, castor oil, liquid dextrose, povidone, 1510, sorbitol, magnesium stearate, liquid paraffin, dyes (Opalux, indigo carmine Blue and sunset yellow), emulsion wax, sucrose.

Duovit - a complex of vitamins for women and men

What vitamins are needed when planning pregnancy?

Review your diet for essential vitamins in advance - three months to a year before you plan to conceive. This will not only increase your chances of conceiving, but will also help the proper intrauterine development of the fetus.

The need for vitamins during pregnancy increases by approximately 1.5-2 times, which is due to the intensification of metabolic processes in the mother’s body, as well as the use of some vitamins to meet the metabolic needs of the growing fetus.

Unfortunately, in Russia, expectant mothers often experience moderate or severe vitamin deficiency, so according to the Research Institute of Nutrition of the Russian Academy of Medical Sciences, 100% of women were found to be deficient in vitamin B6, 96% - B1, 77% - folic acid and 64% - vitamin WITH.

Vitamin B9 (folic acid)

. Folic acid is necessary from the very first days of pregnancy, since already in the second week in the embryo it is possible to identify the part from which the brain, the highest creation of nature, begins to rapidly develop. Folic acid deficiency is one of the main reasons for the birth of premature babies and children with pathologies of the central nervous system. Therefore, already at the pregnancy planning stage, to prevent fetal malformations and other abnormalities, it is mandatory to take vitamin and mineral complexes containing folic acid. It must be borne in mind that when using oral contraceptives, the concentration of folic acid in the blood may decrease. Therefore, taking B9 when planning pregnancy is mandatory for its onset, physiological course, as well as proper development of the fetus.

Vitamin A (retinol).

Normally, an adult's need for vitamin A is met by regular food. The need for additional small doses of vitamin A arises during periods of increased need for it, including during multiple pregnancies, as well as when there is insufficient retinol content in food. The recommended intake level of vitamin A for pregnant women is 1-1.2 mg.

Vitamin E

Helps reduce the risk of pregnancy complications such as preeclampsia (excess fluid accumulation and high blood pressure in the last trimester).

Zinc.

Zinc content decreases during pregnancy by an average of 30 percent. Replenishing the deficiency of this microelement reduces the likelihood of miscarriage, premature birth, complicated labor, low birth weight and toxemia.

In a significant proportion of pregnant and lactating women, multivitamin deficiency is combined with iron deficiency, which is the reason for the widespread occurrence of latent and overt forms of iron deficiency anemia, i.e. anemia. Therefore, during pregnancy, additional iron intake is simply necessary.

In recent years, the problem of insufficient consumption of the most important element - iodine

. The harm caused by this deficiency to the health of mother and child cannot be overestimated. Every pregnant woman must take iodine supplements, because it is important not only for the health of the mother herself, but also for the proper formation of the fetus, since it is responsible for the memory, hearing, mental and physical abilities of the baby.

During pregnancy, you need to consume enough vitamin B6, both for normal growth and to relieve nausea associated with pregnancy hormones.

It is important to remember that an insufficient supply of vitamins and essential mineral salts disrupts the flow of metabolism, interferes with the normal development of the fetus and newborn, wears out the strength and undermines the health of the mother in labor. The most important condition for the birth of a strong baby, his successful growth and development is the full provision of the woman’s body with all the necessary micronutrients.

Be healthy, take care of yourself!

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

B vitamins are involved in the metabolism of proteins, carbohydrates and fats and are indispensable for the proper functioning of the nervous system. Retinol is essential for the development of epithelial cells and for the production of visual pigment. Vitamin D is responsible for calcium and bone mineralization. Ascorbic acid is responsible for the absorption of iron and is a necessary component of redox reactions in the body. Vitamin E is a powerful antioxidant and membrane protector.

Oligoelements and minerals are also extremely important. Calcium ions are involved in the regulation of cardiac muscle tone and in the processes of occurrence of nerve impulses. Phosphorus and calcium are essential elements of bones and teeth . Copper and iron are structural components of red blood cells. Magnesium, zinc, manganese and molybdenum are components of a number of important enzymes.

Pharmacokinetics

Water-soluble vitamins (group B , ascorbic acid and biotin ) are perfectly absorbed within the daily requirement. The remaining amount is excreted in urine and feces.

After intake, lipophilic vitamins A and D are absorbed in the presence of fats in the small intestine. Absorption of alpha-tocopherol ranges from 25% to 80% of the dose taken. These vitamins accumulate in significant quantities in the liver, making them potentially toxic.

