Pharmacy No. 84. Delivery of medicines to your home and office.

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Instructions for use OMEPRAZOLE

Omeprazole 20 mg + clarithromycin 250 mg or 500 mg + metronidazole 400 mg (or 500 mg or tinidazole 500 mg), each taken 2 times a day for one week, or

Omeprazole 40 mg + amoxicillin 500 mg + metronidazole 400 mg (or 500 mg or tinidazole 500 mg), each taken 3 times a day for one week.

After eradication of Helicobacter pylori, further treatment of gastric ulcer in the acute phase should be carried out according to the standard treatment regimen. In cases where, after therapy, the test for Helicobacter pylori remains positive, the course of treatment can be repeated.

Treatment of NSAID-related gastric and duodenal ulcers

The recommended dose is 20 mg/day. For most patients, healing occurs within four weeks. In cases where, after the first course of treatment, the ulcer has not healed completely, a repeat 4-week course is usually prescribed.

To prevent NSAID-related gastric and duodenal ulcers in patients at risk

(age over 60 years, history of stomach and duodenum, history of gastrointestinal bleeding) the recommended dose is 20 mg/day.

Treatment of reflux esophagitis

The recommended dose is 20 mg/day. In most patients, healing occurs within 4 weeks. In cases where, after the first course of treatment, the ulcer has not healed completely, a repeat 4-week course is usually prescribed. In patients with severe reflux esophagitis, a dose of 40 mg/day is recommended, the course of treatment averages 8 weeks.

For long-term treatment of patients with healed reflux esophagitis (in remission), 10 mg/day is prescribed in the form of long courses of maintenance therapy. If necessary, the dose can be increased to 20-40 mg.

For the symptomatic treatment of gastroesophageal reflux disease, the dosage regimen is set individually. Prescribe 10-20 mg/day. The course of treatment is 4 weeks. If symptoms do not disappear after completion of therapy, it is recommended to change the treatment regimen.

Treatment of Zollinger-Ellison syndrome

For Zollinger-Ellison syndrome, the dosage regimen is selected individually and treatment continues according to clinical indications for as long as necessary. The recommended starting dose is 60 mg/day. All patients with severe disease, as well as in cases where other therapeutic methods have not led to the desired result, should be effectively monitored and more than 90% of patients are maintained on a dose of 20-120 mg/day. In cases where the daily dose of omeprazole exceeds 80 mg, the dose should be divided into two doses per day.

Dosage in children

Clinical experience with omeprazole in children is limited . Treatment should be carried out under the supervision of a specialist.

In case of severe reflux esophagitis

resistant to other types of therapy, children over 2 years of age weighing more than 20 kg are prescribed 20 mg/day (equivalent to approximately 1 mg/kg/day). The duration of treatment is 4-8 weeks. Children aged 1 to 2 years are prescribed a dose of 10 mg/day. In this case, the contents of the capsule are poured into 50 ml of drinking water, after mixing, half of this volume of liquid is measured and given to the child to drink. The dose can be increased to 40 mg 1 time/day if necessary.

For the treatment of duodenal ulcer caused by Helicobacter pylori

, children and adolescents, the choice of treatment regimen should be in accordance with national, regional and local guidelines regarding bacterial resistance, duration of treatment (usually 7 days, but sometimes up to 14 days) and appropriate use of antibacterial agents.

Children weighing 15-30 kg:

omeprazole 10 mg + amoxicillin 25 mg/kg + clarithromycin 7.5 mg/kg body weight, each drug 2 times a day for one week.

Omeprazole Renewal

Inside.

Capsules are usually taken in the morning, preferably separately from meals, swallowed whole with half a glass of water. Capsules should not be chewed or crushed. If swallowing is difficult, the contents of the capsule, after opening it, can be mixed with a slightly acidified liquid (juice, yogurt) and used within 30 minutes

Duodenal ulcer

In case of exacerbation of duodenal ulcer, it is recommended to take the drug 20 mg once a day. Typically, the duration of therapy is 2 weeks; if necessary, it is possible to increase the course of therapy for another 2 weeks. Patients with duodenal ulcer resistant to treatment are usually prescribed the drug 40 mg once a day for 4 weeks. To prevent relapses for patients with duodenal ulcer - 20 mg 1 time per day; in some cases, 10 mg once a day may be sufficient (you must take capsules containing 10 mg of omeprazole). If necessary, the dose can be increased to 40 mg 1 time per day.

Stomach ulcer

For exacerbation of gastric ulcer, the recommended dose of the drug is 20 mg once a day. Duration of therapy is 4 weeks. In cases where complete healing does not occur after the first course of using the drug, a repeat 4-week course of treatment is prescribed. Patients with gastric ulcers resistant to treatment are usually prescribed the drug 40 mg once a day, healing is usually achieved within 8 weeks. To prevent relapses, patients with gastric ulcers are recommended to take the drug at a dose of 20 mg once a day. If necessary, the dose can be increased to 40 mg 1 time per day.

