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Viusid (Viusid) powder 3.2 g pack. No. 21 - Instructions

Dosage form

Powder for the preparation of solution for oral administration 3.2 g No. 21.

Compound

One sachet contains:

Active ingredients: glycyrrhizic acid 46.90 mg, glucosamine 690 mg, arginine 720 mg, glycine 393 mg, ascorbic acid 43 mg, pyridoxine hydrochloride 0.59 mg, calcium pantothenate 2.2 mg, folic acid 0.068 mg, cyanocobalamin 0.000395 mg, malic acid 704 mg, zinc sulfate 5 mg.

Excipients: maltodextrin (maltitol), lemon flavor (Brasil 162 A), mint flavor (R 200 AN), sodium methylparaben (E219), neohesperidin, guar gum.

Pharmacological properties

Pharmacokinetics

The effect of the drug is the combined effect of its components, so kinetic observations are not possible.

Pharmacodynamics

The complex of active components of Visuid ensures its biological and clinical effectiveness.

Glycyrrhizic acid has antiviral, anti-inflammatory, antipruritic and immunomodulatory effects. Acts on different types of DNA and RNA viruses in vitro and in vivo (Varicella zoster; Herpes simplex types 1 and 2; various types of human papillomavirus, including oncogenic ones). Interrupts the replication of viruses in the early stages, causes the virion to exit the capsid, thereby preventing its penetration into cells, which is associated with selective dose-dependent inhibition of phosphorylating kinase P. Interacts with virus structures (possibly with proteins), changing various phases of the viral cycle, which accompanied by irreversible inactivation of viral particles that are in a free state outside the cells. Blocks the introduction of active viral particles into the cell, disrupts the ability of the virus to induce the synthesis of new viral particles.

Induces the formation of interferon, which is one of the components of the antiviral effect. Inactivates these viruses in concentrations that are non-toxic for normally functioning cells. Mutant strains of viruses resistant to acyclovir and iodouridine are also highly sensitive to glycyrrhizic acid, like non-mutant strains. The anti-inflammatory activity of glycyrrhizic acid is combined with a stimulating effect on humoral and cellular immunity factors. Significantly inhibits the release of kinins by connective tissue cells in the area of inflammation.

Glucosamine stimulates the biosynthesis of proteoglycans, restores the cartilaginous surfaces of joints and intervertebral discs.

Glycine

It is a central neurotransmitter that regulates metabolism; normalizes and activates protective inhibition processes in the central nervous system, reduces psycho-emotional stress, and increases mental performance. Glycine has glycine- and GABA-ergic, alpha1-adrenergic blocking, antioxidant, and antitoxic effects; regulates the activity of glutamate (NMDA) receptors.

L-glycine (glycacol) - takes part in the synthesis of the most important substances for the body: nucleic acids, glutathione, bile acids, etc. Glycine is used in the synthesis of porphyrin, the precursor of heme in the hemoglobin molecule, as well as purine bases, the most important elements of nucleic acids. Glycine is part of the structure of glutathione, a sulfur-containing substance that plays a special role in the anti-radiation defense system.

Glycine is involved in detoxification reactions, being included in the composition of hippuric acid, as well as in the synthesis of bile acids (glycocholic acid). In addition, glycine is important in the biosynthesis of oxalic acid.

Stimulates the release of glucagon, which metabolizes glycogen into glucose.

Arginine is a mediator of nitric oxide, a factor that relaxes the endothelium of blood vessels of the heart, brain, and peripheral vessels; its effect is manifested in improving cardiac activity, reducing diastolic pressure, and improving microcirculation in various organs. Promotes mental focus, improves the formation of short-term memory. Helps stimulate the immune system by activating T cells.

Ascorbic acid is a water-soluble vitamin that plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps increase the body's resistance.

Ascorbic acid is an integral part of the system that protects the body from the harmful effects of free radicals and other oxidants, and also plays an important role in inflammatory processes and in the mechanism of action of leukocytes. Ascorbic acid is involved in the synthesis of intracellular mucopolysaccharides, which, along with collagen fibers, provide the strength of capillary walls.

Pyridoxine hydrochloride belongs to the group of water-soluble vitamins (vitamin B6). Replenishes vitamin B6 deficiency and has a regulating effect on the metabolism of amino acids and neurotransmitters.

In muscles (including the myocardium), pyridoxine activates the processes of glycogen breakdown and optimizes energy metabolism in them during hypoxia. Provides the synthesis of nicotinic acid (vitamin PP) from tryptophan. Regulates the metabolism of glutamic acid, methionine, cysteine.

In the nervous system, pyridoxine is involved in the synthesis of neurotransmitters: norepinephrine, dopamine, glycine, GABA and serotonin. At the same time, it changes the balance of these mediators towards the predominance of inhibitory mediators - GABA, glycine, and serotonin.

Stimulates heme synthesis in hemoglobin, increases the synthesis of bone marrow iron-binding protein (siderophilin), regulates the metabolism of vitamin B12 and folic acid.

Folic acid in the body is reduced to tetrahydrofolic acid, which is a coenzyme involved in metabolic processes. Necessary for the normal formation of blood cells, including the processes of maturation of megaloblasts and their transformation into normoblasts. It is a cofactor for enzymes involved in the synthesis of purine and pyrimidine bases, DNA and RNA, in the synthesis of proteins, amino acids (methionine, serine), and in choline metabolism.

Folic acid plays an important role in cell division processes, which is especially important for tissues that are actively dividing and differentiating; promotes the connection of protein groups and heme in hemoglobin and myoglobin. Ultimately, it stimulates erythro-, leuko- and thrombocytopoiesis, plastic and regenerative processes in all organs and tissues. Lack of folic acid inhibits the transition from the megaloblastic phase of hematopoiesis to the normoblastic phase and leads to megaloblastic anemia (increased red blood cell volume).