Duovit No. 40 dragee

Instructions for medical use of the drug DUOVIT® Trade name Duovit® International nonproprietary name No Dosage form Dragee Composition One red dragee contains active substances: Retinol palmitate (vitamin A) concentrate (synthetic, oil form) 1.7 million IU/g (equivalent to vitamin A ) - 2.94 mg (5000 units) Cholecalciferol concentrate (oil form) 1 million IU/g (equivalent to vitamin D3) - 0.20 mg (200 units) Ascorbic acid (vitamin C) - 60.00 mg Thiamine nitrate (vitamin B1) - 1.00 mg Riboflavin (vitamin B2) - 1.20 mg Pyridoxine hydrochloride (vitamin B6) - 2.00 mg Cyanocobalamin 0.1% in mannitol (vitamin B12) - 3.00 mg Nicotinamide (vitamin PP) - 13.00 mg Folic acid (vitamin B9) - 0.40 mg Calcium pantothenate (vitamin B5 ) - 5.00 mg Alpha-tocopherol acetate (vitamin E) - 10.00 mg excipients: lactose monohydrate, orange oil 05073, polysorbate 80, glycerin, castor oil (cold pressed), sorbitol, liquid glucose (dry matter), antifoaming agent 1510, magnesium stearate, *Opalux AS-F-2833 G (E 124 + E 110), capol 600 pharma, sucrose. One blue dragee contains the active ingredients: Calcium hydrogen phosphate dihydrate (equivalent to calcium) (equivalent to phosphorus) - 64.50 mg (15.00 mg) (12.00 mg) Iron fumarate (equivalent to iron) - 30.30 mg (10.00 mg) Copper sulfate pentahydrate (equivalent to copper) - 4.00 mg (1.00 mg) Zinc sulfate heptahydrate (equivalent to zinc) - 13.30 mg (3.00 mg) Magnesium lactate dihydrate (equivalent to magnesium) - 200.00 mg (20.00 mg) Manganese sulfate monohydrate (equivalent to manganese) - 3.10 mg (1.00 mg) Sodium molybdate dihydrate (equivalent to molybdenum) - 0.22 mg (0.10 mg) excipients: lactose monohydrate, orange oil 05073, polysorbate 80, glycerin, castor oil (cold pressed), sorbitol, liquid glucose (dry matter), antifoaming agent 1510, magnesium stearate , liquid paraffin, povidone, **Opalux AS-20912 blue (E 132), capol 600 pharmaceutical, sucrose. *Composition of the shell of Opalux AS-F-2833 G (E 124 + E 110): sucrose, purified water, ponceau 4R lake, titanium dioxide, Fd&C yellow #6/sunset yellow FCF aluminum lake, povidone, sodium benzoate **Composition of the shell of Opalux AS-20912 blue (E 132): sucrose, titanium dioxide, purified water, Fd&C blue #2/indigo carmine aluminum lake, povidone, sodium benzoate. Description Hard smooth dragees, covered with a red shell, with a sweet and sour taste (vitamins) and hard smooth dragees, coated with a blue shell (minerals). Pharmacotherapeutic group Multivitamins in combination with other drugs. Multivitamins with other minerals. ATC code A11AA03 Pharmacological properties Pharmacokinetics There are no data available for Duovit®, tablets. However, the absorption, distribution and elimination of individual vitamins and minerals are well known and described in the literature. Water-soluble vitamins (B vitamins, vitamin C and biotin) are very well absorbed within the daily requirement. The amount of excess tissue saturation is excreted in urine, and in some cases in feces. Vitamins are in limited quantities in the body, so they must be consumed regularly to maintain their concentration in tissues. Fat-soluble vitamins A and D, after oral administration, are well absorbed in the small intestine in the presence of fat. Vitamin E absorption is relatively low (from 25 to 85% of the dose). These vitamins are found in large quantities in the liver in the body, so they are more toxic than water-soluble vitamins. The effect of the drug Duovit® is the combined effect of its components, so kinetic observations are not possible; Collectively, the components cannot be traced using markers or bioassays. Pharmacodynamics Duovit® contains vitamins and minerals. Vitamins and minerals are closely related in their activity and additive effectiveness. Often, vitamins and minerals cannot be in the same composition; therefore, they are separated in Duovit®: the red dragee contains vitamins and the blue dragee contains minerals. Duovit® tablets replenish the body's need for vitamins and minerals and prevent their deficiency. Vitamins are biologically active substances that take part in many biochemical processes in the body. B vitamins (B1, B2, B6, pantothenic acid and nicotinamide) take part in the metabolism of carbohydrates, fats and proteins, as well as in the activity of the nervous system. Vitamin A is necessary for the development of epithelial cells and the synthesis of visual pigment. Vitamin D regulates the utilization of calcium and promotes the mineralization of bones and teeth. Vitamin C increases iron absorption and is involved in many redox processes in the body. Vitamin E is a physiological antioxidant that protects membrane walls from damage and maintains their functional activity. Minerals and oligoelements are extremely important for the body. They are included as components of supporting