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Noofen 100 1 g No. 15 portion size for oral administration

Instructions for medical use of the drug NOOFEN 100 Trade name Noofen 100 International nonproprietary name No Dosage form Powder for the preparation of solution for oral administration, 100 mg Composition One sachet contains the active substance - phenibut (g-amino-b-phenylbutyric acid hydrochloride) 100 mg. excipients: mannitol, aspartame, Orange Durarome flavoring. Description Powder from white to light cream color. Inclusions of yellow color are allowed. Pharmacotherapeutic group Psychoanaleptics. Psychostimulants and nootropics. Other psychostimulants and nootropics. ATX code N06BX Pharmacological properties Pharmacokinetics The drug is well absorbed after oral administration and penetrates all tissues of the body, passes well through the blood-brain barrier. Distribution in the liver and kidneys is close to uniform, while in the brain and blood it is less uniform. After 3 hours, a noticeable amount of the administered drug is found in the urine, while the concentration of the drug in the brain tissue does not decrease; it is detected in the brain after another 6 hours. The next day, the drug can only be detected in the urine; it is found in the urine 2 days after administration, but the amount detected is only 5% of the administered dose. The greatest binding of the drug occurs in the liver (80%), it is not specific. With repeated administration, cumulation is not observed. Pharmacodynamics The active substance Noofen 100 is a derivative of g-aminobutyric acid (GABA) and phenylethylamine. Its antihypoxic and antiamnestic effects are dominant. Noofen 100 has nootropic activity, and as a derivative of GABA it has a tranquilizing effect, stimulates learning processes and improves memory, increases physical performance, relieves stress, anxiety, fear and improves sleep, prolongs and enhances the effect of hypnotics, narcotics, antipsychotics and anticonvulsants. Does not affect cholinergic and adrenergic receptors. Noofen 100 lengthens the latent period and shortens the duration and severity of nystagmus. Noofen 100 significantly reduces the manifestations of asthenia and vasovegetative symptoms, including headache, a feeling of heaviness in the head, sleep disturbance, irritability, emotional lability and increases mental performance. Mental indicators (attention, memory, speed and accuracy of sensory-motor reactions) improve under the influence of Noofen, in contrast to the influence of tranquilizers. In patients with asthenia and in emotionally labile patients, from the first days of therapy, their well-being improves, interest and initiative increase, and motivation for active activity without sedation or agitation. It has been established that Noofen 100, used after a traumatic brain injury, increases the number of mitochondria and improves the bioenergetics of the brain. Noofen 100 normalizes lipid peroxidation processes. Indications for use In children - asthenic and anxious-neurotic conditions: restlessness, fear, anxiety; obsessive-compulsive neurosis, psychopathy - treatment of stuttering, enuresis, tics - prevention of stressful conditions, before operations or painful diagnostic tests - dizziness associated with dysfunction of the vestibular apparatus of various origins, for the prevention of motion sickness Method of administration and dosage The contents of the sachet are dissolved in half a glass of warm water and taken orally before meals. The course of treatment is 2-6 weeks. Children from 3 to 4 years old are prescribed 100 mg (1 sachet) 2 times a day, from 5 to 6 years old - 100 mg 2-3 times a day, from 7 to 10 years old. 10 years old - 100 mg 3-4 times a day, from 11 to 14 years old - 200 mg (2 sachets) 2-3 times a day. Children over 14 years of age are prescribed adult doses of Noofen 250 mg tablets, Noofen 250 mg capsules or Noofen 500 mg powder for oral solution. Highest single doses for children: up to 6 years – 100 mg, from 7 to 10 years – 200 mg, from 11 to 14 years – 300 mg. If you miss a dose, take the drug as soon as you remember, but skip it if it is almost time for your next dose. Never take double doses. Side effects Noofen 100 is usually well tolerated. - drowsiness, nausea, increased irritability, agitation, anxiety, headache, dizziness (after the first doses) - allergic reactions (skin rash, itching) sometimes - hepatotoxicity (with long-term use of high doses) If you experience any side effects, which are not listed in this instruction, or any of the side effects mentioned are particularly severe, please consult a doctor. Contraindications - hypersensitivity to the active substance or excipients of the drug - phenylketonuria (Noofen 100 powder contains the sweetener aspartame) Drug interactions Prolongs and enhances the effects of sleeping pills, narcotic analgesics, antiepileptic and antiparkinsonian drugs, tranquilizers and antipsychotics. Special instructions Caution should be exercised in patients with erosive and ulcerative diseases of the gastrointestinal tract due to the irritating effect of the drug. These patients are prescribed smaller doses of the drug. With long-term use, it is necessary to monitor liver function indicators and peripheral blood patterns. Pediatrics The use of the drug in children under 3 years of age has not been studied. Overdose of Noofen 100 is a low-toxic drug; only in a daily dose of 7-14 g with long-term use it can be hepatotoxic. These doses significantly exceed the recommended dose (the average therapeutic dose is 500 – 2500 mg). Eosinophilia and fatty liver were observed only at the highest dose used. There were no such changes when using the drug in lower doses. Symptoms: drowsiness, nausea, vomiting, eosinophilia, decreased blood pressure. Treatment: gastric lavage. Therapy is symptomatic. In case of complications (arterial hypotension, renal failure), auxiliary and symptomatic measures are used. If you suspect an overdose, you should call a doctor. Release form and packaging 1 g mg powder in a laminated bag. 15 sachets each along with instructions for medical use in the state and Russian languages in a cardboard pack. Storage conditions Store in a dry place at a temperature not exceeding 25 °C. Keep out of the reach of children. Shelf life: 2 years The drug cannot be used after the expiration date. Conditions for dispensing from pharmacies According to prescription Manufacturer: OLAINPHARM JSC. Address: st. Rupnitsa 5, Olaine, LV - 2114, Latvia. Owner of the registration certificate LLC "OLFA" Address: st. Dankevicha 4, Kyiv, 02232, Ukraine. Address of the organization receiving claims from consumers regarding product quality in the territory of the Republic of Kazakhstan: 050009 Almaty, 151/115 Abay Ave., office 807 Telephone / fax 007 E-mail

