Antigrippin-Express
Ethanol enhances the sedative effect and promotes the development of acute pancreatitis.
Antidepressants, antiparkinsonian drugs, antipsychotic drugs (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).
Glucocorticosteroids increase the risk of developing glaucoma; with long-term use, they deplete ascorbic acid reserves.
Inducers of microsomal liver enzymes (barbiturates, phenytoin, phenylbutazone, rifampicin, zidovudine, carbamazepine, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, increasing the risk of developing severe intoxications with small overdoses.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxicity.
With long-term combined use with other non-steroidal anti-inflammatory drugs, the risk of developing “analgesic” nephropathy and renal papillary necrosis, and the onset of end-stage renal failure increases.
Diflunisal increases plasma concentrations of paracetamol by 50%, increasing hepatotoxicity.
Long-term use in high doses concomitantly with salicylates increases the risk of developing kidney or bladder cancer.
When used simultaneously with acetylsalicylic acid (ASA), the absorption of ascorbic acid decreases (by about 30%) and its excretion in urine increases, and the excretion of ASA decreases.
Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Drugs of the quinoline series, calcium chloride, when used for a long time, deplete reserves of ascorbic acid; oral contraceptives, fresh juices and alkaline drinks reduce its absorption and assimilation.
Paracetamol, which is part of the drug, reduces the effectiveness of uricosuric drugs; when taken in high doses, it increases the effect of anticoagulant drugs.
Ascorbic acid increases the concentration of benzylpenicillin and tetracyclines in the blood, and at a dose of 5 sachets per day increases the bioavailability of ethinyl estradiol; improves the absorption of iron preparations in the intestine, can increase the excretion of iron when used simultaneously with deferoxamine; reduces the effectiveness of heparin and indirect anticoagulants; increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys and increases the excretion of drugs that have an alkaline reaction (including alkaloids); reduces the blood concentration of oral contraceptives; increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body; reduces the therapeutic effect of antipsychotic drugs - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants; when used simultaneously, it reduces the chronotropic effect of isoprenaline; with long-term use or use in high doses, it may interfere with the interaction of disulfiram and ethanol; in high doses increases the excretion of mexiletine by the kidneys.