tissues or as activators and components of enzymes and hormones. Calcium and phosphorus play a key role in the mineralization of bones and teeth. Calcium ions activate numerous enzymes, take part in regulating the tone of the heart muscle, transmitting nerve impulses, and regulating the permeability of cell membranes. B vitamins, iron and copper are the most important elements for the formation of red blood cells. Magnesium, manganese, zinc and molybdenum, as constituent components of enzymes, participate in reactions important for the body. Indications for use Duovit® is used as a prophylactic agent for conditions accompanied by an increased need for vitamins and minerals: - increased physical and neuropsychic stress - active sports - pregnancy and lactation - irregular, poor nutrition or monotonous diet - insufficient food conversion (in older people, smokers and alcohol abusers) - improper diet (mainly fast foods, dry food, when eating in public canteens) - limited diet (weight loss, diabetes, etc.) - during periods of shortage of fresh vegetables and fruits - period of recovery after illnesses - chemotherapy (as part of complex therapy) - with increased loss of minerals (vomiting, diarrhea, intense menstruation, increased sweating) Method of administration and dosage Duovit® Dragee is recommended to be taken after breakfast. Adults and children over 18 years of age are recommended to take 1 red tablet and 1 blue tablet once a day. The pills should be swallowed whole with a small amount of water. The course of treatment is up to 1 month. Subsequent treatment is possible after a break (from 1 to 3 months) or on the recommendation of a doctor. Side effects Very rare (<1/10,000): -hypersensitivity -Rarely (≥1/10,000 to <1/1,000): - disorders of the gastrointestinal tract, if the pills were taken on an empty stomach Contraindications - hypersensitivity to any of the components of the drug - hypervitaminosis A and D - renal failure - childhood and adolescence up to 18 years. Drug interactions The drug is not recommended to be taken simultaneously with tetracycline antibiotics and antacids. Absorption of minerals and tetracyclines is reduced due to their simultaneous administration. Some antacids reduce the absorption of minerals. If treatment involves the simultaneous use of such drugs, it is necessary to maintain an interval between taking Duovit® and tetracycline antibiotics/antacids for at least 3 months. Special instructions Duovit® must be taken after meals to avoid discomfort in the stomach. Patients suffering from diabetes can take Duovit®, but it must be remembered that the daily dose contains 1.6 g of sugar. Each dragee contains about 0.8 g of sugar. You should consult your doctor or pharmacist regarding simultaneous use with other vitamins, vitamin-mineral and/or mineral complexes. Special instructions and precautions regarding excipients Duovit® contains lactose, sorbitol, glucose and sucrose. The drug is not recommended for patients with hereditary diseases of glucose or galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption or sucrose-isomaltase deficiency. Dyes E124 and E110 can cause an allergic reaction. Features of the influence on the ability to drive a vehicle or potentially dangerous mechanisms. The drug does not affect the ability to drive vehicles and other mechanisms. Overdose Symptoms: weakness, anorexia, nausea, vomiting, diarrhea, weight loss, fever and convulsions (symptoms of hypervitaminosis A, which are likely with long-term use of very large doses), headache, dizziness, sleep disturbance, nausea, vomiting, drowsiness, photophobia and convulsions (symptoms of hypervitaminosis D, which are likely with long-term use of very large doses) Treatment: activated charcoal, gastric lavage; If necessary, carry out symptomatic therapy. Release form and packaging 10 tablets each (5 tablets with red vitamins and 5 tablets with blue minerals) are placed in a blister pack made of polyvinyl chloride/polyvinyl dichloride film and aluminum foil. 4 blister packs together with instructions for medical use in the state and Russian languages are placed in a cardboard pack. Storage conditions Store in original packaging at a temperature not exceeding 25 ºС, in a dry place, protected from light. Shelf life 3 years Do not use after expiration date. Conditions for dispensing from pharmacies Without a prescription Manufacturer KRKA, d.d., Novo Mesto, Slovenia Name and country of the owner of the registration certificate KRKA, d.d., Novo Mesto, Slovenia Address of the organization that accepts claims from consumers on the quality of products (products) in the territory of the Republic of Kazakhstan ) Representative office of “KRKA, tovarna zdravil, dd, Novo mesto” in the Republic of Kazakhstan, 050059, Almaty, Al-Farabi Ave., 19, building 1B, 2nd floor tel. fax www.krka.si