Reviews

Reviews from patients who took the drug Noofen are quite different. Among them there are those who received excellent results, while for others the course of treatment did not help at all. Many agreed that the medicine is completely useless in the treatment of vegetative-vascular dystonia. There are cases of addiction to this drug.

There are many positive reviews from adults after using the product by children, especially in the first year of life. Mothers note that children have become calmer, move more adequately, sleep and eat better.

Doctors note that many take Noofen without a prescription on their own to relieve stress or improve memory, which is completely contraindicated.

Action

Aminophenylbutyric acid, which is part of Noofen, has the following effects on the human body:

calming – removes irritability, neutralizes anxiety and fear, relieves emotional stress;
nootropic – increases mental abilities, improves memory, enhances physical capabilities;
psychomotor – increases the speed of reactions, enhances attention;
physical – eliminates headache severity;
has a positive effect on the quality and duration of sleep.

An important quality of the drug is the absence of drowsiness during its use, and after stopping use, the absence of withdrawal syndrome.

What it is?

Noofen is a nootropic drug for the treatment of disorders of the nervous system and memory.

Nootropics belong to a group of drugs that stimulate metabolic processes in nerve cells. As a result of their influence, the brain works better and tolerates heavy loads well.

Noofen helps solve several problems:

relieves tension;
eliminates anxiety and fear;
improves memory;
promotes good sleep;
increases physical activity.

Noofen contains the main active substance – aminophenylbutyric acid hydrochloride (phenibut). If the drug is released in the form of tablets or capsules, each of them contains 0.25 g of phenibut. And one sachet of Noofen powder contains 100 or 500 mg of the active ingredient.

The medicine contains excipients: lactose, calcium stearate and potato starch.

The manufacturer of the drug is the Latvian pharmaceutical company. There are also analogues from other companies.

Side effects

Noofen generally does not cause serious side effects in adults. The exception is patients with individual intolerance to the drug. Therefore, it is better to familiarize yourself with possible side effects in advance. These include:

headache, dizziness;
drowsiness;
state of strong emotional arousal;
loss of appetite, nausea;
change in stool;
stomach pain, liver dysfunction;
increased activity of liver transminases;
itching, rash, urticaria;
angioedema, anaphylactic shock (rare).

Side effects such as drowsiness and nausea sometimes appear at the beginning of treatment with Noofen and disappear over time.

What is it prescribed for?

Noofen is prescribed for the treatment of various neurological diseases. These can be neuroses, psychopathy, chronic fatigue syndrome, obsessive and anxiety-neurotic conditions. Noofen helps children solve problems with stuttering, enuresis, and tics. For elderly patients, the drug is prescribed for insomnia.

Noofen is prescribed as a prophylactic before operations or unpleasant diagnostic procedures. It calms the nervous system and helps the patient to better tolerate them.

The medicine is used in the complex treatment of alcoholism in combination with other medications to relieve toxicity. It helps relieve mental and somatic disorders during withdrawal syndrome.

The drug is prescribed for the treatment of Meniere's disease, dizziness and problems of the vestibular system.

Noofen is prescribed to women for the treatment of cervicothoracic osteochondrosis and disorders during menopause.

Alcohol compatibility

Despite the fact that Noofen is used in complex treatment for alcoholism, its compatibility with alcohol is zero. It is not recommended to drink alcohol during treatment with Noofen. This is fraught with unpleasant consequences:

The drug enhances the effect of alcohol and can cause severe intoxication of the body even with a small dose of alcohol.
The main substance included in Noofen can cause gastrointestinal disorders and disruption of the functioning of other organs.
There is also an option for the body to develop tolerance to the medicine, when the usual dosage no longer helps. We have to raise it.
The most severe situations that arise as a result of the simultaneous use of medication and alcohol are delirium and deep fainting, turning into a coma.

Treatment of alcoholism with Noofen is possible only as prescribed by a doctor, with the correct dosage. It is not safe to take this drug on your own. This can lead to the following conditions:

nausea, vomiting;
severe gastrointestinal disorders;
dizziness, severe headaches;
skin allergic reactions;
increased anxiety;
panic attacks;
drowsiness and loss of consciousness.