Helicobacter pylori eradication regimens for peptic ulcer disease:

omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg simultaneously 2 times a day for 1 week;
omeprazole 20 mg, clarithromycin 250 mg (alternatively 500 mg), metronidazole 400 mg (or 500 mg, or tinidazole 500 mg) simultaneously 2 times a day for 1 week;
omeprazole 40 mg once a day, as well as amoxicillin 500 mg with metronidazole 400 mg (or 500 mg, or tinidazole 500 mg) both 3 times a day for 1 week.

In cases where after treatment the patient is Helicobacter pylori positive, a second course of treatment is possible.

Treatment of ulcerative-erosive lesions of the stomach and duodenum associated with taking NSAIDs

The recommended dose of omeprazole is 20 mg once a day. The course of treatment is 4 weeks. For patients whose ulcers have not healed, the course can be extended for another 4 weeks.

Prevention of ulcerative-erosive lesions of the stomach and duodenum associated with taking NSAIDs

As a prophylaxis for NSAID-associated ulcerative-erosive lesions of the stomach and duodenum in patients at risk (age over 60 years, history of ulcerative-erosive lesions of the stomach and duodenum, history of bleeding from the upper gastrointestinal tract), the recommended dose is 20 mg of omeprazole 1 time per day.

Treatment of reflux esophagitis

The recommended dose is 20 mg of omeprazole once a day. The course of treatment is 4 weeks. For patients who have not recovered within this period, the course can be extended by 4 weeks. For severe esophagitis, the recommended dose is 40 mg omeprazole once a day, and the course of treatment is 8 weeks.

For maintenance therapy in patients with reflux esophagitis, the recommended dose of omeprazole is 10 mg once a day (capsules containing 10 mg of omeprazole must be taken). If necessary, the dose can be increased to 20-40 mg 1 time per day.

Symptomatic treatment of GERD

The recommended dose is 20 mg 1 time per day. Individual dose adjustment is possible. If symptoms persist after 4 weeks of treatment with omeprazole 20 mg daily, further evaluation is required.

Dyspepsia associated with hyperacidity

The usual dose is 10 mg per day. The maximum daily dose of the drug should not exceed 20 mg. The maximum course of treatment is 14 days. If symptoms do not improve within 2 weeks or if they worsen, you should consult a doctor.

Treatment of Zollinger-Ellison syndrome

The dose is set individually. The recommended starting dose is 60 mg once a day. If necessary, the dose is increased to 80-120 mg per day. At a dose of more than 80 mg, it should be divided into 2 doses.

• Use in children over 2 years of age and body weight ≥ 20 kg in the treatment of reflux esophagitis and the symptomatic treatment of heartburn and acid regurgitation in GERD

– In children over 2 years of age weighing more than 20 kg, the recommended dose is 20 mg once a day. The dose can be increased to 40 mg 1 time per day if necessary.

The course of treatment for reflux esophagitis is 4-8 weeks, for symptomatic treatment of heartburn and sour belching with GERD - 2-4 weeks. If symptoms persist after 2-4 weeks, the patient requires additional examination.

• Treatment of duodenal ulcer caused by Helicobacter pylori in children over 4 years of age

When choosing the appropriate combination therapy, official local and national recommendations in terms of bacterial resistance, duration of treatment (most often 7 days, but sometimes up to 14 days may be required) and appropriate antibacterial agents should be taken into account.

Treatment is carried out under the supervision of a specialist.

– In children weighing 15-30 kg: use in combination with two antibiotics: omeprazole – 10 mg, clarithromycin and amoxicillin in this category of patients are prescribed in a dosage regimen according to the instructions for the use of clarithromycin and amoxicillin (used simultaneously 2 times a day for 1 week).

– In children weighing 31-40 kg: use in combination with two antibiotics: omeprazole – 20 mg, clarithromycin and amoxicillin in this category of patients are prescribed in a dosage regimen according to the instructions for the use of clarithromycin and amoxicillin (used simultaneously 2 times a day for 1 week).

– In children weighing more than 40 kg: use in combination with two antibiotics: omeprazole – 20 mg, clarithromycin and amoxicillin in this category of patients are prescribed in a dosage regimen according to the instructions for the use of clarithromycin and amoxicillin (used simultaneously 2 times a day for 1 weeks).

• Dosage regimen for special groups of patients

For liver failure, 10-20 mg (maximum daily dose 20 mg) is prescribed once a day;
in case of impaired renal function and in elderly patients, no dosage adjustment is required. For more details, see the instructions Omeprazole Renewal LP-006254 dated June 11, 2020