Indications for use

Duovit vitamins are recommended for:

active recreation and sports;
mental and physical overload;
poor nutrition (elderly people, smokers, alcoholics);
unbalanced diet (dry food, fast food);
diets for weight loss;
pregnancy and breastfeeding;
seasonal lack of vegetables and fruits in the diet;
severe loss of minerals (excessive menstruation, vomiting, diarrhea , increased sweating).

Indications

Duovit, film-coated tablets are recommended for:

physical and mental overload (during training, at work or at home);
practicing active sports and active recreation;
insufficient food intake (elderly people, smokers and patients with alcoholism);
irregular and monotonous diet (mainly fast food, dry food);
following a diet for weight loss (for weight loss, diabetes, etc.);
during pregnancy and lactation;
during the period of seasonal deficiency of fruits and vegetables in the diet;
with significant loss of minerals (due to vomiting, diarrhea, heavy menstrual blood loss, increased sweating).

Contraindications

Allergy to the components of the drug, hypervitaminosis A, E or D , renal failure.
Nephrolithiasis, hyperuricemia, gout , erythrocytosis , erythremia, fructose intolerance, thromboembolism , thrombophlebitis , glucose-galactose malabsorption syndrome, copper or iron metabolism disorder , chronic gromerulonephritis , history of sarcoidosis, hypercalciuria , hypercalcemia, thyrotoxicosis, gastric or duodenal ulcer , active tuberculosis
Age less than 10 years.

Side effects

From the immune system: allergic reactions , including anaphylactic shock , Quincke's edema , bronchospasm .
From the side of metabolism: hypercalcemia .
From the nervous system: headache, drowsiness.
From the point of view: visual disturbances.
From the digestive system: nausea, dyspepsia , vomiting, diarrhea , abdominal pain, constipation , increased acidity.
From the skin: urticaria , rash, hyperemia .
From the excretory system: hypercalciuria.
General disorders: hyperthermia , sweating.

With long-term use in large doses, the following occur: hyperuricemia, hyperglycemia, paresthesia, arrhythmias, irritation of the digestive tract mucosa, dry palms and soles, alopecia , seborrheic rash , kidney damage, temporary increase in the concentration of LDH, AST, alkaline phosphatase .

Side effects

Side effects that may occur when using the drug Duovit are classified into the following groups according to the frequency of occurrence: very often (1/10); often (1/100, 1/10); uncommon (1/1000, 1/100); rare (1/10,000, 1/1000); very rare (10,000); frequency unknown (cannot be determined from available data).

Within each group, side effects are presented in order of decreasing severity.

If you take Duovit tablets as directed, they do not cause side effects.

From the immune system: in persons with hypersensitivity, allergic reactions are possible, including anaphylactic shock, angioedema, bronchospasm.

Metabolism and digestion: hypercalcemia.

From the nervous system: headache, dizziness, drowsiness.

From the organ of vision: visual impairment.

From the gastrointestinal tract: dyspeptic disorders, nausea, vomiting, stomach pain, belching, constipation, diarrhea, increased secretion of gastric juice.

From the skin and subcutaneous tissue: skin rashes, urticaria, itching, redness of the skin.

From the kidneys and bladder: urine discoloration, hypercalciuria.

General disorders: hyperthermia, increased excitability, increased sweating.

With prolonged use in high doses, the following side effects occur:

from the side of metabolism and digestion: hyperuricemia, decreased glucose tolerance, hyperglycemia.

From the nervous system: paresthesia.

From the cardiovascular system: arrhythmias.

From the gastrointestinal tract: irritation of the gastrointestinal mucosa.

From the skin and subcutaneous tissue: dryness and cracks on the palms and soles, hair loss, seborrheic rashes.

From the kidneys and bladder: impaired renal function.

Laboratory indicators: transient increase in the activity of AST, LDH, alkaline phosphatase.