Cyanocobalamin has a metabolic and hematopoietic effect. In the body (mainly in the liver) it is converted into a coenzyme form - adenosylcobalamin, or cobamamide, which is the active form of cyanocobalamin and is part of numerous enzymes, incl. part of a reductase that reduces folic acid to tetrahydrofolic acid.

Cobamamide is involved in the transfer of methyl and other one-carbon fragments, therefore it is necessary for the formation of deoxyribose and DNA, creatine, methionine - a donor of methyl groups, in the synthesis of lipotropic factor - choline, for the conversion of methylmalonic acid into succinic acid, which is part of myelin, for the utilization of propionic acid . Necessary for normal hematopoiesis - promotes the maturation of red blood cells.

Activates the blood coagulation system, in high doses causes an increase in thromboplastic activity and prothrombin activity. Reduces the concentration of cholesterol in the blood. Has a beneficial effect on the function of the liver and nervous system. Increases the ability of tissues to regenerate.

Zinc sulfate stimulates the synthesis of nucleic acids, proteins, tissue regeneration, and promotes weight gain. Zinc is necessary for the functioning of insulin, sex hormones, maintains the stability of cell membranes, limiting the release of histamine from mast cells. It limits free radical reactions and prevents damage to cell membranes. Zinc is necessary for the normal activity of lymphoid tissue, alkaline phosphatase, carboxypeptidases, and alcohol dehydrogenase. Zinc increases resistance to infectious diseases, promotes wound healing, accelerates growth, increases performance, improves memory, and prevents hair loss.

Calcium pantothenate

The calcium salt of pantothenic acid is a component of coenzyme A, which plays a central role in acetylation (Krebs cycle), in the metabolism of fats, carbohydrates and amino acids.

Apple acid

Along with succinic and citric acids, it is synthesized by all cells of the body. The use of these very important metabolites, which participate in redox reactions and stimulate energy production through ATP synthesis, allows the body to obtain more energy than through anaerobic oxidation of glucose. Normalizes compensatory metabolic reactions in the tissues of the body of adults and children, activates the oxidative functions of mitochondria.

It has antiviral properties and a pronounced antioxidant effect. Restores the performance of the heart muscle and other body systems during fatigue, after heavy physical exertion and in a post-hypoxic state, making it possible to restore blood pressure in a shorter time (after 10-20 minutes) in case of hypotension. Reduces the toxic effects of alcohol and drugs.

Indications for use

As part of complex therapy:

- hepatitis A, B, C

- herpetic infection (herpes simplex virus types 1 and 2, human papillomavirus, herpes zoster)

- cytomegalovirus infection

- asthenic conditions

— opportunistic infections in HIV-infected patients

- influenza and other acute respiratory viral infections.

Directions for use and doses

Before use, Visuida powder is dissolved in a small amount (100 ml) of water:

For adults

When treating acute viral infections, such as cytomegalovirus, herpes simplex virus, herpes zoster, human papillomavirus infection, it is recommended to take 1 sachet 2 times a day for 3 weeks.

For acute viral hepatitis A, B, C - 1 sachet 2 times a day for 4 weeks, then 1-2 sachets a day 3 times a week, for a long time (3 months)

For chronic forms of hepatitis - 1-2 sachets per day for 2-3 months.

For asthenic conditions, use 1 sachet 2 times a day for 2-3 weeks.

For opportunistic infections in HIV-infected patients -

1 sachet 2 times a day for 1-2 months, then a maintenance dose of 1-2 sachets per day 3 times a week for a long time.

For the prevention and treatment of influenza, ARVI - 2 sachets per day for 7-10 days.

In order to avoid the occurrence of allergic reactions, before starting the course of treatment, it is necessary to carry out trial prescriptions in minimal dosages (¼ sachet 2 times a day for 2-3 days).

For children

For childhood viral infections and ARVI: from 0 to 3 years - 1/4 sachet 3 times a day; from 3-7 years – 1/3 sachet 3 times a day; from 7-12 years – ½ sachet 3 times a day.

Side effects

- allergic reactions in the form of skin rashes

- increased activity of liver transaminases (AST, ALT).

Contraindications

- hypersensitivity to the components of the drug - chronic hepatitis (maximum activity)

Drug interactions

It is not recommended to take Visuid simultaneously with the following medications:

B vitamins (B6, B12), folic acid, vitamins A, C, glycine, calcium pantothenate, Essentiale and other complex drugs that are part of the components of Visuid.

Acts synergistically with ά-interferon, with antiretroviral drugs: acyclovir, ganciclovir, reduces the side effects of antiviral drugs.

When using Visuid together with glucocorticosteroids, it is recommended to reduce the dose of Visuid.

special instructions

Pregnancy and lactation

During pregnancy and lactation, take after consultation with a doctor.

Use in pediatrics

Use for children as prescribed by a doctor.

Features of the effect of the drug on the ability to drive vehicles and potentially dangerous mechanisms

The drug does not affect the ability to drive or perform work that requires increased concentration.

Overdose

There is no data on overdose.

Storage conditions

Store at a temperature not exceeding 25 C.

Keep out of the reach of children!

Shelf life

3 years

Do not use after expiration date.

Vacation conditions

Over the counter.

Recommendations for use

"Viusid" is recommended for increasing the body's immune defense as a restorative and general strengthening agent for various conditions characterized by decreased function of the immune system and the development of immunodeficiency (including such serious diseases as AIDS, cancer, tuberculosis, hepatitis B and C, herpes, papilloma and others) , as well as during influenza epidemics, seasonal acute respiratory infections, during and after treatment of viral and bacterial diseases, in chronic inflammatory processes, including those with an allergic component.