Interaction

Duovit should not be used simultaneously with tetracyclines and antacids , as the absorption of tetracycline and minerals may be reduced. If therapy requires the combined use of these drugs, then the time interval between doses should be at least three hours.

Due to the possible occurrence of hypervitaminosis A, simultaneous use of Duovit with products containing retinol is not recommended.

of vitamin E should be avoided in persons using oral anticoagulants , as the likelihood of bleeding increases.

During treatment with sulfonamides, to prevent the development of crystalluria, it is recommended to avoid excessive amounts of ascorbic acid .

Riboflavin slows down adsorption and reduces the effectiveness of antibacterial drugs. It must be taken more than 3 hours before or after taking the antibiotic.

Overdose

At the recommended dosage, no intoxication is expected. long-term use in high doses can cause hypervitaminosis a and d, although the likelihood of overdose is minimal. An overdose of vitamin D causes weakness, anorexia, nausea, vomiting, diarrhea, weight loss, fever, and convulsions. An overdose of vitamin A can lead to headaches, dizziness, sleep disturbances, nausea, vomiting, drowsiness, photophobia and convulsions. If the above symptoms occur, you should stop taking the drug and consult a doctor immediately. When using vitamin E in high doses, headache, fatigue, nausea, diplopia, muscle weakness, mild creatinuria and gastrointestinal disturbances may occur.

special instructions

Yellowing of urine is possible - this is harmless and is caused by the presence of riboflavin .

People with diabetes need to know that one tablet contains about 800 mg of sugar .

The blue and red dragees contain 1084 mg of sucrose , 330 mg of lactose , 238 mg of sorbitol , 270 mg of glucose , therefore Duovit is not recommended for persons with or glucose intolerance , with glucose or galactose malabsorption and isomaltase or sucrase .

Azo dyes E110 and E124 can cause allergic reactions with asthmatic phenomena .

The development of allergies is also possible in persons with hypersensitivity to acetylsalicylic acid .

Duovit should not be taken together with other products containing minerals and vitamins.

Analogs

Level 4 ATX code matches:
Vitacap

Glutamevit

Bio-Max

Menopace

Lavita

Wellman

Teravit

Gerovital

Kaltsinova

Pregnakea

Oligovit

Multi-Tabs Intensive

Multi-Tabs Junior

Multi-Tabs Perinatal

Multi-Tabs Teen

Multi-Tabs Classic

Multi-Tabs Baby

Special Dragee Merz

Pregnavite

Complivit Trimester

Analogs of Duovit are: Actival Kid , Vitrum , Multimax , Oligovit , Triovit , Teravit .

Duovit price, where to buy

In Russia, the price of Duovit in standard packaging is 92-120 rubles. In Ukraine, the price of Duovit vitamins in the same dosage is on average 67 hryvnia.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Duovit for women tablets p.o.
1.88 g 30 pcs. JSC KRKA, d.d., Novo mesto 668 rub. order
Duovit for men tablets p.o. 1.06 g 30 pcs. JSC KRKA, d.d., Novo Mesto
RUB 692 order
Duovit film-coated tablets No. 40 JSC "KRKA, d.d., Novo mesto"
RUR 389 order

Pharmacy Dialogue

Duovit (other No. 40)KPKA
RUB 362 order
Duovit (other No. 40)KPKA
RUB 377 order
Duovit for men (table no. 30)KPKA
RUR 687 order
Duovit for women (table no. 30)KPKA
RUR 523 order

Pharmacy24

Duovit for men N30 tablets KRKA, Slovenia
198 UAH.order
Duovit N40 tablets KPKA, d.d., Novo Mesto, Slovenia
110 UAH order
Duovit for women N30 tablets KPKA, d.d., Novo Mesto, Slovenia
198 UAH order
Duovit No. 60 tablets KPKA, d.d., Novo mesto, Slovenia
168 UAH order

PaniPharmacy

Duovit Vitamins for men without sugar tab. No. 30 Slovenia, KRKA dd Novo Mesto
213 UAH order
Duovit Vitamins for women without sugar tab. No. 30 Slovenia, KRKA dd Novo Mesto
198 UAH order
Duovit tab. p/o combi-pack. №60 Slovenia, KRKA dd Novo Mesto
172 UAH order
Duovit tab. p/o combi-pack. №40 Slovenia, KRKA dd Novo Mesto
136 UAH order

Note!

Description of the drug Duovit table. p/o combi-pack No. 60 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.